Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms.
Identifieur interne : 000937 ( Main/Corpus ); précédent : 000936; suivant : 000938Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms.
Auteurs : Jia Tang ; Qian Chen ; Ligeng Xu ; Shuai Zhang ; Liangzhu Feng ; Liang Cheng ; Huan Xu ; Zhuang Liu ; Rui PengSource :
- ACS applied materials & interfaces [ 1944-8252 ] ; 2013.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Cell Survival (drug effects), Escherichia coli (drug effects), Graphite (chemistry), Graphite (pharmacology), HEK293 Cells (MeSH), Humans (MeSH), Microbial Viability (drug effects), Nanocomposites (chemistry), Oxides (chemistry), Oxides (pharmacology), Silver (chemistry), Silver (pharmacology), Species Specificity (MeSH), Staphylococcus aureus (drug effects).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Graphite, Oxides, Silver.
- chemical , pharmacology : Anti-Bacterial Agents, Graphite, Oxides, Silver.
- chemistry : Nanocomposites.
- drug effects : Cell Survival, Escherichia coli, Microbial Viability, Staphylococcus aureus.
- HEK293 Cells, Humans, Species Specificity.
Abstract
Recently, graphene oxide (GO) based nanocomposites have raised significant interests in many different areas, one of which being antibacterial agents where sliver nanoparticle (AgNPs) anchored GO (GO-Ag) has shown promising potential. However, to our best knowledge, factors affecting its antibacterial activity as well as the underlying mechanism remain unclear. In this study, we fabricate GO-Ag nanocomposites with different AgNPs to GO ratios and carefully investigate their antibacterial activities against both the Gram-negative (G-) bacteria Escherichia coli ( E. coli ) and the Gram-positive (G+) bacteria Staphylococcus aureus ( S. aureus ). We discover that, compared to AgNPs, GO-Ag nanocomposite with an optimal ratio of AgNPs to GO is much more effective and shows synergistically enhanced, strong antibacterial activities at rather low dose (2.5 μg/mL). The GO-Ag nanocomposite is more toxic to E. coli than that to S. aureus . The antibacterial effects of GO-Ag nanocomposite are further investigated, revealing distinct, species-specific mechanisms. The results demonstrate that GO-Ag nanocomposite functions as a bactericide against the G- E. coli through disrupting bacterial cell wall integrity, whereas it exhibits bacteriostatic effect on the G+ S. aureus by dramatically inhibiting cell division. Our work not only highlights the great promise of using GO-Ag as a highly effective antibacterial agent but also provides more in-depth understandings of the interactions between microorganisms and GO-based nanocomposites.
DOI: 10.1021/am4005495
PubMed: 23586616
Links to Exploration step
pubmed:23586616Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms.</title><author><name sortKey="Tang, Jia" sort="Tang, Jia" uniqKey="Tang J" first="Jia" last="Tang">Jia Tang</name><affiliation><nlm:affiliation>Institute of Functional aNano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Qian" sort="Chen, Qian" uniqKey="Chen Q" first="Qian" last="Chen">Qian Chen</name></author><author><name sortKey="Xu, Ligeng" sort="Xu, Ligeng" uniqKey="Xu L" first="Ligeng" last="Xu">Ligeng Xu</name></author><author><name sortKey="Zhang, Shuai" sort="Zhang, Shuai" uniqKey="Zhang S" first="Shuai" last="Zhang">Shuai Zhang</name></author><author><name sortKey="Feng, Liangzhu" sort="Feng, Liangzhu" uniqKey="Feng L" first="Liangzhu" last="Feng">Liangzhu Feng</name></author><author><name sortKey="Cheng, Liang" sort="Cheng, Liang" uniqKey="Cheng L" first="Liang" last="Cheng">Liang Cheng</name></author><author><name sortKey="Xu, Huan" sort="Xu, Huan" uniqKey="Xu H" first="Huan" last="Xu">Huan Xu</name></author><author><name sortKey="Liu, Zhuang" sort="Liu, Zhuang" uniqKey="Liu Z" first="Zhuang" last="Liu">Zhuang Liu</name></author><author><name sortKey="Peng, Rui" sort="Peng, Rui" uniqKey="Peng R" first="Rui" last="Peng">Rui Peng</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23586616</idno><idno type="pmid">23586616</idno><idno type="doi">10.1021/am4005495</idno><idno type="wicri:Area/Main/Corpus">000937</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000937</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms.</title><author><name sortKey="Tang, Jia" sort="Tang, Jia" uniqKey="Tang J" first="Jia" last="Tang">Jia Tang</name><affiliation><nlm:affiliation>Institute of Functional aNano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Qian" sort="Chen, Qian" uniqKey="Chen Q" first="Qian" last="Chen">Qian Chen</name></author><author><name sortKey="Xu, Ligeng" sort="Xu, Ligeng" uniqKey="Xu L" first="Ligeng" last="Xu">Ligeng Xu</name></author><author><name sortKey="Zhang, Shuai" sort="Zhang, Shuai" uniqKey="Zhang S" first="Shuai" last="Zhang">Shuai Zhang</name></author><author><name sortKey="Feng, Liangzhu" sort="Feng, Liangzhu" uniqKey="Feng L" first="Liangzhu" last="Feng">Liangzhu Feng</name></author><author><name sortKey="Cheng, Liang" sort="Cheng, Liang" uniqKey="Cheng L" first="Liang" last="Cheng">Liang Cheng</name></author><author><name sortKey="Xu, Huan" sort="Xu, Huan" uniqKey="Xu H" first="Huan" last="Xu">Huan Xu</name></author><author><name sortKey="Liu, Zhuang" sort="Liu, Zhuang" uniqKey="Liu Z" first="Zhuang" last="Liu">Zhuang Liu</name></author><author><name sortKey="Peng, Rui" sort="Peng, Rui" uniqKey="Peng R" first="Rui" last="Peng">Rui Peng</name></author></analytic><series><title level="j">ACS applied materials & interfaces</title><idno type="eISSN">1944-8252</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (chemistry)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Cell Survival (drug effects)</term><term>Escherichia coli (drug effects)</term><term>Graphite (chemistry)</term><term>Graphite (pharmacology)</term><term>HEK293 Cells (MeSH)</term><term>Humans (MeSH)</term><term>Microbial Viability (drug effects)</term><term>Nanocomposites (chemistry)</term><term>Oxides (chemistry)</term><term>Oxides (pharmacology)</term><term>Silver (chemistry)</term><term>Silver (pharmacology)</term><term>Species Specificity (MeSH)</term><term>Staphylococcus aureus (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Graphite</term><term>Oxides</term><term>Silver</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Graphite</term><term>Oxides</term><term>Silver</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanocomposites</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Escherichia coli</term><term>Microbial Viability</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>HEK293 Cells</term><term>Humans</term><term>Species Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, graphene oxide (GO) based nanocomposites have raised significant interests in many different areas, one of which being antibacterial agents where sliver nanoparticle (AgNPs) anchored GO (GO-Ag) has shown promising potential. However, to our best knowledge, factors affecting its antibacterial activity as well as the underlying mechanism remain unclear. In this study, we fabricate GO-Ag nanocomposites with different AgNPs to GO ratios and carefully investigate their antibacterial activities against both the Gram-negative (G-) bacteria Escherichia coli ( E. coli ) and the Gram-positive (G+) bacteria Staphylococcus aureus ( S. aureus ). We discover that, compared to AgNPs, GO-Ag nanocomposite with an optimal ratio of AgNPs to GO is much more effective and shows synergistically enhanced, strong antibacterial activities at rather low dose (2.5 μg/mL). The GO-Ag nanocomposite is more toxic to E. coli than that to S. aureus . The antibacterial effects of GO-Ag nanocomposite are further investigated, revealing distinct, species-specific mechanisms. The results demonstrate that GO-Ag nanocomposite functions as a bactericide against the G- E. coli through disrupting bacterial cell wall integrity, whereas it exhibits bacteriostatic effect on the G+ S. aureus by dramatically inhibiting cell division. Our work not only highlights the great promise of using GO-Ag as a highly effective antibacterial agent but also provides more in-depth understandings of the interactions between microorganisms and GO-based nanocomposites.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23586616</PMID><DateCompleted><Year>2013</Year><Month>10</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1944-8252</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>9</Issue><PubDate><Year>2013</Year><Month>May</Month></PubDate></JournalIssue><Title>ACS applied materials & interfaces</Title><ISOAbbreviation>ACS Appl Mater Interfaces</ISOAbbreviation></Journal><ArticleTitle>Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms.</ArticleTitle><Pagination><MedlinePgn>3867-74</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/am4005495</ELocationID><Abstract><AbstractText>Recently, graphene oxide (GO) based nanocomposites have raised significant interests in many different areas, one of which being antibacterial agents where sliver nanoparticle (AgNPs) anchored GO (GO-Ag) has shown promising potential. However, to our best knowledge, factors affecting its antibacterial activity as well as the underlying mechanism remain unclear. In this study, we fabricate GO-Ag nanocomposites with different AgNPs to GO ratios and carefully investigate their antibacterial activities against both the Gram-negative (G-) bacteria Escherichia coli ( E. coli ) and the Gram-positive (G+) bacteria Staphylococcus aureus ( S. aureus ). We discover that, compared to AgNPs, GO-Ag nanocomposite with an optimal ratio of AgNPs to GO is much more effective and shows synergistically enhanced, strong antibacterial activities at rather low dose (2.5 μg/mL). The GO-Ag nanocomposite is more toxic to E. coli than that to S. aureus . The antibacterial effects of GO-Ag nanocomposite are further investigated, revealing distinct, species-specific mechanisms. The results demonstrate that GO-Ag nanocomposite functions as a bactericide against the G- E. coli through disrupting bacterial cell wall integrity, whereas it exhibits bacteriostatic effect on the G+ S. aureus by dramatically inhibiting cell division. Our work not only highlights the great promise of using GO-Ag as a highly effective antibacterial agent but also provides more in-depth understandings of the interactions between microorganisms and GO-based nanocomposites.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Jia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Functional aNano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Qian</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Ligeng</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Shuai</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Liangzhu</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Liang</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Huan</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Zhuang</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Rui</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>04</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Appl Mater 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Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006108" MajorTopicYN="N">Graphite</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050296" MajorTopicYN="N">Microbial Viability</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053761" MajorTopicYN="N">Nanocomposites</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010087" MajorTopicYN="N">Oxides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate 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