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Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

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Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Auteurs : Mark Woods [États-Unis] ; Donald E. Woessner ; A. Dean Sherry

Source :

Chemical Society reviews [ 0306-0012 ] ; 2006.

RBID : PMC:2718840

Abstract

This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718840

DOI: 10.1039/b509907m
PubMed: 16729144
PubMed Central: 2718840

Affiliations:

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PMC:2718840

Le document en format XML

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<author><name sortKey="Woods, Mark" sort="Woods, Mark" uniqKey="Woods M" first="Mark" last="Woods">Mark Woods</name>
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<placeName><region type="state">Texas</region>
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<affiliation><nlm:aff id="A2">Department of Chemistry, University of Texas at Dallas, 2601 N. Floyd Road, Richardson, TX 75080, USA. E-mail:<email>sherry@utdallas.edu</email>
; Fax: + 01 972-883-2925; Tel: + 01 972-883-2907</nlm:aff>
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<author><name sortKey="Woessner, Donald E" sort="Woessner, Donald E" uniqKey="Woessner D" first="Donald E." last="Woessner">Donald E. Woessner</name>
<affiliation><nlm:aff id="A3">Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NE 4.2, Dallas, TX 75390-8568, USA. E-mail:<email>dean.sherry@utsouthwestern.edu</email>
; Fax: + 01 214-645-2744; Tel: + 01 214-645-2720</nlm:aff>
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<author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name>
<affiliation><nlm:aff id="A2">Department of Chemistry, University of Texas at Dallas, 2601 N. Floyd Road, Richardson, TX 75080, USA. E-mail:<email>sherry@utdallas.edu</email>
; Fax: + 01 972-883-2925; Tel: + 01 972-883-2907</nlm:aff>
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<affiliation><nlm:aff id="A3">Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NE 4.2, Dallas, TX 75390-8568, USA. E-mail:<email>dean.sherry@utsouthwestern.edu</email>
; Fax: + 01 214-645-2744; Tel: + 01 214-645-2720</nlm:aff>
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; Fax: + 01 214-645-2744; Tel: + 01 214-645-2720</nlm:aff>
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<author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name>
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; Fax: + 01 972-883-2925; Tel: + 01 972-883-2907</nlm:aff>
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; Fax: + 01 214-645-2744; Tel: + 01 214-645-2720</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p id="P1">This <italic>tutorial review</italic>
 examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.</p>
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<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0335405</journal-id>
<journal-id journal-id-type="pubmed-jr-id">29764</journal-id>
<journal-id journal-id-type="nlm-ta">Chem Soc Rev</journal-id>
<journal-title>Chemical Society reviews</journal-title>
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<title-group><article-title>Paramagnetic lanthanide complexes as PARACEST agents for medical imaging</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Woods</surname>
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<contrib contrib-type="author"><name><surname>Woessner</surname>
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<aff id="A1"><label>a</label>
Macrocyclics, 2110 Research Row, Suite 425, Dallas, TX 75235, USA</aff>
<aff id="A2"><label>b</label>
Department of Chemistry, University of Texas at Dallas, 2601 N. Floyd Road, Richardson, TX 75080, USA. E-mail:<email>sherry@utdallas.edu</email>
; Fax: + 01 972-883-2925; Tel: + 01 972-883-2907</aff>
<aff id="A3"><label>c</label>
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NE 4.2, Dallas, TX 75390-8568, USA. E-mail:<email>dean.sherry@utsouthwestern.edu</email>
; Fax: + 01 214-645-2744; Tel: + 01 214-645-2720</aff>
<pub-date pub-type="nihms-submitted"><day>18</day>
<month>6</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
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<pub-date pub-type="pmc-release"><day>30</day>
<month>7</month>
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<volume>35</volume>
<issue>6</issue>
<fpage>500</fpage>
<lpage>511</lpage>
<permissions><copyright-statement>© The Royal Society of Chemistry 2006</copyright-statement>
<copyright-year>2006</copyright-year>
</permissions>
<abstract><p id="P1">This <italic>tutorial review</italic>
 examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.</p>
</abstract>
<contract-num rid="EB1">R21 EB004285-02</contract-num>
<contract-num rid="EB1">R21 EB004285-01</contract-num>
<contract-sponsor id="EB1">National Institute of Biomedical Imaging and Bioengineering : NIBIB</contract-sponsor>
</article-meta>
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<country name="États-Unis"><region name="Texas"><name sortKey="Woods, Mark" sort="Woods, Mark" uniqKey="Woods M" first="Mark" last="Woods">Mark Woods</name>
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Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki