Optimized MRI contrast for on‐resonance proton exchange processes of PARACEST agents in biological systems
Identifieur interne : 000F99 ( Main/Exploration ); précédent : 000F98; suivant : 001000Optimized MRI contrast for on‐resonance proton exchange processes of PARACEST agents in biological systems
Auteurs : Alex X. Li [Canada] ; Mojmir Suchy [Canada] ; Craig K. Jones [Canada] ; Robert H. E. Hudson [Canada] ; Ravi S. Menon [Canada] ; Robert Bartha [Canada]Source :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 2009-11.
Descripteurs français
- KwdFr :
- Wicri :
English descriptors
- KwdEn :
- Agent concentration, Algorithms, Amide, Amide protons, Annual meeting, Aqueous solution, Aqueous solutions, Bartha, Biological systems, Bloch equations, Bulk water, Bulk water frequency, Bulk water signal decrease, Cest, Cest effect, Chem, Chemical exchange, Chemical shift, Computer Simulation, Contrast Media, Contrast agent, Contrast agents, Current study, Delli castelli, Endogenous macromolecules, Exchange rate, Excitation, Experimental results, Image Enhancement (methods), Image Interpretation, Computer-Assisted (methods), Imaging, Irradiation pulse duration, Macromolecule, Magn, Magn reson, Magnetic Resonance Imaging (methods), Magnetization, Magnetization transfer, Models, Biological, Muscle tissue, Oparachee, Oparachee contrast, Oparachee effect, Oparachee method, Oparachee sensitivity, Optimal pulse duration, Paracest, Paracest agent, Paracest agents, Paracest effect, Phantom, Preparation pulse, Proton, Proton exchange, Proton exchange processes, Proton exchange rate, Protons, Pulse, Pulse duration, Pulse power, Pulse train, Relative magnetization, Relaxation time constants, Reproducibility of Results, Reson, Sensitivity and Specificity, Signal intensity, Simulation, Vinogradov, Vivo, Water chemical shift, Western ontario.
- MESH :
- chemical : Contrast Media, Protons.
- methods : Image Enhancement, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging.
- Teeft :
- Agent concentration, Algorithms, Amide, Amide protons, Annual meeting, Aqueous solution, Aqueous solutions, Bartha, Biological systems, Bloch equations, Bulk water, Bulk water frequency, Bulk water signal decrease, Cest, Cest effect, Chem, Chemical exchange, Chemical shift, Computer Simulation, Contrast agent, Contrast agents, Current study, Delli castelli, Endogenous macromolecules, Exchange rate, Excitation, Experimental results, Imaging, Irradiation pulse duration, Macromolecule, Magn, Magn reson, Magnetization, Magnetization transfer, Models, Biological, Muscle tissue, Oparachee, Oparachee contrast, Oparachee effect, Oparachee method, Oparachee sensitivity, Optimal pulse duration, Paracest, Paracest agent, Paracest agents, Paracest effect, Phantom, Preparation pulse, Proton, Proton exchange, Proton exchange processes, Proton exchange rate, Pulse, Pulse duration, Pulse power, Pulse train, Relative magnetization, Relaxation time constants, Reproducibility of Results, Reson, Sensitivity and Specificity, Signal intensity, Simulation, Vinogradov, Vivo, Water chemical shift, Western ontario.
Abstract
Image contrast associated with paramagnetic chemical exchange saturation transfer agents can be generated by off‐resonance irradiation of agent‐bound water or amide protons or on‐resonance irradiation of bulk water. Previously, a four‐pool model was developed to describe an in vivo system. The model incorporated the magnetization transfer effect from macromolecules when using off‐resonance irradiation. In the current study, this four‐pool model is modified to describe the in vivo system when using on‐resonance irradiation. The influences of pulse power, pulse duration, the chemical shift of bound water, the proton exchange rate between bulk water and bound water, and agent concentration on the on‐resonance paramagnetic agent chemical exchange effects were simulated using a WALTZ‐16 pulse train in the absence and presence of the macromolecule pool. The results demonstrated that while contrast increases with pulse duration in aqueous solution, there is an optimal pulse duration that maximizes on‐resonance paramagnetic agent chemical exchange effects contrast in vivo. This predication was verified by experimental spectroscopic and imaging results from aqueous solution, bovine serum albumin phantoms, and a tissue phantom containing thulium‐DOTAM (1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetamide)‐glycine‐lysine. This model can be used to optimize sequence parameters to maximize in vivo on‐resonance paramagnetic agent chemical exchange effects contrast. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/mrm.22134
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001066
- to stream Istex, to step Curation: 001066
- to stream Istex, to step Checkpoint: 000394
- to stream PubMed, to step Corpus: 000516
- to stream PubMed, to step Curation: 000516
- to stream PubMed, to step Checkpoint: 000516
- to stream Ncbi, to step Merge: 000329
- to stream Ncbi, to step Curation: 000329
- to stream Ncbi, to step Checkpoint: 000329
- to stream Main, to step Merge: 001017
- to stream Main, to step Curation: 000F99
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Optimized MRI contrast for on‐resonance proton exchange processes of PARACEST agents in biological systems</title><author><name sortKey="Li, Alex X" sort="Li, Alex X" uniqKey="Li A" first="Alex X." last="Li">Alex X. Li</name></author><author><name sortKey="Suchy, Mojmir" sort="Suchy, Mojmir" uniqKey="Suchy M" first="Mojmir" last="Suchy">Mojmir Suchy</name></author><author><name sortKey="Jones, Craig K" sort="Jones, Craig K" uniqKey="Jones C" first="Craig K." last="Jones">Craig K. Jones</name></author><author><name sortKey="Hudson, Robert H E" sort="Hudson, Robert H E" uniqKey="Hudson R" first="Robert H. E." last="Hudson">Robert H. E. Hudson</name></author><author><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S." last="Menon">Ravi S. Menon</name></author><author><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4AC7AD3F600234D98CABFC05A71E68E558091456</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mrm.22134</idno><idno type="url">https://api.istex.fr/document/4AC7AD3F600234D98CABFC05A71E68E558091456/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001066</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001066</idno><idno type="wicri:Area/Istex/Curation">001066</idno><idno type="wicri:Area/Istex/Checkpoint">000394</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000394</idno><idno type="wicri:doubleKey">0740-3194:2009:Li A:optimized:mri:contrast</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:19780147</idno><idno type="wicri:Area/PubMed/Corpus">000516</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000516</idno><idno type="wicri:Area/PubMed/Curation">000516</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000516</idno><idno type="wicri:Area/PubMed/Checkpoint">000516</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000516</idno><idno type="wicri:Area/Ncbi/Merge">000329</idno><idno type="wicri:Area/Ncbi/Curation">000329</idno><idno type="wicri:Area/Ncbi/Checkpoint">000329</idno><idno type="wicri:Area/Main/Merge">001017</idno><idno type="wicri:Area/Main/Curation">000F99</idno><idno type="wicri:Area/Main/Exploration">000F99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Optimized MRI contrast for on‐resonance proton exchange processes of PARACEST agents in biological systems</title><author><name sortKey="Li, Alex X" sort="Li, Alex X" uniqKey="Li A" first="Alex X." last="Li">Alex X. Li</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Suchy, Mojmir" sort="Suchy, Mojmir" uniqKey="Suchy M" first="Mojmir" last="Suchy">Mojmir Suchy</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry, University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Craig K" sort="Jones, Craig K" uniqKey="Jones C" first="Craig K." last="Jones">Craig K. Jones</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hudson, Robert H E" sort="Hudson, Robert H E" uniqKey="Hudson R" first="Robert H. E." last="Hudson">Robert H. E. Hudson</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry, University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S." last="Menon">Ravi S. Menon</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Correspondence address: Center for Functional and Metabolic Mapping, Robarts Research Institute, 100 Perth Drive, P.O. Box 5015, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Magnetic Resonance in Medicine</title><title level="j" type="alt">MAGNETIC RESONANCE IN MEDICINE</title><idno type="ISSN">0740-3194</idno><idno type="eISSN">1522-2594</idno><imprint><biblScope unit="vol">62</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1282">1282</biblScope><biblScope unit="page" to="1291">1291</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11">2009-11</date></imprint><idno type="ISSN">0740-3194</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0740-3194</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agent concentration</term><term>Algorithms</term><term>Amide</term><term>Amide protons</term><term>Annual meeting</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bartha</term><term>Biological systems</term><term>Bloch equations</term><term>Bulk water</term><term>Bulk water frequency</term><term>Bulk water signal decrease</term><term>Cest</term><term>Cest effect</term><term>Chem</term><term>Chemical exchange</term><term>Chemical shift</term><term>Computer Simulation</term><term>Contrast Media</term><term>Contrast agent</term><term>Contrast agents</term><term>Current study</term><term>Delli castelli</term><term>Endogenous macromolecules</term><term>Exchange rate</term><term>Excitation</term><term>Experimental results</term><term>Image Enhancement (methods)</term><term>Image Interpretation, Computer-Assisted (methods)</term><term>Imaging</term><term>Irradiation pulse duration</term><term>Macromolecule</term><term>Magn</term><term>Magn reson</term><term>Magnetic Resonance Imaging (methods)</term><term>Magnetization</term><term>Magnetization transfer</term><term>Models, Biological</term><term>Muscle tissue</term><term>Oparachee</term><term>Oparachee contrast</term><term>Oparachee effect</term><term>Oparachee method</term><term>Oparachee sensitivity</term><term>Optimal pulse duration</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Paracest effect</term><term>Phantom</term><term>Preparation pulse</term><term>Proton</term><term>Proton exchange</term><term>Proton exchange processes</term><term>Proton exchange rate</term><term>Protons</term><term>Pulse</term><term>Pulse duration</term><term>Pulse power</term><term>Pulse train</term><term>Relative magnetization</term><term>Relaxation time constants</term><term>Reproducibility of Results</term><term>Reson</term><term>Sensitivity and Specificity</term><term>Signal intensity</term><term>Simulation</term><term>Vinogradov</term><term>Vivo</term><term>Water chemical shift</term><term>Western ontario</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Algorithmes</term><term>Amélioration d'image ()</term><term>Imagerie par résonance magnétique ()</term><term>Interprétation d'image assistée par ordinateur ()</term><term>Modèles biologiques</term><term>Produits de contraste</term><term>Protons</term><term>Reproductibilité des résultats</term><term>Sensibilité et spécificité</term><term>Simulation numérique</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Contrast Media</term><term>Protons</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Enhancement</term><term>Image Interpretation, Computer-Assisted</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Agent concentration</term><term>Algorithms</term><term>Amide</term><term>Amide protons</term><term>Annual meeting</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bartha</term><term>Biological systems</term><term>Bloch equations</term><term>Bulk water</term><term>Bulk water frequency</term><term>Bulk water signal decrease</term><term>Cest</term><term>Cest effect</term><term>Chem</term><term>Chemical exchange</term><term>Chemical shift</term><term>Computer Simulation</term><term>Contrast agent</term><term>Contrast agents</term><term>Current study</term><term>Delli castelli</term><term>Endogenous macromolecules</term><term>Exchange rate</term><term>Excitation</term><term>Experimental results</term><term>Imaging</term><term>Irradiation pulse duration</term><term>Macromolecule</term><term>Magn</term><term>Magn reson</term><term>Magnetization</term><term>Magnetization transfer</term><term>Models, Biological</term><term>Muscle tissue</term><term>Oparachee</term><term>Oparachee contrast</term><term>Oparachee effect</term><term>Oparachee method</term><term>Oparachee sensitivity</term><term>Optimal pulse duration</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Paracest effect</term><term>Phantom</term><term>Preparation pulse</term><term>Proton</term><term>Proton exchange</term><term>Proton exchange processes</term><term>Proton exchange rate</term><term>Pulse</term><term>Pulse duration</term><term>Pulse power</term><term>Pulse train</term><term>Relative magnetization</term><term>Relaxation time constants</term><term>Reproducibility of Results</term><term>Reson</term><term>Sensitivity and Specificity</term><term>Signal intensity</term><term>Simulation</term><term>Vinogradov</term><term>Vivo</term><term>Water chemical shift</term><term>Western ontario</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Algorithmes</term><term>Amélioration d'image</term><term>Imagerie par résonance magnétique</term><term>Interprétation d'image assistée par ordinateur</term><term>Modèles biologiques</term><term>Produits de contraste</term><term>Protons</term><term>Reproductibilité des résultats</term><term>Sensibilité et spécificité</term><term>Simulation numérique</term><term>Taux de change</term><term>Simulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Image contrast associated with paramagnetic chemical exchange saturation transfer agents can be generated by off‐resonance irradiation of agent‐bound water or amide protons or on‐resonance irradiation of bulk water. Previously, a four‐pool model was developed to describe an in vivo system. The model incorporated the magnetization transfer effect from macromolecules when using off‐resonance irradiation. In the current study, this four‐pool model is modified to describe the in vivo system when using on‐resonance irradiation. The influences of pulse power, pulse duration, the chemical shift of bound water, the proton exchange rate between bulk water and bound water, and agent concentration on the on‐resonance paramagnetic agent chemical exchange effects were simulated using a WALTZ‐16 pulse train in the absence and presence of the macromolecule pool. The results demonstrated that while contrast increases with pulse duration in aqueous solution, there is an optimal pulse duration that maximizes on‐resonance paramagnetic agent chemical exchange effects contrast in vivo. This predication was verified by experimental spectroscopic and imaging results from aqueous solution, bovine serum albumin phantoms, and a tissue phantom containing thulium‐DOTAM (1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetamide)‐glycine‐lysine. This model can be used to optimize sequence parameters to maximize in vivo on‐resonance paramagnetic agent chemical exchange effects contrast. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Li, Alex X" sort="Li, Alex X" uniqKey="Li A" first="Alex X." last="Li">Alex X. Li</name></noRegion><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><name sortKey="Hudson, Robert H E" sort="Hudson, Robert H E" uniqKey="Hudson R" first="Robert H. E." last="Hudson">Robert H. E. Hudson</name><name sortKey="Jones, Craig K" sort="Jones, Craig K" uniqKey="Jones C" first="Craig K." last="Jones">Craig K. Jones</name><name sortKey="Li, Alex X" sort="Li, Alex X" uniqKey="Li A" first="Alex X." last="Li">Alex X. Li</name><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S." last="Menon">Ravi S. Menon</name><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S." last="Menon">Ravi S. Menon</name><name sortKey="Suchy, Mojmir" sort="Suchy, Mojmir" uniqKey="Suchy M" first="Mojmir" last="Suchy">Mojmir Suchy</name><name sortKey="Suchy, Mojmir" sort="Suchy, Mojmir" uniqKey="Suchy M" first="Mojmir" last="Suchy">Mojmir Suchy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F99 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F99 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= ThuliumV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:4AC7AD3F600234D98CABFC05A71E68E558091456
|texte= Optimized MRI contrast for on‐resonance proton exchange processes of PARACEST agents in biological systems
}}
| This area was generated with Dilib version V0.6.21. |  |