Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes
Identifieur interne : 001200 ( Main/Exploration ); précédent : 001199; suivant : 001201Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes
Auteurs : Jason M. Zhao ; Yah-El Har-El ; Michael T. Mcmahon ; Jinyuan Zhou ; A. Dean Sherry ; George Sgouros ; Jeff W. M. Bulte ; Peter C. M. Van ZijlSource :
- Journal of the American Chemical Society [ 0002-7863 ] ; 2008.
Abstract
Liposome-based chemical exchange saturation transfer (lipoCEST) agents have shown great sensitivity and potential for molecular magnetic resonance imaging (MRI). Here we demonstrate that the size of liposomes can be exploited to enhance the lipoCEST contrast. A concise analytical model is developed to describe the contrast dependence on size for an ensemble of liposomes. The model attributes the increased lipoCEST contrast in smaller liposomes to their larger surface-to-volume ratio, causing an increased membrane water exchange rate. Experimentally measured rates correlate with size, in agreement with the model. The water permeability of liposomal membrane is found to be 1.11 ± 0.14 μm/s for the specific lipid composition at 22 °C. Availability of the model allows rational design of the size of liposomes and quantification of their properties. These new theoretical and experimental tools are expected to benefit applications of liposomes to sensing the cellular environment, targeting and imaging biological processes, and optimizing drug delivery properties.
Url:
DOI: 10.1021/ja710159q
PubMed: 18361490
PubMed Central: 2759111
Affiliations:
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Zhao</name></author><author><name sortKey="Har El, Yah El" sort="Har El, Yah El" uniqKey="Har El Y" first="Yah-El" last="Har-El">Yah-El Har-El</name></author><author><name sortKey="Mcmahon, Michael T" sort="Mcmahon, Michael T" uniqKey="Mcmahon M" first="Michael T." last="Mcmahon">Michael T. Mcmahon</name></author><author><name sortKey="Zhou, Jinyuan" sort="Zhou, Jinyuan" uniqKey="Zhou J" first="Jinyuan" last="Zhou">Jinyuan Zhou</name></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name></author><author><name sortKey="Sgouros, George" sort="Sgouros, George" uniqKey="Sgouros G" first="George" last="Sgouros">George Sgouros</name></author><author><name sortKey="Bulte, Jeff W M" sort="Bulte, Jeff W M" uniqKey="Bulte J" first="Jeff W. M." last="Bulte">Jeff W. M. Bulte</name></author><author><name sortKey="Van Zijl, Peter C M" sort="Van Zijl, Peter C M" uniqKey="Van Zijl P" first="Peter C. M." last="Van Zijl">Peter C. M. Van Zijl</name></author></analytic><series><title level="j">Journal of the American Chemical Society</title><idno type="ISSN">0002-7863</idno><idno type="eISSN">1520-5126</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P6">Liposome-based chemical exchange saturation transfer (lipoCEST) agents have shown great sensitivity and potential for molecular magnetic resonance imaging (MRI). Here we demonstrate that the size of liposomes can be exploited to enhance the lipoCEST contrast. A concise analytical model is developed to describe the contrast dependence on size for an ensemble of liposomes. The model attributes the increased lipoCEST contrast in smaller liposomes to their larger surface-to-volume ratio, causing an increased membrane water exchange rate. Experimentally measured rates correlate with size, in agreement with the model. The water permeability of liposomal membrane is found to be 1.11 ± 0.14 μm/s for the specific lipid composition at 22 °C. Availability of the model allows rational design of the size of liposomes and quantification of their properties. These new theoretical and experimental tools are expected to benefit applications of liposomes to sensing the cellular environment, targeting and imaging biological processes, and optimizing drug delivery properties.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bulte, Jeff W M" sort="Bulte, Jeff W M" uniqKey="Bulte J" first="Jeff W. M." last="Bulte">Jeff W. M. Bulte</name><name sortKey="Har El, Yah El" sort="Har El, Yah El" uniqKey="Har El Y" first="Yah-El" last="Har-El">Yah-El Har-El</name><name sortKey="Mcmahon, Michael T" sort="Mcmahon, Michael T" uniqKey="Mcmahon M" first="Michael T." last="Mcmahon">Michael T. Mcmahon</name><name sortKey="Sgouros, George" sort="Sgouros, George" uniqKey="Sgouros G" first="George" last="Sgouros">George Sgouros</name><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name><name sortKey="Van Zijl, Peter C M" sort="Van Zijl, Peter C M" uniqKey="Van Zijl P" first="Peter C. M." last="Van Zijl">Peter C. M. Van Zijl</name><name sortKey="Zhao, Jason M" sort="Zhao, Jason M" uniqKey="Zhao J" first="Jason M." last="Zhao">Jason M. Zhao</name><name sortKey="Zhou, Jinyuan" sort="Zhou, Jinyuan" uniqKey="Zhou J" first="Jinyuan" last="Zhou">Jinyuan Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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