Non-cytotoxic silver nanoparticle-polysaccharide nanocomposites with antimicrobial activity.
Identifieur interne : 000B45 ( Main/Corpus ); précédent : 000B44; suivant : 000B46Non-cytotoxic silver nanoparticle-polysaccharide nanocomposites with antimicrobial activity.
Auteurs : Andrea Travan ; Chiara Pelillo ; Ivan Donati ; Eleonora Marsich ; Monica Benincasa ; Tommaso Scarpa ; Sabrina Semeraro ; Gianluca Turco ; Renato Gennaro ; Sergio PaolettiSource :
- Biomacromolecules [ 1526-4602 ] ; 2009.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Escherichia coli (drug effects), Flow Cytometry (MeSH), Hydrogels (MeSH), Mass Spectrometry (MeSH), Metal Nanoparticles (MeSH), Microbial Sensitivity Tests (MeSH), Microscopy, Electron, Transmission (MeSH), Pseudomonas aeruginosa (drug effects), Silver (chemistry), Spectrophotometry, Ultraviolet (MeSH), Staphylococcus aureus (drug effects).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Silver.
- chemical , pharmacology : Anti-Bacterial Agents.
- drug effects : Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus.
- Flow Cytometry, Hydrogels, Mass Spectrometry, Metal Nanoparticles, Microbial Sensitivity Tests, Microscopy, Electron, Transmission, Spectrophotometry, Ultraviolet.
Abstract
In this work we study (i) the formation and stabilization of silver nanoparticles in a bioactive chitosan-derived polysaccharide solution, (ii) the antimicrobial properties, either in solution or in 3D hydrogel structures, obtained by mixtures with the polysaccharide alginate, and (iii) the cytotoxicity of the latter nanocomposite materials on different eukaryotic cell lines. Antimicrobial results show that these nanocomposite systems display a very effective bactericidal activity toward both Gram+ and Gram- bacteria. However, the hydrogel does not show any cytotoxic effect toward three different eukaryotic cell lines. This is due to the fact that the nanoparticles, immobilized in the gel matrix, can exert their antimicrobial activity by simple contact with the bacterial membrane, while they can not be uptaken and internalized by eukaryotic cells. This novel finding could advantageously contribute to responding to the growing concerns on the toxicity of nanoparticles and facilitate the use of silver-biopolymer composites in the preparation of biomaterials.
DOI: 10.1021/bm900039x
PubMed: 19405545
Links to Exploration step
pubmed:19405545Le document en format XML
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Benincasa</name></author><author><name sortKey="Scarpa, Tommaso" sort="Scarpa, Tommaso" uniqKey="Scarpa T" first="Tommaso" last="Scarpa">Tommaso Scarpa</name></author><author><name sortKey="Semeraro, Sabrina" sort="Semeraro, Sabrina" uniqKey="Semeraro S" first="Sabrina" last="Semeraro">Sabrina Semeraro</name></author><author><name sortKey="Turco, Gianluca" sort="Turco, Gianluca" uniqKey="Turco G" first="Gianluca" last="Turco">Gianluca Turco</name></author><author><name sortKey="Gennaro, Renato" sort="Gennaro, Renato" uniqKey="Gennaro R" first="Renato" last="Gennaro">Renato Gennaro</name></author><author><name sortKey="Paoletti, Sergio" sort="Paoletti, Sergio" uniqKey="Paoletti S" first="Sergio" last="Paoletti">Sergio Paoletti</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19405545</idno><idno type="pmid">19405545</idno><idno type="doi">10.1021/bm900039x</idno><idno 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Marsich</name></author><author><name sortKey="Benincasa, Monica" sort="Benincasa, Monica" uniqKey="Benincasa M" first="Monica" last="Benincasa">Monica Benincasa</name></author><author><name sortKey="Scarpa, Tommaso" sort="Scarpa, Tommaso" uniqKey="Scarpa T" first="Tommaso" last="Scarpa">Tommaso Scarpa</name></author><author><name sortKey="Semeraro, Sabrina" sort="Semeraro, Sabrina" uniqKey="Semeraro S" first="Sabrina" last="Semeraro">Sabrina Semeraro</name></author><author><name sortKey="Turco, Gianluca" sort="Turco, Gianluca" uniqKey="Turco G" first="Gianluca" last="Turco">Gianluca Turco</name></author><author><name sortKey="Gennaro, Renato" sort="Gennaro, Renato" uniqKey="Gennaro R" first="Renato" last="Gennaro">Renato Gennaro</name></author><author><name sortKey="Paoletti, Sergio" sort="Paoletti, Sergio" uniqKey="Paoletti S" first="Sergio" last="Paoletti">Sergio Paoletti</name></author></analytic><series><title level="j">Biomacromolecules</title><idno 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xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Escherichia coli</term><term>Pseudomonas aeruginosa</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Flow Cytometry</term><term>Hydrogels</term><term>Mass Spectrometry</term><term>Metal Nanoparticles</term><term>Microbial Sensitivity Tests</term><term>Microscopy, Electron, Transmission</term><term>Spectrophotometry, Ultraviolet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this work we study (i) the formation and stabilization of silver nanoparticles in a bioactive chitosan-derived polysaccharide solution, (ii) the antimicrobial properties, either in solution or in 3D hydrogel structures, obtained by mixtures with the polysaccharide alginate, and (iii) the cytotoxicity of the latter nanocomposite materials on different eukaryotic cell lines. Antimicrobial results show that these nanocomposite systems display a very effective bactericidal activity toward both Gram+ and Gram- bacteria. However, the hydrogel does not show any cytotoxic effect toward three different eukaryotic cell lines. This is due to the fact that the nanoparticles, immobilized in the gel matrix, can exert their antimicrobial activity by simple contact with the bacterial membrane, while they can not be uptaken and internalized by eukaryotic cells. This novel finding could advantageously contribute to responding to the growing concerns on the toxicity of nanoparticles and facilitate the use of silver-biopolymer composites in the preparation of biomaterials.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19405545</PMID><DateCompleted><Year>2009</Year><Month>10</Month><Day>09</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1526-4602</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>6</Issue><PubDate><Year>2009</Year><Month>Jun</Month><Day>08</Day></PubDate></JournalIssue><Title>Biomacromolecules</Title><ISOAbbreviation>Biomacromolecules</ISOAbbreviation></Journal><ArticleTitle>Non-cytotoxic silver nanoparticle-polysaccharide nanocomposites with antimicrobial activity.</ArticleTitle><Pagination><MedlinePgn>1429-35</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/bm900039x</ELocationID><Abstract><AbstractText>In this work we study (i) the formation and stabilization of silver nanoparticles in a bioactive chitosan-derived polysaccharide solution, (ii) the antimicrobial properties, either in solution or in 3D hydrogel structures, obtained by mixtures with the polysaccharide alginate, and (iii) the cytotoxicity of the latter nanocomposite materials on different eukaryotic cell lines. Antimicrobial results show that these nanocomposite systems display a very effective bactericidal activity toward both Gram+ and Gram- bacteria. However, the hydrogel does not show any cytotoxic effect toward three different eukaryotic cell lines. This is due to the fact that the nanoparticles, immobilized in the gel matrix, can exert their antimicrobial activity by simple contact with the bacterial membrane, while they can not be uptaken and internalized by eukaryotic cells. This novel finding could advantageously contribute to responding to the growing concerns on the toxicity of nanoparticles and facilitate the use of silver-biopolymer composites in the preparation of biomaterials.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Travan</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Life Sciences, University of Trieste, Trieste, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pelillo</LastName><ForeName>Chiara</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Donati</LastName><ForeName>Ivan</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Marsich</LastName><ForeName>Eleonora</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Benincasa</LastName><ForeName>Monica</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Scarpa</LastName><ForeName>Tommaso</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Semeraro</LastName><ForeName>Sabrina</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Turco</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Gennaro</LastName><ForeName>Renato</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Paoletti</LastName><ForeName>Sergio</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biomacromolecules</MedlineTA><NlmUniqueID>100892849</NlmUniqueID><ISSNLinking>1525-7797</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020100">Hydrogels</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance UI="D012834">Silver</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005434" MajorTopicYN="N">Flow Cytometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020100" MajorTopicYN="N">Hydrogels</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053768" MajorTopicYN="Y">Metal Nanoparticles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046529" MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011550" MajorTopicYN="N">Pseudomonas aeruginosa</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013056" MajorTopicYN="N">Spectrophotometry, Ultraviolet</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>5</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>5</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>10</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19405545</ArticleId><ArticleId IdType="doi">10.1021/bm900039x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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