Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent
Identifieur interne : 000273 ( Ncbi/Checkpoint ); précédent : 000272; suivant : 000274Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent
Auteurs : Daniel Coman [États-Unis] ; Hubert K. Trubel [États-Unis, Allemagne] ; Robert E. Rycyna [États-Unis] ; Fahmeed Hyder [États-Unis]Source :
- NMR in biomedicine [ 0952-3480 ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Thulium.
- chemical : Protons.
- methods : Magnetic Resonance Spectroscopy, Thermography.
- physiology : Body Temperature, Brain.
- Algorithms, Animals, Hydrogen-Ion Concentration, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity.
Abstract
Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly due to lack of precise and non-invasive methods. At 11.7T, we demonstrate that a thulium-based macrocyclic complex infused through the blood stream can be used to obtain temperature and pH maps of rat brain
Url:
DOI: 10.1002/nbm.1312
PubMed: 19130468
PubMed Central: 2735415
Affiliations:
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<term>Hydrogen-Ion Concentration</term>
<term>Magnetic Resonance Spectroscopy (methods)</term>
<term>Protons</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
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<term>Sensitivity and Specificity</term>
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<term>Concentration en ions d'hydrogène</term>
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<term>Protons</term>
<term>Rat Sprague-Dawley</term>
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<term>Reproductibilité des résultats</term>
<term>Sensibilité et spécificité</term>
<term>Spectroscopie par résonance magnétique ()</term>
<term>Température du corps (physiologie)</term>
<term>Thermographie ()</term>
<term>Thulium (analyse)</term>
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<term>Hydrogen-Ion Concentration</term>
<term>Rats</term>
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<term>Sensitivity and Specificity</term>
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<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Reproductibilité des résultats</term>
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<front><div type="abstract" xml:lang="en"><p id="P3">Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly due to lack of precise and non-invasive methods. At 11.7T, we demonstrate that a thulium-based macrocyclic complex infused through the blood stream can be used to obtain temperature and pH maps of rat brain <italic>in vivo</italic>
by <sup>1</sup>
H chemical shift imaging (CSI) of the sensor itself in conjunction with a multi-parametric model that depends on several proton resonances of the sensor. Accuracies of temperature and pH determination with the thulium sensor – which has a predominantly extracellular presence – depend on stable signals during the course of the CSI experiment as well as redundancy for temperature and pH sensitivities contained within the observed signals. The thulium-based method compared well with other methods for temperature (<sup>1</sup>
H magnetic resonance spectroscopy (MRS) of N-acetyl aspartate and water; copper-constantan thermocouple wire) and pH (<sup>31</sup>
P MRS of inorganic phosphate and phosphocreatine) assessment, as established by <italic>in vitro</italic>
and <italic>in vivo</italic>
studies. <italic>In vitro</italic>
studies in phantoms with two compartments of differing pH values observed under different ambient temperature conditions generated precise temperature and pH distribution maps. <italic>In vivo</italic>
studies in α-chloralose anesthetized and renal-ligated rats revealed temperature (33–34 °C) and pH (7.3–7.4) distributions in the cerebral cortex which are in agreement with observations by other methods. These results demonstrate that the thulium sensor can be used to measure temperature and pH distributions in rat brain <italic>in vivo</italic>
simultaneously and accurately with <sup>1</sup>
H CSI.</p>
</div>
</front>
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