LrgpV1, Main, Exploration, bibRecordById, PMC:1112065

The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes

Identifieur interne : 001374 ( Main/Exploration ); précédent : 001373; suivant : 001375

The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes

Auteurs : Muriel Masi ; Jean-Marie Pagès ; Claude Villard ; Elizabeth Pradel

Source :

Journal of Bacteriology [ 0021-9193 ] ; 2005.

RBID : PMC:1112065

Abstract

The Enterobacter aerogenes eefABC locus, which encodes a tripartite efflux pump, was cloned by complementation of an Escherichia coli tolC mutant. E. aerogenes ΔacrA expressing EefABC became less susceptible to a wide range of antibiotics. Data from eef::lacZ fusions showed that eefABC was not transcribed in the various laboratory conditions tested. However, increased transcription from Peef was observed in an E. coli hns mutant. In addition, EefA was detected in E. aerogenes expressing a dominant negative E. coli hns allele.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112065

DOI: 10.1128/JB.187.11.3894-3897.2005
PubMed: 15901719
PubMed Central: 1112065

Affiliations:

Le document en format XML

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 Multidrug Efflux Pump Operon Is Repressed by H-NS in <italic>Enterobacter aerogenes</italic>
</title>
<author><name sortKey="Masi, Muriel" sort="Masi, Muriel" uniqKey="Masi M" first="Muriel" last="Masi">Muriel Masi</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pages, Jean Marie" sort="Pages, Jean Marie" uniqKey="Pages J" first="Jean-Marie" last="Pagès">Jean-Marie Pagès</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pradel, Elizabeth" sort="Pradel, Elizabeth" uniqKey="Pradel E" first="Elizabeth" last="Pradel">Elizabeth Pradel</name>
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 Multidrug Efflux Pump Operon Is Repressed by H-NS in <italic>Enterobacter aerogenes</italic>
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<author><name sortKey="Masi, Muriel" sort="Masi, Muriel" uniqKey="Masi M" first="Muriel" last="Masi">Muriel Masi</name>
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<author><name sortKey="Pages, Jean Marie" sort="Pages, Jean Marie" uniqKey="Pages J" first="Jean-Marie" last="Pagès">Jean-Marie Pagès</name>
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<author><name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name>
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<author><name sortKey="Pradel, Elizabeth" sort="Pradel, Elizabeth" uniqKey="Pradel E" first="Elizabeth" last="Pradel">Elizabeth Pradel</name>
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<series><title level="j">Journal of Bacteriology</title>
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<front><div type="abstract" xml:lang="en"><p>The <italic>Enterobacter aerogenes eefABC</italic>
 locus, which encodes a tripartite efflux pump, was cloned by complementation of an <italic>Escherichia coli tolC</italic>
 mutant. <italic>E. aerogenes</italic>
 Δ<italic>acrA</italic>
 expressing EefABC became less susceptible to a wide range of antibiotics. Data from <italic>eef</italic>
::<italic>lacZ</italic>
 fusions showed that <italic>eefABC</italic>
 was not transcribed in the various laboratory conditions tested. However, increased transcription from P<italic>eef</italic>
 was observed in an <italic>E. coli hns</italic>
 mutant. In addition, EefA was detected in <italic>E. aerogenes</italic>
 expressing a dominant negative <italic>E. coli hns</italic>
 allele.</p>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Masi, Muriel" sort="Masi, Muriel" uniqKey="Masi M" first="Muriel" last="Masi">Muriel Masi</name>
<name sortKey="Pages, Jean Marie" sort="Pages, Jean Marie" uniqKey="Pages J" first="Jean-Marie" last="Pagès">Jean-Marie Pagès</name>
<name sortKey="Pradel, Elizabeth" sort="Pradel, Elizabeth" uniqKey="Pradel E" first="Elizabeth" last="Pradel">Elizabeth Pradel</name>
<name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name>
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The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes

The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes

Source :

Abstract

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