SilverBacteriV1, Main, Corpus, bibRecord, 000281

Biological and Physicochemical Assessment of Middle Ear Prosthesis.

Identifieur interne : 000281 ( Main/Corpus ); précédent : 000280; suivant : 000282

Biological and Physicochemical Assessment of Middle Ear Prosthesis.

Auteurs : Magdalena Zi Bka ; Michał Dziadek ; Aleksandra Kr Licka

Source :

Polymers [ 2073-4360 ] ; 2019.

RBID : pubmed:30960063

Abstract

Polymers modified with bioactive nanoparticles are a promising solution for patients who need a tissue replacement. Modern implants, thanks to bioactive and bactericidal functions, facilitate the healing and regeneration process of the replaced tissue. The aim of this study was to assess whether silver nanoparticles (AgNPs) could support antibacterial function without cytotoxic effect and deterioration of biostability. This article describes biological and physiochemical aspects concerning a new polymeric middle ear implant (Otoimplant) enriched with silver nanoparticles. This kind of prosthesis is a promising implant for the reconstruction of ossicles in ossiculoplasty. We found that incorporation of silver nanoparticles into a polymeric matrix resulted in bactericidal efficacy against Gram-positive and Gram-negative bacteria, both resistant to antibiotics and basic strains. Our prostheses do not show cytotoxic effect and are a suitable biomaterial platform for effective culture of Saos2 and NHOst osteoblastic cells. The in vitro incubation of the samples in distilled water revealed that surface parameters, such as roughness, may slightly increase as a result of unveiling nanoparticles. However, the prolonged immersion does not change mechanical parameters. During one-year incubation, the prosthesis proved to retain stable values of Young's modulus, tensile strength, propagation of longitudinal ultrasonic waves, pH, and conductivity.

DOI: 10.3390/polym11010079
PubMed: 30960063
PubMed Central: PMC6402019

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pubmed:30960063

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<author><name sortKey="Zi Bka, Magdalena" sort="Zi Bka, Magdalena" uniqKey="Zi Bka M" first="Magdalena" last="Zi Bka">Magdalena Zi Bka</name>
<affiliation><nlm:affiliation>AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Ceramics and Refractories, 30-059 Krakow, Poland. ziabka@agh.edu.pl.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dziadek, Michal" sort="Dziadek, Michal" uniqKey="Dziadek M" first="Michał" last="Dziadek">Michał Dziadek</name>
<affiliation><nlm:affiliation>AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Glass Technology and Amorphous Coatings, 30-059 Krakow, Poland. dziadek@agh.edu.pl.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kr Licka, Aleksandra" sort="Kr Licka, Aleksandra" uniqKey="Kr Licka A" first="Aleksandra" last="Kr Licka">Aleksandra Kr Licka</name>
<affiliation><nlm:affiliation>University of Gdansk, Intercollegiate Faculty of Biotechnology UG-GUMed, Department of Biotechnology, Laboratory of Biologically Active Compounds, 80-307 Gdansk, Poland. aleksandra.krolicka@biotech.ug.edu.pl.</nlm:affiliation>
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<front><div type="abstract" xml:lang="en">Polymers modified with bioactive nanoparticles are a promising solution for patients who need a tissue replacement. Modern implants, thanks to bioactive and bactericidal functions, facilitate the healing and regeneration process of the replaced tissue. The aim of this study was to assess whether silver nanoparticles (AgNPs) could support antibacterial function without cytotoxic effect and deterioration of biostability. This article describes biological and physiochemical aspects concerning a new polymeric middle ear implant (Otoimplant) enriched with silver nanoparticles. This kind of prosthesis is a promising implant for the reconstruction of ossicles in ossiculoplasty. We found that incorporation of silver nanoparticles into a polymeric matrix resulted in bactericidal efficacy against Gram-positive and Gram-negative bacteria, both resistant to antibiotics and basic strains. Our prostheses do not show cytotoxic effect and are a suitable biomaterial platform for effective culture of Saos2 and NHOst osteoblastic cells. The in vitro incubation of the samples in distilled water revealed that surface parameters, such as roughness, may slightly increase as a result of unveiling nanoparticles. However, the prolonged immersion does not change mechanical parameters. During one-year incubation, the prosthesis proved to retain stable values of Young's modulus, tensile strength, propagation of longitudinal ultrasonic waves, pH, and conductivity.</div>
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<DateRevised><Year>2020</Year>
<Month>09</Month>
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<Abstract><AbstractText>Polymers modified with bioactive nanoparticles are a promising solution for patients who need a tissue replacement. Modern implants, thanks to bioactive and bactericidal functions, facilitate the healing and regeneration process of the replaced tissue. The aim of this study was to assess whether silver nanoparticles (AgNPs) could support antibacterial function without cytotoxic effect and deterioration of biostability. This article describes biological and physiochemical aspects concerning a new polymeric middle ear implant (Otoimplant) enriched with silver nanoparticles. This kind of prosthesis is a promising implant for the reconstruction of ossicles in ossiculoplasty. We found that incorporation of silver nanoparticles into a polymeric matrix resulted in bactericidal efficacy against Gram-positive and Gram-negative bacteria, both resistant to antibiotics and basic strains. Our prostheses do not show cytotoxic effect and are a suitable biomaterial platform for effective culture of Saos2 and NHOst osteoblastic cells. The in vitro incubation of the samples in distilled water revealed that surface parameters, such as roughness, may slightly increase as a result of unveiling nanoparticles. However, the prolonged immersion does not change mechanical parameters. During one-year incubation, the prosthesis proved to retain stable values of Young's modulus, tensile strength, propagation of longitudinal ultrasonic waves, pH, and conductivity.</AbstractText>
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Biological and Physicochemical Assessment of Middle Ear Prosthesis.

Biological and Physicochemical Assessment of Middle Ear Prosthesis.

Source :

Abstract

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