Gene expression profiles of hepatocytes treated with La (NO3) 3 of rare earth in rats
Identifieur interne : 000098 ( Ncbi/Merge ); précédent : 000097; suivant : 000099Gene expression profiles of hepatocytes treated with La (NO3) 3 of rare earth in rats
Auteurs : Hui Zhao ; Wei-Dong Hao ; Hou-En Xu ; Lan-Qin Shang ; You-Yong LuSource :
- World Journal of Gastroenterology : WJG [ 1007-9327 ] ; 2004.
Abstract
AIM: To compare the gene expression between La (NO3) 3-exposed and control rats
METHODS: Rats were fed La (NO3) 3 once daily at a dose of 20 mg/kg for one month by gavage. Gene expression of hepatocytes was detected using mRNA differential display (DD) technique and cDNA microarray and compared between treated and control groups.
RESULTS: Six differentially expressed sequence tags were cloned by DD, of which five were up regulated and one was down regulated in treated rats. Two sequences were determined. One band was novel. The other shared 100% sequence homology with AU080263 Sugano mouse brain mncb Mus musculus cDNA clone MNCb-5435 5’. With DNA microarray, 136 differentially expressed genes were identified including 131 over-expressed genes and 5 under-expressed genes. Most of these differentially expressed genes were cell signal and transmission genes, genes associated with metabolism, protein translation and synthesis.
CONCLUSION: La (NO3) 3 could change the expression levels of some kinds of genes. Further analysis of the differentially expressed genes would be helpful for understanding the wide biological effect spectrum of rare earth elements.
Url:
DOI: 10.3748/wjg.v10.i11.1625
PubMed: 15162537
PubMed Central: 4572766
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) <sub>3</sub>
of rare earth in rats</title>
<author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name>
</author>
<author><name sortKey="Hao, Wei Dong" sort="Hao, Wei Dong" uniqKey="Hao W" first="Wei-Dong" last="Hao">Wei-Dong Hao</name>
</author>
<author><name sortKey="Xu, Hou En" sort="Xu, Hou En" uniqKey="Xu H" first="Hou-En" last="Xu">Hou-En Xu</name>
</author>
<author><name sortKey="Shang, Lan Qin" sort="Shang, Lan Qin" uniqKey="Shang L" first="Lan-Qin" last="Shang">Lan-Qin Shang</name>
</author>
<author><name sortKey="Lu, You Yong" sort="Lu, You Yong" uniqKey="Lu Y" first="You-Yong" last="Lu">You-Yong Lu</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gene expression profiles of hepatocytes treated with La (NO<sub>3</sub>
) <sub>3</sub>
of rare earth in rats</title>
<author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name>
</author>
<author><name sortKey="Hao, Wei Dong" sort="Hao, Wei Dong" uniqKey="Hao W" first="Wei-Dong" last="Hao">Wei-Dong Hao</name>
</author>
<author><name sortKey="Xu, Hou En" sort="Xu, Hou En" uniqKey="Xu H" first="Hou-En" last="Xu">Hou-En Xu</name>
</author>
<author><name sortKey="Shang, Lan Qin" sort="Shang, Lan Qin" uniqKey="Shang L" first="Lan-Qin" last="Shang">Lan-Qin Shang</name>
</author>
<author><name sortKey="Lu, You Yong" sort="Lu, You Yong" uniqKey="Lu Y" first="You-Yong" last="Lu">You-Yong Lu</name>
</author>
</analytic>
<series><title level="j">World Journal of Gastroenterology : WJG</title>
<idno type="ISSN">1007-9327</idno>
<idno type="eISSN">2219-2840</idno>
<imprint><date when="2004">2004</date>
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<front><div type="abstract" xml:lang="en"><p>AIM: To compare the gene expression between La (NO<sub>3</sub>
) <sub>3</sub>
-exposed and control rats <italic>in vivo</italic>
.</p>
<p>METHODS: Rats were fed La (NO<sub>3</sub>
) <sub>3</sub>
once daily at a dose of 20 mg/kg for one month by gavage. Gene expression of hepatocytes was detected using mRNA differential display (DD) technique and cDNA microarray and compared between treated and control groups.</p>
<p>RESULTS: Six differentially expressed sequence tags were cloned by DD, of which five were up regulated and one was down regulated in treated rats. Two sequences were determined. One band was novel. The other shared 100% sequence homology with AU080263 Sugano mouse brain mncb Mus musculus cDNA clone MNCb-5435 5’. With DNA microarray, 136 differentially expressed genes were identified including 131 over-expressed genes and 5 under-expressed genes. Most of these differentially expressed genes were cell signal and transmission genes, genes associated with metabolism, protein translation and synthesis.</p>
<p>CONCLUSION: La (NO<sub>3</sub>
) <sub>3</sub>
could change the expression levels of some kinds of genes. Further analysis of the differentially expressed genes would be helpful for understanding the wide biological effect spectrum of rare earth elements.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id>
<journal-id journal-id-type="iso-abbrev">World J. Gastroenterol</journal-id>
<journal-id journal-id-type="publisher-id">WJG</journal-id>
<journal-title-group><journal-title>World Journal of Gastroenterology : WJG</journal-title>
</journal-title-group>
<issn pub-type="ppub">1007-9327</issn>
<issn pub-type="epub">2219-2840</issn>
<publisher><publisher-name>Baishideng Publishing Group Inc</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">15162537</article-id>
<article-id pub-id-type="pmc">4572766</article-id>
<article-id pub-id-type="other">jWJG.v10.i11.pg1625</article-id>
<article-id pub-id-type="doi">10.3748/wjg.v10.i11.1625</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Basic Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Gene expression profiles of hepatocytes treated with La (NO<sub>3</sub>
) <sub>3</sub>
of rare earth in rats</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Hui</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hao</surname>
<given-names>Wei-Dong</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Xu</surname>
<given-names>Hou-En</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Shang</surname>
<given-names>Lan-Qin</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lu</surname>
<given-names>You-Yong</given-names>
</name>
</contrib>
<aff>Hui Zhao, Wei-Dong Hao, Hou-En Xu, Lan-Qin Shang, Department of Toxicology, Peking University Health Science Center, Beijing 100083, China</aff>
<aff>You-Yong Lu, School of Oncology, Beijing Institute for Cancer Research, Peking University, Beijing 100034, China</aff>
</contrib-group>
<author-notes><fn><p>Author contributions: All authors contributed equally to the work.</p>
<p>Correspondence to: Wei-Dong Hao, Department of Toxicology, Peking University Health Science Center, No 38 Xue Yuan Road, Beijing 100083, China. <email>whao@bjmu.edu.cn</email>
</p>
<p>Telephone: +86-10-82802352 Fax: +86-10-62015583</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>1</day>
<month>6</month>
<year>2004</year>
</pub-date>
<pub-date pub-type="epub"><day>1</day>
<month>6</month>
<year>2004</year>
</pub-date>
<volume>10</volume>
<issue>11</issue>
<fpage>1625</fpage>
<lpage>1629</lpage>
<history><date date-type="received"><day>1</day>
<month>8</month>
<year>2002</year>
</date>
<date date-type="rev-recd"><day>4</day>
<month>8</month>
<year>2002</year>
</date>
<date date-type="accepted"><day>31</day>
<month>8</month>
<year>2002</year>
</date>
</history>
<permissions><copyright-statement>©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.</copyright-statement>
<copyright-year>2004</copyright-year>
</permissions>
<abstract><p>AIM: To compare the gene expression between La (NO<sub>3</sub>
) <sub>3</sub>
-exposed and control rats <italic>in vivo</italic>
.</p>
<p>METHODS: Rats were fed La (NO<sub>3</sub>
) <sub>3</sub>
once daily at a dose of 20 mg/kg for one month by gavage. Gene expression of hepatocytes was detected using mRNA differential display (DD) technique and cDNA microarray and compared between treated and control groups.</p>
<p>RESULTS: Six differentially expressed sequence tags were cloned by DD, of which five were up regulated and one was down regulated in treated rats. Two sequences were determined. One band was novel. The other shared 100% sequence homology with AU080263 Sugano mouse brain mncb Mus musculus cDNA clone MNCb-5435 5’. With DNA microarray, 136 differentially expressed genes were identified including 131 over-expressed genes and 5 under-expressed genes. Most of these differentially expressed genes were cell signal and transmission genes, genes associated with metabolism, protein translation and synthesis.</p>
<p>CONCLUSION: La (NO<sub>3</sub>
) <sub>3</sub>
could change the expression levels of some kinds of genes. Further analysis of the differentially expressed genes would be helpful for understanding the wide biological effect spectrum of rare earth elements.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Hao, Wei Dong" sort="Hao, Wei Dong" uniqKey="Hao W" first="Wei-Dong" last="Hao">Wei-Dong Hao</name>
<name sortKey="Lu, You Yong" sort="Lu, You Yong" uniqKey="Lu Y" first="You-Yong" last="Lu">You-Yong Lu</name>
<name sortKey="Shang, Lan Qin" sort="Shang, Lan Qin" uniqKey="Shang L" first="Lan-Qin" last="Shang">Lan-Qin Shang</name>
<name sortKey="Xu, Hou En" sort="Xu, Hou En" uniqKey="Xu H" first="Hou-En" last="Xu">Hou-En Xu</name>
<name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name>
</noCountry>
</tree>
</affiliations>
</record>
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