The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes
Identifieur interne : 000111 ( Pmc/Checkpoint ); précédent : 000110; suivant : 000112The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes
Auteurs : Muriel Masi ; Jean-Marie Pagès ; Claude Villard ; Elizabeth PradelSource :
- Journal of Bacteriology [ 0021-9193 ] ; 2005.
Abstract
The
Url:
DOI: 10.1128/JB.187.11.3894-3897.2005
PubMed: 15901719
PubMed Central: 1112065
Affiliations:
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PMC:1112065Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The <italic>eefABC</italic>
Multidrug Efflux Pump Operon Is Repressed by H-NS in <italic>Enterobacter aerogenes</italic>
</title>
<author><name sortKey="Masi, Muriel" sort="Masi, Muriel" uniqKey="Masi M" first="Muriel" last="Masi">Muriel Masi</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
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<author><name sortKey="Pages, Jean Marie" sort="Pages, Jean Marie" uniqKey="Pages J" first="Jean-Marie" last="Pagès">Jean-Marie Pagès</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
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<author><name sortKey="Pradel, Elizabeth" sort="Pradel, Elizabeth" uniqKey="Pradel E" first="Elizabeth" last="Pradel">Elizabeth Pradel</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The <italic>eefABC</italic>
Multidrug Efflux Pump Operon Is Repressed by H-NS in <italic>Enterobacter aerogenes</italic>
</title>
<author><name sortKey="Masi, Muriel" sort="Masi, Muriel" uniqKey="Masi M" first="Muriel" last="Masi">Muriel Masi</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pages, Jean Marie" sort="Pages, Jean Marie" uniqKey="Pages J" first="Jean-Marie" last="Pagès">Jean-Marie Pagès</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pradel, Elizabeth" sort="Pradel, Elizabeth" uniqKey="Pradel E" first="Elizabeth" last="Pradel">Elizabeth Pradel</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Bacteriology</title>
<idno type="ISSN">0021-9193</idno>
<idno type="eISSN">1098-5530</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The <italic>Enterobacter aerogenes eefABC</italic>
locus, which encodes a tripartite efflux pump, was cloned by complementation of an <italic>Escherichia coli tolC</italic>
mutant. <italic>E. aerogenes</italic>
Δ<italic>acrA</italic>
expressing EefABC became less susceptible to a wide range of antibiotics. Data from <italic>eef</italic>
::<italic>lacZ</italic>
fusions showed that <italic>eefABC</italic>
was not transcribed in the various laboratory conditions tested. However, increased transcription from P<italic>eef</italic>
was observed in an <italic>E. coli hns</italic>
mutant. In addition, EefA was detected in <italic>E. aerogenes</italic>
expressing a dominant negative <italic>E. coli hns</italic>
allele.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Bacteriol</journal-id>
<journal-id journal-id-type="publisher-id">jb</journal-id>
<journal-title>Journal of Bacteriology</journal-title>
<issn pub-type="ppub">0021-9193</issn>
<issn pub-type="epub">1098-5530</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">15901719</article-id>
<article-id pub-id-type="pmc">1112065</article-id>
<article-id pub-id-type="publisher-id">1821-04</article-id>
<article-id pub-id-type="doi">10.1128/JB.187.11.3894-3897.2005</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Gene Regulation</subject>
</subj-group>
</article-categories>
<title-group><article-title>The <italic>eefABC</italic>
Multidrug Efflux Pump Operon Is Repressed by H-NS in <italic>Enterobacter aerogenes</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Masi</surname>
<given-names>Muriel</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pagès</surname>
<given-names>Jean-Marie</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Villard</surname>
<given-names>Claude</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pradel</surname>
<given-names>Elizabeth</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="fn" rid="fn1">†</xref>
</contrib>
</contrib-group>
<aff id="aff1">Enveloppe bactérienne, Perméabilité et Antibiotiques, EA2197, IFR 48, Faculté de Médecine, Marseille, France ,<label>1</label>
Plate-forme Protéomique, Faculté de Pharmacie, Marseille, France<label>2</label>
</aff>
<author-notes><fn id="cor1"><label>*</label>
<p>Corresponding author. Mailing address: EA2197, Faculté de Médecine, 27 Bd. Jean Moulin, 13385 Marseille cedex 05, France. Phone: 33 (0) 4 91 32 45 87. Fax: 33 (0) 4 91 32 46 06. E-mail: <email>jean-marie.pages@medecine.univ-mrs.fr</email>
.</p>
</fn>
<fn id="fn1"><label>†</label>
<p>Present address: CIML, Inserm U631, case 906, 13288 Marseille cedex 09, France.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>6</month>
<year>2005</year>
</pub-date>
<volume>187</volume>
<issue>11</issue>
<fpage>3894</fpage>
<lpage>3897</lpage>
<history><date date-type="received"><day>15</day>
<month>12</month>
<year>2004</year>
</date>
<date date-type="accepted"><day>18</day>
<month>2</month>
<year>2005</year>
</date>
</history>
<copyright-statement>Copyright © 2005, American Society for Microbiology</copyright-statement>
<copyright-year>2005</copyright-year>
<abstract><p>The <italic>Enterobacter aerogenes eefABC</italic>
locus, which encodes a tripartite efflux pump, was cloned by complementation of an <italic>Escherichia coli tolC</italic>
mutant. <italic>E. aerogenes</italic>
Δ<italic>acrA</italic>
expressing EefABC became less susceptible to a wide range of antibiotics. Data from <italic>eef</italic>
::<italic>lacZ</italic>
fusions showed that <italic>eefABC</italic>
was not transcribed in the various laboratory conditions tested. However, increased transcription from P<italic>eef</italic>
was observed in an <italic>E. coli hns</italic>
mutant. In addition, EefA was detected in <italic>E. aerogenes</italic>
expressing a dominant negative <italic>E. coli hns</italic>
allele.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Masi, Muriel" sort="Masi, Muriel" uniqKey="Masi M" first="Muriel" last="Masi">Muriel Masi</name>
<name sortKey="Pages, Jean Marie" sort="Pages, Jean Marie" uniqKey="Pages J" first="Jean-Marie" last="Pagès">Jean-Marie Pagès</name>
<name sortKey="Pradel, Elizabeth" sort="Pradel, Elizabeth" uniqKey="Pradel E" first="Elizabeth" last="Pradel">Elizabeth Pradel</name>
<name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name>
</noCountry>
</tree>
</affiliations>
</record>
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