ThuliumV1, Ncbi, Curation, bibRecord, 000273

Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent

Identifieur interne : 000273 ( Ncbi/Curation ); précédent : 000272; suivant : 000274

Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent

Auteurs : Daniel Coman [États-Unis] ; Hubert K. Trubel [États-Unis, Allemagne] ; Robert E. Rycyna [États-Unis] ; Fahmeed Hyder [États-Unis]

Source :

NMR in biomedicine [ 0952-3480 ] ; 2009.

RBID : PMC:2735415

Descripteurs français

KwdFr :
- Algorithmes, Animaux, Concentration en ions d'hydrogène, Encéphale (physiologie), Protons, Rat Sprague-Dawley, Rats, Reproductibilité des résultats, Sensibilité et spécificité, Spectroscopie par résonance magnétique (), Température du corps (physiologie), Thermographie (), Thulium (analyse).
MESH :
- analyse : Thulium.
- physiologie : Encéphale, Température du corps.
- Algorithmes, Animaux, Concentration en ions d'hydrogène, Protons, Rat Sprague-Dawley, Rats, Reproductibilité des résultats, Sensibilité et spécificité, Spectroscopie par résonance magnétique, Thermographie.

English descriptors

KwdEn :
- Algorithms, Animals, Body Temperature (physiology), Brain (physiology), Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy (methods), Protons, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Thermography (methods), Thulium (analysis).
MESH :
- chemical , analysis : Thulium.
- chemical : Protons.
- methods : Magnetic Resonance Spectroscopy, Thermography.
- physiology : Body Temperature, Brain.
- Algorithms, Animals, Hydrogen-Ion Concentration, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity.

Abstract

Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly due to lack of precise and non-invasive methods. At 11.7T, we demonstrate that a thulium-based macrocyclic complex infused through the blood stream can be used to obtain temperature and pH maps of rat brain in vivo by ¹H chemical shift imaging (CSI) of the sensor itself in conjunction with a multi-parametric model that depends on several proton resonances of the sensor. Accuracies of temperature and pH determination with the thulium sensor – which has a predominantly extracellular presence – depend on stable signals during the course of the CSI experiment as well as redundancy for temperature and pH sensitivities contained within the observed signals. The thulium-based method compared well with other methods for temperature (¹H magnetic resonance spectroscopy (MRS) of N-acetyl aspartate and water; copper-constantan thermocouple wire) and pH (³¹P MRS of inorganic phosphate and phosphocreatine) assessment, as established by in vitro and in vivo studies. In vitro studies in phantoms with two compartments of differing pH values observed under different ambient temperature conditions generated precise temperature and pH distribution maps. In vivo studies in α-chloralose anesthetized and renal-ligated rats revealed temperature (33–34 °C) and pH (7.3–7.4) distributions in the cerebral cortex which are in agreement with observations by other methods. These results demonstrate that the thulium sensor can be used to measure temperature and pH distributions in rat brain in vivo simultaneously and accurately with ¹H CSI.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735415

DOI: 10.1002/nbm.1312
PubMed: 19130468
PubMed Central: 2735415

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<term>Hydrogen-Ion Concentration</term>
<term>Magnetic Resonance Spectroscopy (methods)</term>
<term>Protons</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
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<term>Thulium (analysis)</term>
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<term>Protons</term>
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<term>Rats</term>
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<term>Sensibilité et spécificité</term>
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<term>Température du corps (physiologie)</term>
<term>Thermographie ()</term>
<term>Thulium (analyse)</term>
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<term>Hydrogen-Ion Concentration</term>
<term>Rats</term>
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<term>Reproducibility of Results</term>
<term>Sensitivity and Specificity</term>
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<term>Animaux</term>
<term>Concentration en ions d'hydrogène</term>
<term>Protons</term>
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<term>Rats</term>
<term>Reproductibilité des résultats</term>
<term>Sensibilité et spécificité</term>
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<front><div type="abstract" xml:lang="en"><p id="P3">Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly due to lack of precise and non-invasive methods. At 11.7T, we demonstrate that a thulium-based macrocyclic complex infused through the blood stream can be used to obtain temperature and pH maps of rat brain <italic>in vivo</italic>
 by <sup>1</sup>
H chemical shift imaging (CSI) of the sensor itself in conjunction with a multi-parametric model that depends on several proton resonances of the sensor. Accuracies of temperature and pH determination with the thulium sensor – which has a predominantly extracellular presence – depend on stable signals during the course of the CSI experiment as well as redundancy for temperature and pH sensitivities contained within the observed signals. The thulium-based method compared well with other methods for temperature (<sup>1</sup>
H magnetic resonance spectroscopy (MRS) of N-acetyl aspartate and water; copper-constantan thermocouple wire) and pH (<sup>31</sup>
P MRS of inorganic phosphate and phosphocreatine) assessment, as established by <italic>in vitro</italic>
 and <italic>in vivo</italic>
 studies. <italic>In vitro</italic>
 studies in phantoms with two compartments of differing pH values observed under different ambient temperature conditions generated precise temperature and pH distribution maps. <italic>In vivo</italic>
 studies in α-chloralose anesthetized and renal-ligated rats revealed temperature (33–34 °C) and pH (7.3–7.4) distributions in the cerebral cortex which are in agreement with observations by other methods. These results demonstrate that the thulium sensor can be used to measure temperature and pH distributions in rat brain <italic>in vivo</italic>
 simultaneously and accurately with <sup>1</sup>
H CSI.</p>
</div>
</front>
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Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent

Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent

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Abstract

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