Somatotopic organization of human somatosensory cortices for pain: a single trial fMRI study.
Identifieur interne : 000105 ( Ncbi/Checkpoint ); précédent : 000104; suivant : 000106Somatotopic organization of human somatosensory cortices for pain: a single trial fMRI study.
Auteurs : U. Bingel [Allemagne] ; J. Lorenz ; V. Glauche ; R. Knab ; J. Gl Scher ; C. Weiller ; C. BüchelSource :
- NeuroImage [ 1053-8119 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Cartographie cérébrale, Cortex somatosensoriel (physiologie), Dominance cérébrale (physiologie), Femelle, Humains, Imagerie par résonance magnétique, Imagerie tridimensionnelle, Lasers, Latéralité fonctionnelle (physiologie), Main (innervation), Mâle, Mécanorécepteurs (physiologie), Nocicepteurs (physiologie), Orientation (physiologie), Peau (innervation), Pied (innervation), Seuil nociceptif (physiologie), Température cutanée (physiologie), Toucher (physiologie), Traitement d'image par ordinateur, Valeurs de référence, Voies afférentes (physiologie).
- MESH :
- physiologie : Cortex somatosensoriel, Dominance cérébrale, Latéralité fonctionnelle, Mécanorécepteurs, Nocicepteurs, Orientation, Seuil nociceptif, Température cutanée, Toucher, Voies afférentes.
- innervation : Adulte, Cartographie cérébrale, Femelle, Humains, Imagerie par résonance magnétique, Imagerie tridimensionnelle, Lasers, Main, Mâle, Peau, Pied, Traitement d'image par ordinateur, Valeurs de référence.
English descriptors
- KwdEn :
- Adult, Afferent Pathways (physiology), Brain Mapping, Dominance, Cerebral (physiology), Female, Foot (innervation), Functional Laterality (physiology), Hand (innervation), Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Lasers, Magnetic Resonance Imaging, Male, Mechanoreceptors (physiology), Nociceptors (physiology), Orientation (physiology), Pain Threshold (physiology), Reference Values, Skin (innervation), Skin Temperature (physiology), Somatosensory Cortex (physiology), Touch (physiology).
- MESH :
- innervation : Foot, Hand, Skin.
- physiology : Afferent Pathways, Dominance, Cerebral, Functional Laterality, Mechanoreceptors, Nociceptors, Orientation, Pain Threshold, Skin Temperature, Somatosensory Cortex, Touch.
- Adult, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Lasers, Magnetic Resonance Imaging, Male, Reference Values.
Abstract
The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior. However, how the brain localizes nociceptive information without additional information from somatotopically organized mechano-receptive pathways is not well understood. To investigate the somatotopic organization of the nociceptive system, we applied Thulium-YAG-laser evoked pain stimuli, which have no concomitant tactile component, to the dorsum of the left hand and foot in randomized order. We used single-trial functional magnetic resonance imaging (fMRI) to assess differential hemodynamic responses to hand and foot stimulation for the group and in a single subject approach. The primary somatosensory cortex (SI) shows a clear somatotopic organization ipsi- and contralaterally to painful stimulation. Furthermore, a differential representation of hand and foot stimulation appeared within the contralateral opercular--insular region of the secondary somatosensory cortex (SII). This result provides evidence that both SI and SII encode spatial information of nociceptive stimuli without additional information from the tactile system and highlights the concept of a redundant representation of basic discriminative stimulus features in human somatosensory cortices, which seems adequate in view of the evolutionary importance of pain perception.
DOI: 10.1016/j.neuroimage.2004.05.021
PubMed: 15325369
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000676
- to stream PubMed, to step Curation: 000676
- to stream PubMed, to step Checkpoint: 000676
- to stream Ncbi, to step Merge: 000105
- to stream Ncbi, to step Curation: 000105
Links to Exploration step
pubmed:15325369Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Somatotopic organization of human somatosensory cortices for pain: a single trial fMRI study.</title>
<author><name sortKey="Bingel, U" sort="Bingel, U" uniqKey="Bingel U" first="U" last="Bingel">U. Bingel</name>
<affiliation wicri:level="1"><nlm:affiliation>Cognitive Neuroscience Laboratory, Department of Neurology, Hamburg University Medical School, Germany. bingel@uke.uni-hamburg.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cognitive Neuroscience Laboratory, Department of Neurology, Hamburg University Medical School</wicri:regionArea>
<wicri:noRegion>Hamburg University Medical School</wicri:noRegion>
<wicri:noRegion>Hamburg University Medical School</wicri:noRegion>
<wicri:noRegion>Hamburg University Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lorenz, J" sort="Lorenz, J" uniqKey="Lorenz J" first="J" last="Lorenz">J. Lorenz</name>
</author>
<author><name sortKey="Glauche, V" sort="Glauche, V" uniqKey="Glauche V" first="V" last="Glauche">V. Glauche</name>
</author>
<author><name sortKey="Knab, R" sort="Knab, R" uniqKey="Knab R" first="R" last="Knab">R. Knab</name>
</author>
<author><name sortKey="Gl Scher, J" sort="Gl Scher, J" uniqKey="Gl Scher J" first="J" last="Gl Scher">J. Gl Scher</name>
</author>
<author><name sortKey="Weiller, C" sort="Weiller, C" uniqKey="Weiller C" first="C" last="Weiller">C. Weiller</name>
</author>
<author><name sortKey="Buchel, C" sort="Buchel, C" uniqKey="Buchel C" first="C" last="Büchel">C. Büchel</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2004">2004</date>
<idno type="RBID">pubmed:15325369</idno>
<idno type="pmid">15325369</idno>
<idno type="doi">10.1016/j.neuroimage.2004.05.021</idno>
<idno type="wicri:Area/PubMed/Corpus">000676</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000676</idno>
<idno type="wicri:Area/PubMed/Curation">000676</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000676</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000676</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000676</idno>
<idno type="wicri:Area/Ncbi/Merge">000105</idno>
<idno type="wicri:Area/Ncbi/Curation">000105</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000105</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Somatotopic organization of human somatosensory cortices for pain: a single trial fMRI study.</title>
<author><name sortKey="Bingel, U" sort="Bingel, U" uniqKey="Bingel U" first="U" last="Bingel">U. Bingel</name>
<affiliation wicri:level="1"><nlm:affiliation>Cognitive Neuroscience Laboratory, Department of Neurology, Hamburg University Medical School, Germany. bingel@uke.uni-hamburg.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cognitive Neuroscience Laboratory, Department of Neurology, Hamburg University Medical School</wicri:regionArea>
<wicri:noRegion>Hamburg University Medical School</wicri:noRegion>
<wicri:noRegion>Hamburg University Medical School</wicri:noRegion>
<wicri:noRegion>Hamburg University Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lorenz, J" sort="Lorenz, J" uniqKey="Lorenz J" first="J" last="Lorenz">J. Lorenz</name>
</author>
<author><name sortKey="Glauche, V" sort="Glauche, V" uniqKey="Glauche V" first="V" last="Glauche">V. Glauche</name>
</author>
<author><name sortKey="Knab, R" sort="Knab, R" uniqKey="Knab R" first="R" last="Knab">R. Knab</name>
</author>
<author><name sortKey="Gl Scher, J" sort="Gl Scher, J" uniqKey="Gl Scher J" first="J" last="Gl Scher">J. Gl Scher</name>
</author>
<author><name sortKey="Weiller, C" sort="Weiller, C" uniqKey="Weiller C" first="C" last="Weiller">C. Weiller</name>
</author>
<author><name sortKey="Buchel, C" sort="Buchel, C" uniqKey="Buchel C" first="C" last="Büchel">C. Büchel</name>
</author>
</analytic>
<series><title level="j">NeuroImage</title>
<idno type="ISSN">1053-8119</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Afferent Pathways (physiology)</term>
<term>Brain Mapping</term>
<term>Dominance, Cerebral (physiology)</term>
<term>Female</term>
<term>Foot (innervation)</term>
<term>Functional Laterality (physiology)</term>
<term>Hand (innervation)</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Imaging, Three-Dimensional</term>
<term>Lasers</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Mechanoreceptors (physiology)</term>
<term>Nociceptors (physiology)</term>
<term>Orientation (physiology)</term>
<term>Pain Threshold (physiology)</term>
<term>Reference Values</term>
<term>Skin (innervation)</term>
<term>Skin Temperature (physiology)</term>
<term>Somatosensory Cortex (physiology)</term>
<term>Touch (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Cartographie cérébrale</term>
<term>Cortex somatosensoriel (physiologie)</term>
<term>Dominance cérébrale (physiologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Imagerie tridimensionnelle</term>
<term>Lasers</term>
<term>Latéralité fonctionnelle (physiologie)</term>
<term>Main (innervation)</term>
<term>Mâle</term>
<term>Mécanorécepteurs (physiologie)</term>
<term>Nocicepteurs (physiologie)</term>
<term>Orientation (physiologie)</term>
<term>Peau (innervation)</term>
<term>Pied (innervation)</term>
<term>Seuil nociceptif (physiologie)</term>
<term>Température cutanée (physiologie)</term>
<term>Toucher (physiologie)</term>
<term>Traitement d'image par ordinateur</term>
<term>Valeurs de référence</term>
<term>Voies afférentes (physiologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Foot</term>
<term>Hand</term>
<term>Skin</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cortex somatosensoriel</term>
<term>Dominance cérébrale</term>
<term>Latéralité fonctionnelle</term>
<term>Mécanorécepteurs</term>
<term>Nocicepteurs</term>
<term>Orientation</term>
<term>Seuil nociceptif</term>
<term>Température cutanée</term>
<term>Toucher</term>
<term>Voies afférentes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Afferent Pathways</term>
<term>Dominance, Cerebral</term>
<term>Functional Laterality</term>
<term>Mechanoreceptors</term>
<term>Nociceptors</term>
<term>Orientation</term>
<term>Pain Threshold</term>
<term>Skin Temperature</term>
<term>Somatosensory Cortex</term>
<term>Touch</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Brain Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Imaging, Three-Dimensional</term>
<term>Lasers</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Reference Values</term>
</keywords>
<keywords scheme="MESH" qualifier="innervation" xml:lang="fr"><term>Adulte</term>
<term>Cartographie cérébrale</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Imagerie tridimensionnelle</term>
<term>Lasers</term>
<term>Main</term>
<term>Mâle</term>
<term>Peau</term>
<term>Pied</term>
<term>Traitement d'image par ordinateur</term>
<term>Valeurs de référence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior. However, how the brain localizes nociceptive information without additional information from somatotopically organized mechano-receptive pathways is not well understood. To investigate the somatotopic organization of the nociceptive system, we applied Thulium-YAG-laser evoked pain stimuli, which have no concomitant tactile component, to the dorsum of the left hand and foot in randomized order. We used single-trial functional magnetic resonance imaging (fMRI) to assess differential hemodynamic responses to hand and foot stimulation for the group and in a single subject approach. The primary somatosensory cortex (SI) shows a clear somatotopic organization ipsi- and contralaterally to painful stimulation. Furthermore, a differential representation of hand and foot stimulation appeared within the contralateral opercular--insular region of the secondary somatosensory cortex (SII). This result provides evidence that both SI and SII encode spatial information of nociceptive stimuli without additional information from the tactile system and highlights the concept of a redundant representation of basic discriminative stimulus features in human somatosensory cortices, which seems adequate in view of the evolutionary importance of pain perception.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
</list>
<tree><noCountry><name sortKey="Buchel, C" sort="Buchel, C" uniqKey="Buchel C" first="C" last="Büchel">C. Büchel</name>
<name sortKey="Gl Scher, J" sort="Gl Scher, J" uniqKey="Gl Scher J" first="J" last="Gl Scher">J. Gl Scher</name>
<name sortKey="Glauche, V" sort="Glauche, V" uniqKey="Glauche V" first="V" last="Glauche">V. Glauche</name>
<name sortKey="Knab, R" sort="Knab, R" uniqKey="Knab R" first="R" last="Knab">R. Knab</name>
<name sortKey="Lorenz, J" sort="Lorenz, J" uniqKey="Lorenz J" first="J" last="Lorenz">J. Lorenz</name>
<name sortKey="Weiller, C" sort="Weiller, C" uniqKey="Weiller C" first="C" last="Weiller">C. Weiller</name>
</noCountry>
<country name="Allemagne"><noRegion><name sortKey="Bingel, U" sort="Bingel, U" uniqKey="Bingel U" first="U" last="Bingel">U. Bingel</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000105 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000105 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Terre |area= ThuliumV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= pubmed:15325369 |texte= Somatotopic organization of human somatosensory cortices for pain: a single trial fMRI study. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:15325369" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ThuliumV1
![]() | This area was generated with Dilib version V0.6.21. | ![]() |