ThuliumV1, Ncbi, Checkpoint, bibRecord, 000098

Gene expression profiles of hepatocytes treated with La (NO3) 3 of rare earth in rats

Identifieur interne : 000098 ( Ncbi/Checkpoint ); précédent : 000097; suivant : 000099

Gene expression profiles of hepatocytes treated with La (NO3) 3 of rare earth in rats

Auteurs : Hui Zhao ; Wei-Dong Hao ; Hou-En Xu ; Lan-Qin Shang ; You-Yong Lu

Source :

World Journal of Gastroenterology : WJG [ 1007-9327 ] ; 2004.

RBID : PMC:4572766

Abstract

AIM: To compare the gene expression between La (NO₃) ₃-exposed and control rats in vivo.

METHODS: Rats were fed La (NO₃) ₃ once daily at a dose of 20 mg/kg for one month by gavage. Gene expression of hepatocytes was detected using mRNA differential display (DD) technique and cDNA microarray and compared between treated and control groups.

RESULTS: Six differentially expressed sequence tags were cloned by DD, of which five were up regulated and one was down regulated in treated rats. Two sequences were determined. One band was novel. The other shared 100% sequence homology with AU080263 Sugano mouse brain mncb Mus musculus cDNA clone MNCb-5435 5’. With DNA microarray, 136 differentially expressed genes were identified including 131 over-expressed genes and 5 under-expressed genes. Most of these differentially expressed genes were cell signal and transmission genes, genes associated with metabolism, protein translation and synthesis.

CONCLUSION: La (NO₃) ₃ could change the expression levels of some kinds of genes. Further analysis of the differentially expressed genes would be helpful for understanding the wide biological effect spectrum of rare earth elements.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572766

DOI: 10.3748/wjg.v10.i11.1625
PubMed: 15162537
PubMed Central: 4572766

Affiliations:

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PMC:4572766

Le document en format XML

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) <sub>3</sub>
 of rare earth in rats</title>
<author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name>
</author>
<author><name sortKey="Hao, Wei Dong" sort="Hao, Wei Dong" uniqKey="Hao W" first="Wei-Dong" last="Hao">Wei-Dong Hao</name>
</author>
<author><name sortKey="Xu, Hou En" sort="Xu, Hou En" uniqKey="Xu H" first="Hou-En" last="Xu">Hou-En Xu</name>
</author>
<author><name sortKey="Shang, Lan Qin" sort="Shang, Lan Qin" uniqKey="Shang L" first="Lan-Qin" last="Shang">Lan-Qin Shang</name>
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<author><name sortKey="Lu, You Yong" sort="Lu, You Yong" uniqKey="Lu Y" first="You-Yong" last="Lu">You-Yong Lu</name>
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 of rare earth in rats</title>
<author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name>
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<author><name sortKey="Hao, Wei Dong" sort="Hao, Wei Dong" uniqKey="Hao W" first="Wei-Dong" last="Hao">Wei-Dong Hao</name>
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<author><name sortKey="Xu, Hou En" sort="Xu, Hou En" uniqKey="Xu H" first="Hou-En" last="Xu">Hou-En Xu</name>
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<author><name sortKey="Shang, Lan Qin" sort="Shang, Lan Qin" uniqKey="Shang L" first="Lan-Qin" last="Shang">Lan-Qin Shang</name>
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<author><name sortKey="Lu, You Yong" sort="Lu, You Yong" uniqKey="Lu Y" first="You-Yong" last="Lu">You-Yong Lu</name>
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<series><title level="j">World Journal of Gastroenterology : WJG</title>
<idno type="ISSN">1007-9327</idno>
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<front><div type="abstract" xml:lang="en"><p>AIM: To compare the gene expression between La (NO<sub>3</sub>
) <sub>3</sub>
-exposed and control rats <italic>in vivo</italic>
.</p>
<p>METHODS: Rats were fed La (NO<sub>3</sub>
) <sub>3</sub>
 once daily at a dose of 20 mg/kg for one month by gavage. Gene expression of hepatocytes was detected using mRNA differential display (DD) technique and cDNA microarray and compared between treated and control groups.</p>
<p>RESULTS: Six differentially expressed sequence tags were cloned by DD, of which five were up regulated and one was down regulated in treated rats. Two sequences were determined. One band was novel. The other shared 100% sequence homology with AU080263 Sugano mouse brain mncb Mus musculus cDNA clone MNCb-5435 5’. With DNA microarray, 136 differentially expressed genes were identified including 131 over-expressed genes and 5 under-expressed genes. Most of these differentially expressed genes were cell signal and transmission genes, genes associated with metabolism, protein translation and synthesis.</p>
<p>CONCLUSION: La (NO<sub>3</sub>
) <sub>3</sub>
 could change the expression levels of some kinds of genes. Further analysis of the differentially expressed genes would be helpful for understanding the wide biological effect spectrum of rare earth elements.</p>
</div>
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<tree><noCountry><name sortKey="Hao, Wei Dong" sort="Hao, Wei Dong" uniqKey="Hao W" first="Wei-Dong" last="Hao">Wei-Dong Hao</name>
<name sortKey="Lu, You Yong" sort="Lu, You Yong" uniqKey="Lu Y" first="You-Yong" last="Lu">You-Yong Lu</name>
<name sortKey="Shang, Lan Qin" sort="Shang, Lan Qin" uniqKey="Shang L" first="Lan-Qin" last="Shang">Lan-Qin Shang</name>
<name sortKey="Xu, Hou En" sort="Xu, Hou En" uniqKey="Xu H" first="Hou-En" last="Xu">Hou-En Xu</name>
<name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name>
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Gene expression profiles of hepatocytes treated with La (NO3) 3 of rare earth in rats

Gene expression profiles of hepatocytes treated with La (NO3) 3 of rare earth in rats

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki