Characterization of synergistic antibacterial effect of silver nanoparticles and ebselen.
Identifieur interne : 000244 ( Main/Corpus ); précédent : 000243; suivant : 000245Characterization of synergistic antibacterial effect of silver nanoparticles and ebselen.
Auteurs : Xueqing Chen ; Heming Chen ; Hongying Zhang ; Yanjuan Peng ; Fuchang Deng ; Jiye Gao ; Chunli Chai ; Song Tang ; Xin Zuo ; Jun Lu ; Huamao DuSource :
- Artificial cells, nanomedicine, and biotechnology [ 2169-141X ] ; 2019.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Anti-Bacterial Agents (toxicity), Ascorbic Acid (pharmacology), Azoles (pharmacology), Drug Resistance, Multiple (drug effects), Drug Synergism (MeSH), Escherichia coli (drug effects), HeLa Cells (MeSH), Humans (MeSH), Metal Nanoparticles (MeSH), Microbial Sensitivity Tests (MeSH), Organoselenium Compounds (pharmacology), Reactive Oxygen Species (metabolism), Silver (chemistry), Silver (pharmacology), Silver (toxicity), Staphylococcus aureus (drug effects).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Silver.
- chemical , metabolism : Reactive Oxygen Species.
- chemical , pharmacology : Anti-Bacterial Agents, Ascorbic Acid, Azoles, Organoselenium Compounds, Silver.
- chemical , toxicity : Anti-Bacterial Agents, Silver.
- drug effects : Drug Resistance, Multiple, Escherichia coli, Staphylococcus aureus.
- Drug Synergism, HeLa Cells, Humans, Metal Nanoparticles, Microbial Sensitivity Tests.
Abstract
The emerging and spreading of multi-drug resistant (MDR) bacteria have been becoming one of the most severe threats to human health. Enhancing oxidative stress as mimicking immune system was considered as a potential strategy to fight against infection of MDR bacteria. In this study, we investigated the antibacterial efficiency of such a strategy which combines silver nanoparticles (AgNPs) with ebselen. The results showed that AgNPs and ebselen combination had significant synergistic killing effects both on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro, including model strains of China Veterinary Culture Collection and MDR clinical isolates, which is similar as the combination of silver ion and ebselen. AgNPs exhibited to be a strong inhibitor of bacterial thioredoxin reductase, same as a free silver ion. Ebselen mitigated the cytotoxicity of AgNPs to HeLa cells. However, in a bacteria-cell coexistence condition, the synergistic bactericidal effect was only observed on S. aureus (p<.05), while the temporary synergistic inhibitory effect on E. coli within 4 hours treatment (p<.01). In mice infection model, a combination of AgNPs and ebselen did not increase protection against the challenge of clinical E. coli CQ10 strain. Our data demonstrated that AgNPs and ebselen combination may be a promising strategy to fight against the increasingly MDR bacteria targeting bacterial thiol redox system.
DOI: 10.1080/21691401.2019.1648278
PubMed: 31387398
Links to Exploration step
pubmed:31387398Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of synergistic antibacterial effect of silver nanoparticles and ebselen.</title><author><name sortKey="Chen, Xueqing" sort="Chen, Xueqing" uniqKey="Chen X" first="Xueqing" last="Chen">Xueqing Chen</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Heming" sort="Chen, Heming" uniqKey="Chen H" first="Heming" last="Chen">Heming Chen</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Hongying" sort="Zhang, Hongying" uniqKey="Zhang H" first="Hongying" last="Zhang">Hongying Zhang</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Peng, Yanjuan" sort="Peng, Yanjuan" uniqKey="Peng Y" first="Yanjuan" last="Peng">Yanjuan Peng</name><affiliation><nlm:affiliation>b Department of Production and Management, Tibet Autonomous Region Veterinary Biologics Factory , Lasa , Tibet , China.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Fuchang" sort="Deng, Fuchang" uniqKey="Deng F" first="Fuchang" last="Deng">Fuchang Deng</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Jiye" sort="Gao, Jiye" uniqKey="Gao J" first="Jiye" last="Gao">Jiye Gao</name><affiliation><nlm:affiliation>c College of Animal Science, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chai, Chunli" sort="Chai, Chunli" uniqKey="Chai C" first="Chunli" last="Chai">Chunli Chai</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Song" sort="Tang, Song" uniqKey="Tang S" first="Song" last="Tang">Song Tang</name><affiliation><nlm:affiliation>d Chinese Center for Disease Control and Prevention, National Institute of Environmental Health , Beijing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Zuo, Xin" sort="Zuo, Xin" uniqKey="Zuo X" first="Xin" last="Zuo">Xin Zuo</name><affiliation><nlm:affiliation>e Ministry of Education, College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Lu, Jun" sort="Lu, Jun" uniqKey="Lu J" first="Jun" last="Lu">Jun Lu</name><affiliation><nlm:affiliation>e Ministry of Education, College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Du, Huamao" sort="Du, Huamao" uniqKey="Du H" first="Huamao" last="Du">Huamao Du</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31387398</idno><idno type="pmid">31387398</idno><idno type="doi">10.1080/21691401.2019.1648278</idno><idno type="wicri:Area/Main/Corpus">000244</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000244</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization of synergistic antibacterial effect of silver nanoparticles and ebselen.</title><author><name sortKey="Chen, Xueqing" sort="Chen, Xueqing" uniqKey="Chen X" first="Xueqing" last="Chen">Xueqing Chen</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Heming" sort="Chen, Heming" uniqKey="Chen H" first="Heming" last="Chen">Heming Chen</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Hongying" sort="Zhang, Hongying" uniqKey="Zhang H" first="Hongying" last="Zhang">Hongying Zhang</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Peng, Yanjuan" sort="Peng, Yanjuan" uniqKey="Peng Y" first="Yanjuan" last="Peng">Yanjuan Peng</name><affiliation><nlm:affiliation>b Department of Production and Management, Tibet Autonomous Region Veterinary Biologics Factory , Lasa , Tibet , China.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Fuchang" sort="Deng, Fuchang" uniqKey="Deng F" first="Fuchang" last="Deng">Fuchang Deng</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Jiye" sort="Gao, Jiye" uniqKey="Gao J" first="Jiye" last="Gao">Jiye Gao</name><affiliation><nlm:affiliation>c College of Animal Science, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chai, Chunli" sort="Chai, Chunli" uniqKey="Chai C" first="Chunli" last="Chai">Chunli Chai</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Song" sort="Tang, Song" uniqKey="Tang S" first="Song" last="Tang">Song Tang</name><affiliation><nlm:affiliation>d Chinese Center for Disease Control and Prevention, National Institute of Environmental Health , Beijing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Zuo, Xin" sort="Zuo, Xin" uniqKey="Zuo X" first="Xin" last="Zuo">Xin Zuo</name><affiliation><nlm:affiliation>e Ministry of Education, College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Lu, Jun" sort="Lu, Jun" uniqKey="Lu J" first="Jun" last="Lu">Jun Lu</name><affiliation><nlm:affiliation>e Ministry of Education, College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Du, Huamao" sort="Du, Huamao" uniqKey="Du H" first="Huamao" last="Du">Huamao Du</name><affiliation><nlm:affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Artificial cells, nanomedicine, and biotechnology</title><idno type="eISSN">2169-141X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (chemistry)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Anti-Bacterial Agents (toxicity)</term><term>Ascorbic Acid (pharmacology)</term><term>Azoles (pharmacology)</term><term>Drug Resistance, Multiple (drug effects)</term><term>Drug Synergism (MeSH)</term><term>Escherichia coli (drug effects)</term><term>HeLa Cells (MeSH)</term><term>Humans (MeSH)</term><term>Metal Nanoparticles (MeSH)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Organoselenium Compounds (pharmacology)</term><term>Reactive Oxygen Species (metabolism)</term><term>Silver (chemistry)</term><term>Silver (pharmacology)</term><term>Silver (toxicity)</term><term>Staphylococcus aureus (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Silver</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Ascorbic Acid</term><term>Azoles</term><term>Organoselenium Compounds</term><term>Silver</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Silver</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drug Resistance, Multiple</term><term>Escherichia coli</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Synergism</term><term>HeLa Cells</term><term>Humans</term><term>Metal Nanoparticles</term><term>Microbial Sensitivity Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The emerging and spreading of multi-drug resistant (MDR) bacteria have been becoming one of the most severe threats to human health. Enhancing oxidative stress as mimicking immune system was considered as a potential strategy to fight against infection of MDR bacteria. In this study, we investigated the antibacterial efficiency of such a strategy which combines silver nanoparticles (AgNPs) with ebselen. The results showed that AgNPs and ebselen combination had significant synergistic killing effects both on <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>) <i>in vitro</i>, including model strains of China Veterinary Culture Collection and MDR clinical isolates, which is similar as the combination of silver ion and ebselen. AgNPs exhibited to be a strong inhibitor of bacterial thioredoxin reductase, same as a free silver ion. Ebselen mitigated the cytotoxicity of AgNPs to HeLa cells. However, in a bacteria-cell coexistence condition, the synergistic bactericidal effect was only observed on <i>S. aureus</i> (<i>p</i><.05), while the temporary synergistic inhibitory effect on <i>E. coli</i> within 4 hours treatment (<i>p</i><.01). In mice infection model, a combination of AgNPs and ebselen did not increase protection against the challenge of clinical <i>E. coli</i> CQ10 strain. Our data demonstrated that AgNPs and ebselen combination may be a promising strategy to fight against the increasingly MDR bacteria targeting bacterial thiol redox system.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31387398</PMID><DateCompleted><Year>2019</Year><Month>12</Month><Day>30</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2169-141X</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Artificial cells, nanomedicine, and biotechnology</Title><ISOAbbreviation>Artif Cells Nanomed Biotechnol</ISOAbbreviation></Journal><ArticleTitle>Characterization of synergistic antibacterial effect of silver nanoparticles and ebselen.</ArticleTitle><Pagination><MedlinePgn>3338-3349</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/21691401.2019.1648278</ELocationID><Abstract><AbstractText>The emerging and spreading of multi-drug resistant (MDR) bacteria have been becoming one of the most severe threats to human health. Enhancing oxidative stress as mimicking immune system was considered as a potential strategy to fight against infection of MDR bacteria. In this study, we investigated the antibacterial efficiency of such a strategy which combines silver nanoparticles (AgNPs) with ebselen. The results showed that AgNPs and ebselen combination had significant synergistic killing effects both on <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>) <i>in vitro</i>, including model strains of China Veterinary Culture Collection and MDR clinical isolates, which is similar as the combination of silver ion and ebselen. AgNPs exhibited to be a strong inhibitor of bacterial thioredoxin reductase, same as a free silver ion. Ebselen mitigated the cytotoxicity of AgNPs to HeLa cells. However, in a bacteria-cell coexistence condition, the synergistic bactericidal effect was only observed on <i>S. aureus</i> (<i>p</i><.05), while the temporary synergistic inhibitory effect on <i>E. coli</i> within 4 hours treatment (<i>p</i><.01). In mice infection model, a combination of AgNPs and ebselen did not increase protection against the challenge of clinical <i>E. coli</i> CQ10 strain. Our data demonstrated that AgNPs and ebselen combination may be a promising strategy to fight against the increasingly MDR bacteria targeting bacterial thiol redox system.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xueqing</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Heming</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Hongying</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Yanjuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>b Department of Production and Management, Tibet Autonomous Region Veterinary Biologics Factory , Lasa , Tibet , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Fuchang</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Jiye</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>c College of Animal Science, Southwest University , Chongqing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chai</LastName><ForeName>Chunli</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Song</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>d Chinese Center for Disease Control and Prevention, National Institute of Environmental Health , Beijing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zuo</LastName><ForeName>Xin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>e Ministry of Education, College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Southwest University , Chongqing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>e Ministry of Education, College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Southwest University , Chongqing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Huamao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>a College of Biotechnology, Southwest University , Chongqing , China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Artif Cells Nanomed Biotechnol</MedlineTA><NlmUniqueID>101594777</NlmUniqueID><ISSNLinking>2169-1401</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001393">Azoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016566">Organoselenium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance UI="D012834">Silver</NameOfSubstance></Chemical><Chemical><RegistryNumber>40X2P7DPGH</RegistryNumber><NameOfSubstance UI="C042986">ebselen</NameOfSubstance></Chemical><Chemical><RegistryNumber>PQ6CK8PD0R</RegistryNumber><NameOfSubstance UI="D001205">Ascorbic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001205" MajorTopicYN="N">Ascorbic Acid</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001393" MajorTopicYN="N">Azoles</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018432" MajorTopicYN="N">Drug Resistance, Multiple</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004357" MajorTopicYN="N">Drug Synergism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053768" MajorTopicYN="Y">Metal Nanoparticles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016566" MajorTopicYN="N">Organoselenium Compounds</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Silver nanoparticles</Keyword><Keyword MajorTopicYN="N">ebselen</Keyword><Keyword MajorTopicYN="N">multi-drug resistance bacteria</Keyword><Keyword MajorTopicYN="N">oxidative stress</Keyword><Keyword MajorTopicYN="N">synergistic antibacterial effect</Keyword><Keyword MajorTopicYN="N">thioredoxin reductase</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>12</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31387398</ArticleId><ArticleId IdType="doi">10.1080/21691401.2019.1648278</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Terre/explor/SilverBacteriV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000244 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000244 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Terre
|area= SilverBacteriV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:31387398
|texte= Characterization of synergistic antibacterial effect of silver nanoparticles and ebselen.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:31387398" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a SilverBacteriV1
| This area was generated with Dilib version V0.6.38. |  |