The development of an experimental multiple serogroups vaccine for Neisseria meningitidis.
Identifieur interne : 000887 ( Main/Corpus ); précédent : 000886; suivant : 000888The development of an experimental multiple serogroups vaccine for Neisseria meningitidis.
Auteurs : Valerian B. Pinto ; Robert Burden ; Allyn Wagner ; Elizabeth E. Moran ; Che-Hung LeeSource :
- PloS one [ 1932-6203 ] ; 2013.
English descriptors
- KwdEn :
- Animals (MeSH), Antigens, Bacterial (genetics), Antigens, Bacterial (immunology), Bacterial Outer Membrane Proteins (genetics), Bacterial Outer Membrane Proteins (immunology), Cross Reactions (immunology), Cytokines (blood), Endotoxins (metabolism), Meningitis, Meningococcal (metabolism), Meningitis, Meningococcal (prevention & control), Meningococcal Vaccines (genetics), Meningococcal Vaccines (immunology), Mice (MeSH), Neisseria meningitidis (classification), Neisseria meningitidis (genetics), Neisseria meningitidis (immunology), Neisseria meningitidis, Serogroup B (genetics), Neisseria meningitidis, Serogroup B (immunology), Serotyping (MeSH), Vaccines, Conjugate (genetics), Vaccines, Conjugate (immunology).
- MESH :
- chemical , blood : Cytokines.
- chemical , genetics : Antigens, Bacterial, Bacterial Outer Membrane Proteins, Meningococcal Vaccines, Vaccines, Conjugate.
- chemical , immunology : Antigens, Bacterial, Bacterial Outer Membrane Proteins, Meningococcal Vaccines, Vaccines, Conjugate.
- classification : Neisseria meningitidis.
- genetics : Neisseria meningitidis, Neisseria meningitidis, Serogroup B.
- immunology : Cross Reactions, Neisseria meningitidis, Neisseria meningitidis, Serogroup B.
- chemical , metabolism : Endotoxins, Meningitis, Meningococcal.
- prevention & control : Meningitis, Meningococcal.
- Animals, Mice, Serotyping.
Abstract
A native outer membrane vesicles (NOMV) vaccine was developed from three antigenically diverse strains of Neisseria meningitidis that express the L1,8, L2, and L3,7 lipooligosaccharide (LOS) immunotypes, and whose synX, and lpxL1 genes were deleted.. Immunogenicity studies in mice showed that the vaccine induced bactericidal antibody against serogroups B, C, W, Y and X N. meningitidis strains. However, this experimental NOMV vaccine was not effective against serogroup A N. meningitidis strains. N. meningitidis capsular polysaccharide (PS) from serogroups A, C, W and Y were effective at inducing bactericidal antibody when conjugated to either tetanus toxoid or the fHbp1-fHbp2 fusion protein fHbp(1+2). The combination of the NOMV vaccine and the N. meningitidis serogroup A capsular polysaccharide (MAPS) protein conjugate was capable of inducing bactericidal antibodies against a limited number of N. meningitidis strains from serogroups A, B, C, W, Y and X tested in this study.
DOI: 10.1371/journal.pone.0079304
PubMed: 24244473
PubMed Central: PMC3828347
Links to Exploration step
pubmed:24244473Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The development of an experimental multiple serogroups vaccine for Neisseria meningitidis.</title><author><name sortKey="Pinto, Valerian B" sort="Pinto, Valerian B" uniqKey="Pinto V" first="Valerian B" last="Pinto">Valerian B. Pinto</name><affiliation><nlm:affiliation>Division of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research (WRAIR), Silver Springs, Maryland, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Burden, Robert" sort="Burden, Robert" uniqKey="Burden R" first="Robert" last="Burden">Robert Burden</name></author><author><name sortKey="Wagner, Allyn" sort="Wagner, Allyn" uniqKey="Wagner A" first="Allyn" last="Wagner">Allyn Wagner</name></author><author><name sortKey="Moran, Elizabeth E" sort="Moran, Elizabeth E" uniqKey="Moran E" first="Elizabeth E" last="Moran">Elizabeth E. Moran</name></author><author><name sortKey="Lee, Che Hung" sort="Lee, Che Hung" uniqKey="Lee C" first="Che-Hung" last="Lee">Che-Hung Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24244473</idno><idno type="pmid">24244473</idno><idno type="doi">10.1371/journal.pone.0079304</idno><idno type="pmc">PMC3828347</idno><idno type="wicri:Area/Main/Corpus">000887</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000887</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The development of an experimental multiple serogroups vaccine for Neisseria meningitidis.</title><author><name sortKey="Pinto, Valerian B" sort="Pinto, Valerian B" uniqKey="Pinto V" first="Valerian B" last="Pinto">Valerian B. Pinto</name><affiliation><nlm:affiliation>Division of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research (WRAIR), Silver Springs, Maryland, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Burden, Robert" sort="Burden, Robert" uniqKey="Burden R" first="Robert" last="Burden">Robert Burden</name></author><author><name sortKey="Wagner, Allyn" sort="Wagner, Allyn" uniqKey="Wagner A" first="Allyn" last="Wagner">Allyn Wagner</name></author><author><name sortKey="Moran, Elizabeth E" sort="Moran, Elizabeth E" uniqKey="Moran E" first="Elizabeth E" last="Moran">Elizabeth E. Moran</name></author><author><name sortKey="Lee, Che Hung" sort="Lee, Che Hung" uniqKey="Lee C" first="Che-Hung" last="Lee">Che-Hung Lee</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antigens, Bacterial (genetics)</term><term>Antigens, Bacterial (immunology)</term><term>Bacterial Outer Membrane Proteins (genetics)</term><term>Bacterial Outer Membrane Proteins (immunology)</term><term>Cross Reactions (immunology)</term><term>Cytokines (blood)</term><term>Endotoxins (metabolism)</term><term>Meningitis, Meningococcal (metabolism)</term><term>Meningitis, Meningococcal (prevention & control)</term><term>Meningococcal Vaccines (genetics)</term><term>Meningococcal Vaccines (immunology)</term><term>Mice (MeSH)</term><term>Neisseria meningitidis (classification)</term><term>Neisseria meningitidis (genetics)</term><term>Neisseria meningitidis (immunology)</term><term>Neisseria meningitidis, Serogroup B (genetics)</term><term>Neisseria meningitidis, Serogroup B (immunology)</term><term>Serotyping (MeSH)</term><term>Vaccines, Conjugate (genetics)</term><term>Vaccines, Conjugate (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Bacterial</term><term>Bacterial Outer Membrane Proteins</term><term>Meningococcal Vaccines</term><term>Vaccines, Conjugate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Bacterial</term><term>Bacterial Outer Membrane Proteins</term><term>Meningococcal Vaccines</term><term>Vaccines, Conjugate</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Neisseria meningitidis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Neisseria meningitidis</term><term>Neisseria meningitidis, Serogroup B</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cross Reactions</term><term>Neisseria meningitidis</term><term>Neisseria meningitidis, Serogroup B</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Endotoxins</term><term>Meningitis, Meningococcal</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Meningitis, Meningococcal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term><term>Serotyping</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A native outer membrane vesicles (NOMV) vaccine was developed from three antigenically diverse strains of Neisseria meningitidis that express the L1,8, L2, and L3,7 lipooligosaccharide (LOS) immunotypes, and whose synX, and lpxL1 genes were deleted.. Immunogenicity studies in mice showed that the vaccine induced bactericidal antibody against serogroups B, C, W, Y and X N. meningitidis strains. However, this experimental NOMV vaccine was not effective against serogroup A N. meningitidis strains. N. meningitidis capsular polysaccharide (PS) from serogroups A, C, W and Y were effective at inducing bactericidal antibody when conjugated to either tetanus toxoid or the fHbp1-fHbp2 fusion protein fHbp(1+2). The combination of the NOMV vaccine and the N. meningitidis serogroup A capsular polysaccharide (MAPS) protein conjugate was capable of inducing bactericidal antibodies against a limited number of N. meningitidis strains from serogroups A, B, C, W, Y and X tested in this study. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24244473</PMID><DateCompleted><Year>2014</Year><Month>11</Month><Day>24</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>11</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>The development of an experimental multiple serogroups vaccine for Neisseria meningitidis.</ArticleTitle><Pagination><MedlinePgn>e79304</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0079304</ELocationID><Abstract><AbstractText>A native outer membrane vesicles (NOMV) vaccine was developed from three antigenically diverse strains of Neisseria meningitidis that express the L1,8, L2, and L3,7 lipooligosaccharide (LOS) immunotypes, and whose synX, and lpxL1 genes were deleted.. Immunogenicity studies in mice showed that the vaccine induced bactericidal antibody against serogroups B, C, W, Y and X N. meningitidis strains. However, this experimental NOMV vaccine was not effective against serogroup A N. meningitidis strains. N. meningitidis capsular polysaccharide (PS) from serogroups A, C, W and Y were effective at inducing bactericidal antibody when conjugated to either tetanus toxoid or the fHbp1-fHbp2 fusion protein fHbp(1+2). The combination of the NOMV vaccine and the N. meningitidis serogroup A capsular polysaccharide (MAPS) protein conjugate was capable of inducing bactericidal antibodies against a limited number of N. meningitidis strains from serogroups A, B, C, W, Y and X tested in this study. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pinto</LastName><ForeName>Valerian B</ForeName><Initials>VB</Initials><AffiliationInfo><Affiliation>Division of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research (WRAIR), Silver Springs, Maryland, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burden</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Wagner</LastName><ForeName>Allyn</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Moran</LastName><ForeName>Elizabeth E</ForeName><Initials>EE</Initials></Author><Author 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MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003429" MajorTopicYN="N">Cross Reactions</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004731" MajorTopicYN="N">Endotoxins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008585" MajorTopicYN="N">Meningitis, Meningococcal</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D022401" MajorTopicYN="N">Meningococcal 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