Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration.
Identifieur interne : 000245 ( Main/Corpus ); précédent : 000244; suivant : 000246Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration.
Auteurs : Marcin Wekwejt ; Anna Michno ; Karolina Truchan ; Anna Pałubicka ; Beata Wieczko- Urek ; Anna Maria Osyczka ; Andrzej Zieli SkiSource :
- Nanomaterials (Basel, Switzerland) [ 2079-4991 ] ; 2019.
Abstract
Bacterial infections due to bone replacement surgeries require modifications of bone cement with antibacterial components. This study aimed to investigate whether the incorporation of gentamicin or nanometals into bone cement may reduce and to what extent bacterial growth without the loss of overall cytocompatibility and adverse effects in vitro. The bone cement Cemex was used as the base material, modified either with gentamicin sulfate or nanometals: Silver or copper. The inhibition of bacterial adhesion and growth was examined against five different bacterial strains along with integrity of erythrocytes, viability of blood platelets, and dental pulp stem cells. Bone cement modified with nanoAg or nanoCu revealed greater bactericidal effects and prevented the biofilm formation better compared to antibiotic-loaded bone cement. The cement containing nanoAg displayed good cytocompatibility without noticeable hemolysis of erythrocytes or blood platelet disfunction and good viability of dental pulp stem cells (DPSC). On the contrary, the nanoCu cement enhanced hemolysis of erythrocytes, reduced the platelets aggregation, and decreased DPSC viability. Based on these studies, we suggest the modification of bone cement with nanoAg may be a good strategy to provide improved implant fixative for bone regeneration purposes.
DOI: 10.3390/nano9081114
PubMed: 31382557
PubMed Central: PMC6722923
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last="Truchan">Karolina Truchan</name><affiliation><nlm:affiliation>Department of Biology and Cell Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Palubicka, Anna" sort="Palubicka, Anna" uniqKey="Palubicka A" first="Anna" last="Pałubicka">Anna Pałubicka</name><affiliation><nlm:affiliation>Department of Laboratory Diagnostics and Microbiology with Blood Bank, Specialist Hospital in Kościerzyna, 83-400 Kościerzyna, Poland.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Surgical Oncologic, Medical University of Gdańsk, 80-210 Gdańsk, Poland.</nlm:affiliation></affiliation></author><author><name sortKey=" Wieczko Urek, Beata" sort=" Wieczko Urek, Beata" uniqKey=" Wieczko Urek B" first="Beata" last=" Wieczko- Urek">Beata Wieczko- Urek</name><affiliation><nlm:affiliation>Biomaterials Division, Department of Materials Engineering and Bonding, Gdańsk University of Technology, 80-233 Gdańsk, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Osyczka, Anna Maria" sort="Osyczka, Anna Maria" uniqKey="Osyczka A" first="Anna Maria" last="Osyczka">Anna Maria Osyczka</name><affiliation><nlm:affiliation>Department of Biology and Cell Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Zieli Ski, Andrzej" sort="Zieli Ski, Andrzej" uniqKey="Zieli Ski A" first="Andrzej" last="Zieli Ski">Andrzej Zieli Ski</name><affiliation><nlm:affiliation>Biomaterials Division, Department of Materials Engineering and Bonding, Gdańsk University of Technology, 80-233 Gdańsk, Poland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31382557</idno><idno 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Biochemistry, Department of Laboratory Medicine, Medical University of Gdańsk, 80-210 Gdańsk, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Truchan, Karolina" sort="Truchan, Karolina" uniqKey="Truchan K" first="Karolina" last="Truchan">Karolina Truchan</name><affiliation><nlm:affiliation>Department of Biology and Cell Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Palubicka, Anna" sort="Palubicka, Anna" uniqKey="Palubicka A" first="Anna" last="Pałubicka">Anna Pałubicka</name><affiliation><nlm:affiliation>Department of Laboratory Diagnostics and Microbiology with Blood Bank, Specialist Hospital in Kościerzyna, 83-400 Kościerzyna, Poland.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Surgical Oncologic, Medical University of Gdańsk, 80-210 Gdańsk, Poland.</nlm:affiliation></affiliation></author><author><name sortKey=" Wieczko Urek, Beata" sort=" Wieczko Urek, Beata" uniqKey=" Wieczko Urek B" first="Beata" last=" Wieczko- Urek">Beata Wieczko- Urek</name><affiliation><nlm:affiliation>Biomaterials Division, Department of Materials Engineering and Bonding, Gdańsk University of Technology, 80-233 Gdańsk, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Osyczka, Anna Maria" sort="Osyczka, Anna Maria" uniqKey="Osyczka A" first="Anna Maria" last="Osyczka">Anna Maria Osyczka</name><affiliation><nlm:affiliation>Department of Biology and Cell Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Zieli Ski, Andrzej" sort="Zieli Ski, Andrzej" uniqKey="Zieli Ski A" first="Andrzej" last="Zieli Ski">Andrzej Zieli Ski</name><affiliation><nlm:affiliation>Biomaterials Division, Department of Materials Engineering and Bonding, Gdańsk University of Technology, 80-233 Gdańsk, Poland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nanomaterials (Basel, Switzerland)</title><idno type="ISSN">2079-4991</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bacterial infections due to bone replacement surgeries require modifications of bone cement with antibacterial components. This study aimed to investigate whether the incorporation of gentamicin or nanometals into bone cement may reduce and to what extent bacterial growth without the loss of overall cytocompatibility and adverse effects in vitro. The bone cement Cemex was used as the base material, modified either with gentamicin sulfate or nanometals: Silver or copper. The inhibition of bacterial adhesion and growth was examined against five different bacterial strains along with integrity of erythrocytes, viability of blood platelets, and dental pulp stem cells. Bone cement modified with nanoAg or nanoCu revealed greater bactericidal effects and prevented the biofilm formation better compared to antibiotic-loaded bone cement. The cement containing nanoAg displayed good cytocompatibility without noticeable hemolysis of erythrocytes or blood platelet disfunction and good viability of dental pulp stem cells (DPSC). On the contrary, the nanoCu cement enhanced hemolysis of erythrocytes, reduced the platelets aggregation, and decreased DPSC viability. Based on these studies, we suggest the modification of bone cement with nanoAg may be a good strategy to provide improved implant fixative for bone regeneration purposes.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31382557</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2079-4991</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>8</Issue><PubDate><Year>2019</Year><Month>Aug</Month><Day>03</Day></PubDate></JournalIssue><Title>Nanomaterials (Basel, Switzerland)</Title><ISOAbbreviation>Nanomaterials (Basel)</ISOAbbreviation></Journal><ArticleTitle>Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E1114</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/nano9081114</ELocationID><Abstract><AbstractText>Bacterial infections due to bone replacement surgeries require modifications of bone cement with antibacterial components. This study aimed to investigate whether the incorporation of gentamicin or nanometals into bone cement may reduce and to what extent bacterial growth without the loss of overall cytocompatibility and adverse effects in vitro. The bone cement Cemex was used as the base material, modified either with gentamicin sulfate or nanometals: Silver or copper. The inhibition of bacterial adhesion and growth was examined against five different bacterial strains along with integrity of erythrocytes, viability of blood platelets, and dental pulp stem cells. Bone cement modified with nanoAg or nanoCu revealed greater bactericidal effects and prevented the biofilm formation better compared to antibiotic-loaded bone cement. The cement containing nanoAg displayed good cytocompatibility without noticeable hemolysis of erythrocytes or blood platelet disfunction and good viability of dental pulp stem cells (DPSC). On the contrary, the nanoCu cement enhanced hemolysis of erythrocytes, reduced the platelets aggregation, and decreased DPSC viability. Based on these studies, we suggest the modification of bone cement with nanoAg may be a good strategy to provide improved implant fixative for bone regeneration purposes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wekwejt</LastName><ForeName>Marcin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Biomaterials Division, Department of Materials Engineering and Bonding, Gdańsk University of Technology, 80-233 Gdańsk, Poland. marcin.wekwejt@pg.edu.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michno</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Chair of Clinical Biochemistry, Department of Laboratory Medicine, Medical University of Gdańsk, 80-210 Gdańsk, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Truchan</LastName><ForeName>Karolina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Biology and Cell Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pałubicka</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Laboratory Diagnostics and Microbiology with Blood Bank, Specialist Hospital in Kościerzyna, 83-400 Kościerzyna, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Surgical Oncologic, Medical University of Gdańsk, 80-210 Gdańsk, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Świeczko-Żurek</LastName><ForeName>Beata</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Biomaterials Division, Department of Materials Engineering and Bonding, Gdańsk University of Technology, 80-233 Gdańsk, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osyczka</LastName><ForeName>Anna Maria</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Biology and Cell Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zieliński</LastName><ForeName>Andrzej</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Biomaterials Division, Department of Materials Engineering and Bonding, Gdańsk University of Technology, 80-233 Gdańsk, Poland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>ST-57; 2016/21/B/NZ5/00217</GrantID><Agency>This work was supported in part by the Medical University of Gdańsk fund and the AMO NSC grant</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>08</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Nanomaterials (Basel)</MedlineTA><NlmUniqueID>101610216</NlmUniqueID><ISSNLinking>2079-4991</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">antibacterial properties</Keyword><Keyword MajorTopicYN="N">bone cement</Keyword><Keyword MajorTopicYN="N">cell viability</Keyword><Keyword MajorTopicYN="N">hemolysis</Keyword><Keyword MajorTopicYN="N">nanometals</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>07</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>07</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate 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