Optimized MRI contrast for on‐resonance proton exchange processes of PARACEST agents in biological systems
Identifieur interne : 001066 ( Istex/Curation ); précédent : 001065; suivant : 001067Optimized MRI contrast for on‐resonance proton exchange processes of PARACEST agents in biological systems
Auteurs : Alex X. Li [Canada] ; Mojmir Suchy [Canada] ; Craig K. Jones [Canada] ; Robert H. E. Hudson [Canada] ; Ravi S. Menon [Canada] ; Robert Bartha [Canada]Source :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 2009-11.
Descripteurs français
- Wicri :
- topic : Taux de change, Simulation.
English descriptors
- KwdEn :
- Agent concentration, Amide, Amide protons, Annual meeting, Aqueous solution, Aqueous solutions, Bartha, Biological systems, Bloch equations, Bulk water, Bulk water frequency, Bulk water signal decrease, Cest, Cest effect, Chem, Chemical exchange, Chemical shift, Contrast agent, Contrast agents, Current study, Delli castelli, Endogenous macromolecules, Exchange rate, Excitation, Experimental results, Imaging, Irradiation pulse duration, Macromolecule, Magn, Magn reson, Magnetization, Magnetization transfer, Muscle tissue, Oparachee, Oparachee contrast, Oparachee effect, Oparachee method, Oparachee sensitivity, Optimal pulse duration, Paracest, Paracest agent, Paracest agents, Paracest effect, Phantom, Preparation pulse, Proton, Proton exchange, Proton exchange processes, Proton exchange rate, Pulse, Pulse duration, Pulse power, Pulse train, Relative magnetization, Relaxation time constants, Reson, Signal intensity, Simulation, Vinogradov, Vivo, Water chemical shift, Western ontario.
- Teeft :
- Agent concentration, Amide, Amide protons, Annual meeting, Aqueous solution, Aqueous solutions, Bartha, Biological systems, Bloch equations, Bulk water, Bulk water frequency, Bulk water signal decrease, Cest, Cest effect, Chem, Chemical exchange, Chemical shift, Contrast agent, Contrast agents, Current study, Delli castelli, Endogenous macromolecules, Exchange rate, Excitation, Experimental results, Imaging, Irradiation pulse duration, Macromolecule, Magn, Magn reson, Magnetization, Magnetization transfer, Muscle tissue, Oparachee, Oparachee contrast, Oparachee effect, Oparachee method, Oparachee sensitivity, Optimal pulse duration, Paracest, Paracest agent, Paracest agents, Paracest effect, Phantom, Preparation pulse, Proton, Proton exchange, Proton exchange processes, Proton exchange rate, Pulse, Pulse duration, Pulse power, Pulse train, Relative magnetization, Relaxation time constants, Reson, Signal intensity, Simulation, Vinogradov, Vivo, Water chemical shift, Western ontario.
Abstract
Image contrast associated with paramagnetic chemical exchange saturation transfer agents can be generated by off‐resonance irradiation of agent‐bound water or amide protons or on‐resonance irradiation of bulk water. Previously, a four‐pool model was developed to describe an in vivo system. The model incorporated the magnetization transfer effect from macromolecules when using off‐resonance irradiation. In the current study, this four‐pool model is modified to describe the in vivo system when using on‐resonance irradiation. The influences of pulse power, pulse duration, the chemical shift of bound water, the proton exchange rate between bulk water and bound water, and agent concentration on the on‐resonance paramagnetic agent chemical exchange effects were simulated using a WALTZ‐16 pulse train in the absence and presence of the macromolecule pool. The results demonstrated that while contrast increases with pulse duration in aqueous solution, there is an optimal pulse duration that maximizes on‐resonance paramagnetic agent chemical exchange effects contrast in vivo. This predication was verified by experimental spectroscopic and imaging results from aqueous solution, bovine serum albumin phantoms, and a tissue phantom containing thulium‐DOTAM (1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetamide)‐glycine‐lysine. This model can be used to optimize sequence parameters to maximize in vivo on‐resonance paramagnetic agent chemical exchange effects contrast. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/mrm.22134
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Li</name><affiliation wicri:level="1"><mods:affiliation>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Western Ontario, London, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Suchy, Mojmir" sort="Suchy, Mojmir" uniqKey="Suchy M" first="Mojmir" last="Suchy">Mojmir Suchy</name><affiliation wicri:level="1"><mods:affiliation>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, University of Western Ontario, London, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry, University of Western Ontario, London, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Jones, Craig K" sort="Jones, Craig K" uniqKey="Jones C" first="Craig K." last="Jones">Craig K. Jones</name><affiliation wicri:level="1"><mods:affiliation>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Hudson, Robert H E" sort="Hudson, Robert H E" uniqKey="Hudson R" first="Robert H. E." last="Hudson">Robert H. E. Hudson</name><affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, University of Western Ontario, London, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry, University of Western Ontario, London, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S." last="Menon">Ravi S. 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Box 5015, London, Ontario, N6A 5K8 Canada===</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Correspondence address: Center for Functional and Metabolic Mapping, Robarts Research Institute, 100 Perth Drive, P.O. Box 5015, London, Ontario</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Magnetic Resonance in Medicine</title><title level="j" type="alt">MAGNETIC RESONANCE IN MEDICINE</title><idno type="ISSN">0740-3194</idno><idno type="eISSN">1522-2594</idno><imprint><biblScope unit="vol">62</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1282">1282</biblScope><biblScope unit="page" to="1291">1291</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11">2009-11</date></imprint><idno type="ISSN">0740-3194</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0740-3194</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agent concentration</term><term>Amide</term><term>Amide protons</term><term>Annual meeting</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bartha</term><term>Biological systems</term><term>Bloch equations</term><term>Bulk water</term><term>Bulk water frequency</term><term>Bulk water signal decrease</term><term>Cest</term><term>Cest effect</term><term>Chem</term><term>Chemical exchange</term><term>Chemical shift</term><term>Contrast agent</term><term>Contrast agents</term><term>Current study</term><term>Delli castelli</term><term>Endogenous macromolecules</term><term>Exchange rate</term><term>Excitation</term><term>Experimental results</term><term>Imaging</term><term>Irradiation pulse duration</term><term>Macromolecule</term><term>Magn</term><term>Magn reson</term><term>Magnetization</term><term>Magnetization transfer</term><term>Muscle tissue</term><term>Oparachee</term><term>Oparachee contrast</term><term>Oparachee effect</term><term>Oparachee method</term><term>Oparachee sensitivity</term><term>Optimal pulse duration</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Paracest effect</term><term>Phantom</term><term>Preparation pulse</term><term>Proton</term><term>Proton exchange</term><term>Proton exchange processes</term><term>Proton exchange rate</term><term>Pulse</term><term>Pulse duration</term><term>Pulse power</term><term>Pulse train</term><term>Relative magnetization</term><term>Relaxation time constants</term><term>Reson</term><term>Signal intensity</term><term>Simulation</term><term>Vinogradov</term><term>Vivo</term><term>Water chemical shift</term><term>Western ontario</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Agent concentration</term><term>Amide</term><term>Amide protons</term><term>Annual meeting</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bartha</term><term>Biological systems</term><term>Bloch equations</term><term>Bulk water</term><term>Bulk water frequency</term><term>Bulk water signal decrease</term><term>Cest</term><term>Cest effect</term><term>Chem</term><term>Chemical exchange</term><term>Chemical shift</term><term>Contrast agent</term><term>Contrast agents</term><term>Current study</term><term>Delli castelli</term><term>Endogenous macromolecules</term><term>Exchange rate</term><term>Excitation</term><term>Experimental results</term><term>Imaging</term><term>Irradiation pulse duration</term><term>Macromolecule</term><term>Magn</term><term>Magn reson</term><term>Magnetization</term><term>Magnetization transfer</term><term>Muscle tissue</term><term>Oparachee</term><term>Oparachee contrast</term><term>Oparachee effect</term><term>Oparachee method</term><term>Oparachee sensitivity</term><term>Optimal pulse duration</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Paracest effect</term><term>Phantom</term><term>Preparation pulse</term><term>Proton</term><term>Proton exchange</term><term>Proton exchange processes</term><term>Proton exchange rate</term><term>Pulse</term><term>Pulse duration</term><term>Pulse power</term><term>Pulse train</term><term>Relative magnetization</term><term>Relaxation time constants</term><term>Reson</term><term>Signal intensity</term><term>Simulation</term><term>Vinogradov</term><term>Vivo</term><term>Water chemical shift</term><term>Western ontario</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Taux de change</term><term>Simulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Image contrast associated with paramagnetic chemical exchange saturation transfer agents can be generated by off‐resonance irradiation of agent‐bound water or amide protons or on‐resonance irradiation of bulk water. Previously, a four‐pool model was developed to describe an in vivo system. The model incorporated the magnetization transfer effect from macromolecules when using off‐resonance irradiation. In the current study, this four‐pool model is modified to describe the in vivo system when using on‐resonance irradiation. The influences of pulse power, pulse duration, the chemical shift of bound water, the proton exchange rate between bulk water and bound water, and agent concentration on the on‐resonance paramagnetic agent chemical exchange effects were simulated using a WALTZ‐16 pulse train in the absence and presence of the macromolecule pool. The results demonstrated that while contrast increases with pulse duration in aqueous solution, there is an optimal pulse duration that maximizes on‐resonance paramagnetic agent chemical exchange effects contrast in vivo. This predication was verified by experimental spectroscopic and imaging results from aqueous solution, bovine serum albumin phantoms, and a tissue phantom containing thulium‐DOTAM (1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetamide)‐glycine‐lysine. This model can be used to optimize sequence parameters to maximize in vivo on‐resonance paramagnetic agent chemical exchange effects contrast. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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