Vancomycin-modified Fe3O4@SiO2@Ag microflowers as effective antimicrobial agents.
Identifieur interne : 000560 ( Main/Corpus ); précédent : 000559; suivant : 000561Vancomycin-modified Fe3O4@SiO2@Ag microflowers as effective antimicrobial agents.
Auteurs : Chongwen Wang ; Kehan Zhang ; Zhe Zhou ; Qingjun Li ; Liting Shao ; Rong Zhang Hao ; Rui Xiao ; Shengqi WangSource :
- International journal of nanomedicine [ 1178-2013 ] ; 2017.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacokinetics), Anti-Bacterial Agents (pharmacology), Cell Wall (drug effects), Drug Evaluation, Preclinical (methods), Drug Synergism (MeSH), Escherichia coli (drug effects), Ferrosoferric Oxide (chemistry), Magnetite Nanoparticles (administration & dosage), Magnetite Nanoparticles (chemistry), Methicillin-Resistant Staphylococcus aureus (drug effects), Microbial Sensitivity Tests (MeSH), Nanostructures (administration & dosage), Nanostructures (chemistry), Silicon Dioxide (chemistry), Silicon Dioxide (pharmacology), Silver (chemistry), Silver (pharmacology), Vancomycin (chemistry), Vancomycin (pharmacokinetics), Vancomycin (pharmacology).
- MESH :
- chemical , administration & dosage : Magnetite Nanoparticles.
- chemical , chemistry : Anti-Bacterial Agents, Ferrosoferric Oxide, Magnetite Nanoparticles, Silicon Dioxide, Silver, Vancomycin.
- chemical , pharmacokinetics : Anti-Bacterial Agents, Vancomycin.
- chemical , pharmacology : Anti-Bacterial Agents, Silicon Dioxide, Silver, Vancomycin.
- administration & dosage : Nanostructures.
- chemistry : Nanostructures.
- drug effects : Cell Wall, Escherichia coli, Methicillin-Resistant Staphylococcus aureus.
- methods : Drug Evaluation, Preclinical.
- Drug Synergism, Microbial Sensitivity Tests.
Abstract
Nanomaterials combined with antibiotics exhibit synergistic effects and have gained increasing interest as promising antimicrobial agents. In this study, vancomycin-modified magnetic-based silver microflowers (Van/Fe3O4@SiO2@Ag microflowers) were rationally designed and prepared to achieve strong bactericidal ability, a wide antimicrobial spectrum, and good recyclability. High-performance Fe3O4@SiO2@Ag microflowers served as a multifunction-supporting matrix and exhibited sufficient magnetic response property due to their 200 nm Fe3O4 core. The microflowers also possessed a highly branched flower-like Ag shell that provided a large surface area for effective Ag ion release and bacterial contact. The modified-vancomycin layer was effectively bound to the cell wall of bacteria to increase the permeability of the cell membrane and facilitate the entry of the Ag ions into the bacterium, resulting in cell death. As such, the fabricated Van/Fe3O4@SiO2@Ag microflowers were predicted to be an effective and environment-friendly antibacterial agent. This hypothesis was verified through sterilization of Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus, with minimum inhibitory concentrations of 10 and 20 μg mL-1, respectively. The microflowers also showed enhanced effect compared with bare Fe3O4@SiO2@Ag microflowers and free-form vancomycin, confirming the synergistic effects of the combination of the two components. Moreover, the antimicrobial effect was maintained at more than 90% after five cycling assays, indicating the high stability of the product. These findings reveal that Van/Fe3O4@SiO2@Ag microflowers exhibit promising applications in the antibacterial fields.
DOI: 10.2147/IJN.S132570
PubMed: 28450783
PubMed Central: PMC5399987
Links to Exploration step
pubmed:28450783Le document en format XML
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O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers as effective antimicrobial agents.</title>
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O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers as effective antimicrobial agents.</title>
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<author><name sortKey="Zhang, Kehan" sort="Zhang, Kehan" uniqKey="Zhang K" first="Kehan" last="Zhang">Kehan Zhang</name>
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<term>Anti-Bacterial Agents (pharmacology)</term>
<term>Cell Wall (drug effects)</term>
<term>Drug Evaluation, Preclinical (methods)</term>
<term>Drug Synergism (MeSH)</term>
<term>Escherichia coli (drug effects)</term>
<term>Ferrosoferric Oxide (chemistry)</term>
<term>Magnetite Nanoparticles (administration & dosage)</term>
<term>Magnetite Nanoparticles (chemistry)</term>
<term>Methicillin-Resistant Staphylococcus aureus (drug effects)</term>
<term>Microbial Sensitivity Tests (MeSH)</term>
<term>Nanostructures (administration & dosage)</term>
<term>Nanostructures (chemistry)</term>
<term>Silicon Dioxide (chemistry)</term>
<term>Silicon Dioxide (pharmacology)</term>
<term>Silver (chemistry)</term>
<term>Silver (pharmacology)</term>
<term>Vancomycin (chemistry)</term>
<term>Vancomycin (pharmacokinetics)</term>
<term>Vancomycin (pharmacology)</term>
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<term>Ferrosoferric Oxide</term>
<term>Magnetite Nanoparticles</term>
<term>Silicon Dioxide</term>
<term>Silver</term>
<term>Vancomycin</term>
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<term>Vancomycin</term>
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<term>Silicon Dioxide</term>
<term>Silver</term>
<term>Vancomycin</term>
</keywords>
<keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Nanostructures</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanostructures</term>
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<term>Methicillin-Resistant Staphylococcus aureus</term>
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<front><div type="abstract" xml:lang="en">Nanomaterials combined with antibiotics exhibit synergistic effects and have gained increasing interest as promising antimicrobial agents. In this study, vancomycin-modified magnetic-based silver microflowers (Van/Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers) were rationally designed and prepared to achieve strong bactericidal ability, a wide antimicrobial spectrum, and good recyclability. High-performance Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers served as a multifunction-supporting matrix and exhibited sufficient magnetic response property due to their 200 nm Fe<sub>3</sub>
O<sub>4</sub>
core. The microflowers also possessed a highly branched flower-like Ag shell that provided a large surface area for effective Ag ion release and bacterial contact. The modified-vancomycin layer was effectively bound to the cell wall of bacteria to increase the permeability of the cell membrane and facilitate the entry of the Ag ions into the bacterium, resulting in cell death. As such, the fabricated Van/Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers were predicted to be an effective and environment-friendly antibacterial agent. This hypothesis was verified through sterilization of Gram-negative <i>Escherichia coli</i>
and Gram-positive methicillin-resistant <i>Staphylococcus aureus</i>
, with minimum inhibitory concentrations of 10 and 20 μg mL<sup>-1</sup>
, respectively. The microflowers also showed enhanced effect compared with bare Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers and free-form vancomycin, confirming the synergistic effects of the combination of the two components. Moreover, the antimicrobial effect was maintained at more than 90% after five cycling assays, indicating the high stability of the product. These findings reveal that Van/Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers exhibit promising applications in the antibacterial fields.</div>
</front>
</TEI>
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<Month>09</Month>
<Day>19</Day>
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<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>02</Day>
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<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1178-2013</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<PubDate><Year>2017</Year>
</PubDate>
</JournalIssue>
<Title>International journal of nanomedicine</Title>
<ISOAbbreviation>Int J Nanomedicine</ISOAbbreviation>
</Journal>
<ArticleTitle>Vancomycin-modified Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers as effective antimicrobial agents.</ArticleTitle>
<Pagination><MedlinePgn>3077-3094</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.2147/IJN.S132570</ELocationID>
<Abstract><AbstractText>Nanomaterials combined with antibiotics exhibit synergistic effects and have gained increasing interest as promising antimicrobial agents. In this study, vancomycin-modified magnetic-based silver microflowers (Van/Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers) were rationally designed and prepared to achieve strong bactericidal ability, a wide antimicrobial spectrum, and good recyclability. High-performance Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers served as a multifunction-supporting matrix and exhibited sufficient magnetic response property due to their 200 nm Fe<sub>3</sub>
O<sub>4</sub>
core. The microflowers also possessed a highly branched flower-like Ag shell that provided a large surface area for effective Ag ion release and bacterial contact. The modified-vancomycin layer was effectively bound to the cell wall of bacteria to increase the permeability of the cell membrane and facilitate the entry of the Ag ions into the bacterium, resulting in cell death. As such, the fabricated Van/Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers were predicted to be an effective and environment-friendly antibacterial agent. This hypothesis was verified through sterilization of Gram-negative <i>Escherichia coli</i>
and Gram-positive methicillin-resistant <i>Staphylococcus aureus</i>
, with minimum inhibitory concentrations of 10 and 20 μg mL<sup>-1</sup>
, respectively. The microflowers also showed enhanced effect compared with bare Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers and free-form vancomycin, confirming the synergistic effects of the combination of the two components. Moreover, the antimicrobial effect was maintained at more than 90% after five cycling assays, indicating the high stability of the product. These findings reveal that Van/Fe<sub>3</sub>
O<sub>4</sub>
@SiO<sub>2</sub>
@Ag microflowers exhibit promising applications in the antibacterial fields.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Chongwen</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>College of Life Sciences & Bio-Engineering, Beijing University of Technology.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, Beijing Institute of Radiation Medicine, Beijing.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Zhang</LastName>
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<AffiliationInfo><Affiliation>Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, Beijing Institute of Radiation Medicine, Beijing.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Qingjun</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, Beijing Institute of Radiation Medicine, Beijing.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shao</LastName>
<ForeName>Liting</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, Beijing Institute of Radiation Medicine, Beijing.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hao</LastName>
<ForeName>Rong Zhang</ForeName>
<Initials>RZ</Initials>
<AffiliationInfo><Affiliation>Institute for Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Rui</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, Beijing Institute of Radiation Medicine, Beijing.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Shengqi</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>College of Life Sciences & Bio-Engineering, Beijing University of Technology.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, Beijing Institute of Radiation Medicine, Beijing.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
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<Acronym>AA</Acronym>
<Agency>NIAAA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<Month>04</Month>
<Day>13</Day>
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<MedlineTA>Int J Nanomedicine</MedlineTA>
<NlmUniqueID>101263847</NlmUniqueID>
<ISSNLinking>1176-9114</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002473" MajorTopicYN="N">Cell Wall</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
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<MeshHeading><DescriptorName UI="D004353" MajorTopicYN="N">Drug Evaluation, Preclinical</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D058185" MajorTopicYN="N">Magnetite Nanoparticles</DescriptorName>
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<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055624" MajorTopicYN="N">Methicillin-Resistant Staphylococcus aureus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049329" MajorTopicYN="N">Nanostructures</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012822" MajorTopicYN="N">Silicon Dioxide</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014640" MajorTopicYN="N">Vancomycin</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ag shell</Keyword>
<Keyword MajorTopicYN="N">antibiotic-resistant bacteria</Keyword>
<Keyword MajorTopicYN="N">biological properties</Keyword>
<Keyword MajorTopicYN="N">magnetic composites</Keyword>
<Keyword MajorTopicYN="N">surface area</Keyword>
</KeywordList>
<CoiStatement>Disclosure The authors report no conflicts of interest in this work.</CoiStatement>
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