THC:YAG laser sclerostomy with mitomycin subconjunctival injection in rabbits.
Identifieur interne : 003578 ( Main/Exploration ); précédent : 003577; suivant : 003579THC:YAG laser sclerostomy with mitomycin subconjunctival injection in rabbits.
Auteurs : T H Wang ; P T Hung ; T C HoSource :
- Journal of ocular pharmacology [ 8756-3320 ] ; 1992.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Mitomycines.
- anatomopathologie : Conjonctive.
- usage thérapeutique : Mitomycines.
- Animaux, Cicatrisation de plaie, Conjonctive, Fibrose, Injections, Lapins, Pression intraoculaire, Sclérostomie, Thérapie laser.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Mitomycins.
- drug effects : Conjunctiva, Intraocular Pressure, Wound Healing.
- pathology : Conjunctiva.
- prevention & control : Fibrosis.
- chemical , therapeutic use : Mitomycins.
- Animals, Injections, Laser Therapy, Rabbits, Sclerostomy.
Abstract
We performed sclerostomy using THC:YAG laser (thulium, holmium, chromium doped YAG crystal) and subconjunctival injection of mitomycin soon after the filtering process in rabbits to observe the lowering effect of intraocular pressure(IOP) and filtering bleb formation. A 1-mm conjunctiva wound was made 12 mm away from the sclerostomy site to allow the entry of the optic probe for delivering energy. Forty-eight rabbits were divided into 3 groups. After sclerostomy, Group I received 0.2 ml normal saline subconjunctival injection and Group II and III received 0.2 ml mitomycin injection of 0.1 and 0.2 mg/ml respectively. One eye of each rabbit was randomly selected for the experiment while the fellow eye served as control. The bleb lasted 1.4 +/- 0.5 days (or 1 to 2 days) in Group I, 8.5 +/- 4.5 days (or 4 to 17 days) in Group II and 15.4 +/- 10.9 days (or 4 to 37 days) in Group III. The IOP lowering effect was significantly enhanced in Group III. The postoperative complication was minimal corneal punctate erosion in the mitomycin group, but all of them, however, resolved within one week. The results demonstrated that mitomycin is effective in prolonging the filtering effect produced by the THC:YAG laser.
PubMed: 1484263
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">THC:YAG laser sclerostomy with mitomycin subconjunctival injection in rabbits.</title><author><name sortKey="Wang, T H" sort="Wang, T H" uniqKey="Wang T" first="T H" last="Wang">T H Wang</name><affiliation><nlm:affiliation>Department of Ophthalmology, National Taiwan University Hospital, Taipei.</nlm:affiliation><wicri:noCountry code="subField">Taipei</wicri:noCountry></affiliation></author><author><name sortKey="Hung, P T" sort="Hung, P T" uniqKey="Hung P" first="P T" last="Hung">P T Hung</name></author><author><name sortKey="Ho, T C" sort="Ho, T C" uniqKey="Ho T" first="T C" last="Ho">T C Ho</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1484263</idno><idno type="pmid">1484263</idno><idno type="wicri:Area/PubMed/Corpus">000802</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" 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of Ophthalmology, National Taiwan University Hospital, Taipei.</nlm:affiliation><wicri:noCountry code="subField">Taipei</wicri:noCountry></affiliation></author><author><name sortKey="Hung, P T" sort="Hung, P T" uniqKey="Hung P" first="P T" last="Hung">P T Hung</name></author><author><name sortKey="Ho, T C" sort="Ho, T C" uniqKey="Ho T" first="T C" last="Ho">T C Ho</name></author></analytic><series><title level="j">Journal of ocular pharmacology</title><idno type="ISSN">8756-3320</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Conjunctiva (drug effects)</term><term>Conjunctiva (pathology)</term><term>Fibrosis (prevention & control)</term><term>Injections</term><term>Intraocular Pressure (drug effects)</term><term>Laser Therapy</term><term>Mitomycins (administration & dosage)</term><term>Mitomycins (therapeutic use)</term><term>Rabbits</term><term>Sclerostomy</term><term>Wound Healing (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cicatrisation de plaie ()</term><term>Conjonctive ()</term><term>Conjonctive (anatomopathologie)</term><term>Fibrose ()</term><term>Injections</term><term>Lapins</term><term>Mitomycines (administration et posologie)</term><term>Mitomycines (usage thérapeutique)</term><term>Pression intraoculaire ()</term><term>Sclérostomie</term><term>Thérapie laser</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Mitomycins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Mitomycines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Conjonctive</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Conjunctiva</term><term>Intraocular Pressure</term><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Conjunctiva</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Fibrosis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Mitomycins</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Mitomycines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Injections</term><term>Laser Therapy</term><term>Rabbits</term><term>Sclerostomy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cicatrisation de plaie</term><term>Conjonctive</term><term>Fibrose</term><term>Injections</term><term>Lapins</term><term>Pression intraoculaire</term><term>Sclérostomie</term><term>Thérapie laser</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed sclerostomy using THC:YAG laser (thulium, holmium, chromium doped YAG crystal) and subconjunctival injection of mitomycin soon after the filtering process in rabbits to observe the lowering effect of intraocular pressure(IOP) and filtering bleb formation. A 1-mm conjunctiva wound was made 12 mm away from the sclerostomy site to allow the entry of the optic probe for delivering energy. Forty-eight rabbits were divided into 3 groups. After sclerostomy, Group I received 0.2 ml normal saline subconjunctival injection and Group II and III received 0.2 ml mitomycin injection of 0.1 and 0.2 mg/ml respectively. One eye of each rabbit was randomly selected for the experiment while the fellow eye served as control. The bleb lasted 1.4 +/- 0.5 days (or 1 to 2 days) in Group I, 8.5 +/- 4.5 days (or 4 to 17 days) in Group II and 15.4 +/- 10.9 days (or 4 to 37 days) in Group III. The IOP lowering effect was significantly enhanced in Group III. The postoperative complication was minimal corneal punctate erosion in the mitomycin group, but all of them, however, resolved within one week. The results demonstrated that mitomycin is effective in prolonging the filtering effect produced by the THC:YAG laser.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ho, T C" sort="Ho, T C" uniqKey="Ho T" first="T C" last="Ho">T C Ho</name><name sortKey="Hung, P T" sort="Hung, P T" uniqKey="Hung P" first="P T" last="Hung">P T Hung</name><name sortKey="Wang, T H" sort="Wang, T H" uniqKey="Wang T" first="T H" last="Wang">T H Wang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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