LrgpV1, Hal, Corpus, bibRecord, 000779

Modulation of photosensitization processes for an improved targeted photodynamic therapy

Identifieur interne : 000779 ( Hal/Corpus ); précédent : 000778; suivant : 000780

Modulation of photosensitization processes for an improved targeted photodynamic therapy

Auteurs : Marc Verhille ; Pierre Couleaud ; Régis Vanderesse ; Daniel Brault ; Muriel Barberi-Heyob ; Céline Frochot

Source :

Current Medicinal Chemistry [ 0929-8673 ] ; 2010-09-22.

RBID : Hal:hal-00521040

Abstract

Photodynamic therapy (PDT) is a cancer treatment modality involving the combination of light, a photosensitizer (PS) and molecular oxygen, which results in the production of cytotoxic reactive oxygen species (ROS). Singlet oxygen (1O2) is one of the most important of these ROS. Because the lifetime and diffusion of 1O2 is very limited, a controllable singlet oxygen generation with high selectivity and localization would lead to more efficient and reliable PDT. The lack of selective accumulation of the PS‟s within tumour tissue is a major problem in PDT. Targeted PDT would offer the advantage to enhance photodynamic efficiency by directly targeting diseased cells or tissues. Many attempts have been made to either selectively deliver light to diseased tissues or increase the uptake of the photoactive compounds by the target cells. The review will survey the literature regarding the multi-level control of 1O2 production for PDT applications. The mechanisms of ROS formation are described. The different strategies leading to targeted formation of 1O2 are developed. Some activatable PDT agents have been based on energy transfer between PS‟s by control of the aggregation/disaggregation. The concept of molecular beacon based on quenching-dequenching upon protease cleavage is capable of precise control of 1O2 by responding to specific cancer-associated biomarkers.

Url:

https://hal.archives-ouvertes.fr/hal-00521040

Links to Exploration step

Hal:hal-00521040

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modulation of photosensitization processes for an improved targeted photodynamic therapy</title>
<author><name sortKey="Verhille, Marc" sort="Verhille, Marc" uniqKey="Verhille M" first="Marc" last="Verhille">Marc Verhille</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-1155" status="OLD"><orgName>Département de Chimie Physique des Réactions</orgName>
<orgName type="acronym">DCPR</orgName>
<desc><address><addrLine>1 Rue Grandville - BP 20451 54001 NANCY CEDEX</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ensic.inpl-nancy.fr/DCPR</ref>
</desc>
<listRelation><relation name="UMR7630" active="#struct-441569" type="direct"></relation>
<relation active="#struct-300293" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7630" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300293" type="direct"><org type="institution" xml:id="struct-300293" status="OLD"><orgName>Institut National Polytechnique de Lorraine</orgName>
<orgName type="acronym">INPL</orgName>
<date type="end">2011-12-31</date>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Couleaud, Pierre" sort="Couleaud, Pierre" uniqKey="Couleaud P" first="Pierre" last="Couleaud">Pierre Couleaud</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-1155" status="OLD"><orgName>Département de Chimie Physique des Réactions</orgName>
<orgName type="acronym">DCPR</orgName>
<desc><address><addrLine>1 Rue Grandville - BP 20451 54001 NANCY CEDEX</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ensic.inpl-nancy.fr/DCPR</ref>
</desc>
<listRelation><relation name="UMR7630" active="#struct-441569" type="direct"></relation>
<relation active="#struct-300293" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7630" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300293" type="direct"><org type="institution" xml:id="struct-300293" status="OLD"><orgName>Institut National Polytechnique de Lorraine</orgName>
<orgName type="acronym">INPL</orgName>
<date type="end">2011-12-31</date>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-439403" status="VALID"><idno type="IdUnivLorraine">[UL]RQE--</idno>
<idno type="RNSR">199112614E</idno>
<idno type="IdRef">152527311</idno>
<orgName>Laboratoire de Chimie Physique Macromoléculaire</orgName>
<orgName type="acronym">LCPM</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue Grandville, BP 20451, 54000 Nancy</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://lcpm.univ-lorraine.fr/</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7375" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7375" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Brault, Daniel" sort="Brault, Daniel" uniqKey="Brault D" first="Daniel" last="Brault">Daniel Brault</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-73720" status="VALID"><orgName>Médicaments Photoactivables - Photochimiothérapie</orgName>
<orgName type="acronym">PHOTOMED</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
<listRelation><relation name="GDR3049" active="#struct-441569" type="direct"></relation>
<relation active="#struct-341038" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="GDR3049" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-341038" type="direct"><org type="institution" xml:id="struct-341038" status="VALID"><orgName>Institut de Chimie du CNRS</orgName>
<orgName type="acronym">INC</orgName>
<desc><address><addrLine>3 Rue Michel-Ange75 016 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/inc</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-73720" status="VALID"><orgName>Médicaments Photoactivables - Photochimiothérapie</orgName>
<orgName type="acronym">PHOTOMED</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
<listRelation><relation name="GDR3049" active="#struct-441569" type="direct"></relation>
<relation active="#struct-341038" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="GDR3049" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-341038" type="direct"><org type="institution" xml:id="struct-341038" status="VALID"><orgName>Institut de Chimie du CNRS</orgName>
<orgName type="acronym">INC</orgName>
<desc><address><addrLine>3 Rue Michel-Ange75 016 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/inc</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-73720" status="VALID"><orgName>Médicaments Photoactivables - Photochimiothérapie</orgName>
<orgName type="acronym">PHOTOMED</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
<listRelation><relation name="GDR3049" active="#struct-441569" type="direct"></relation>
<relation active="#struct-341038" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="GDR3049" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-341038" type="direct"><org type="institution" xml:id="struct-341038" status="VALID"><orgName>Institut de Chimie du CNRS</orgName>
<orgName type="acronym">INC</orgName>
<desc><address><addrLine>3 Rue Michel-Ange75 016 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/inc</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00521040</idno>
<idno type="halId">hal-00521040</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00521040</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00521040</idno>
<date when="2010-09-22">2010-09-22</date>
<idno type="wicri:Area/Hal/Corpus">000779</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Modulation of photosensitization processes for an improved targeted photodynamic therapy</title>
<author><name sortKey="Verhille, Marc" sort="Verhille, Marc" uniqKey="Verhille M" first="Marc" last="Verhille">Marc Verhille</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-1155" status="OLD"><orgName>Département de Chimie Physique des Réactions</orgName>
<orgName type="acronym">DCPR</orgName>
<desc><address><addrLine>1 Rue Grandville - BP 20451 54001 NANCY CEDEX</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ensic.inpl-nancy.fr/DCPR</ref>
</desc>
<listRelation><relation name="UMR7630" active="#struct-441569" type="direct"></relation>
<relation active="#struct-300293" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7630" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300293" type="direct"><org type="institution" xml:id="struct-300293" status="OLD"><orgName>Institut National Polytechnique de Lorraine</orgName>
<orgName type="acronym">INPL</orgName>
<date type="end">2011-12-31</date>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Couleaud, Pierre" sort="Couleaud, Pierre" uniqKey="Couleaud P" first="Pierre" last="Couleaud">Pierre Couleaud</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-1155" status="OLD"><orgName>Département de Chimie Physique des Réactions</orgName>
<orgName type="acronym">DCPR</orgName>
<desc><address><addrLine>1 Rue Grandville - BP 20451 54001 NANCY CEDEX</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ensic.inpl-nancy.fr/DCPR</ref>
</desc>
<listRelation><relation name="UMR7630" active="#struct-441569" type="direct"></relation>
<relation active="#struct-300293" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7630" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300293" type="direct"><org type="institution" xml:id="struct-300293" status="OLD"><orgName>Institut National Polytechnique de Lorraine</orgName>
<orgName type="acronym">INPL</orgName>
<date type="end">2011-12-31</date>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-439403" status="VALID"><idno type="IdUnivLorraine">[UL]RQE--</idno>
<idno type="RNSR">199112614E</idno>
<idno type="IdRef">152527311</idno>
<orgName>Laboratoire de Chimie Physique Macromoléculaire</orgName>
<orgName type="acronym">LCPM</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue Grandville, BP 20451, 54000 Nancy</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://lcpm.univ-lorraine.fr/</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7375" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7375" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Brault, Daniel" sort="Brault, Daniel" uniqKey="Brault D" first="Daniel" last="Brault">Daniel Brault</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-73720" status="VALID"><orgName>Médicaments Photoactivables - Photochimiothérapie</orgName>
<orgName type="acronym">PHOTOMED</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
<listRelation><relation name="GDR3049" active="#struct-441569" type="direct"></relation>
<relation active="#struct-341038" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="GDR3049" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-341038" type="direct"><org type="institution" xml:id="struct-341038" status="VALID"><orgName>Institut de Chimie du CNRS</orgName>
<orgName type="acronym">INC</orgName>
<desc><address><addrLine>3 Rue Michel-Ange75 016 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/inc</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-73720" status="VALID"><orgName>Médicaments Photoactivables - Photochimiothérapie</orgName>
<orgName type="acronym">PHOTOMED</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
<listRelation><relation name="GDR3049" active="#struct-441569" type="direct"></relation>
<relation active="#struct-341038" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="GDR3049" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-341038" type="direct"><org type="institution" xml:id="struct-341038" status="VALID"><orgName>Institut de Chimie du CNRS</orgName>
<orgName type="acronym">INC</orgName>
<desc><address><addrLine>3 Rue Michel-Ange75 016 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/inc</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-73720" status="VALID"><orgName>Médicaments Photoactivables - Photochimiothérapie</orgName>
<orgName type="acronym">PHOTOMED</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
<listRelation><relation name="GDR3049" active="#struct-441569" type="direct"></relation>
<relation active="#struct-341038" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="GDR3049" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-341038" type="direct"><org type="institution" xml:id="struct-341038" status="VALID"><orgName>Institut de Chimie du CNRS</orgName>
<orgName type="acronym">INC</orgName>
<desc><address><addrLine>3 Rue Michel-Ange75 016 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/inc</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Current Medicinal Chemistry</title>
<idno type="ISSN">0929-8673</idno>
<imprint><date type="datePub">2010-09-22</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Photodynamic therapy (PDT) is a cancer treatment modality involving the combination of light, a photosensitizer (PS) and molecular oxygen, which results in the production of cytotoxic reactive oxygen species (ROS). Singlet oxygen (1O2) is one of the most important of these ROS. Because the lifetime and diffusion of 1O2 is very limited, a controllable singlet oxygen generation with high selectivity and localization would lead to more efficient and reliable PDT. The lack of selective accumulation of the PS‟s within tumour tissue is a major problem in PDT. Targeted PDT would offer the advantage to enhance photodynamic efficiency by directly targeting diseased cells or tissues. Many attempts have been made to either selectively deliver light to diseased tissues or increase the uptake of the photoactive compounds by the target cells. The review will survey the literature regarding the multi-level control of 1O2 production for PDT applications. The mechanisms of ROS formation are described. The different strategies leading to targeted formation of 1O2 are developed. Some activatable PDT agents have been based on energy transfer between PS‟s by control of the aggregation/disaggregation. The concept of molecular beacon based on quenching-dequenching upon protease cleavage is capable of precise control of 1O2 by responding to specific cancer-associated biomarkers.</div>
</front>
</TEI>
<hal api="V3"><titleStmt><title xml:lang="en">Modulation of photosensitization processes for an improved targeted photodynamic therapy</title>
<author role="aut"><persName><forename type="first">Marc</forename>
<surname>Verhille</surname>
</persName>
<email></email>
<idno type="halauthor">450703</idno>
<affiliation ref="#struct-1155"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Pierre</forename>
<surname>Couleaud</surname>
</persName>
<email></email>
<idno type="halauthor">354053</idno>
<affiliation ref="#struct-1155"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Régis</forename>
<surname>Vanderesse</surname>
</persName>
<email></email>
<idno type="halauthor">128649</idno>
<affiliation ref="#struct-439403"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Daniel</forename>
<surname>Brault</surname>
</persName>
<email></email>
<idno type="halauthor">191338</idno>
<affiliation ref="#struct-73720"></affiliation>
<affiliation ref="#struct-128730"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Muriel</forename>
<surname>Barberi-Heyob</surname>
</persName>
<email></email>
<idno type="halauthor">89501</idno>
<affiliation ref="#struct-73720"></affiliation>
<affiliation ref="#struct-1001"></affiliation>
<affiliation ref="#struct-101696"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Céline</forename>
<surname>Frochot</surname>
</persName>
<email></email>
<idno type="halauthor">133064</idno>
<affiliation ref="#struct-73720"></affiliation>
<affiliation ref="#struct-211875"></affiliation>
</author>
<editor role="depositor"><persName><forename>Didier</forename>
<surname>Wolf</surname>
</persName>
<email>Didier.Wolf@univ-lorraine.fr</email>
</editor>
</titleStmt>
<editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2010-09-24 18:13:51</date>
<date type="whenModified">2016-05-18 01:09:44</date>
<date type="whenReleased">2010-09-24 18:13:51</date>
<date type="whenProduced">2010-09-22</date>
</edition>
<respStmt><resp>contributor</resp>
<name key="114907"><persName><forename>Didier</forename>
<surname>Wolf</surname>
</persName>
<email>Didier.Wolf@univ-lorraine.fr</email>
</name>
</respStmt>
</editionStmt>
<publicationStmt><distributor>CCSD</distributor>
<idno type="halId">hal-00521040</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00521040</idno>
<idno type="halBibtex">verhille:hal-00521040</idno>
<idno type="halRefHtml">Current Medicinal Chemistry, Bentham Science Publishers, 2010, 17 (32), pp.3925-3943</idno>
<idno type="halRef">Current Medicinal Chemistry, Bentham Science Publishers, 2010, 17 (32), pp.3925-3943</idno>
</publicationStmt>
<seriesStmt><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
<idno type="stamp" n="CRAN">Centre de Recherche en Automatique de Nancy</idno>
<idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno>
<idno type="stamp" n="LRGP-UL">LRGP</idno>
<idno type="stamp" n="INPL">Institut National Polytechnique de Lorraine</idno>
<idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
<idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
</seriesStmt>
<notesStmt><note type="audience" n="2">International</note>
<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
</notesStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Modulation of photosensitization processes for an improved targeted photodynamic therapy</title>
<author role="aut"><persName><forename type="first">Marc</forename>
<surname>Verhille</surname>
</persName>
<idno type="halAuthorId">450703</idno>
<affiliation ref="#struct-1155"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Pierre</forename>
<surname>Couleaud</surname>
</persName>
<idno type="halAuthorId">354053</idno>
<affiliation ref="#struct-1155"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Régis</forename>
<surname>Vanderesse</surname>
</persName>
<idno type="halAuthorId">128649</idno>
<affiliation ref="#struct-439403"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Daniel</forename>
<surname>Brault</surname>
</persName>
<idno type="halAuthorId">191338</idno>
<affiliation ref="#struct-73720"></affiliation>
<affiliation ref="#struct-128730"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Muriel</forename>
<surname>Barberi-Heyob</surname>
</persName>
<idno type="halAuthorId">89501</idno>
<affiliation ref="#struct-73720"></affiliation>
<affiliation ref="#struct-1001"></affiliation>
<affiliation ref="#struct-101696"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Céline</forename>
<surname>Frochot</surname>
</persName>
<idno type="halAuthorId">133064</idno>
<affiliation ref="#struct-73720"></affiliation>
<affiliation ref="#struct-211875"></affiliation>
</author>
</analytic>
<monogr><idno type="halJournalId" status="VALID">12266</idno>
<idno type="issn">0929-8673</idno>
<title level="j">Current Medicinal Chemistry</title>
<imprint><publisher>Bentham Science Publishers</publisher>
<biblScope unit="volume">17</biblScope>
<biblScope unit="issue">32</biblScope>
<biblScope unit="pp">3925-3943</biblScope>
<date type="datePub">2010-09-22</date>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
<profileDesc><langUsage><language ident="en">English</language>
</langUsage>
<textClass><classCode scheme="halDomain" n="sdv.ib">Life Sciences [q-bio]/Bioengineering</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">Photodynamic therapy (PDT) is a cancer treatment modality involving the combination of light, a photosensitizer (PS) and molecular oxygen, which results in the production of cytotoxic reactive oxygen species (ROS). Singlet oxygen (1O2) is one of the most important of these ROS. Because the lifetime and diffusion of 1O2 is very limited, a controllable singlet oxygen generation with high selectivity and localization would lead to more efficient and reliable PDT. The lack of selective accumulation of the PS‟s within tumour tissue is a major problem in PDT. Targeted PDT would offer the advantage to enhance photodynamic efficiency by directly targeting diseased cells or tissues. Many attempts have been made to either selectively deliver light to diseased tissues or increase the uptake of the photoactive compounds by the target cells. The review will survey the literature regarding the multi-level control of 1O2 production for PDT applications. The mechanisms of ROS formation are described. The different strategies leading to targeted formation of 1O2 are developed. Some activatable PDT agents have been based on energy transfer between PS‟s by control of the aggregation/disaggregation. The concept of molecular beacon based on quenching-dequenching upon protease cleavage is capable of precise control of 1O2 by responding to specific cancer-associated biomarkers.</abstract>
</profileDesc>
</hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/LrgpV1/Data/Hal/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000779 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Corpus/biblio.hfd -nk 000779 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Lorraine
   |area=    LrgpV1
   |flux=    Hal
   |étape=   Corpus
   |type=    RBID
   |clé=     Hal:hal-00521040
   |texte=   Modulation of photosensitization processes for an improved targeted photodynamic therapy
}}

This area was generated with Dilib version V0.6.32.
Data generation: Sat Nov 11 15:47:48 2017. Site generation: Wed Mar 6 23:31:34 2024

	Serveur d'exploration sur le LRGP
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le LRGP

Modulation of photosensitization processes for an improved targeted photodynamic therapy

Modulation of photosensitization processes for an improved targeted photodynamic therapy

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri