Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis
Identifieur interne : 001C70 ( Main/Exploration ); précédent : 001C69; suivant : 001C71Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis
Auteurs : Jörg Spiegel [Allemagne] ; Christiane Hansen [Allemagne] ; Ulf Baumg Rtner [Allemagne] ; Hanns Christian Hopf [Allemagne] ; Rolf-Detlef Treede [Allemagne]Source :
- Clinical neurophysiology [ 1388-2457 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anti-inflammatoires, Femelle, Humains, Hydrocortisone (usage thérapeutique), Imagerie par résonance magnétique, Immunoglobuline G (métabolisme), Jambe (physiopathologie), Lasers, Main (physiopathologie), Mâle, Potentiels évoqués somatosensoriels (physiologie), Rayons infrarouges, Reproductibilité des résultats, Sclérose en plaques (anatomopathologie), Sclérose en plaques (physiopathologie), Sclérose en plaques (traitement médicamenteux), Seuils sensoriels, Temps de réaction, Tractus spinothalamiques (physiopathologie), Électroencéphalographie, Études cas-témoins.
- MESH :
- anatomopathologie : Sclérose en plaques.
- métabolisme : Immunoglobuline G.
- physiologie : Potentiels évoqués somatosensoriels.
- physiopathologie : Jambe, Main, Sclérose en plaques, Tractus spinothalamiques.
- traitement médicamenteux : Sclérose en plaques.
- usage thérapeutique : Hydrocortisone.
- Pascal (Inist)
- Adulte, Adulte d'âge moyen, Anti-inflammatoires, Electrodiagnostic, Femelle, Humains, Imagerie par résonance magnétique, Lasers, Mâle, Potentiel évoqué somatosensoriel, Rayons infrarouges, Reproductibilité des résultats, Seuils sensoriels, Stimulus nociceptif, Sensibilité, Faisceau spinothalamique, Sclérose en plaques, Homme, Comparaison intraindividuelle, Nociception, Temps de réaction, Électroencéphalographie, Études cas-témoins.
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Anti-Inflammatory Agents, Case-Control Studies, Electrodiagnosis, Electroencephalography, Evoked Potentials, Somatosensory (physiology), Female, Hand (physiopathology), Human, Humans, Hydrocortisone (therapeutic use), Immunoglobulin G (metabolism), Infrared Rays, Intraindividual comparison, Lasers, Leg (physiopathology), Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis (drug therapy), Multiple Sclerosis (pathology), Multiple Sclerosis (physiopathology), Multiple sclerosis, Nociception, Noxious stimulus, Reaction Time, Reproducibility of Results, Sensitivity, Sensory Thresholds, Somatosensory evoked potential, Spinothalamic Tracts (physiopathology), Spinothalamic bundle.
- MESH :
- chemical , metabolism : Immunoglobulin G.
- chemical , therapeutic use : Hydrocortisone.
- chemical : Anti-Inflammatory Agents.
- drug therapy : Multiple Sclerosis.
- pathology : Multiple Sclerosis.
- physiology : Evoked Potentials, Somatosensory.
- physiopathology : Hand, Leg, Multiple Sclerosis, Spinothalamic Tracts.
- Adult, Case-Control Studies, Electroencephalography, Female, Humans, Infrared Rays, Lasers, Magnetic Resonance Imaging, Male, Middle Aged, Reaction Time, Reproducibility of Results, Sensory Thresholds.
Abstract
Objective: Somatosensory evoked potentials (SEPs) play a less important role in the diagnosis of multiple sclerosis (MS) than visually evoked potentials. Since standard SEPs only reflect the dorsal column function, we now investigated spinothalamic tract function in patients with MS using laser-evoked potentials (LEPs). Methods: LEPs to thulium laser stimuli (3 ms, 540 mJ, 5 mm diameter) were recorded from 3 midline positions (Fz, Cz, Pz) in 20 patients with MS, and 6 patients with possible but unconfirmed MS. Peak latencies and peak-to-peak amplitude of the vertex potential negativity (N2) and positivity (P2) were evaluated and compared with normative values from 22 healthy control subjects. Median and tibial nerve SEPs were recorded with standard methods. Depending on the results of sensory testing, two skin areas (both hands, both feet, or one hand and foot of the same body side) were assessed in each patient. Results: In group comparisons, LEPs in patients with MS were significantly delayed and reduced in amplitude compared with healthy subjects (P < 0.001) or patients with suspected but unconfirmed MS (P < 0.05). In intraindividual comparisons within the patients with MS, LEP amplitude was significantly lower (P < 0.01) and latencies were significantly longer (N2: P < 0.01; P2: P < 0.05) for a clinically hypoalgesic skin area than an unaffected control area. On a single case basis, LEPs were abnormal in 12 (60%) and SEPs in 8 (40%) of the patients with MS; combined analysis of LEPs and SEPs raised sensitivity to 75% (15 patients). LEPs were also abnormal for 7 skin areas with clinically normal nociception and thermal sensitivity, indicating subclinical lesions. Standard SEPs detected subclinical lesions in 5 areas with normal tactile sensitivity. Conclusions: In patients with multiple sclerosis, spinothalamic tract function and LEPs were impaired more often than dorsal column function and SEPs. LEPs also detected subclinical lesions. Combined assessment of LEPs and SEPs can help to document dissemination of demyelinating CNS lesions and thus contribute to the diagnosis of multiple sclerosis.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pascal, to step Corpus: 000B20
- to stream Pascal, to step Curation: 000B20
- to stream Pascal, to step Checkpoint: 000B27
- to stream Main, to step Merge: 001D41
- to stream PubMed, to step Corpus: 000700
- to stream PubMed, to step Curation: 000700
- to stream PubMed, to step Checkpoint: 000700
- to stream Ncbi, to step Merge: 000052
- to stream Ncbi, to step Curation: 000052
- to stream Ncbi, to step Checkpoint: 000052
- to stream Main, to step Merge: 001C72
- to stream Main, to step Curation: 001C70
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis</title>
<author><name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21</s1>
<s2>55099 Mainz</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>Saarstrasse 21</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hansen, Christiane" sort="Hansen, Christiane" uniqKey="Hansen C" first="Christiane" last="Hansen">Christiane Hansen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21</s1>
<s2>55099 Mainz</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>Saarstrasse 21</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, Johannes Gutenberg-University</s1>
<s2>Mainz</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baumg Rtner, Ulf" sort="Baumg Rtner, Ulf" uniqKey="Baumg Rtner U" first="Ulf" last="Baumg Rtner">Ulf Baumg Rtner</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21</s1>
<s2>55099 Mainz</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>Saarstrasse 21</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hopf, Hanns Christian" sort="Hopf, Hanns Christian" uniqKey="Hopf H" first="Hanns Christian" last="Hopf">Hanns Christian Hopf</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, Johannes Gutenberg-University</s1>
<s2>Mainz</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Treede, Rolf Detlef" sort="Treede, Rolf Detlef" uniqKey="Treede R" first="Rolf-Detlef" last="Treede">Rolf-Detlef Treede</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21</s1>
<s2>55099 Mainz</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>Saarstrasse 21</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">03-0449528</idno>
<date when="2003">2003</date>
<idno type="stanalyst">PASCAL 03-0449528 INIST</idno>
<idno type="RBID">Pascal:03-0449528</idno>
<idno type="wicri:Area/Pascal/Corpus">000B20</idno>
<idno type="wicri:Area/Pascal/Curation">000B20</idno>
<idno type="wicri:Area/Pascal/Checkpoint">000B27</idno>
<idno type="wicri:explorRef" wicri:stream="Pascal" wicri:step="Checkpoint">000B27</idno>
<idno type="wicri:doubleKey">1388-2457:2003:Spiegel J:sensitivity:of:laser</idno>
<idno type="wicri:Area/Main/Merge">001D41</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:12804667</idno>
<idno type="wicri:Area/PubMed/Corpus">000700</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000700</idno>
<idno type="wicri:Area/PubMed/Curation">000700</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000700</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000700</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000700</idno>
<idno type="wicri:Area/Ncbi/Merge">000052</idno>
<idno type="wicri:Area/Ncbi/Curation">000052</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000052</idno>
<idno type="wicri:doubleKey">1388-2457:2003:Spiegel J:sensitivity:of:laser</idno>
<idno type="wicri:Area/Main/Merge">001C72</idno>
<idno type="wicri:Area/Main/Curation">001C70</idno>
<idno type="wicri:Area/Main/Exploration">001C70</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis</title>
<author><name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21</s1>
<s2>55099 Mainz</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>Saarstrasse 21</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hansen, Christiane" sort="Hansen, Christiane" uniqKey="Hansen C" first="Christiane" last="Hansen">Christiane Hansen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21</s1>
<s2>55099 Mainz</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>Saarstrasse 21</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, Johannes Gutenberg-University</s1>
<s2>Mainz</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baumg Rtner, Ulf" sort="Baumg Rtner, Ulf" uniqKey="Baumg Rtner U" first="Ulf" last="Baumg Rtner">Ulf Baumg Rtner</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21</s1>
<s2>55099 Mainz</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>Saarstrasse 21</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hopf, Hanns Christian" sort="Hopf, Hanns Christian" uniqKey="Hopf H" first="Hanns Christian" last="Hopf">Hanns Christian Hopf</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, Johannes Gutenberg-University</s1>
<s2>Mainz</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Treede, Rolf Detlef" sort="Treede, Rolf Detlef" uniqKey="Treede R" first="Rolf-Detlef" last="Treede">Rolf-Detlef Treede</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21</s1>
<s2>55099 Mainz</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>Saarstrasse 21</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Clinical neurophysiology</title>
<title level="j" type="abbreviated">Clin. neurophysiol.</title>
<idno type="ISSN">1388-2457</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Clinical neurophysiology</title>
<title level="j" type="abbreviated">Clin. neurophysiol.</title>
<idno type="ISSN">1388-2457</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Anti-Inflammatory Agents</term>
<term>Case-Control Studies</term>
<term>Electrodiagnosis</term>
<term>Electroencephalography</term>
<term>Evoked Potentials, Somatosensory (physiology)</term>
<term>Female</term>
<term>Hand (physiopathology)</term>
<term>Human</term>
<term>Humans</term>
<term>Hydrocortisone (therapeutic use)</term>
<term>Immunoglobulin G (metabolism)</term>
<term>Infrared Rays</term>
<term>Intraindividual comparison</term>
<term>Lasers</term>
<term>Leg (physiopathology)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple Sclerosis (drug therapy)</term>
<term>Multiple Sclerosis (pathology)</term>
<term>Multiple Sclerosis (physiopathology)</term>
<term>Multiple sclerosis</term>
<term>Nociception</term>
<term>Noxious stimulus</term>
<term>Reaction Time</term>
<term>Reproducibility of Results</term>
<term>Sensitivity</term>
<term>Sensory Thresholds</term>
<term>Somatosensory evoked potential</term>
<term>Spinothalamic Tracts (physiopathology)</term>
<term>Spinothalamic bundle</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anti-inflammatoires</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hydrocortisone (usage thérapeutique)</term>
<term>Imagerie par résonance magnétique</term>
<term>Immunoglobuline G (métabolisme)</term>
<term>Jambe (physiopathologie)</term>
<term>Lasers</term>
<term>Main (physiopathologie)</term>
<term>Mâle</term>
<term>Potentiels évoqués somatosensoriels (physiologie)</term>
<term>Rayons infrarouges</term>
<term>Reproductibilité des résultats</term>
<term>Sclérose en plaques (anatomopathologie)</term>
<term>Sclérose en plaques (physiopathologie)</term>
<term>Sclérose en plaques (traitement médicamenteux)</term>
<term>Seuils sensoriels</term>
<term>Temps de réaction</term>
<term>Tractus spinothalamiques (physiopathologie)</term>
<term>Électroencéphalographie</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Anti-Inflammatory Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Sclérose en plaques</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple Sclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple Sclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Potentiels évoqués somatosensoriels</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Somatosensory</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Jambe</term>
<term>Main</term>
<term>Sclérose en plaques</term>
<term>Tractus spinothalamiques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hand</term>
<term>Leg</term>
<term>Multiple Sclerosis</term>
<term>Spinothalamic Tracts</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Sclérose en plaques</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Case-Control Studies</term>
<term>Electroencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Infrared Rays</term>
<term>Lasers</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reaction Time</term>
<term>Reproducibility of Results</term>
<term>Sensory Thresholds</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anti-inflammatoires</term>
<term>Electrodiagnostic</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Lasers</term>
<term>Mâle</term>
<term>Potentiel évoqué somatosensoriel</term>
<term>Rayons infrarouges</term>
<term>Reproductibilité des résultats</term>
<term>Seuils sensoriels</term>
<term>Stimulus nociceptif</term>
<term>Sensibilité</term>
<term>Faisceau spinothalamique</term>
<term>Sclérose en plaques</term>
<term>Homme</term>
<term>Comparaison intraindividuelle</term>
<term>Nociception</term>
<term>Temps de réaction</term>
<term>Électroencéphalographie</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: Somatosensory evoked potentials (SEPs) play a less important role in the diagnosis of multiple sclerosis (MS) than visually evoked potentials. Since standard SEPs only reflect the dorsal column function, we now investigated spinothalamic tract function in patients with MS using laser-evoked potentials (LEPs). Methods: LEPs to thulium laser stimuli (3 ms, 540 mJ, 5 mm diameter) were recorded from 3 midline positions (Fz, Cz, Pz) in 20 patients with MS, and 6 patients with possible but unconfirmed MS. Peak latencies and peak-to-peak amplitude of the vertex potential negativity (N2) and positivity (P2) were evaluated and compared with normative values from 22 healthy control subjects. Median and tibial nerve SEPs were recorded with standard methods. Depending on the results of sensory testing, two skin areas (both hands, both feet, or one hand and foot of the same body side) were assessed in each patient. Results: In group comparisons, LEPs in patients with MS were significantly delayed and reduced in amplitude compared with healthy subjects (P < 0.001) or patients with suspected but unconfirmed MS (P < 0.05). In intraindividual comparisons within the patients with MS, LEP amplitude was significantly lower (P < 0.01) and latencies were significantly longer (N2: P < 0.01; P2: P < 0.05) for a clinically hypoalgesic skin area than an unaffected control area. On a single case basis, LEPs were abnormal in 12 (60%) and SEPs in 8 (40%) of the patients with MS; combined analysis of LEPs and SEPs raised sensitivity to 75% (15 patients). LEPs were also abnormal for 7 skin areas with clinically normal nociception and thermal sensitivity, indicating subclinical lesions. Standard SEPs detected subclinical lesions in 5 areas with normal tactile sensitivity. Conclusions: In patients with multiple sclerosis, spinothalamic tract function and LEPs were impaired more often than dorsal column function and SEPs. LEPs also detected subclinical lesions. Combined assessment of LEPs and SEPs can help to document dissemination of demyelinating CNS lesions and thus contribute to the diagnosis of multiple sclerosis.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Rhénanie-Palatinat</li>
</region>
<settlement><li>Mayence</li>
</settlement>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name>
</noRegion>
<name sortKey="Baumg Rtner, Ulf" sort="Baumg Rtner, Ulf" uniqKey="Baumg Rtner U" first="Ulf" last="Baumg Rtner">Ulf Baumg Rtner</name>
<name sortKey="Hansen, Christiane" sort="Hansen, Christiane" uniqKey="Hansen C" first="Christiane" last="Hansen">Christiane Hansen</name>
<name sortKey="Hansen, Christiane" sort="Hansen, Christiane" uniqKey="Hansen C" first="Christiane" last="Hansen">Christiane Hansen</name>
<name sortKey="Hopf, Hanns Christian" sort="Hopf, Hanns Christian" uniqKey="Hopf H" first="Hanns Christian" last="Hopf">Hanns Christian Hopf</name>
<name sortKey="Treede, Rolf Detlef" sort="Treede, Rolf Detlef" uniqKey="Treede R" first="Rolf-Detlef" last="Treede">Rolf-Detlef Treede</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C70 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001C70 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Terre |area= ThuliumV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:03-0449528 |texte= Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis }}
![]() | This area was generated with Dilib version V0.6.21. | ![]() |