Infrared neural stimulation of human spinal nerve roots in vivo
Identifieur interne : 000055 ( Pmc/Curation ); précédent : 000054; suivant : 000056Infrared neural stimulation of human spinal nerve roots in vivo
Auteurs : Jonathan M. Cayce [États-Unis] ; Jonathon D. Wells [États-Unis] ; Jonathan D. Malphrus [États-Unis] ; Chris Kao [États-Unis] ; Sharon Thomsen [États-Unis] ; Noel B. Tulipan [États-Unis] ; Peter E. Konrad [États-Unis] ; E. Duco Jansen [États-Unis] ; Anita Mahadevan-Jansen [États-Unis]Source :
- Neurophotonics [ 2329-423X ] ; 2015.
Abstract
Infrared neural stimulation (INS) is a neurostimulation modality that uses pulsed infrared light to evoke artifact-free, spatially precise neural activity with a noncontact interface; however, the technique has not been demonstrated in humans. The objective of this study is to demonstrate the safety and efficacy of INS in humans
Url:
DOI: 10.1117/1.NPh.2.1.015007
PubMed: 26157986
PubMed Central: 4478764
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<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>University of Texas</institution>
, Department of Biomedical Engineering, Austin, Texas, and 500 Discovery View Drive, Sequim, Washington 98382,<country>United States</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Tulipan, Noel B" sort="Tulipan, Noel B" uniqKey="Tulipan N" first="Noel B." last="Tulipan">Noel B. Tulipan</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Vanderbilt University</institution>
, Department of Neurological Surgery, 1161 21st Avenue, Nashville, Tennessee 37232-2380,<country>United States</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Konrad, Peter E" sort="Konrad, Peter E" uniqKey="Konrad P" first="Peter E." last="Konrad">Peter E. Konrad</name>
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<author><name sortKey="Jansen, E Duco" sort="Jansen, E Duco" uniqKey="Jansen E" first="E. Duco" last="Jansen">E. Duco Jansen</name>
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<author><name sortKey="Mahadevan Jansen, Anita" sort="Mahadevan Jansen, Anita" uniqKey="Mahadevan Jansen A" first="Anita" last="Mahadevan-Jansen">Anita Mahadevan-Jansen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vanderbilt University</institution>
, Department of Biomedical Engineering, 5824 Stevenson Center, Station B, Box 351631 Nashville, Tennessee 37235-1631,<country>United States</country>
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<series><title level="j">Neurophotonics</title>
<idno type="ISSN">2329-423X</idno>
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<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><title>Abstract.</title>
<p>Infrared neural stimulation (INS) is a neurostimulation modality that uses pulsed infrared light to evoke artifact-free, spatially precise neural activity with a noncontact interface; however, the technique has not been demonstrated in humans. The objective of this study is to demonstrate the safety and efficacy of INS in humans <italic>in vivo</italic>
. The feasibility of INS in humans was assessed in patients (<inline-formula><mml:math id="M1"><mml:mrow><mml:mi>n</mml:mi>
<mml:mo>=</mml:mo>
<mml:mn>7</mml:mn>
</mml:mrow>
</mml:math>
</inline-formula>
) undergoing selective dorsal root rhizotomy, where hyperactive dorsal roots, identified for transection, were stimulated <italic>in vivo</italic>
with INS on two to three sites per nerve with electromyogram recordings acquired throughout the stimulation. The stimulated dorsal root was removed and histology was performed to determine thermal damage thresholds of INS. Threshold activation of human dorsal rootlets occurred in 63% of nerves for radiant exposures between 0.53 and <inline-formula><mml:math id="M2"><mml:mrow><mml:mn>1.23</mml:mn>
<mml:mtext> </mml:mtext>
<mml:mtext> </mml:mtext>
<mml:mi mathvariant="normal">J</mml:mi>
<mml:mo stretchy="false">/</mml:mo>
<mml:msup><mml:mrow><mml:mi>cm</mml:mi>
</mml:mrow>
<mml:mrow><mml:mn>2</mml:mn>
</mml:mrow>
</mml:msup>
</mml:mrow>
</mml:math>
</inline-formula>
. In all cases, only one or two monitored muscle groups were activated from INS stimulation of a hyperactive spinal root identified by electrical stimulation. Thermal damage was first noted at <inline-formula><mml:math id="M3"><mml:mrow><mml:mn>1.09</mml:mn>
<mml:mtext> </mml:mtext>
<mml:mtext> </mml:mtext>
<mml:mi mathvariant="normal">J</mml:mi>
<mml:mo stretchy="false">/</mml:mo>
<mml:msup><mml:mrow><mml:mi>cm</mml:mi>
</mml:mrow>
<mml:mrow><mml:mn>2</mml:mn>
</mml:mrow>
</mml:msup>
</mml:mrow>
</mml:math>
</inline-formula>
and a <inline-formula><mml:math id="M4"><mml:mrow><mml:mn>2</mml:mn>
<mml:mo>∶</mml:mo>
<mml:mn>1</mml:mn>
</mml:mrow>
</mml:math>
</inline-formula>
safety ratio was identified. These findings demonstrate the success of INS as a fresh approach for activating human nerves <italic>in vivo</italic>
and providing the necessary safety data needed to pursue clinically driven therapeutic and diagnostic applications of INS in humans.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurophotonics</journal-id>
<journal-id journal-id-type="iso-abbrev">Neurophotonics</journal-id>
<journal-id journal-id-type="coden">NEUROW</journal-id>
<journal-id journal-id-type="publisher-id">NPh</journal-id>
<journal-title-group><journal-title>Neurophotonics</journal-title>
</journal-title-group>
<issn pub-type="ppub">2329-423X</issn>
<issn pub-type="epub">2329-4248</issn>
<publisher><publisher-name>Society of Photo-Optical Instrumentation Engineers</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26157986</article-id>
<article-id pub-id-type="pmc">4478764</article-id>
<article-id pub-id-type="doi">10.1117/1.NPh.2.1.015007</article-id>
<article-id pub-id-type="publisher-manuscript">NPH-14075R</article-id>
<article-id pub-id-type="publisher-id">14075R</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Papers</subject>
</subj-group>
<subj-group subj-group-type="SPIE-art-type"><subject>Paper</subject>
</subj-group>
</article-categories>
<title-group><article-title>Infrared neural stimulation of human spinal nerve roots <italic>in vivo</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Cayce</surname>
<given-names>Jonathan M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">a</xref>
<xref ref-type="other" rid="b1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wells</surname>
<given-names>Jonathon D.</given-names>
</name>
<xref ref-type="aff" rid="aff2">b</xref>
<xref ref-type="other" rid="b2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Malphrus</surname>
<given-names>Jonathan D.</given-names>
</name>
<xref ref-type="aff" rid="aff1">a</xref>
<xref ref-type="other" rid="b3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kao</surname>
<given-names>Chris</given-names>
</name>
<xref ref-type="aff" rid="aff3">c</xref>
<xref ref-type="other" rid="b4"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thomsen</surname>
<given-names>Sharon</given-names>
</name>
<xref ref-type="aff" rid="aff4">d</xref>
<xref ref-type="other" rid="b5"></xref>
<xref ref-type="author-notes" rid="fn1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tulipan</surname>
<given-names>Noel B.</given-names>
</name>
<xref ref-type="aff" rid="aff3">c</xref>
<xref ref-type="other" rid="b6"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Konrad</surname>
<given-names>Peter E.</given-names>
</name>
<xref ref-type="aff" rid="aff1">a</xref>
<xref ref-type="aff" rid="aff3">c</xref>
<xref ref-type="other" rid="b7"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jansen</surname>
<given-names>E. Duco</given-names>
</name>
<xref ref-type="aff" rid="aff1">a</xref>
<xref ref-type="aff" rid="aff3">c</xref>
<xref ref-type="other" rid="b8"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mahadevan-Jansen</surname>
<given-names>Anita</given-names>
</name>
<xref ref-type="aff" rid="aff1">a</xref>
<xref ref-type="aff" rid="aff3">c</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
<xref ref-type="other" rid="b9"></xref>
</contrib>
<aff id="aff1"><label>a</label>
<institution>Vanderbilt University</institution>
, Department of Biomedical Engineering, 5824 Stevenson Center, Station B, Box 351631 Nashville, Tennessee 37235-1631,<country>United States</country>
</aff>
<aff id="aff2"><label>b</label>
<institution>Lockheed Martin</institution>
, 22121 20th Avenue SE, Bothell, Washington 98021,<country>United States</country>
</aff>
<aff id="aff3"><label>c</label>
<institution>Vanderbilt University</institution>
, Department of Neurological Surgery, 1161 21st Avenue, Nashville, Tennessee 37232-2380,<country>United States</country>
</aff>
<aff id="aff4"><label>d</label>
<institution>University of Texas</institution>
, Department of Biomedical Engineering, Austin, Texas, and 500 Discovery View Drive, Sequim, Washington 98382,<country>United States</country>
</aff>
</contrib-group>
<author-notes><corresp id="cor1"><label>*</label>
Address all correspondence to: Anita Mahadevan-Jansen, E-mail: <email>anita.mahadevan-jansen@vanderbilt.edu</email>
</corresp>
<fn id="fn1"><label>†</label>
<p>Retired pathologist.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>23</day>
<month>2</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>1</month>
<year>2015</year>
</pub-date>
<volume>2</volume>
<issue>1</issue>
<elocation-id>015007</elocation-id>
<history><date date-type="received"><day>12</day>
<month>11</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>12</day>
<month>1</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Society of Photo-Optical Instrumentation Engineers</copyright-holder>
<license license-type="ccc"><license-p>2329-423X/2015/<price>$25.00</price>
© 2015 SPIE</license-p>
</license>
</permissions>
<abstract><title>Abstract.</title>
<p>Infrared neural stimulation (INS) is a neurostimulation modality that uses pulsed infrared light to evoke artifact-free, spatially precise neural activity with a noncontact interface; however, the technique has not been demonstrated in humans. The objective of this study is to demonstrate the safety and efficacy of INS in humans <italic>in vivo</italic>
. The feasibility of INS in humans was assessed in patients (<inline-formula><mml:math id="M1"><mml:mrow><mml:mi>n</mml:mi>
<mml:mo>=</mml:mo>
<mml:mn>7</mml:mn>
</mml:mrow>
</mml:math>
</inline-formula>
) undergoing selective dorsal root rhizotomy, where hyperactive dorsal roots, identified for transection, were stimulated <italic>in vivo</italic>
with INS on two to three sites per nerve with electromyogram recordings acquired throughout the stimulation. The stimulated dorsal root was removed and histology was performed to determine thermal damage thresholds of INS. Threshold activation of human dorsal rootlets occurred in 63% of nerves for radiant exposures between 0.53 and <inline-formula><mml:math id="M2"><mml:mrow><mml:mn>1.23</mml:mn>
<mml:mtext> </mml:mtext>
<mml:mtext> </mml:mtext>
<mml:mi mathvariant="normal">J</mml:mi>
<mml:mo stretchy="false">/</mml:mo>
<mml:msup><mml:mrow><mml:mi>cm</mml:mi>
</mml:mrow>
<mml:mrow><mml:mn>2</mml:mn>
</mml:mrow>
</mml:msup>
</mml:mrow>
</mml:math>
</inline-formula>
. In all cases, only one or two monitored muscle groups were activated from INS stimulation of a hyperactive spinal root identified by electrical stimulation. Thermal damage was first noted at <inline-formula><mml:math id="M3"><mml:mrow><mml:mn>1.09</mml:mn>
<mml:mtext> </mml:mtext>
<mml:mtext> </mml:mtext>
<mml:mi mathvariant="normal">J</mml:mi>
<mml:mo stretchy="false">/</mml:mo>
<mml:msup><mml:mrow><mml:mi>cm</mml:mi>
</mml:mrow>
<mml:mrow><mml:mn>2</mml:mn>
</mml:mrow>
</mml:msup>
</mml:mrow>
</mml:math>
</inline-formula>
and a <inline-formula><mml:math id="M4"><mml:mrow><mml:mn>2</mml:mn>
<mml:mo>∶</mml:mo>
<mml:mn>1</mml:mn>
</mml:mrow>
</mml:math>
</inline-formula>
safety ratio was identified. These findings demonstrate the success of INS as a fresh approach for activating human nerves <italic>in vivo</italic>
and providing the necessary safety data needed to pursue clinically driven therapeutic and diagnostic applications of INS in humans.</p>
</abstract>
<kwd-group><title>Keywords:</title>
<kwd>infrared neural stimulation</kwd>
<kwd>neurophotonics</kwd>
<kwd>spinal nerve roots</kwd>
<kwd>electromyography</kwd>
<kwd>optics</kwd>
</kwd-group>
<funding-group><award-group id="sp1"><funding-source>W. M. Keck Foundation Free Electron Laser Center, MFEL/AFOSR program</funding-source>
<award-id>FA9550-04-1-0045</award-id>
</award-group>
<award-group id="sp2"><funding-source>National Institutes of Health</funding-source>
<award-id>R01 NS052407-01</award-id>
</award-group>
</funding-group>
<counts><fig-count count="4"></fig-count>
<table-count count="0"></table-count>
<ref-count count="51"></ref-count>
<page-count count="9"></page-count>
</counts>
<custom-meta-group><custom-meta><meta-name>running-head</meta-name>
<meta-value>Cayce et al.: Infrared neural stimulation of human spinal nerve roots <italic>in vivo</italic>
</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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