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1H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging

Identifieur interne : 000559 ( Ncbi/Merge ); précédent : 000558; suivant : 000560

1H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging

Auteurs : Yan Yang [République populaire de Chine] ; Daniel T. Schühle ; Guangping Dai ; Jamu Alford ; Peter Caravan

Source :

Contrast media & molecular imaging [ 1555-4309 ] ; 2012.

RBID : PMC:3321363

Abstract

Proton-based chemical shift imaging (CSI) probes were encapsulated inside nano-carriers to increase the sensivitity of the reporters. Co-encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321363

DOI: 10.1002/cmmi.490
PubMed: 22434641
PubMed Central: 3321363

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PMC:3321363

Le document en format XML

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H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging</title>
<author><name sortKey="Yang, Yan" sort="Yang, Yan" uniqKey="Yang Y" first="Yan" last="Yang">Yan Yang</name>
<affiliation><nlm:aff id="A1">A.A. Martinos Center for Biomedical Imaging Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA. Fax: (+1) 617-726-7422</nlm:aff>
<wicri:noCountry code="subfield">USA. Fax: (+1) 617-726-7422</wicri:noCountry>
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H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Proton-based chemical shift imaging (CSI) probes were encapsulated inside nano-carriers to increase the sensivitity of the reporters. Co-encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">101286760</journal-id>
<journal-id journal-id-type="pubmed-jr-id">33141</journal-id>
<journal-id journal-id-type="nlm-ta">Contrast Media Mol Imaging</journal-id>
<journal-id journal-id-type="iso-abbrev">Contrast Media Mol Imaging</journal-id>
<journal-title-group><journal-title>Contrast media & molecular imaging</journal-title>
</journal-title-group>
<issn pub-type="ppub">1555-4309</issn>
<issn pub-type="epub">1555-4317</issn>
</journal-meta>
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<article-id pub-id-type="doi">10.1002/cmmi.490</article-id>
<article-id pub-id-type="manuscript">NIHMS365220</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title><sup>1</sup>
H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Yan</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
<xref rid="FN1" ref-type="author-notes">‡</xref>
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<contrib contrib-type="author"><name><surname>Schühle</surname>
<given-names>Daniel T.</given-names>
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<xref ref-type="aff" rid="A1">a</xref>
<xref rid="FN1" ref-type="author-notes">‡</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dai</surname>
<given-names>Guangping</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alford</surname>
<given-names>Jamu</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Caravan</surname>
<given-names>Peter</given-names>
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<email>caravan@nmr.mgh.harvard.edu</email>
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<aff id="A1"><label>a</label>
A.A. Martinos Center for Biomedical Imaging Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA. Fax: (+1) 617-726-7422</aff>
<aff id="A2"><label>b</label>
Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, Hubei Province, China</aff>
<author-notes><fn id="FN1" fn-type="equal"><label>‡</label>
<p>Both authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>20</day>
<month>3</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><season>Mar-Apr</season>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>3</month>
<year>2013</year>
</pub-date>
<volume>7</volume>
<issue>2</issue>
<fpage>276</fpage>
<lpage>279</lpage>
<abstract><p id="P1">Proton-based chemical shift imaging (CSI) probes were encapsulated inside nano-carriers to increase the sensivitity of the reporters. Co-encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source>
<award-id>S10 RR025563-01 || RR</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute of Biomedical Imaging and Bioengineering : NIBIB</funding-source>
<award-id>R01 EB009062-03 || EB</award-id>
</award-group>
<award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source>
<award-id>P41 RR014075-06 || RR</award-id>
</award-group>
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<name sortKey="Dai, Guangping" sort="Dai, Guangping" uniqKey="Dai G" first="Guangping" last="Dai">Guangping Dai</name>
<name sortKey="Schuhle, Daniel T" sort="Schuhle, Daniel T" uniqKey="Schuhle D" first="Daniel T." last="Schühle">Daniel T. Schühle</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Yang, Yan" sort="Yang, Yan" uniqKey="Yang Y" first="Yan" last="Yang">Yan Yang</name>
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1H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging

1H Chemical Shift Magnetic Resonance Imaging Probes with High Sensitivity for Multiplex Imaging

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Abstract

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