Paramagnetic lanthanide complexes as PARACEST agents for medical imaging
Identifieur interne : 001755 ( Main/Merge ); précédent : 001754; suivant : 001756Paramagnetic lanthanide complexes as PARACEST agents for medical imaging
Auteurs : Mark Woods [États-Unis] ; Donald E. Woessner [États-Unis] ; A. Dean Sherry [États-Unis]Source :
- Chemical Society Reviews [ 0306-0012 ] ; 2006.
Descripteurs français
English descriptors
- KwdEn :
- Aime, Amide, Amide protons, Angew, Barbituric acid, Boltzmann, Boltzmann distribution, Bulk magnetization, Bulk water, Bulk water protons, Bulk water signal, Castelli, Cest, Cest agent, Cest agents, Cest effect, Cest effects, Cest peak, Cest spectra, Cest spectrum, Chem, Chemical exchange, Chemical shift, Contrast agent, Contrast agents, Delli, Delli castelli, Direct saturation, Endogenous anions, Exchange process, Exchangeable, Exchangeable protons, Glucose, High energy, Image contrast, Imaging, Lactate, Lanthanide, Lanthanide ions, Liposome, Magn, Magnetic field, Magnetization, Other sugars, Paracest, Paracest agent, Paracest agents, Presaturation, Presaturation pulse, Proton, Proton exchange, Pulse train, Ratiometric, Ratiometric approach, Relaxation times, Residence lifetime, Reson, Royal society, Shift reagent, Signal intensity, Slow exchange condition, Solvent, Solvent water, Solvent water peak, Solvent water signal, Supramolecular, Supramolecular assembly, Terreno, Water exchange, Water exchange rate, Water molecule, Water molecules, Water protons, Zhang.
- Teeft :
- Aime, Amide, Amide protons, Angew, Barbituric acid, Boltzmann, Boltzmann distribution, Bulk magnetization, Bulk water, Bulk water protons, Bulk water signal, Castelli, Cest, Cest agent, Cest agents, Cest effect, Cest effects, Cest peak, Cest spectra, Cest spectrum, Chem, Chemical exchange, Chemical shift, Contrast agent, Contrast agents, Delli, Delli castelli, Direct saturation, Endogenous anions, Exchange process, Exchangeable, Exchangeable protons, Glucose, High energy, Image contrast, Imaging, Lactate, Lanthanide, Lanthanide ions, Liposome, Magn, Magnetic field, Magnetization, Other sugars, Paracest, Paracest agent, Paracest agents, Presaturation, Presaturation pulse, Proton, Proton exchange, Pulse train, Ratiometric, Ratiometric approach, Relaxation times, Residence lifetime, Reson, Royal society, Shift reagent, Signal intensity, Slow exchange condition, Solvent, Solvent water, Solvent water peak, Solvent water signal, Supramolecular, Supramolecular assembly, Terreno, Water exchange, Water exchange rate, Water molecule, Water molecules, Water protons, Zhang.
Abstract
This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.
Url:
- https://api.istex.fr/document/F29A711CE636857EC91D6C10177EF0921E86DA71/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718840
DOI: 10.1039/b509907m
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ISTEX:F29A711CE636857EC91D6C10177EF0921E86DA71Le document en format XML
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Rev.</title><idno type="ISSN">0306-0012</idno><idno type="eISSN">1460-4744</idno><imprint><publisher>The Royal Society of Chemistry.</publisher><date type="published" when="2006">2006</date><biblScope unit="volume">35</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="500">500</biblScope><biblScope unit="page" to="511">511</biblScope></imprint><idno type="ISSN">0306-0012</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-0012</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aime</term><term>Amide</term><term>Amide protons</term><term>Angew</term><term>Barbituric acid</term><term>Boltzmann</term><term>Boltzmann distribution</term><term>Bulk magnetization</term><term>Bulk water</term><term>Bulk water protons</term><term>Bulk water signal</term><term>Castelli</term><term>Cest</term><term>Cest agent</term><term>Cest agents</term><term>Cest effect</term><term>Cest effects</term><term>Cest peak</term><term>Cest spectra</term><term>Cest spectrum</term><term>Chem</term><term>Chemical exchange</term><term>Chemical shift</term><term>Contrast agent</term><term>Contrast agents</term><term>Delli</term><term>Delli castelli</term><term>Direct saturation</term><term>Endogenous anions</term><term>Exchange process</term><term>Exchangeable</term><term>Exchangeable protons</term><term>Glucose</term><term>High energy</term><term>Image contrast</term><term>Imaging</term><term>Lactate</term><term>Lanthanide</term><term>Lanthanide ions</term><term>Liposome</term><term>Magn</term><term>Magnetic field</term><term>Magnetization</term><term>Other sugars</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Presaturation</term><term>Presaturation pulse</term><term>Proton</term><term>Proton exchange</term><term>Pulse train</term><term>Ratiometric</term><term>Ratiometric approach</term><term>Relaxation times</term><term>Residence lifetime</term><term>Reson</term><term>Royal society</term><term>Shift reagent</term><term>Signal intensity</term><term>Slow exchange condition</term><term>Solvent</term><term>Solvent water</term><term>Solvent water peak</term><term>Solvent water signal</term><term>Supramolecular</term><term>Supramolecular assembly</term><term>Terreno</term><term>Water exchange</term><term>Water exchange rate</term><term>Water molecule</term><term>Water molecules</term><term>Water protons</term><term>Zhang</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Aime</term><term>Amide</term><term>Amide protons</term><term>Angew</term><term>Barbituric acid</term><term>Boltzmann</term><term>Boltzmann distribution</term><term>Bulk magnetization</term><term>Bulk water</term><term>Bulk water protons</term><term>Bulk water signal</term><term>Castelli</term><term>Cest</term><term>Cest agent</term><term>Cest agents</term><term>Cest effect</term><term>Cest effects</term><term>Cest peak</term><term>Cest spectra</term><term>Cest spectrum</term><term>Chem</term><term>Chemical exchange</term><term>Chemical shift</term><term>Contrast agent</term><term>Contrast agents</term><term>Delli</term><term>Delli castelli</term><term>Direct saturation</term><term>Endogenous anions</term><term>Exchange process</term><term>Exchangeable</term><term>Exchangeable protons</term><term>Glucose</term><term>High energy</term><term>Image contrast</term><term>Imaging</term><term>Lactate</term><term>Lanthanide</term><term>Lanthanide ions</term><term>Liposome</term><term>Magn</term><term>Magnetic field</term><term>Magnetization</term><term>Other sugars</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Presaturation</term><term>Presaturation pulse</term><term>Proton</term><term>Proton exchange</term><term>Pulse train</term><term>Ratiometric</term><term>Ratiometric approach</term><term>Relaxation times</term><term>Residence lifetime</term><term>Reson</term><term>Royal society</term><term>Shift reagent</term><term>Signal intensity</term><term>Slow exchange condition</term><term>Solvent</term><term>Solvent water</term><term>Solvent water peak</term><term>Solvent water signal</term><term>Supramolecular</term><term>Supramolecular assembly</term><term>Terreno</term><term>Water exchange</term><term>Water exchange rate</term><term>Water molecule</term><term>Water molecules</term><term>Water protons</term><term>Zhang</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Glucose</term><term>Solvant</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.</div></front></TEI><double doi="10.1039/b509907m"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Paramagnetic lanthanide complexes as PARACEST agents for medical imaging</title><author wicri:is="90%"><name sortKey="Woods, Mark" sort="Woods, Mark" uniqKey="Woods M" first="Mark" last="Woods">Mark Woods</name></author><author wicri:is="90%"><name sortKey="Woessner, Donald E" sort="Woessner, Donald E" uniqKey="Woessner D" first="Donald E." last="Woessner">Donald E. Woessner</name></author><author wicri:is="90%"><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. 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Floyd Road, TX 75080, Richardson</wicri:regionArea><wicri:noRegion>Richardson</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author wicri:is="90%"><name sortKey="Woessner, Donald E" sort="Woessner, Donald E" uniqKey="Woessner D" first="Donald E." last="Woessner">Donald E. Woessner</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NE 4.2, TX 75390-8568, Dallas</wicri:regionArea><wicri:noRegion>Dallas</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author wicri:is="90%"><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, University of Texas at Dallas, 2601 N. Floyd Road, TX 75080, Richardson</wicri:regionArea><wicri:noRegion>Richardson</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NE 4.2, TX 75390-8568, Dallas</wicri:regionArea><wicri:noRegion>Dallas</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Chemical Society Reviews</title><title level="j" type="abbrev">Chem. Soc. Rev.</title><idno type="ISSN">0306-0012</idno><idno type="eISSN">1460-4744</idno><imprint><publisher>The Royal Society of Chemistry.</publisher><date type="published" when="2006">2006</date><biblScope unit="volume">35</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="500">500</biblScope><biblScope unit="page" to="511">511</biblScope></imprint><idno type="ISSN">0306-0012</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-0012</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aime</term><term>Amide</term><term>Amide protons</term><term>Angew</term><term>Barbituric acid</term><term>Boltzmann</term><term>Boltzmann distribution</term><term>Bulk magnetization</term><term>Bulk water</term><term>Bulk water protons</term><term>Bulk water signal</term><term>Castelli</term><term>Cest</term><term>Cest agent</term><term>Cest agents</term><term>Cest effect</term><term>Cest effects</term><term>Cest peak</term><term>Cest spectra</term><term>Cest spectrum</term><term>Chem</term><term>Chemical exchange</term><term>Chemical shift</term><term>Contrast agent</term><term>Contrast agents</term><term>Delli</term><term>Delli castelli</term><term>Direct saturation</term><term>Endogenous anions</term><term>Exchange process</term><term>Exchangeable</term><term>Exchangeable protons</term><term>Glucose</term><term>High energy</term><term>Image contrast</term><term>Imaging</term><term>Lactate</term><term>Lanthanide</term><term>Lanthanide ions</term><term>Liposome</term><term>Magn</term><term>Magnetic field</term><term>Magnetization</term><term>Other sugars</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Presaturation</term><term>Presaturation pulse</term><term>Proton</term><term>Proton exchange</term><term>Pulse train</term><term>Ratiometric</term><term>Ratiometric approach</term><term>Relaxation times</term><term>Residence lifetime</term><term>Reson</term><term>Royal society</term><term>Shift reagent</term><term>Signal intensity</term><term>Slow exchange condition</term><term>Solvent</term><term>Solvent water</term><term>Solvent water peak</term><term>Solvent water signal</term><term>Supramolecular</term><term>Supramolecular assembly</term><term>Terreno</term><term>Water exchange</term><term>Water exchange rate</term><term>Water molecule</term><term>Water molecules</term><term>Water protons</term><term>Zhang</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Aime</term><term>Amide</term><term>Amide protons</term><term>Angew</term><term>Barbituric acid</term><term>Boltzmann</term><term>Boltzmann distribution</term><term>Bulk magnetization</term><term>Bulk water</term><term>Bulk water protons</term><term>Bulk water signal</term><term>Castelli</term><term>Cest</term><term>Cest agent</term><term>Cest agents</term><term>Cest effect</term><term>Cest effects</term><term>Cest peak</term><term>Cest spectra</term><term>Cest spectrum</term><term>Chem</term><term>Chemical exchange</term><term>Chemical shift</term><term>Contrast agent</term><term>Contrast agents</term><term>Delli</term><term>Delli castelli</term><term>Direct saturation</term><term>Endogenous anions</term><term>Exchange process</term><term>Exchangeable</term><term>Exchangeable protons</term><term>Glucose</term><term>High energy</term><term>Image contrast</term><term>Imaging</term><term>Lactate</term><term>Lanthanide</term><term>Lanthanide ions</term><term>Liposome</term><term>Magn</term><term>Magnetic field</term><term>Magnetization</term><term>Other sugars</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Presaturation</term><term>Presaturation pulse</term><term>Proton</term><term>Proton exchange</term><term>Pulse train</term><term>Ratiometric</term><term>Ratiometric approach</term><term>Relaxation times</term><term>Residence lifetime</term><term>Reson</term><term>Royal society</term><term>Shift reagent</term><term>Signal intensity</term><term>Slow exchange condition</term><term>Solvent</term><term>Solvent water</term><term>Solvent water peak</term><term>Solvent water signal</term><term>Supramolecular</term><term>Supramolecular assembly</term><term>Terreno</term><term>Water exchange</term><term>Water exchange rate</term><term>Water molecule</term><term>Water molecules</term><term>Water protons</term><term>Zhang</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Glucose</term><term>Solvant</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Paramagnetic lanthanide complexes as PARACEST agents for medical imaging</title><author><name sortKey="Woods, Mark" sort="Woods, Mark" uniqKey="Woods M" first="Mark" last="Woods">Mark Woods</name><affiliation wicri:level="2"><nlm:aff id="A1">Macrocyclics, 2110 Research Row, Suite 425, Dallas, TX 75235, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Macrocyclics, 2110 Research Row, Suite 425, Dallas, TX 75235</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation><nlm:aff id="A2">Department of Chemistry, University of Texas at Dallas, 2601 N. Floyd Road, Richardson, TX 75080, USA. E-mail:<email>sherry@utdallas.edu</email>; Fax: + 01 972-883-2925; Tel: + 01 972-883-2907</nlm:aff></affiliation></author><author><name sortKey="Woessner, Donald E" sort="Woessner, Donald E" uniqKey="Woessner D" first="Donald E." last="Woessner">Donald E. Woessner</name><affiliation><nlm:aff id="A3">Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NE 4.2, Dallas, TX 75390-8568, USA. E-mail:<email>dean.sherry@utsouthwestern.edu</email>; Fax: + 01 214-645-2744; Tel: + 01 214-645-2720</nlm:aff></affiliation></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name><affiliation><nlm:aff id="A2">Department of Chemistry, University of Texas at Dallas, 2601 N. Floyd Road, Richardson, TX 75080, USA. E-mail:<email>sherry@utdallas.edu</email>; Fax: + 01 972-883-2925; Tel: + 01 972-883-2907</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NE 4.2, Dallas, TX 75390-8568, USA. E-mail:<email>dean.sherry@utsouthwestern.edu</email>; Fax: + 01 214-645-2744; Tel: + 01 214-645-2720</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16729144</idno><idno type="pmc">2718840</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718840</idno><idno type="RBID">PMC:2718840</idno><idno type="doi">10.1039/b509907m</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000214</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000214</idno><idno type="wicri:Area/Pmc/Curation">000214</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000214</idno><idno type="wicri:Area/Pmc/Checkpoint">000362</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000362</idno><idno type="wicri:Area/Ncbi/Merge">000154</idno><idno type="wicri:Area/Ncbi/Curation">000154</idno><idno type="wicri:Area/Ncbi/Checkpoint">000154</idno><idno type="wicri:doubleKey">0306-0012:2006:Woods M:paramagnetic:lanthanide:complexes</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Paramagnetic lanthanide complexes as PARACEST agents for medical imaging</title><author><name sortKey="Woods, Mark" sort="Woods, Mark" uniqKey="Woods M" first="Mark" last="Woods">Mark Woods</name><affiliation wicri:level="2"><nlm:aff id="A1">Macrocyclics, 2110 Research Row, Suite 425, Dallas, TX 75235, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Macrocyclics, 2110 Research Row, Suite 425, Dallas, TX 75235</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation><nlm:aff id="A2">Department of Chemistry, University of Texas at Dallas, 2601 N. Floyd Road, Richardson, TX 75080, USA. E-mail:<email>sherry@utdallas.edu</email>; Fax: + 01 972-883-2925; Tel: + 01 972-883-2907</nlm:aff></affiliation></author><author><name sortKey="Woessner, Donald E" sort="Woessner, Donald E" uniqKey="Woessner D" first="Donald E." last="Woessner">Donald E. Woessner</name><affiliation><nlm:aff id="A3">Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NE 4.2, Dallas, TX 75390-8568, USA. E-mail:<email>dean.sherry@utsouthwestern.edu</email>; Fax: + 01 214-645-2744; Tel: + 01 214-645-2720</nlm:aff></affiliation></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name><affiliation><nlm:aff id="A2">Department of Chemistry, University of Texas at Dallas, 2601 N. Floyd Road, Richardson, TX 75080, USA. E-mail:<email>sherry@utdallas.edu</email>; Fax: + 01 972-883-2925; Tel: + 01 972-883-2907</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NE 4.2, Dallas, TX 75390-8568, USA. E-mail:<email>dean.sherry@utsouthwestern.edu</email>; Fax: + 01 214-645-2744; Tel: + 01 214-645-2720</nlm:aff></affiliation></author></analytic><series><title level="j">Chemical Society reviews</title><idno type="ISSN">0306-0012</idno><idno type="eISSN">1460-4744</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">This <italic>tutorial review</italic> examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.</p></div></front></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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