LrgpV1, Pmc, Corpus, bibRecord, 000078

Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in Haemophilus influenzae Involves a Mechanism Similar to That Required for O-Antigen Synthesis

Identifieur interne : 000078 ( Pmc/Corpus ); précédent : 000077; suivant : 000079

Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in Haemophilus influenzae Involves a Mechanism Similar to That Required for O-Antigen Synthesis

Auteurs : Derek W. Hood ; Gaynor Randle ; Andrew D. Cox ; Katherine Makepeace ; Jianjun Li ; Elke K. H. Schweda ; James C. Richards ; E. Richard Moxon

Source :

Journal of Bacteriology [ 0021-9193 ] ; 2004.

RBID : PMC:523191

Abstract

It is generally thought that mucosal bacterial pathogens of the genera Haemophilus, Neisseria, and Moraxella elaborate lipopolysaccharide (LPS) that is fundamentally different from that of enteric organisms that express O-specific polysaccharide side chains. Haemophilus influenzae elaborates short-chain LPS that has a role in the pathogenesis of H. influenzae infections. We show that the synthesis of LPS in this organism can no longer be as clearly distinguished from that in other gram-negative bacteria that express an O antigen. We provide evidence that a region of the H. influenzae genome, the hmg locus, is involved in the synthesis of glycoforms in which tetrasaccharide units are added en bloc, not stepwise, to the normal core glycoforms, similar to the biosynthesis of an O-antigen.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC523191

DOI: 10.1128/JB.186.21.7429-7439.2004
PubMed: 15489455
PubMed Central: 523191

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PMC:523191

Le document en format XML

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 Involves a Mechanism Similar to That Required for O-Antigen Synthesis</title>
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<author><name sortKey="Li, Jianjun" sort="Li, Jianjun" uniqKey="Li J" first="Jianjun" last="Li">Jianjun Li</name>
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<author><name sortKey="Schweda, Elke K H" sort="Schweda, Elke K H" uniqKey="Schweda E" first="Elke K. H." last="Schweda">Elke K. H. Schweda</name>
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<author><name sortKey="Richards, James C" sort="Richards, James C" uniqKey="Richards J" first="James C." last="Richards">James C. Richards</name>
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<author><name sortKey="Moxon, E Richard" sort="Moxon, E Richard" uniqKey="Moxon E" first="E. Richard" last="Moxon">E. Richard Moxon</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in <italic>Haemophilus influenzae</italic>
 Involves a Mechanism Similar to That Required for O-Antigen Synthesis</title>
<author><name sortKey="Hood, Derek W" sort="Hood, Derek W" uniqKey="Hood D" first="Derek W." last="Hood">Derek W. Hood</name>
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<author><name sortKey="Makepeace, Katherine" sort="Makepeace, Katherine" uniqKey="Makepeace K" first="Katherine" last="Makepeace">Katherine Makepeace</name>
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<author><name sortKey="Li, Jianjun" sort="Li, Jianjun" uniqKey="Li J" first="Jianjun" last="Li">Jianjun Li</name>
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<author><name sortKey="Schweda, Elke K H" sort="Schweda, Elke K H" uniqKey="Schweda E" first="Elke K. H." last="Schweda">Elke K. H. Schweda</name>
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<author><name sortKey="Richards, James C" sort="Richards, James C" uniqKey="Richards J" first="James C." last="Richards">James C. Richards</name>
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</affiliation>
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<author><name sortKey="Moxon, E Richard" sort="Moxon, E Richard" uniqKey="Moxon E" first="E. Richard" last="Moxon">E. Richard Moxon</name>
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<series><title level="j">Journal of Bacteriology</title>
<idno type="ISSN">0021-9193</idno>
<idno type="eISSN">1098-5530</idno>
<imprint><date when="2004">2004</date>
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<front><div type="abstract" xml:lang="en"><p>It is generally thought that mucosal bacterial pathogens of the genera <italic>Haemophilus</italic>
, <italic>Neisseria</italic>
, and <italic>Moraxella</italic>
 elaborate lipopolysaccharide (LPS) that is fundamentally different from that of enteric organisms that express O-specific polysaccharide side chains. <italic>Haemophilus influenzae</italic>
 elaborates short-chain LPS that has a role in the pathogenesis of <italic>H. influenzae</italic>
 infections. We show that the synthesis of LPS in this organism can no longer be as clearly distinguished from that in other gram-negative bacteria that express an O antigen. We provide evidence that a region of the <italic>H. influenzae</italic>
 genome, the <italic>hmg</italic>
 locus, is involved in the synthesis of glycoforms in which tetrasaccharide units are added en bloc, not stepwise, to the normal core glycoforms, similar to the biosynthesis of an O-antigen.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Bacteriol</journal-id>
<journal-id journal-id-type="publisher-id">jb</journal-id>
<journal-title>Journal of Bacteriology</journal-title>
<issn pub-type="ppub">0021-9193</issn>
<issn pub-type="epub">1098-5530</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">15489455</article-id>
<article-id pub-id-type="pmc">523191</article-id>
<article-id pub-id-type="publisher-id">0548-04</article-id>
<article-id pub-id-type="doi">10.1128/JB.186.21.7429-7439.2004</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Molecular Biology of Pathogens</subject>
</subj-group>
</article-categories>
<title-group><article-title>Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in <italic>Haemophilus influenzae</italic>
 Involves a Mechanism Similar to That Required for O-Antigen Synthesis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Hood</surname>
<given-names>Derek W.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Randle</surname>
<given-names>Gaynor</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cox</surname>
<given-names>Andrew D.</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Makepeace</surname>
<given-names>Katherine</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Jianjun</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schweda</surname>
<given-names>Elke K. H.</given-names>
</name>
<xref ref-type="aff" rid="aff1">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Richards</surname>
<given-names>James C.</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moxon</surname>
<given-names>E. Richard</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
</contrib-group>
<aff id="aff1">Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom,<label>1</label>
 Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada,<label>2</label>
 Clinical Research Centre, Karolinska Institutet and University College of South Stockholm, NOVUM, Huddinge, Sweden<label>3</label>
</aff>
<author-notes><fn id="cor1"><label>*</label>
<p>Corresponding author. Mailing address: Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom. Phone: (44) 1865 222347. Fax: (44) 1865 222626. E-mail: <email>derek.hood@paediatrics.oxford.ac.uk</email>
.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>11</month>
<year>2004</year>
</pub-date>
<volume>186</volume>
<issue>21</issue>
<fpage>7429</fpage>
<lpage>7439</lpage>
<history><date date-type="received"><day>15</day>
<month>4</month>
<year>2004</year>
</date>
<date date-type="accepted"><day>10</day>
<month>8</month>
<year>2004</year>
</date>
</history>
<copyright-statement>Copyright © 2004, American Society for Microbiology</copyright-statement>
<copyright-year>2004</copyright-year>
<abstract><p>It is generally thought that mucosal bacterial pathogens of the genera <italic>Haemophilus</italic>
, <italic>Neisseria</italic>
, and <italic>Moraxella</italic>
 elaborate lipopolysaccharide (LPS) that is fundamentally different from that of enteric organisms that express O-specific polysaccharide side chains. <italic>Haemophilus influenzae</italic>
 elaborates short-chain LPS that has a role in the pathogenesis of <italic>H. influenzae</italic>
 infections. We show that the synthesis of LPS in this organism can no longer be as clearly distinguished from that in other gram-negative bacteria that express an O antigen. We provide evidence that a region of the <italic>H. influenzae</italic>
 genome, the <italic>hmg</italic>
 locus, is involved in the synthesis of glycoforms in which tetrasaccharide units are added en bloc, not stepwise, to the normal core glycoforms, similar to the biosynthesis of an O-antigen.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>

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Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in Haemophilus influenzae Involves a Mechanism Similar to That Required for O-Antigen Synthesis

Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in Haemophilus influenzae Involves a Mechanism Similar to That Required for O-Antigen Synthesis

Source :

Abstract

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