2,5-Anhydro-D-mannitol increases hepatocyte sodium: transduction of a hepatic hunger stimulus?
Identifieur interne : 001C09 ( Main/Exploration ); précédent : 001C08; suivant : 001C102,5-Anhydro-D-mannitol increases hepatocyte sodium: transduction of a hepatic hunger stimulus?
Auteurs : Mark I. Friedman [États-Unis] ; Grazyna Graczyk-Millbrandt ; Hong Ji ; Nancy E. Rawson ; Mary D. OsbakkenSource :
- Biochimica et biophysica acta [ 0006-3002 ] ; 2003.
Descripteurs français
- KwdFr :
- Adénosine triphosphate (déficit), Animaux, Comportement alimentaire (), Comportement alimentaire (physiologie), Faim (), Faim (physiologie), Foie (cytologie), Foie (physiologie), Fructose (métabolisme), Fructose (pharmacologie), Hépatocytes (), Hépatocytes (enzymologie), Mannitol (analogues et dérivés), Mannitol (pharmacologie), Membrane cellulaire (), Membrane cellulaire (enzymologie), Mâle, Métabolisme énergétique (), Métabolisme énergétique (physiologie), Rat Sprague-Dawley, Rats, Régulation de l'appétit (), Régulation de l'appétit (physiologie), Régulation positive (), Régulation positive (physiologie), Sodium (métabolisme), Sodium-Potassium-Exchanging ATPase (), Sodium-Potassium-Exchanging ATPase (métabolisme), Spectroscopie par résonance magnétique, Transduction du signal (), Transduction du signal (physiologie).
- MESH :
- analogues et dérivés : Mannitol.
- cytologie : Foie.
- déficit : Adénosine triphosphate.
- enzymologie : Hépatocytes, Membrane cellulaire.
- métabolisme : Fructose, Sodium, Sodium-Potassium-Exchanging ATPase.
- pharmacologie : Fructose, Mannitol.
- physiologie : Comportement alimentaire, Faim, Foie, Métabolisme énergétique, Régulation de l'appétit, Régulation positive, Transduction du signal.
- Animaux, Comportement alimentaire, Faim, Hépatocytes, Membrane cellulaire, Mâle, Métabolisme énergétique, Rat Sprague-Dawley, Rats, Régulation de l'appétit, Régulation positive, Sodium-Potassium-Exchanging ATPase, Spectroscopie par résonance magnétique, Transduction du signal.
English descriptors
- KwdEn :
- Adenosine Triphosphate (deficiency), Animals, Appetite Regulation (drug effects), Appetite Regulation (physiology), Cell Membrane (drug effects), Cell Membrane (enzymology), Energy Metabolism (drug effects), Energy Metabolism (physiology), Feeding Behavior (drug effects), Feeding Behavior (physiology), Fructose (metabolism), Fructose (pharmacology), Hepatocytes (drug effects), Hepatocytes (enzymology), Hunger (drug effects), Hunger (physiology), Liver (cytology), Liver (physiology), Magnetic Resonance Spectroscopy, Male, Mannitol (analogs & derivatives), Mannitol (pharmacology), Rats, Rats, Sprague-Dawley, Signal Transduction (drug effects), Signal Transduction (physiology), Sodium (metabolism), Sodium-Potassium-Exchanging ATPase (drug effects), Sodium-Potassium-Exchanging ATPase (metabolism), Up-Regulation (drug effects), Up-Regulation (physiology).
- MESH :
- chemical , analogs & derivatives : Mannitol.
- chemical , deficiency : Adenosine Triphosphate.
- cytology : Liver.
- drug effects : Appetite Regulation, Cell Membrane, Energy Metabolism, Feeding Behavior, Hepatocytes, Hunger, Signal Transduction, Sodium-Potassium-Exchanging ATPase, Up-Regulation.
- enzymology : Cell Membrane, Hepatocytes.
- chemical , metabolism : Fructose, Sodium, Sodium-Potassium-Exchanging ATPase.
- chemical , pharmacology : Fructose, Mannitol.
- physiology : Appetite Regulation, Energy Metabolism, Feeding Behavior, Hunger, Liver, Signal Transduction, Up-Regulation.
- Animals, Magnetic Resonance Spectroscopy, Male, Rats, Rats, Sprague-Dawley.
Abstract
To test the hypothesis that decreased hepatocyte ATP is transduced into a hepatic neuronal signal via a change in sodium pump activity, we examined the effect of 2,5-anhydro-D-mannitol (2,5-AM), which stimulates feeding behavior in rats, on intracellular sodium levels using 23Na nuclear magnetic resonance (NMR) spectroscopy. Isolated hepatocytes suspended in agarose beads were superfused with either 2.5 mM 2,5-AM or fructose in the presence of the paramagnetic shift reagent, thulium(III)(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonate)). Superfusion with 2,5-AM decreased hepatocyte ATP and increased intracellular sodium levels compared with superfusion with either fructose or shift reagent alone starting within 15 min of exposure, reaching a maximum level of 120% of baseline by 30 min and declining gradually thereafter over the next 90 min. Superfusion with fructose, which also decreased hepatocyte ATP but by less than half the amount seen with 2,5-AM, had no significant effect on cellular sodium levels. The results support the hypothesis that changes in sodium pump activity could participate in transducing a hunger stimulus associated with hepatocyte energy status into a signal for hunger.
PubMed: 12972293
Affiliations:
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Le document en format XML
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Friedman</name><affiliation wicri:level="2"><nlm:affiliation>Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. friedman@monell.org</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Graczyk Millbrandt, Grazyna" sort="Graczyk Millbrandt, Grazyna" uniqKey="Graczyk Millbrandt G" first="Grazyna" last="Graczyk-Millbrandt">Grazyna Graczyk-Millbrandt</name></author><author><name sortKey="Ji, Hong" sort="Ji, Hong" uniqKey="Ji H" first="Hong" last="Ji">Hong Ji</name></author><author><name sortKey="Rawson, Nancy E" sort="Rawson, Nancy E" uniqKey="Rawson N" first="Nancy E" last="Rawson">Nancy E. Rawson</name></author><author><name sortKey="Osbakken, Mary D" sort="Osbakken, Mary D" uniqKey="Osbakken M" first="Mary D" last="Osbakken">Mary D. 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Friedman</name><affiliation wicri:level="2"><nlm:affiliation>Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. friedman@monell.org</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Graczyk Millbrandt, Grazyna" sort="Graczyk Millbrandt, Grazyna" uniqKey="Graczyk Millbrandt G" first="Grazyna" last="Graczyk-Millbrandt">Grazyna Graczyk-Millbrandt</name></author><author><name sortKey="Ji, Hong" sort="Ji, Hong" uniqKey="Ji H" first="Hong" last="Ji">Hong Ji</name></author><author><name sortKey="Rawson, Nancy E" sort="Rawson, Nancy E" uniqKey="Rawson N" first="Nancy E" last="Rawson">Nancy E. Rawson</name></author><author><name sortKey="Osbakken, Mary D" sort="Osbakken, Mary D" uniqKey="Osbakken M" first="Mary D" last="Osbakken">Mary D. Osbakken</name></author></analytic><series><title level="j">Biochimica et biophysica acta</title><idno type="ISSN">0006-3002</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Triphosphate (deficiency)</term><term>Animals</term><term>Appetite Regulation (drug effects)</term><term>Appetite Regulation (physiology)</term><term>Cell Membrane (drug effects)</term><term>Cell Membrane (enzymology)</term><term>Energy Metabolism (drug effects)</term><term>Energy Metabolism (physiology)</term><term>Feeding Behavior (drug effects)</term><term>Feeding Behavior (physiology)</term><term>Fructose (metabolism)</term><term>Fructose (pharmacology)</term><term>Hepatocytes (drug effects)</term><term>Hepatocytes (enzymology)</term><term>Hunger (drug effects)</term><term>Hunger (physiology)</term><term>Liver (cytology)</term><term>Liver (physiology)</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Mannitol (analogs & derivatives)</term><term>Mannitol (pharmacology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Signal Transduction (drug effects)</term><term>Signal Transduction (physiology)</term><term>Sodium (metabolism)</term><term>Sodium-Potassium-Exchanging ATPase (drug effects)</term><term>Sodium-Potassium-Exchanging ATPase (metabolism)</term><term>Up-Regulation (drug effects)</term><term>Up-Regulation (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénosine triphosphate (déficit)</term><term>Animaux</term><term>Comportement alimentaire ()</term><term>Comportement alimentaire (physiologie)</term><term>Faim ()</term><term>Faim (physiologie)</term><term>Foie (cytologie)</term><term>Foie (physiologie)</term><term>Fructose (métabolisme)</term><term>Fructose (pharmacologie)</term><term>Hépatocytes ()</term><term>Hépatocytes (enzymologie)</term><term>Mannitol (analogues et dérivés)</term><term>Mannitol (pharmacologie)</term><term>Membrane cellulaire ()</term><term>Membrane cellulaire (enzymologie)</term><term>Mâle</term><term>Métabolisme énergétique ()</term><term>Métabolisme énergétique (physiologie)</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Régulation de l'appétit ()</term><term>Régulation de l'appétit (physiologie)</term><term>Régulation positive ()</term><term>Régulation positive (physiologie)</term><term>Sodium (métabolisme)</term><term>Sodium-Potassium-Exchanging ATPase ()</term><term>Sodium-Potassium-Exchanging ATPase (métabolisme)</term><term>Spectroscopie par résonance magnétique</term><term>Transduction du signal ()</term><term>Transduction du signal (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Mannitol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Adenosine Triphosphate</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Mannitol</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Appetite Regulation</term><term>Cell Membrane</term><term>Energy Metabolism</term><term>Feeding Behavior</term><term>Hepatocytes</term><term>Hunger</term><term>Signal Transduction</term><term>Sodium-Potassium-Exchanging ATPase</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Adénosine triphosphate</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Hépatocytes</term><term>Membrane cellulaire</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Cell Membrane</term><term>Hepatocytes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fructose</term><term>Sodium</term><term>Sodium-Potassium-Exchanging ATPase</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Fructose</term><term>Sodium</term><term>Sodium-Potassium-Exchanging ATPase</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Fructose</term><term>Mannitol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Fructose</term><term>Mannitol</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Comportement alimentaire</term><term>Faim</term><term>Foie</term><term>Métabolisme énergétique</term><term>Régulation de l'appétit</term><term>Régulation positive</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Appetite Regulation</term><term>Energy Metabolism</term><term>Feeding Behavior</term><term>Hunger</term><term>Liver</term><term>Signal Transduction</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Comportement alimentaire</term><term>Faim</term><term>Hépatocytes</term><term>Membrane cellulaire</term><term>Mâle</term><term>Métabolisme énergétique</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Régulation de l'appétit</term><term>Régulation positive</term><term>Sodium-Potassium-Exchanging ATPase</term><term>Spectroscopie par résonance magnétique</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To test the hypothesis that decreased hepatocyte ATP is transduced into a hepatic neuronal signal via a change in sodium pump activity, we examined the effect of 2,5-anhydro-D-mannitol (2,5-AM), which stimulates feeding behavior in rats, on intracellular sodium levels using 23Na nuclear magnetic resonance (NMR) spectroscopy. Isolated hepatocytes suspended in agarose beads were superfused with either 2.5 mM 2,5-AM or fructose in the presence of the paramagnetic shift reagent, thulium(III)(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonate)). Superfusion with 2,5-AM decreased hepatocyte ATP and increased intracellular sodium levels compared with superfusion with either fructose or shift reagent alone starting within 15 min of exposure, reaching a maximum level of 120% of baseline by 30 min and declining gradually thereafter over the next 90 min. Superfusion with fructose, which also decreased hepatocyte ATP but by less than half the amount seen with 2,5-AM, had no significant effect on cellular sodium levels. The results support the hypothesis that changes in sodium pump activity could participate in transducing a hunger stimulus associated with hepatocyte energy status into a signal for hunger.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Graczyk Millbrandt, Grazyna" sort="Graczyk Millbrandt, Grazyna" uniqKey="Graczyk Millbrandt G" first="Grazyna" last="Graczyk-Millbrandt">Grazyna Graczyk-Millbrandt</name><name sortKey="Ji, Hong" sort="Ji, Hong" uniqKey="Ji H" first="Hong" last="Ji">Hong Ji</name><name sortKey="Osbakken, Mary D" sort="Osbakken, Mary D" uniqKey="Osbakken M" first="Mary D" last="Osbakken">Mary D. Osbakken</name><name sortKey="Rawson, Nancy E" sort="Rawson, Nancy E" uniqKey="Rawson N" first="Nancy E" last="Rawson">Nancy E. Rawson</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Friedman, Mark I" sort="Friedman, Mark I" uniqKey="Friedman M" first="Mark I" last="Friedman">Mark I. Friedman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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