2,5-Anhydro-D-mannitol increases hepatocyte sodium: transduction of a hepatic hunger stimulus?
Identifieur interne : 000689 ( PubMed/Corpus ); précédent : 000688; suivant : 0006902,5-Anhydro-D-mannitol increases hepatocyte sodium: transduction of a hepatic hunger stimulus?
Auteurs : Mark I. Friedman ; Grazyna Graczyk-Millbrandt ; Hong Ji ; Nancy E. Rawson ; Mary D. OsbakkenSource :
- Biochimica et biophysica acta [ 0006-3002 ] ; 2003.
English descriptors
- KwdEn :
- Adenosine Triphosphate (deficiency), Animals, Appetite Regulation (drug effects), Appetite Regulation (physiology), Cell Membrane (drug effects), Cell Membrane (enzymology), Energy Metabolism (drug effects), Energy Metabolism (physiology), Feeding Behavior (drug effects), Feeding Behavior (physiology), Fructose (metabolism), Fructose (pharmacology), Hepatocytes (drug effects), Hepatocytes (enzymology), Hunger (drug effects), Hunger (physiology), Liver (cytology), Liver (physiology), Magnetic Resonance Spectroscopy, Male, Mannitol (analogs & derivatives), Mannitol (pharmacology), Rats, Rats, Sprague-Dawley, Signal Transduction (drug effects), Signal Transduction (physiology), Sodium (metabolism), Sodium-Potassium-Exchanging ATPase (drug effects), Sodium-Potassium-Exchanging ATPase (metabolism), Up-Regulation (drug effects), Up-Regulation (physiology).
- MESH :
- chemical , analogs & derivatives : Mannitol.
- chemical , deficiency : Adenosine Triphosphate.
- cytology : Liver.
- drug effects : Appetite Regulation, Cell Membrane, Energy Metabolism, Feeding Behavior, Hepatocytes, Hunger, Signal Transduction, Sodium-Potassium-Exchanging ATPase, Up-Regulation.
- enzymology : Cell Membrane, Hepatocytes.
- chemical , metabolism : Fructose, Sodium, Sodium-Potassium-Exchanging ATPase.
- chemical , pharmacology : Fructose, Mannitol.
- physiology : Appetite Regulation, Energy Metabolism, Feeding Behavior, Hunger, Liver, Signal Transduction, Up-Regulation.
- Animals, Magnetic Resonance Spectroscopy, Male, Rats, Rats, Sprague-Dawley.
Abstract
To test the hypothesis that decreased hepatocyte ATP is transduced into a hepatic neuronal signal via a change in sodium pump activity, we examined the effect of 2,5-anhydro-D-mannitol (2,5-AM), which stimulates feeding behavior in rats, on intracellular sodium levels using 23Na nuclear magnetic resonance (NMR) spectroscopy. Isolated hepatocytes suspended in agarose beads were superfused with either 2.5 mM 2,5-AM or fructose in the presence of the paramagnetic shift reagent, thulium(III)(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonate)). Superfusion with 2,5-AM decreased hepatocyte ATP and increased intracellular sodium levels compared with superfusion with either fructose or shift reagent alone starting within 15 min of exposure, reaching a maximum level of 120% of baseline by 30 min and declining gradually thereafter over the next 90 min. Superfusion with fructose, which also decreased hepatocyte ATP but by less than half the amount seen with 2,5-AM, had no significant effect on cellular sodium levels. The results support the hypothesis that changes in sodium pump activity could participate in transducing a hunger stimulus associated with hepatocyte energy status into a signal for hunger.
PubMed: 12972293
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pubmed:12972293Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">2,5-Anhydro-D-mannitol increases hepatocyte sodium: transduction of a hepatic hunger stimulus?</title><author><name sortKey="Friedman, Mark I" sort="Friedman, Mark I" uniqKey="Friedman M" first="Mark I" last="Friedman">Mark I. Friedman</name><affiliation><nlm:affiliation>Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. friedman@monell.org</nlm:affiliation></affiliation></author><author><name sortKey="Graczyk Millbrandt, Grazyna" sort="Graczyk Millbrandt, Grazyna" uniqKey="Graczyk Millbrandt G" first="Grazyna" last="Graczyk-Millbrandt">Grazyna Graczyk-Millbrandt</name></author><author><name sortKey="Ji, Hong" sort="Ji, Hong" uniqKey="Ji H" first="Hong" last="Ji">Hong Ji</name></author><author><name sortKey="Rawson, Nancy E" sort="Rawson, Nancy E" uniqKey="Rawson N" first="Nancy E" last="Rawson">Nancy E. Rawson</name></author><author><name sortKey="Osbakken, Mary D" sort="Osbakken, Mary D" uniqKey="Osbakken M" first="Mary D" last="Osbakken">Mary D. Osbakken</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12972293</idno><idno type="pmid">12972293</idno><idno type="wicri:Area/PubMed/Corpus">000689</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000689</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">2,5-Anhydro-D-mannitol increases hepatocyte sodium: transduction of a hepatic hunger stimulus?</title><author><name sortKey="Friedman, Mark I" sort="Friedman, Mark I" uniqKey="Friedman M" first="Mark I" last="Friedman">Mark I. Friedman</name><affiliation><nlm:affiliation>Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. friedman@monell.org</nlm:affiliation></affiliation></author><author><name sortKey="Graczyk Millbrandt, Grazyna" sort="Graczyk Millbrandt, Grazyna" uniqKey="Graczyk Millbrandt G" first="Grazyna" last="Graczyk-Millbrandt">Grazyna Graczyk-Millbrandt</name></author><author><name sortKey="Ji, Hong" sort="Ji, Hong" uniqKey="Ji H" first="Hong" last="Ji">Hong Ji</name></author><author><name sortKey="Rawson, Nancy E" sort="Rawson, Nancy E" uniqKey="Rawson N" first="Nancy E" last="Rawson">Nancy E. Rawson</name></author><author><name sortKey="Osbakken, Mary D" sort="Osbakken, Mary D" uniqKey="Osbakken M" first="Mary D" last="Osbakken">Mary D. Osbakken</name></author></analytic><series><title level="j">Biochimica et biophysica acta</title><idno type="ISSN">0006-3002</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Triphosphate (deficiency)</term><term>Animals</term><term>Appetite Regulation (drug effects)</term><term>Appetite Regulation (physiology)</term><term>Cell Membrane (drug effects)</term><term>Cell Membrane (enzymology)</term><term>Energy Metabolism (drug effects)</term><term>Energy Metabolism (physiology)</term><term>Feeding Behavior (drug effects)</term><term>Feeding Behavior (physiology)</term><term>Fructose (metabolism)</term><term>Fructose (pharmacology)</term><term>Hepatocytes (drug effects)</term><term>Hepatocytes (enzymology)</term><term>Hunger (drug effects)</term><term>Hunger (physiology)</term><term>Liver (cytology)</term><term>Liver (physiology)</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Mannitol (analogs & derivatives)</term><term>Mannitol (pharmacology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Signal Transduction (drug effects)</term><term>Signal Transduction (physiology)</term><term>Sodium (metabolism)</term><term>Sodium-Potassium-Exchanging ATPase (drug effects)</term><term>Sodium-Potassium-Exchanging ATPase (metabolism)</term><term>Up-Regulation (drug effects)</term><term>Up-Regulation (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Mannitol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Adenosine Triphosphate</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Appetite Regulation</term><term>Cell Membrane</term><term>Energy Metabolism</term><term>Feeding Behavior</term><term>Hepatocytes</term><term>Hunger</term><term>Signal Transduction</term><term>Sodium-Potassium-Exchanging ATPase</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Cell Membrane</term><term>Hepatocytes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fructose</term><term>Sodium</term><term>Sodium-Potassium-Exchanging ATPase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Fructose</term><term>Mannitol</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Appetite Regulation</term><term>Energy Metabolism</term><term>Feeding Behavior</term><term>Hunger</term><term>Liver</term><term>Signal Transduction</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To test the hypothesis that decreased hepatocyte ATP is transduced into a hepatic neuronal signal via a change in sodium pump activity, we examined the effect of 2,5-anhydro-D-mannitol (2,5-AM), which stimulates feeding behavior in rats, on intracellular sodium levels using 23Na nuclear magnetic resonance (NMR) spectroscopy. Isolated hepatocytes suspended in agarose beads were superfused with either 2.5 mM 2,5-AM or fructose in the presence of the paramagnetic shift reagent, thulium(III)(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonate)). Superfusion with 2,5-AM decreased hepatocyte ATP and increased intracellular sodium levels compared with superfusion with either fructose or shift reagent alone starting within 15 min of exposure, reaching a maximum level of 120% of baseline by 30 min and declining gradually thereafter over the next 90 min. Superfusion with fructose, which also decreased hepatocyte ATP but by less than half the amount seen with 2,5-AM, had no significant effect on cellular sodium levels. The results support the hypothesis that changes in sodium pump activity could participate in transducing a hunger stimulus associated with hepatocyte energy status into a signal for hunger.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">12972293</PMID><DateCreated><Year>2003</Year><Month>09</Month><Day>15</Day></DateCreated><DateCompleted><Year>2003</Year><Month>10</Month><Day>28</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0006-3002</ISSN><JournalIssue CitedMedium="Print"><Volume>1642</Volume><Issue>1-2</Issue><PubDate><Year>2003</Year><Month>Sep</Month><Day>23</Day></PubDate></JournalIssue><Title>Biochimica et biophysica acta</Title><ISOAbbreviation>Biochim. Biophys. Acta</ISOAbbreviation></Journal><ArticleTitle>2,5-Anhydro-D-mannitol increases hepatocyte sodium: transduction of a hepatic hunger stimulus?</ArticleTitle><Pagination><MedlinePgn>53-8</MedlinePgn></Pagination><Abstract><AbstractText>To test the hypothesis that decreased hepatocyte ATP is transduced into a hepatic neuronal signal via a change in sodium pump activity, we examined the effect of 2,5-anhydro-D-mannitol (2,5-AM), which stimulates feeding behavior in rats, on intracellular sodium levels using 23Na nuclear magnetic resonance (NMR) spectroscopy. Isolated hepatocytes suspended in agarose beads were superfused with either 2.5 mM 2,5-AM or fructose in the presence of the paramagnetic shift reagent, thulium(III)(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonate)). Superfusion with 2,5-AM decreased hepatocyte ATP and increased intracellular sodium levels compared with superfusion with either fructose or shift reagent alone starting within 15 min of exposure, reaching a maximum level of 120% of baseline by 30 min and declining gradually thereafter over the next 90 min. Superfusion with fructose, which also decreased hepatocyte ATP but by less than half the amount seen with 2,5-AM, had no significant effect on cellular sodium levels. The results support the hypothesis that changes in sodium pump activity could participate in transducing a hunger stimulus associated with hepatocyte energy status into a signal for hunger.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Friedman</LastName><ForeName>Mark I</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. friedman@monell.org</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Graczyk-Millbrandt</LastName><ForeName>Grazyna</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Ji</LastName><ForeName>Hong</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Rawson</LastName><ForeName>Nancy E</ForeName><Initials>NE</Initials></Author><Author ValidYN="Y"><LastName>Osbakken</LastName><ForeName>Mary D</ForeName><Initials>MD</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DK-53109</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biochim Biophys Acta</MedlineTA><NlmUniqueID>0217513</NlmUniqueID><ISSNLinking>0006-3002</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>30237-26-4</RegistryNumber><NameOfSubstance UI="D005632">Fructose</NameOfSubstance></Chemical><Chemical><RegistryNumber>3OWL53L36A</RegistryNumber><NameOfSubstance UI="D008353">Mannitol</NameOfSubstance></Chemical><Chemical><RegistryNumber>41107-82-8</RegistryNumber><NameOfSubstance UI="C031765">2,5-anhydromannitol</NameOfSubstance></Chemical><Chemical><RegistryNumber>8L70Q75FXE</RegistryNumber><NameOfSubstance UI="D000255">Adenosine Triphosphate</NameOfSubstance></Chemical><Chemical><RegistryNumber>9NEZ333N27</RegistryNumber><NameOfSubstance UI="D012964">Sodium</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.3.9</RegistryNumber><NameOfSubstance UI="D000254">Sodium-Potassium-Exchanging ATPase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000255">Adenosine Triphosphate</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000172">deficiency</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001069">Appetite Regulation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002462">Cell Membrane</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000201">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004734">Energy Metabolism</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005247">Feeding Behavior</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005632">Fructose</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D022781">Hepatocytes</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000201">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006815">Hunger</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008099">Liver</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000166">cytology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009682">Magnetic Resonance Spectroscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008353">Mannitol</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000031">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017207">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015398">Signal Transduction</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012964">Sodium</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000254">Sodium-Potassium-Exchanging ATPase</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015854">Up-Regulation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>9</Month><Day>16</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>10</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>9</Month><Day>16</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12972293</ArticleId><ArticleId IdType="pii">S0167488903000983</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix 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