Modulation of Photosensitization Processes for an Improved Targeted Photodynamic Therapy
Identifieur interne : 000E34 ( Main/Exploration ); précédent : 000E33; suivant : 000E35Modulation of Photosensitization Processes for an Improved Targeted Photodynamic Therapy
Auteurs : M. Verhille [France] ; P. Couleaud [France] ; R. Vanderesse [France] ; D. Brault [France] ; M. Barberi-Heyob [France] ; C. Frochot [France]Source :
- Current medicinal chemistry [ 0929-8673 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Photodynamic therapy (PDT) is a cancer treatment modality involving the combination of light, a photosensitizer (PS) and molecular oxygen, which results in the production of cytotoxic reactive oxygen species (ROS). Singlet oxygen (1O2) is one of the most important of these ROS. Because the lifetime and diffusion of 1O2 is very limited, a controllable singlet oxygen generation with high selectivity and localization would lead to more efficient and reliable PDT. The lack of selective accumulation of the PS within tumour tissue is a major problem in PDT. Targeted PDT would offer the advantage to enhance photodynamic efficiency by directly targeting diseased cells or tissues. Many attempts have been made to either selectively deliver light to diseased tissues or increase the uptake of the photoactive compounds by the target cells. The review will survey the literature regarding the multi-level control of 1O2 production for PDT applications. The mechanisms of ROS formation are described. The different strategies leading to targeted formation of 1O2 are developed. Some active PDT agents have been based on energy transfer between PS by control of the aggregation/disaggregation. The concept of molecular beacon based on quenching-dequenching upon protease cleavage is capable of precise control of 1O2 by responding to specific cancer-associated biomarkers.
Url:
Affiliations:
- France
- Grand Est, Lorraine (région), Île-de-France
- EVRY, Nancy, Vandœuvre-lès-Nancy
- Nancy-Université
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Le document en format XML
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Vanderesse</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Chimie Physique Macromoléculaire (LCPM), Nancy-Université, CNRS, 1 rue Grandville BP 20451</s1><s2>54001 Nancy</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Nancy-Université</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>GDR CNRS 3049 "Médicaments Phatoactivables-Phatachimiathérapie (PHOTOMED)</s1><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>GDR CNRS 3049 "Médicaments Phatoactivables-Phatachimiathérapie (PHOTOMED)</wicri:noRegion><wicri:noRegion>GDR CNRS 3049 "Médicaments Phatoactivables-Phatachimiathérapie (PHOTOMED)</wicri:noRegion></affiliation></author><author><name sortKey="Brault, D" sort="Brault, D" uniqKey="Brault D" first="D." last="Brault">D. 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Genavenir 8, 5, rue Henri Desbruères</s1><s2>91030 EVRY</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">EVRY</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>GDR CNRS 3049 "Médicaments Phatoactivables-Phatachimiathérapie (PHOTOMED)</s1><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>GDR CNRS 3049 "Médicaments Phatoactivables-Phatachimiathérapie (PHOTOMED)</wicri:noRegion><wicri:noRegion>GDR CNRS 3049 "Médicaments Phatoactivables-Phatachimiathérapie (PHOTOMED)</wicri:noRegion></affiliation></author><author><name sortKey="Barberi Heyob, M" sort="Barberi Heyob, M" uniqKey="Barberi Heyob M" first="M." last="Barberi-Heyob">M. Barberi-Heyob</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre de Recherche en Automatique de Nancy (CRAN), Nancy-Université, CNRS, Centre Alexis Vautrin</s1><s2>Vandœuvre-lès-Nancy</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Nancy-Université</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>GDR CNRS 3049 "Médicaments Phatoactivables-Phatachimiathérapie (PHOTOMED)</s1><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>GDR CNRS 3049 "Médicaments Phatoactivables-Phatachimiathérapie (PHOTOMED)</wicri:noRegion><wicri:noRegion>GDR CNRS 3049 "Médicaments Phatoactivables-Phatachimiathérapie (PHOTOMED)</wicri:noRegion></affiliation></author><author><name sortKey="Frochot, C" sort="Frochot, C" uniqKey="Frochot C" first="C." last="Frochot">C. Frochot</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratoire Réactions et Génie des Procédés (LRGP), Nancy-Université, CNRS, 1 rue Grandville BP 20451</s1><s2>54001, Nancy</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Nancy-Université</orgName></affiliation></author></analytic><series><title level="j" type="main">Current medicinal chemistry</title><title level="j" type="abbreviated">Curr. med. chem.</title><idno type="ISSN">0929-8673</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Current medicinal chemistry</title><title level="j" type="abbreviated">Curr. med. chem.</title><idno type="ISSN">0929-8673</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Modulation</term><term>Oxidative stress</term><term>Photodynamic therapy</term><term>Photosensitization</term><term>Review</term><term>Singlet state</term><term>Targeted therapy</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Modulation</term><term>Photosensibilisation</term><term>Photothérapie dynamique</term><term>Thérapeutique ciblée</term><term>Etat singulet</term><term>Article synthèse</term><term>Stress oxydatif</term><term>Oxygène actif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Photodynamic therapy (PDT) is a cancer treatment modality involving the combination of light, a photosensitizer (PS) and molecular oxygen, which results in the production of cytotoxic reactive oxygen species (ROS). Singlet oxygen (<sup>1</sup>O<sub>2</sub>) is one of the most important of these ROS. Because the lifetime and diffusion of <sup>1</sup>O<sub>2</sub> is very limited, a controllable singlet oxygen generation with high selectivity and localization would lead to more efficient and reliable PDT. The lack of selective accumulation of the PS within tumour tissue is a major problem in PDT. Targeted PDT would offer the advantage to enhance photodynamic efficiency by directly targeting diseased cells or tissues. Many attempts have been made to either selectively deliver light to diseased tissues or increase the uptake of the photoactive compounds by the target cells. The review will survey the literature regarding the multi-level control of <sup>1</sup>O<sub>2</sub> production for PDT applications. The mechanisms of ROS formation are described. The different strategies leading to targeted formation of <sup>1</sup>O<sub>2</sub> are developed. Some active PDT agents have been based on energy transfer between PS by control of the aggregation/disaggregation. The concept of molecular beacon based on quenching-dequenching upon protease cleavage is capable of precise control of <sup>1</sup>O<sub>2</sub> by responding to specific cancer-associated biomarkers.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Grand Est</li><li>Lorraine (région)</li><li>Île-de-France</li></region><settlement><li>EVRY</li><li>Nancy</li><li>Vandœuvre-lès-Nancy</li></settlement><orgName><li>Nancy-Université</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Verhille, M" sort="Verhille, M" uniqKey="Verhille M" first="M." last="Verhille">M. Verhille</name></region><name sortKey="Barberi Heyob, M" sort="Barberi Heyob, M" uniqKey="Barberi Heyob M" first="M." last="Barberi-Heyob">M. Barberi-Heyob</name><name sortKey="Barberi Heyob, M" sort="Barberi Heyob, M" uniqKey="Barberi Heyob M" first="M." last="Barberi-Heyob">M. Barberi-Heyob</name><name sortKey="Brault, D" sort="Brault, D" uniqKey="Brault D" first="D." last="Brault">D. Brault</name><name sortKey="Brault, D" sort="Brault, D" uniqKey="Brault D" first="D." last="Brault">D. Brault</name><name sortKey="Couleaud, P" sort="Couleaud, P" uniqKey="Couleaud P" first="P." last="Couleaud">P. Couleaud</name><name sortKey="Frochot, C" sort="Frochot, C" uniqKey="Frochot C" first="C." last="Frochot">C. Frochot</name><name sortKey="Vanderesse, R" sort="Vanderesse, R" uniqKey="Vanderesse R" first="R." last="Vanderesse">R. Vanderesse</name><name sortKey="Vanderesse, R" sort="Vanderesse, R" uniqKey="Vanderesse R" first="R." last="Vanderesse">R. Vanderesse</name><name sortKey="Verhille, M" sort="Verhille, M" uniqKey="Verhille M" first="M." last="Verhille">M. 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