Non‐invasive temperature imaging with thulium 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetramethyl‐1,4,7,10‐tetraacetic acid (TmDOTMA−)
Identifieur interne : 000637 ( Istex/Checkpoint ); précédent : 000636; suivant : 000638Non‐invasive temperature imaging with thulium 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetramethyl‐1,4,7,10‐tetraacetic acid (TmDOTMA−)
Auteurs : Sait Kubilay Pakin [États-Unis] ; S. K. Hekmatyar [États-Unis] ; Paige Hopewell [États-Unis] ; Andriy Babsky [États-Unis] ; Navin Bansal [États-Unis]Source :
- NMR in Biomedicine [ 0952-3480 ] ; 2006-02.
Descripteurs français
- Wicri :
- topic : Droit d'auteur, Collecte de données.
English descriptors
- KwdEn :
- Acceptable dose, Bansal, Biomed, Body weight, Chemical shift, Chemical shift imaging, Chemical shifts, Chess water suppression, Clinical applications, Copyright, Data collection, Data matrix, Echo time, Equivalent protons, Hyperthermia, Imaging, Imaging experiments, Imaging parameters, Imaging sequence, Imaging temperature, Imaging temperature changes, Imaging tmdotma, John wiley sons, Lanthanide, Lanthanide complexes, Magn, Mapping temperature changes, Matrix, Methyl, Methyl groups, Methyl signal, Paramagnetic lanthanide complexes, Phantom, Phase images, Phase shift, Rectal temperature, Regional temperature changes, Regression analysis, Representative transaxial slices, Reson, Same depth, Second half, Signal transients, Spectroscopic imaging, Strong water signal, Temperature change, Temperature changes, Temperature dependence, Temperature imaging, Temperature imaging method, Temperature mapping, Temperature measurement, Temperature probes, Temperature sensitivity, Thermometry, Thulium, Tmdota, Tmdotma, Total imaging time, Transaxial, Vivo, Vivo temperature changes, Water image, Water signal.
- Teeft :
- Acceptable dose, Bansal, Biomed, Body weight, Chemical shift, Chemical shift imaging, Chemical shifts, Chess water suppression, Clinical applications, Copyright, Data collection, Data matrix, Echo time, Equivalent protons, Hyperthermia, Imaging, Imaging experiments, Imaging parameters, Imaging sequence, Imaging temperature, Imaging temperature changes, Imaging tmdotma, John wiley sons, Lanthanide, Lanthanide complexes, Magn, Mapping temperature changes, Matrix, Methyl, Methyl groups, Methyl signal, Paramagnetic lanthanide complexes, Phantom, Phase images, Phase shift, Rectal temperature, Regional temperature changes, Regression analysis, Representative transaxial slices, Reson, Same depth, Second half, Signal transients, Spectroscopic imaging, Strong water signal, Temperature change, Temperature changes, Temperature dependence, Temperature imaging, Temperature imaging method, Temperature mapping, Temperature measurement, Temperature probes, Temperature sensitivity, Thermometry, Thulium, Tmdota, Tmdotma, Total imaging time, Transaxial, Vivo, Vivo temperature changes, Water image, Water signal.
Abstract
Non‐invasive thermometry using hyperfine‐shifted MR signals from paramagnetic lanthanide complexes has attracted attention recently because the chemical shifts of these complexes are many times more sensitive to temperature than the water 1H signal. Among all the lanthanide complexes examined thus far, thulium tetramethyl‐1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetate (TmDOTMA−) appears to be the most suitable for MR thermometry. In this paper, the feasibility of imaging the methyl 1H signal from TmDOTMA− using a frequency‐selective radiofrequency excitation pulse and chemical shift‐selective (CHESS) water suppression is demonstrated. A temperature imaging method using a phase‐sensitive spin‐echo imaging sequence was validated in phantom experiments. A comparison of regional temperature changes measured with fiber‐optic probes and the temperatures calculated from the phase shift near each probe showed that the accuracy of imaging the temperature with TmDOTMA− is at least 0.1–0.2°C. The feasibility of imaging temperature changes in an intact rat at 0.5–0.6 mmol/kg dose in only a few minutes is demonstrated. Similar to commonly used MRI contrast agents, the lanthanide complex does not cross the blood–brain barrier. TmDOTMA− may prove useful for temperature imaging in many biomedical applications but further studies relating to acceptable dose and signal‐to‐noise ratio are necessary before clinical applications. Copyright © 2006 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/nbm.1010
Affiliations:
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type="state">Indiana</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">NMR in Biomedicine</title><title level="j" type="alt">NMR IN BIOMEDICINE</title><idno type="ISSN">0952-3480</idno><idno type="eISSN">1099-1492</idno><imprint><biblScope unit="vol">19</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="116">116</biblScope><biblScope unit="page" to="124">124</biblScope><biblScope unit="page-count">9</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2006-02">2006-02</date></imprint><idno type="ISSN">0952-3480</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0952-3480</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acceptable dose</term><term>Bansal</term><term>Biomed</term><term>Body weight</term><term>Chemical shift</term><term>Chemical shift imaging</term><term>Chemical shifts</term><term>Chess water suppression</term><term>Clinical applications</term><term>Copyright</term><term>Data collection</term><term>Data matrix</term><term>Echo time</term><term>Equivalent protons</term><term>Hyperthermia</term><term>Imaging</term><term>Imaging experiments</term><term>Imaging parameters</term><term>Imaging sequence</term><term>Imaging temperature</term><term>Imaging temperature changes</term><term>Imaging tmdotma</term><term>John wiley sons</term><term>Lanthanide</term><term>Lanthanide complexes</term><term>Magn</term><term>Mapping temperature changes</term><term>Matrix</term><term>Methyl</term><term>Methyl groups</term><term>Methyl signal</term><term>Paramagnetic lanthanide complexes</term><term>Phantom</term><term>Phase images</term><term>Phase shift</term><term>Rectal temperature</term><term>Regional temperature changes</term><term>Regression analysis</term><term>Representative transaxial slices</term><term>Reson</term><term>Same depth</term><term>Second half</term><term>Signal transients</term><term>Spectroscopic imaging</term><term>Strong water signal</term><term>Temperature change</term><term>Temperature changes</term><term>Temperature dependence</term><term>Temperature imaging</term><term>Temperature imaging method</term><term>Temperature mapping</term><term>Temperature measurement</term><term>Temperature probes</term><term>Temperature sensitivity</term><term>Thermometry</term><term>Thulium</term><term>Tmdota</term><term>Tmdotma</term><term>Total imaging time</term><term>Transaxial</term><term>Vivo</term><term>Vivo temperature changes</term><term>Water image</term><term>Water signal</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acceptable dose</term><term>Bansal</term><term>Biomed</term><term>Body weight</term><term>Chemical shift</term><term>Chemical shift imaging</term><term>Chemical shifts</term><term>Chess water suppression</term><term>Clinical applications</term><term>Copyright</term><term>Data collection</term><term>Data matrix</term><term>Echo time</term><term>Equivalent protons</term><term>Hyperthermia</term><term>Imaging</term><term>Imaging experiments</term><term>Imaging parameters</term><term>Imaging sequence</term><term>Imaging temperature</term><term>Imaging temperature changes</term><term>Imaging tmdotma</term><term>John wiley sons</term><term>Lanthanide</term><term>Lanthanide complexes</term><term>Magn</term><term>Mapping temperature changes</term><term>Matrix</term><term>Methyl</term><term>Methyl groups</term><term>Methyl signal</term><term>Paramagnetic lanthanide complexes</term><term>Phantom</term><term>Phase images</term><term>Phase shift</term><term>Rectal temperature</term><term>Regional temperature changes</term><term>Regression analysis</term><term>Representative transaxial slices</term><term>Reson</term><term>Same depth</term><term>Second half</term><term>Signal transients</term><term>Spectroscopic imaging</term><term>Strong water signal</term><term>Temperature change</term><term>Temperature changes</term><term>Temperature dependence</term><term>Temperature imaging</term><term>Temperature imaging method</term><term>Temperature mapping</term><term>Temperature measurement</term><term>Temperature probes</term><term>Temperature sensitivity</term><term>Thermometry</term><term>Thulium</term><term>Tmdota</term><term>Tmdotma</term><term>Total imaging time</term><term>Transaxial</term><term>Vivo</term><term>Vivo temperature changes</term><term>Water image</term><term>Water signal</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Droit d'auteur</term><term>Collecte de données</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non‐invasive thermometry using hyperfine‐shifted MR signals from paramagnetic lanthanide complexes has attracted attention recently because the chemical shifts of these complexes are many times more sensitive to temperature than the water 1H signal. Among all the lanthanide complexes examined thus far, thulium tetramethyl‐1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetate (TmDOTMA−) appears to be the most suitable for MR thermometry. In this paper, the feasibility of imaging the methyl 1H signal from TmDOTMA− using a frequency‐selective radiofrequency excitation pulse and chemical shift‐selective (CHESS) water suppression is demonstrated. A temperature imaging method using a phase‐sensitive spin‐echo imaging sequence was validated in phantom experiments. A comparison of regional temperature changes measured with fiber‐optic probes and the temperatures calculated from the phase shift near each probe showed that the accuracy of imaging the temperature with TmDOTMA− is at least 0.1–0.2°C. The feasibility of imaging temperature changes in an intact rat at 0.5–0.6 mmol/kg dose in only a few minutes is demonstrated. Similar to commonly used MRI contrast agents, the lanthanide complex does not cross the blood–brain barrier. TmDOTMA− may prove useful for temperature imaging in many biomedical applications but further studies relating to acceptable dose and signal‐to‐noise ratio are necessary before clinical applications. Copyright © 2006 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Pakin, Sait Kubilay" sort="Pakin, Sait Kubilay" uniqKey="Pakin S" first="Sait Kubilay" last="Pakin">Sait Kubilay Pakin</name></region><name sortKey="Babsky, Andriy" sort="Babsky, Andriy" uniqKey="Babsky A" first="Andriy" last="Babsky">Andriy Babsky</name><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name><name sortKey="Hekmatyar, S K" sort="Hekmatyar, S K" uniqKey="Hekmatyar S" first="S. K." last="Hekmatyar">S. K. Hekmatyar</name><name sortKey="Hopewell, Paige" sort="Hopewell, Paige" uniqKey="Hopewell P" first="Paige" last="Hopewell">Paige Hopewell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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