Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA-).
Identifieur interne : 000138 ( Ncbi/Curation ); précédent : 000137; suivant : 000139Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA-).
Auteurs : Sait Kubilay Pakin [États-Unis] ; S K Hekmatyar ; Paige Hopewell ; Andriy Babsky ; Navin BansalSource :
- NMR in biomedicine [ 0952-3480 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Composés organométalliques, Encéphale (physiologie), Fantômes en imagerie, Imagerie par résonance magnétique (), Imagerie par résonance magnétique (instrumentation), Interprétation d'image assistée par ordinateur (), Rats, Rats de lignée F344, Reproductibilité des résultats, Régulation de la température corporelle (physiologie), Sensibilité et spécificité, Thermographie (), Études de faisabilité.
- MESH :
- physiologie : Encéphale, Régulation de la température corporelle.
- Animaux, Composés organométalliques, Fantômes en imagerie, Imagerie par résonance magnétique, Interprétation d'image assistée par ordinateur, Rats, Rats de lignée F344, Reproductibilité des résultats, Sensibilité et spécificité, Thermographie, Études de faisabilité.
English descriptors
- KwdEn :
- Animals, Body Temperature Regulation (physiology), Brain (physiology), Feasibility Studies, Image Interpretation, Computer-Assisted (methods), Magnetic Resonance Imaging (instrumentation), Magnetic Resonance Imaging (methods), Organometallic Compounds, Phantoms, Imaging, Rats, Rats, Inbred F344, Reproducibility of Results, Sensitivity and Specificity, Thermography (methods).
- MESH :
- chemical : Organometallic Compounds.
- instrumentation : Magnetic Resonance Imaging.
- methods : Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Thermography.
- physiology : Body Temperature Regulation, Brain.
- Animals, Feasibility Studies, Phantoms, Imaging, Rats, Rats, Inbred F344, Reproducibility of Results, Sensitivity and Specificity.
Abstract
Non-invasive thermometry using hyperfine-shifted MR signals from paramagnetic lanthanide complexes has attracted attention recently because the chemical shifts of these complexes are many times more sensitive to temperature than the water 1H signal. Among all the lanthanide complexes examined thus far, thulium tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTMA-) appears to be the most suitable for MR thermometry. In this paper, the feasibility of imaging the methyl 1H signal from TmDOTMA- using a frequency-selective radiofrequency excitation pulse and chemical shift-selective (CHESS) water suppression is demonstrated. A temperature imaging method using a phase-sensitive spin-echo imaging sequence was validated in phantom experiments. A comparison of regional temperature changes measured with fiber-optic probes and the temperatures calculated from the phase shift near each probe showed that the accuracy of imaging the temperature with TmDOTMA- is at least 0.1-0.2 degrees C. The feasibility of imaging temperature changes in an intact rat at 0.5-0.6 mmol/kg dose in only a few minutes is demonstrated. Similar to commonly used MRI contrast agents, the lanthanide complex does not cross the blood-brain barrier. TmDOTMA- may prove useful for temperature imaging in many biomedical applications but further studies relating to acceptable dose and signal-to-noise ratio are necessary before clinical applications.
DOI: 10.1002/nbm.1010
PubMed: 16404728
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pubmed:16404728Le document en format XML
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first="Paige" last="Hopewell">Paige Hopewell</name></author><author><name sortKey="Babsky, Andriy" sort="Babsky, Andriy" uniqKey="Babsky A" first="Andriy" last="Babsky">Andriy Babsky</name></author><author><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/nbm.1010</idno><idno type="RBID">pubmed:16404728</idno><idno type="pmid">16404728</idno><idno type="wicri:Area/PubMed/Corpus">000647</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000647</idno><idno type="wicri:Area/PubMed/Curation">000647</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000647</idno><idno type="wicri:Area/PubMed/Checkpoint">000647</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000647</idno><idno 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Hekmatyar</name></author><author><name sortKey="Hopewell, Paige" sort="Hopewell, Paige" uniqKey="Hopewell P" first="Paige" last="Hopewell">Paige Hopewell</name></author><author><name sortKey="Babsky, Andriy" sort="Babsky, Andriy" uniqKey="Babsky A" first="Andriy" last="Babsky">Andriy Babsky</name></author><author><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name></author></analytic><series><title level="j">NMR in biomedicine</title><idno type="ISSN">0952-3480</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Body Temperature Regulation (physiology)</term><term>Brain (physiology)</term><term>Feasibility Studies</term><term>Image Interpretation, Computer-Assisted (methods)</term><term>Magnetic Resonance Imaging (instrumentation)</term><term>Magnetic Resonance Imaging (methods)</term><term>Organometallic Compounds</term><term>Phantoms, Imaging</term><term>Rats</term><term>Rats, Inbred F344</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Thermography (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Composés organométalliques</term><term>Encéphale (physiologie)</term><term>Fantômes en imagerie</term><term>Imagerie par résonance magnétique ()</term><term>Imagerie par résonance magnétique (instrumentation)</term><term>Interprétation d'image assistée par ordinateur ()</term><term>Rats</term><term>Rats de lignée F344</term><term>Reproductibilité des résultats</term><term>Régulation de la température corporelle (physiologie)</term><term>Sensibilité et spécificité</term><term>Thermographie ()</term><term>Études de faisabilité</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Interpretation, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Thermography</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Encéphale</term><term>Régulation de la température corporelle</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Body Temperature Regulation</term><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Feasibility Studies</term><term>Phantoms, Imaging</term><term>Rats</term><term>Rats, Inbred F344</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Composés organométalliques</term><term>Fantômes en imagerie</term><term>Imagerie par résonance magnétique</term><term>Interprétation d'image assistée par ordinateur</term><term>Rats</term><term>Rats de lignée F344</term><term>Reproductibilité des résultats</term><term>Sensibilité et spécificité</term><term>Thermographie</term><term>Études de faisabilité</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non-invasive thermometry using hyperfine-shifted MR signals from paramagnetic lanthanide complexes has attracted attention recently because the chemical shifts of these complexes are many times more sensitive to temperature than the water 1H signal. Among all the lanthanide complexes examined thus far, thulium tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTMA-) appears to be the most suitable for MR thermometry. In this paper, the feasibility of imaging the methyl 1H signal from TmDOTMA- using a frequency-selective radiofrequency excitation pulse and chemical shift-selective (CHESS) water suppression is demonstrated. A temperature imaging method using a phase-sensitive spin-echo imaging sequence was validated in phantom experiments. A comparison of regional temperature changes measured with fiber-optic probes and the temperatures calculated from the phase shift near each probe showed that the accuracy of imaging the temperature with TmDOTMA- is at least 0.1-0.2 degrees C. The feasibility of imaging temperature changes in an intact rat at 0.5-0.6 mmol/kg dose in only a few minutes is demonstrated. Similar to commonly used MRI contrast agents, the lanthanide complex does not cross the blood-brain barrier. TmDOTMA- may prove useful for temperature imaging in many biomedical applications but further studies relating to acceptable dose and signal-to-noise ratio are necessary before clinical applications.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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