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1H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging

Identifieur interne : 000559 ( Ncbi/Curation ); précédent : 000558; suivant : 000560

1H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging

Auteurs : Yan Yang [République populaire de Chine] ; Daniel T. Schühle ; Guangping Dai ; Jamu Alford ; Peter Caravan

Source :

Contrast media & molecular imaging [ 1555-4309 ] ; 2012.

RBID : PMC:3321363

Abstract

Proton-based chemical shift imaging (CSI) probes were encapsulated inside nano-carriers to increase the sensivitity of the reporters. Co-encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321363

DOI: 10.1002/cmmi.490
PubMed: 22434641
PubMed Central: 3321363

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Yan Yang

<affiliation><nlm:aff id="A1">A.A. Martinos Center for Biomedical Imaging Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA. Fax: (+1) 617-726-7422</nlm:aff>
<wicri:noCountry code="subfield">USA. Fax: (+1) 617-726-7422</wicri:noCountry>
</affiliation>

<affiliation wicri:level="1"><nlm:aff id="A2">Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, Hubei Province, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>

Daniel T. Schühle

<affiliation><nlm:aff id="A1">A.A. Martinos Center for Biomedical Imaging Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA. Fax: (+1) 617-726-7422</nlm:aff>
<wicri:noCountry code="subfield">USA. Fax: (+1) 617-726-7422</wicri:noCountry>
</affiliation>

Guangping Dai

<affiliation><nlm:aff id="A1">A.A. Martinos Center for Biomedical Imaging Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA. Fax: (+1) 617-726-7422</nlm:aff>
<wicri:noCountry code="subfield">USA. Fax: (+1) 617-726-7422</wicri:noCountry>
</affiliation>

Jamu Alford

<affiliation><nlm:aff id="A1">A.A. Martinos Center for Biomedical Imaging Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA. Fax: (+1) 617-726-7422</nlm:aff>
<wicri:noCountry code="subfield">USA. Fax: (+1) 617-726-7422</wicri:noCountry>
</affiliation>

Peter Caravan

<affiliation><nlm:aff id="A1">A.A. Martinos Center for Biomedical Imaging Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA. Fax: (+1) 617-726-7422</nlm:aff>
<wicri:noCountry code="subfield">USA. Fax: (+1) 617-726-7422</wicri:noCountry>
</affiliation>

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H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging</title>
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H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging</title>
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1H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging

1H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging

Source :

Abstract

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