Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in Haemophilus influenzae Involves a Mechanism Similar to That Required for O-Antigen Synthesis
Identifieur interne : 000066 ( Ncbi/Curation ); précédent : 000065; suivant : 000067Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in Haemophilus influenzae Involves a Mechanism Similar to That Required for O-Antigen Synthesis
Auteurs : Derek W. Hood ; Gaynor Randle ; Andrew D. Cox ; Katherine Makepeace ; Jianjun Li ; Elke K. H. Schweda ; James C. Richards ; E. Richard MoxonSource :
- Journal of Bacteriology [ 0021-9193 ] ; 2004.
Abstract
It is generally thought that mucosal bacterial pathogens of the genera
Url:
DOI: 10.1128/JB.186.21.7429-7439.2004
PubMed: 15489455
PubMed Central: 523191
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PMC:523191Le document en format XML
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Involves a Mechanism Similar to That Required for O-Antigen Synthesis</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in <italic>Haemophilus influenzae</italic>
Involves a Mechanism Similar to That Required for O-Antigen Synthesis</title>
<author><name sortKey="Hood, Derek W" sort="Hood, Derek W" uniqKey="Hood D" first="Derek W." last="Hood">Derek W. Hood</name>
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<author><name sortKey="Li, Jianjun" sort="Li, Jianjun" uniqKey="Li J" first="Jianjun" last="Li">Jianjun Li</name>
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<series><title level="j">Journal of Bacteriology</title>
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<front><div type="abstract" xml:lang="en"><p>It is generally thought that mucosal bacterial pathogens of the genera <italic>Haemophilus</italic>
, <italic>Neisseria</italic>
, and <italic>Moraxella</italic>
elaborate lipopolysaccharide (LPS) that is fundamentally different from that of enteric organisms that express O-specific polysaccharide side chains. <italic>Haemophilus influenzae</italic>
elaborates short-chain LPS that has a role in the pathogenesis of <italic>H. influenzae</italic>
infections. We show that the synthesis of LPS in this organism can no longer be as clearly distinguished from that in other gram-negative bacteria that express an O antigen. We provide evidence that a region of the <italic>H. influenzae</italic>
genome, the <italic>hmg</italic>
locus, is involved in the synthesis of glycoforms in which tetrasaccharide units are added en bloc, not stepwise, to the normal core glycoforms, similar to the biosynthesis of an O-antigen.</p>
</div>
</front>
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