Metal-Organic Framework/Ag-Based Hybrid Nanoagents for Rapid and Synergistic Bacterial Eradication.
Identifieur interne : 000098 ( Main/Exploration ); précédent : 000097; suivant : 000099Metal-Organic Framework/Ag-Based Hybrid Nanoagents for Rapid and Synergistic Bacterial Eradication.
Auteurs : Ye Yang [République populaire de Chine] ; Xizheng Wu [République populaire de Chine] ; Chao He [République populaire de Chine] ; Jianbo Huang [République populaire de Chine] ; Shiqi Yin [République populaire de Chine] ; Mi Zhou [République populaire de Chine] ; Lang Ma [République populaire de Chine] ; Weifeng Zhao [République populaire de Chine] ; Li Qiu [République populaire de Chine] ; Chong Cheng [République populaire de Chine, Allemagne] ; Changsheng Zhao [République populaire de Chine]Source :
- ACS applied materials & interfaces [ 1944-8252 ] ; 2020.
Descripteurs français
- KwdFr :
- Argent (composition chimique), Escherichia coli (effets des médicaments et des substances chimiques), Escherichia coli (pathogénicité), Humains (MeSH), Infections bactériennes (microbiologie), Infections bactériennes (traitement médicamenteux), Nanocomposites (composition chimique), Nanoparticules métalliques (composition chimique), Rayons infrarouges (MeSH), Réseaux organométalliques (composition chimique), Réseaux organométalliques (pharmacologie), Staphylococcus aureus (effets des médicaments et des substances chimiques), Staphylococcus aureus (pathogénicité).
- MESH :
- composition chimique : Argent, Nanocomposites, Nanoparticules métalliques, Réseaux organométalliques.
- effets des médicaments et des substances chimiques : Escherichia coli, Staphylococcus aureus.
- microbiologie : Infections bactériennes.
- pathogénicité : Escherichia coli, Staphylococcus aureus.
- pharmacologie : Réseaux organométalliques.
- traitement médicamenteux : Infections bactériennes.
- Humains, Rayons infrarouges.
English descriptors
- KwdEn :
- Bacterial Infections (drug therapy), Bacterial Infections (microbiology), Escherichia coli (drug effects), Escherichia coli (pathogenicity), Humans (MeSH), Infrared Rays (MeSH), Metal Nanoparticles (chemistry), Metal-Organic Frameworks (chemistry), Metal-Organic Frameworks (pharmacology), Nanocomposites (chemistry), Silver (chemistry), Staphylococcus aureus (drug effects), Staphylococcus aureus (pathogenicity).
- MESH :
- chemical , chemistry : Metal-Organic Frameworks, Silver.
- chemistry : Metal Nanoparticles, Nanocomposites.
- drug effects : Escherichia coli, Staphylococcus aureus.
- drug therapy : Bacterial Infections.
- microbiology : Bacterial Infections.
- pathogenicity : Escherichia coli, Staphylococcus aureus.
- chemical , pharmacology : Metal-Organic Frameworks.
- Humans, Infrared Rays.
Abstract
Recent emerged metal-organic frameworks (MOFs), as superior drug carriers, provide novel strategies to combat pathogenic bacterial infections. Although various antibacterial metal ions can be easily introduced in MOFs for chemical bacterial ablation, such a single-model bactericidal method suffers from high-dose use, limited antibacterial efficiency, and slow sterilization rate. Hence, developing a dual bactericidal system is urgently required. Herein, we report an MOF/Ag-derived nanocomposite with efficient metal-ion-releasing capability and robust photo-to-thermal conversion effect for synergistic sterilization. The MOF-derived nanocarbon consisting of metallic zinc and a graphitic-like carbon framework is first synthesized, and then Ag nanoparticles (AgNPs) are evenly introduced via the displacement reaction between Zn and Ag+. Upon near-infrared irradiation, the fabricated nanoagents can generate massive heat to destroy bacterial membranes. Meanwhile, abundant Zn2+ and Ag+ ions are released to make chemical damage to bacterial intracellular substances. Systematic antibacterial experiments reveal that such dual-antibacterial effort can endow the nanoagents with nearly 100% bactericidal ratio for highly concentrated bacteria at a very low dosage (0.16 mg/mL). Furthermore, the nanoagents exhibit less cytotoxicity, which provides potential possibilities for the applications in the biological field. In vivo assessment indicates that the nanocomposites can realize rapid and safe wound sterilization and are expected to be an alternative to antibiotics. Overall, we present an easily fabricated structure-engineered nanocomposite with chemical and photothermal effects for broad-spectrum bacterial sterilization.
DOI: 10.1021/acsami.0c01666
PubMed: 32129070
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Bacterial Infections (microbiology)</term>
<term>Escherichia coli (drug effects)</term>
<term>Escherichia coli (pathogenicity)</term>
<term>Humans (MeSH)</term>
<term>Infrared Rays (MeSH)</term>
<term>Metal Nanoparticles (chemistry)</term>
<term>Metal-Organic Frameworks (chemistry)</term>
<term>Metal-Organic Frameworks (pharmacology)</term>
<term>Nanocomposites (chemistry)</term>
<term>Silver (chemistry)</term>
<term>Staphylococcus aureus (drug effects)</term>
<term>Staphylococcus aureus (pathogenicity)</term>
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<term>Escherichia coli (effets des médicaments et des substances chimiques)</term>
<term>Escherichia coli (pathogénicité)</term>
<term>Humains (MeSH)</term>
<term>Infections bactériennes (microbiologie)</term>
<term>Infections bactériennes (traitement médicamenteux)</term>
<term>Nanocomposites (composition chimique)</term>
<term>Nanoparticules métalliques (composition chimique)</term>
<term>Rayons infrarouges (MeSH)</term>
<term>Réseaux organométalliques (composition chimique)</term>
<term>Réseaux organométalliques (pharmacologie)</term>
<term>Staphylococcus aureus (effets des médicaments et des substances chimiques)</term>
<term>Staphylococcus aureus (pathogénicité)</term>
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<term>Nanocomposites</term>
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<term>Nanocomposites</term>
<term>Nanoparticules métalliques</term>
<term>Réseaux organométalliques</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Escherichia coli</term>
<term>Staphylococcus aureus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bacterial Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Escherichia coli</term>
<term>Staphylococcus aureus</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections bactériennes</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bacterial Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Escherichia coli</term>
<term>Staphylococcus aureus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Escherichia coli</term>
<term>Staphylococcus aureus</term>
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<front><div type="abstract" xml:lang="en">Recent emerged metal-organic frameworks (MOFs), as superior drug carriers, provide novel strategies to combat pathogenic bacterial infections. Although various antibacterial metal ions can be easily introduced in MOFs for chemical bacterial ablation, such a single-model bactericidal method suffers from high-dose use, limited antibacterial efficiency, and slow sterilization rate. Hence, developing a dual bactericidal system is urgently required. Herein, we report an MOF/Ag-derived nanocomposite with efficient metal-ion-releasing capability and robust photo-to-thermal conversion effect for synergistic sterilization. The MOF-derived nanocarbon consisting of metallic zinc and a graphitic-like carbon framework is first synthesized, and then Ag nanoparticles (AgNPs) are evenly introduced via the displacement reaction between Zn and Ag<sup>+</sup>
. Upon near-infrared irradiation, the fabricated nanoagents can generate massive heat to destroy bacterial membranes. Meanwhile, abundant Zn<sup>2+</sup>
and Ag<sup>+</sup>
ions are released to make chemical damage to bacterial intracellular substances. Systematic antibacterial experiments reveal that such dual-antibacterial effort can endow the nanoagents with nearly 100% bactericidal ratio for highly concentrated bacteria at a very low dosage (0.16 mg/mL). Furthermore, the nanoagents exhibit less cytotoxicity, which provides potential possibilities for the applications in the biological field. <i>In vivo</i>
assessment indicates that the nanocomposites can realize rapid and safe wound sterilization and are expected to be an alternative to antibiotics. Overall, we present an easily fabricated structure-engineered nanocomposite with chemical and photothermal effects for broad-spectrum bacterial sterilization.</div>
</front>
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<ArticleTitle>Metal-Organic Framework/Ag-Based Hybrid Nanoagents for Rapid and Synergistic Bacterial Eradication.</ArticleTitle>
<Pagination><MedlinePgn>13698-13708</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1021/acsami.0c01666</ELocationID>
<Abstract><AbstractText>Recent emerged metal-organic frameworks (MOFs), as superior drug carriers, provide novel strategies to combat pathogenic bacterial infections. Although various antibacterial metal ions can be easily introduced in MOFs for chemical bacterial ablation, such a single-model bactericidal method suffers from high-dose use, limited antibacterial efficiency, and slow sterilization rate. Hence, developing a dual bactericidal system is urgently required. Herein, we report an MOF/Ag-derived nanocomposite with efficient metal-ion-releasing capability and robust photo-to-thermal conversion effect for synergistic sterilization. The MOF-derived nanocarbon consisting of metallic zinc and a graphitic-like carbon framework is first synthesized, and then Ag nanoparticles (AgNPs) are evenly introduced via the displacement reaction between Zn and Ag<sup>+</sup>
. Upon near-infrared irradiation, the fabricated nanoagents can generate massive heat to destroy bacterial membranes. Meanwhile, abundant Zn<sup>2+</sup>
and Ag<sup>+</sup>
ions are released to make chemical damage to bacterial intracellular substances. Systematic antibacterial experiments reveal that such dual-antibacterial effort can endow the nanoagents with nearly 100% bactericidal ratio for highly concentrated bacteria at a very low dosage (0.16 mg/mL). Furthermore, the nanoagents exhibit less cytotoxicity, which provides potential possibilities for the applications in the biological field. <i>In vivo</i>
assessment indicates that the nanocomposites can realize rapid and safe wound sterilization and are expected to be an alternative to antibiotics. Overall, we present an easily fabricated structure-engineered nanocomposite with chemical and photothermal effects for broad-spectrum bacterial sterilization.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Ye</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Xizheng</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Chao</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Jianbo</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratory of Ultrasound Imaging Drug, Department of Ultrasound, West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yin</LastName>
<ForeName>Shiqi</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Mi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Lang</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratory of Ultrasound Imaging Drug, Department of Ultrasound, West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Weifeng</ForeName>
<Initials>W</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-2689-0251</Identifier>
<AffiliationInfo><Affiliation>College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qiu</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-2685-9799</Identifier>
<AffiliationInfo><Affiliation>Laboratory of Ultrasound Imaging Drug, Department of Ultrasound, West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cheng</LastName>
<ForeName>Chong</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-6872-2240</Identifier>
<AffiliationInfo><Affiliation>College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Changsheng</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4619-3499</Identifier>
<AffiliationInfo><Affiliation>College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>03</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>ACS Appl Mater Interfaces</MedlineTA>
<NlmUniqueID>101504991</NlmUniqueID>
<ISSNLinking>1944-8244</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000073396">Metal-Organic Frameworks</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>3M4G523W1G</RegistryNumber>
<NameOfSubstance UI="D012834">Silver</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007259" MajorTopicYN="N">Infrared Rays</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053768" MajorTopicYN="N">Metal Nanoparticles</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073396" MajorTopicYN="N">Metal-Organic Frameworks</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053761" MajorTopicYN="N">Nanocomposites</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bacterial sterilization</Keyword>
<Keyword MajorTopicYN="N">hybrid nanoagents</Keyword>
<Keyword MajorTopicYN="N">metal−organic framework</Keyword>
<Keyword MajorTopicYN="N">photothermal therapy</Keyword>
<Keyword MajorTopicYN="N">wound disinfection</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>3</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>12</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>3</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32129070</ArticleId>
<ArticleId IdType="doi">10.1021/acsami.0c01666</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>République populaire de Chine</li>
</country>
<region><li>Berlin</li>
</region>
<settlement><li>Berlin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Ye" sort="Yang, Ye" uniqKey="Yang Y" first="Ye" last="Yang">Ye Yang</name>
</noRegion>
<name sortKey="Cheng, Chong" sort="Cheng, Chong" uniqKey="Cheng C" first="Chong" last="Cheng">Chong Cheng</name>
<name sortKey="He, Chao" sort="He, Chao" uniqKey="He C" first="Chao" last="He">Chao He</name>
<name sortKey="Huang, Jianbo" sort="Huang, Jianbo" uniqKey="Huang J" first="Jianbo" last="Huang">Jianbo Huang</name>
<name sortKey="Ma, Lang" sort="Ma, Lang" uniqKey="Ma L" first="Lang" last="Ma">Lang Ma</name>
<name sortKey="Qiu, Li" sort="Qiu, Li" uniqKey="Qiu L" first="Li" last="Qiu">Li Qiu</name>
<name sortKey="Wu, Xizheng" sort="Wu, Xizheng" uniqKey="Wu X" first="Xizheng" last="Wu">Xizheng Wu</name>
<name sortKey="Yin, Shiqi" sort="Yin, Shiqi" uniqKey="Yin S" first="Shiqi" last="Yin">Shiqi Yin</name>
<name sortKey="Zhao, Changsheng" sort="Zhao, Changsheng" uniqKey="Zhao C" first="Changsheng" last="Zhao">Changsheng Zhao</name>
<name sortKey="Zhao, Weifeng" sort="Zhao, Weifeng" uniqKey="Zhao W" first="Weifeng" last="Zhao">Weifeng Zhao</name>
<name sortKey="Zhou, Mi" sort="Zhou, Mi" uniqKey="Zhou M" first="Mi" last="Zhou">Mi Zhou</name>
</country>
<country name="Allemagne"><region name="Berlin"><name sortKey="Cheng, Chong" sort="Cheng, Chong" uniqKey="Cheng C" first="Chong" last="Cheng">Chong Cheng</name>
</region>
</country>
</tree>
</affiliations>
</record>
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