Bimetallic silver-platinum nanoparticles with combined osteo-promotive and antimicrobial activity.
Identifieur interne : 000282 ( Main/Corpus ); précédent : 000281; suivant : 000283Bimetallic silver-platinum nanoparticles with combined osteo-promotive and antimicrobial activity.
Auteurs : Marina Breisch ; Viktoria Grasmik ; Kateryna Loza ; Kevin Pappert ; Alexander Rostek ; Nadine Ziegler ; Alfred Ludwig ; Marc Heggen ; Matthias Epple ; Jörg C. Tiller ; Thomas A. Schildhauer ; Manfred Köller ; Christina SengstockSource :
- Nanotechnology [ 1361-6528 ] ; 2019.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Cell Differentiation (drug effects), Cell Line (MeSH), Escherichia coli (drug effects), Escherichia coli Infections (drug therapy), Humans (MeSH), Mesenchymal Stem Cells (cytology), Mesenchymal Stem Cells (drug effects), Metal Nanoparticles (chemistry), Osteogenesis (drug effects), Platinum (chemistry), Platinum (pharmacology), Silver (chemistry), Silver (pharmacology), Staphylococcal Infections (drug therapy), Staphylococcus aureus (drug effects).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Platinum, Silver.
- chemical , pharmacology : Anti-Bacterial Agents, Platinum, Silver.
- chemistry : Metal Nanoparticles.
- cytology : Mesenchymal Stem Cells.
- drug effects : Cell Differentiation, Escherichia coli, Mesenchymal Stem Cells, Osteogenesis, Staphylococcus aureus.
- drug therapy : Escherichia coli Infections, Staphylococcal Infections.
- Cell Line, Humans.
Abstract
Bimetallic alloyed silver-platinum nanoparticles (AgPt NP) with different metal composition from Ag10Pt90 to Ag90Pt10 in steps of 20 mol% were synthesized. The biological effects of AgPt NP, including cellular uptake, cell viability, osteogenic differentiation and osteoclastogenesis as well as the antimicrobial activity towards Staphylococcus aureus and Escherichia coli were analyzed in comparison to pure Ag NP and pure Pt NP. The uptake of NP into human mesenchymal stem cells was confirmed by cross-sectional focused-ion beam preparation and observation by scanning and transmission electron microscopy in combination with energy-dispersive x-ray analysis. Lower cytotoxicity and antimicrobial activity were observed for AgPt NP compared to pure Ag NP. Thus, an enhanced Ag ion release due to a possible sacrificial anode effect was not achieved. Nevertheless, a Ag content of at least 50 mol% was sufficient to induce bactericidal effects against both Staphylococcus aureus and Escherichia coli. In addition, a Pt-related (≥50 mol% Pt) osteo-promotive activity on human mesenchymal stem cells was observed by enhanced cell calcification and alkaline phosphatase activity. In contrast, the osteoclastogenesis of rat primary precursor osteoclasts was inhibited. In summary, these results demonstrate a combinatory osteo-promotive and antimicrobial activity of bimetallic Ag50Pt50 NP.
DOI: 10.1088/1361-6528/ab172b
PubMed: 30959494
Links to Exploration step
pubmed:30959494Le document en format XML
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Tiller</name></author><author><name sortKey="Schildhauer, Thomas A" sort="Schildhauer, Thomas A" uniqKey="Schildhauer T" first="Thomas A" last="Schildhauer">Thomas A. Schildhauer</name></author><author><name sortKey="Koller, Manfred" sort="Koller, Manfred" uniqKey="Koller M" first="Manfred" last="Köller">Manfred Köller</name></author><author><name sortKey="Sengstock, Christina" sort="Sengstock, Christina" uniqKey="Sengstock C" first="Christina" last="Sengstock">Christina Sengstock</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30959494</idno><idno type="pmid">30959494</idno><idno type="doi">10.1088/1361-6528/ab172b</idno><idno type="wicri:Area/Main/Corpus">000282</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000282</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bimetallic silver-platinum nanoparticles with combined osteo-promotive and antimicrobial activity.</title><author><name sortKey="Breisch, Marina" sort="Breisch, Marina" uniqKey="Breisch M" first="Marina" last="Breisch">Marina Breisch</name><affiliation><nlm:affiliation>BG University Hospital Bergmannsheil Bochum/Surgical Research, Ruhr University Bochum, Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Grasmik, Viktoria" sort="Grasmik, Viktoria" uniqKey="Grasmik V" first="Viktoria" last="Grasmik">Viktoria Grasmik</name></author><author><name sortKey="Loza, Kateryna" sort="Loza, Kateryna" uniqKey="Loza K" first="Kateryna" last="Loza">Kateryna Loza</name></author><author><name sortKey="Pappert, Kevin" sort="Pappert, Kevin" uniqKey="Pappert K" first="Kevin" last="Pappert">Kevin Pappert</name></author><author><name sortKey="Rostek, Alexander" sort="Rostek, Alexander" uniqKey="Rostek A" first="Alexander" last="Rostek">Alexander Rostek</name></author><author><name sortKey="Ziegler, Nadine" sort="Ziegler, Nadine" uniqKey="Ziegler N" first="Nadine" last="Ziegler">Nadine Ziegler</name></author><author><name sortKey="Ludwig, Alfred" sort="Ludwig, Alfred" uniqKey="Ludwig A" first="Alfred" last="Ludwig">Alfred Ludwig</name></author><author><name sortKey="Heggen, Marc" sort="Heggen, Marc" uniqKey="Heggen M" first="Marc" last="Heggen">Marc Heggen</name></author><author><name sortKey="Epple, Matthias" sort="Epple, Matthias" uniqKey="Epple M" first="Matthias" last="Epple">Matthias Epple</name></author><author><name sortKey="Tiller, Jorg C" sort="Tiller, Jorg C" uniqKey="Tiller J" first="Jörg C" last="Tiller">Jörg C. Tiller</name></author><author><name sortKey="Schildhauer, Thomas A" sort="Schildhauer, Thomas A" uniqKey="Schildhauer T" first="Thomas A" last="Schildhauer">Thomas A. Schildhauer</name></author><author><name sortKey="Koller, Manfred" sort="Koller, Manfred" uniqKey="Koller M" first="Manfred" last="Köller">Manfred Köller</name></author><author><name sortKey="Sengstock, Christina" sort="Sengstock, Christina" uniqKey="Sengstock C" first="Christina" last="Sengstock">Christina Sengstock</name></author></analytic><series><title level="j">Nanotechnology</title><idno type="eISSN">1361-6528</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (chemistry)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Cell Differentiation (drug effects)</term><term>Cell Line (MeSH)</term><term>Escherichia coli (drug effects)</term><term>Escherichia coli Infections (drug therapy)</term><term>Humans (MeSH)</term><term>Mesenchymal Stem Cells (cytology)</term><term>Mesenchymal Stem Cells (drug effects)</term><term>Metal Nanoparticles (chemistry)</term><term>Osteogenesis (drug effects)</term><term>Platinum (chemistry)</term><term>Platinum (pharmacology)</term><term>Silver (chemistry)</term><term>Silver (pharmacology)</term><term>Staphylococcal Infections (drug therapy)</term><term>Staphylococcus aureus (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Platinum</term><term>Silver</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Platinum</term><term>Silver</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mesenchymal Stem Cells</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Differentiation</term><term>Escherichia coli</term><term>Mesenchymal Stem Cells</term><term>Osteogenesis</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Escherichia coli Infections</term><term>Staphylococcal Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bimetallic alloyed silver-platinum nanoparticles (AgPt NP) with different metal composition from Ag<sub>10</sub>Pt<sub>90</sub> to Ag<sub>90</sub>Pt<sub>10</sub> in steps of 20 mol% were synthesized. The biological effects of AgPt NP, including cellular uptake, cell viability, osteogenic differentiation and osteoclastogenesis as well as the antimicrobial activity towards Staphylococcus aureus and Escherichia coli were analyzed in comparison to pure Ag NP and pure Pt NP. The uptake of NP into human mesenchymal stem cells was confirmed by cross-sectional focused-ion beam preparation and observation by scanning and transmission electron microscopy in combination with energy-dispersive x-ray analysis. Lower cytotoxicity and antimicrobial activity were observed for AgPt NP compared to pure Ag NP. Thus, an enhanced Ag ion release due to a possible sacrificial anode effect was not achieved. Nevertheless, a Ag content of at least 50 mol% was sufficient to induce bactericidal effects against both Staphylococcus aureus and Escherichia coli. In addition, a Pt-related (≥50 mol% Pt) osteo-promotive activity on human mesenchymal stem cells was observed by enhanced cell calcification and alkaline phosphatase activity. In contrast, the osteoclastogenesis of rat primary precursor osteoclasts was inhibited. In summary, these results demonstrate a combinatory osteo-promotive and antimicrobial activity of bimetallic Ag<sub>50</sub>Pt<sub>50</sub> NP.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30959494</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1361-6528</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>30</Issue><PubDate><Year>2019</Year><Month>Jul</Month><Day>26</Day></PubDate></JournalIssue><Title>Nanotechnology</Title><ISOAbbreviation>Nanotechnology</ISOAbbreviation></Journal><ArticleTitle>Bimetallic silver-platinum nanoparticles with combined osteo-promotive and antimicrobial activity.</ArticleTitle><Pagination><MedlinePgn>305101</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1088/1361-6528/ab172b</ELocationID><Abstract><AbstractText>Bimetallic alloyed silver-platinum nanoparticles (AgPt NP) with different metal composition from Ag<sub>10</sub>Pt<sub>90</sub> to Ag<sub>90</sub>Pt<sub>10</sub> in steps of 20 mol% were synthesized. The biological effects of AgPt NP, including cellular uptake, cell viability, osteogenic differentiation and osteoclastogenesis as well as the antimicrobial activity towards Staphylococcus aureus and Escherichia coli were analyzed in comparison to pure Ag NP and pure Pt NP. The uptake of NP into human mesenchymal stem cells was confirmed by cross-sectional focused-ion beam preparation and observation by scanning and transmission electron microscopy in combination with energy-dispersive x-ray analysis. Lower cytotoxicity and antimicrobial activity were observed for AgPt NP compared to pure Ag NP. Thus, an enhanced Ag ion release due to a possible sacrificial anode effect was not achieved. Nevertheless, a Ag content of at least 50 mol% was sufficient to induce bactericidal effects against both Staphylococcus aureus and Escherichia coli. In addition, a Pt-related (≥50 mol% Pt) osteo-promotive activity on human mesenchymal stem cells was observed by enhanced cell calcification and alkaline phosphatase activity. In contrast, the osteoclastogenesis of rat primary precursor osteoclasts was inhibited. In summary, these results demonstrate a combinatory osteo-promotive and antimicrobial activity of bimetallic Ag<sub>50</sub>Pt<sub>50</sub> NP.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Breisch</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>BG University Hospital Bergmannsheil Bochum/Surgical Research, Ruhr University Bochum, Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grasmik</LastName><ForeName>Viktoria</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Loza</LastName><ForeName>Kateryna</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Pappert</LastName><ForeName>Kevin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Rostek</LastName><ForeName>Alexander</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ziegler</LastName><ForeName>Nadine</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Ludwig</LastName><ForeName>Alfred</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Heggen</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Epple</LastName><ForeName>Matthias</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Tiller</LastName><ForeName>Jörg C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Schildhauer</LastName><ForeName>Thomas A</ForeName><Initials>TA</Initials></Author><Author ValidYN="Y"><LastName>Köller</LastName><ForeName>Manfred</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Sengstock</LastName><ForeName>Christina</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>04</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nanotechnology</MedlineTA><NlmUniqueID>101241272</NlmUniqueID><ISSNLinking>0957-4484</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance UI="D012834">Silver</NameOfSubstance></Chemical><Chemical><RegistryNumber>49DFR088MY</RegistryNumber><NameOfSubstance UI="D010984">Platinum</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004927" MajorTopicYN="N">Escherichia coli Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059630" MajorTopicYN="N">Mesenchymal Stem Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053768" MajorTopicYN="Y">Metal Nanoparticles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010984" MajorTopicYN="N">Platinum</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013203" MajorTopicYN="N">Staphylococcal Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30959494</ArticleId><ArticleId IdType="doi">10.1088/1361-6528/ab172b</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix 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