Physicochemical properties and cellular toxicity of (poly)aminoalkoxysilanes-functionalized ZnO quantum dots
Identifieur interne : 000648 ( Istex/Curation ); précédent : 000647; suivant : 000649Physicochemical properties and cellular toxicity of (poly)aminoalkoxysilanes-functionalized ZnO quantum dots
Auteurs : Abdelhay Aboulaich [France] ; Carmen-Mihaela Tilmaciu [France] ; Christophe Merlin [France] ; Cdric Mercier [France] ; Hlne Guilloteau [France] ; Ghouti Medjahdi [France] ; Raphal Schneider [France]Source :
- Nanotechnology [ 0957-4484 ] ; 2012-08-24.
Descripteurs français
- Wicri :
- topic : éthanol, Nanotechnologie.
English descriptors
- KwdEn :
- Aboulaich, Absorption spectra, Acros organics, Aeaps, Aetpe, Amine, Amine groups, Aptms, Aptms ligand, Aqueous media, Aqueous medium, Average diameter, Bioavailable, Biological medium, Calibration curve, Calibration curves, Characteristic peaks, Chem, Coli, Colloidal stability, Complete growth arrest, Corresponding histograms, Crucial role, Cytotoxic effects, Cytotoxicity, Different concentrations, Dynamic light, Effective masses, Emission spectra, Escherichia coli, Ethanol, Excitation, Excitonic absorption, Fundamental parameters approach, Good accordance, Growth inhibition tests, Gure, Hydrodynamic diameter, Hydrodynamic diameters, Induction factors, Large number, Ligand, Luminescence values, Mater, Microtiter plates, Moussodia balan, Nanocrystals, Nanoparticles, Nanotechnology, Narrow size distribution, Oleic acid, Particle size, Phys, Positive charges, Powder diffraction, Primary amine groups, Primary source, Room temperature, Same medium, Siloxane shell, Status solidi, Surface functionalization, Surface hydroxyl groups, Tetramethylammonium hydroxide, Toluene, Topas application, Toxicity, Transmission electron microscopy, Uorescent probes, Water molecules, Yellow emission, Zhang, Zinc acetate.
- Teeft :
- Aboulaich, Absorption spectra, Acros organics, Aeaps, Aetpe, Amine, Amine groups, Aptms, Aptms ligand, Aqueous media, Aqueous medium, Average diameter, Bioavailable, Biological medium, Calibration curve, Calibration curves, Characteristic peaks, Chem, Coli, Colloidal stability, Complete growth arrest, Corresponding histograms, Crucial role, Cytotoxic effects, Cytotoxicity, Different concentrations, Dynamic light, Effective masses, Emission spectra, Escherichia coli, Ethanol, Excitation, Excitonic absorption, Fundamental parameters approach, Good accordance, Growth inhibition tests, Gure, Hydrodynamic diameter, Hydrodynamic diameters, Induction factors, Large number, Ligand, Luminescence values, Mater, Microtiter plates, Moussodia balan, Nanocrystals, Nanoparticles, Nanotechnology, Narrow size distribution, Oleic acid, Particle size, Phys, Positive charges, Powder diffraction, Primary amine groups, Primary source, Room temperature, Same medium, Siloxane shell, Status solidi, Surface functionalization, Surface hydroxyl groups, Tetramethylammonium hydroxide, Toluene, Topas application, Toxicity, Transmission electron microscopy, Uorescent probes, Water molecules, Yellow emission, Zhang, Zinc acetate.
Abstract
Luminescent ZnO nanocrystals were synthesized by basic hydrolysis of Zn(OAc)2 in the presence of oleic acid and then functionalized with (poly)aminotrimethoxysilanes in the presence of tetramethylammonium hydroxide to render the QDs water-dispersible. The highest photoluminescence quantum yield (17%) was achieved using N1-(2-aminoethyl)-N2-[3-(trimethoxysilyl)propyl]-1,2-ethanediamine as surface ligand. Transmission electron microscopy and powder x-ray diffraction showed highly crystalline materials with a ZnO nanoparticle diameter of about 4nm. The cytotoxicity of the different siloxane-capped ZnO QDs towards growing Escherichia coli bacterial cells was evaluated in MOPS-minimal medium. Although concentrations of 5mM in QDs caused a complete growth arrest in E.coli, siloxane-capped ZnO QDs appeared weakly toxic at lower doses (0.5 or 1mM). The concentration of bioavailable Zn 2+ ions leaked from ZnO QDs was evaluated using the biosensor bacteria Cupriavidus metallidurans AE1433. The results obtained clearly demonstrate that concentrations of bioavailable Zn2+ are too low to explain the inhibitory effects of the ZnO QDs against bacteria cells at 1mM and that the siloxane shell prevents ZnO QDs from dissolution contrary to uncapped ZnO nanoparticles. Because of their low cytotoxicity, good biocompatibility, low cost and large number of functional amine end groups, which makes them easy to tailor for end-user purposes, siloxane-capped ZnO QDs offer a high potential as fluorescent probes and as biosensors.
Url:
DOI: 10.1088/0957-4484/23/33/335101
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000648
Links to Exploration step
ISTEX:E2AA84F9AC193229D3CBB8CC7CF133A6B15C5A46Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Physicochemical properties and cellular toxicity of (poly)aminoalkoxysilanes-functionalized ZnO quantum dots</title><author><name sortKey="Aboulaich, Abdelhay" sort="Aboulaich, Abdelhay" uniqKey="Aboulaich A" first="Abdelhay" last="Aboulaich">Abdelhay Aboulaich</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Tilmaciu, Carmen Mihaela" sort="Tilmaciu, Carmen Mihaela" uniqKey="Tilmaciu C" first="Carmen-Mihaela" last="Tilmaciu">Carmen-Mihaela Tilmaciu</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Merlin, Christophe" sort="Merlin, Christophe" uniqKey="Merlin C" first="Christophe" last="Merlin">Christophe Merlin</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Chimie Physique et Microbiologie pour lEnvironnement (LCPME), UMR 7564, CNRS-Universit de Lorraine, 15 Avenue du Charmois, F-54500 Vandoeuvre-ls-Nancy, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique et Microbiologie pour lEnvironnement (LCPME), UMR 7564, CNRS-Universit de Lorraine, 15 Avenue du Charmois, F-54500 Vandoeuvre-ls-Nancy</wicri:regionArea></affiliation></author><author><name sortKey="Mercier, Cdric" sort="Mercier, Cdric" uniqKey="Mercier C" first="Cdric" last="Mercier">Cdric Mercier</name><affiliation wicri:level="1"><mods:affiliation>Institut Jean Lamour (IJL), UMR 7198, CNRS-Universit de Lorraine, BP 70239, F-54506 Vandoeuvre-ls-Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Jean Lamour (IJL), UMR 7198, CNRS-Universit de Lorraine, BP 70239, F-54506 Vandoeuvre-ls-Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Guilloteau, Hlne" sort="Guilloteau, Hlne" uniqKey="Guilloteau H" first="Hlne" last="Guilloteau">Hlne Guilloteau</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Chimie Physique et Microbiologie pour lEnvironnement (LCPME), UMR 7564, CNRS-Universit de Lorraine, 15 Avenue du Charmois, F-54500 Vandoeuvre-ls-Nancy, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique et Microbiologie pour lEnvironnement (LCPME), UMR 7564, CNRS-Universit de Lorraine, 15 Avenue du Charmois, F-54500 Vandoeuvre-ls-Nancy</wicri:regionArea></affiliation></author><author><name sortKey="Medjahdi, Ghouti" sort="Medjahdi, Ghouti" uniqKey="Medjahdi G" first="Ghouti" last="Medjahdi">Ghouti Medjahdi</name><affiliation wicri:level="1"><mods:affiliation>Institut Jean Lamour (IJL), UMR 7198, CNRS-Universit de Lorraine, BP 70239, F-54506 Vandoeuvre-ls-Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Jean Lamour (IJL), UMR 7198, CNRS-Universit de Lorraine, BP 70239, F-54506 Vandoeuvre-ls-Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Schneider, Raphal" sort="Schneider, Raphal" uniqKey="Schneider R" first="Raphal" last="Schneider">Raphal Schneider</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: raphael.schneider@univ-lorraine.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E2AA84F9AC193229D3CBB8CC7CF133A6B15C5A46</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1088/0957-4484/23/33/335101</idno><idno type="url">https://api.istex.fr/document/E2AA84F9AC193229D3CBB8CC7CF133A6B15C5A46/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000648</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000648</idno><idno type="wicri:Area/Istex/Curation">000648</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Physicochemical properties and cellular toxicity of (poly)aminoalkoxysilanes-functionalized ZnO quantum dots</title><author><name sortKey="Aboulaich, Abdelhay" sort="Aboulaich, Abdelhay" uniqKey="Aboulaich A" first="Abdelhay" last="Aboulaich">Abdelhay Aboulaich</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Tilmaciu, Carmen Mihaela" sort="Tilmaciu, Carmen Mihaela" uniqKey="Tilmaciu C" first="Carmen-Mihaela" last="Tilmaciu">Carmen-Mihaela Tilmaciu</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Merlin, Christophe" sort="Merlin, Christophe" uniqKey="Merlin C" first="Christophe" last="Merlin">Christophe Merlin</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Chimie Physique et Microbiologie pour lEnvironnement (LCPME), UMR 7564, CNRS-Universit de Lorraine, 15 Avenue du Charmois, F-54500 Vandoeuvre-ls-Nancy, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique et Microbiologie pour lEnvironnement (LCPME), UMR 7564, CNRS-Universit de Lorraine, 15 Avenue du Charmois, F-54500 Vandoeuvre-ls-Nancy</wicri:regionArea></affiliation></author><author><name sortKey="Mercier, Cdric" sort="Mercier, Cdric" uniqKey="Mercier C" first="Cdric" last="Mercier">Cdric Mercier</name><affiliation wicri:level="1"><mods:affiliation>Institut Jean Lamour (IJL), UMR 7198, CNRS-Universit de Lorraine, BP 70239, F-54506 Vandoeuvre-ls-Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Jean Lamour (IJL), UMR 7198, CNRS-Universit de Lorraine, BP 70239, F-54506 Vandoeuvre-ls-Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Guilloteau, Hlne" sort="Guilloteau, Hlne" uniqKey="Guilloteau H" first="Hlne" last="Guilloteau">Hlne Guilloteau</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Chimie Physique et Microbiologie pour lEnvironnement (LCPME), UMR 7564, CNRS-Universit de Lorraine, 15 Avenue du Charmois, F-54500 Vandoeuvre-ls-Nancy, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique et Microbiologie pour lEnvironnement (LCPME), UMR 7564, CNRS-Universit de Lorraine, 15 Avenue du Charmois, F-54500 Vandoeuvre-ls-Nancy</wicri:regionArea></affiliation></author><author><name sortKey="Medjahdi, Ghouti" sort="Medjahdi, Ghouti" uniqKey="Medjahdi G" first="Ghouti" last="Medjahdi">Ghouti Medjahdi</name><affiliation wicri:level="1"><mods:affiliation>Institut Jean Lamour (IJL), UMR 7198, CNRS-Universit de Lorraine, BP 70239, F-54506 Vandoeuvre-ls-Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Jean Lamour (IJL), UMR 7198, CNRS-Universit de Lorraine, BP 70239, F-54506 Vandoeuvre-ls-Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Schneider, Raphal" sort="Schneider, Raphal" uniqKey="Schneider R" first="Raphal" last="Schneider">Raphal Schneider</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Ractions et Gnie des Procds (LRGP), UPR 3349, CNRS-Universit de Lorraine, 1 rue Grandville, F-54001 Nancy Cedex</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: raphael.schneider@univ-lorraine.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Nanotechnology</title><idno type="ISSN">0957-4484</idno><idno type="eISSN">1361-6528</idno><imprint><publisher>IOP Publishing</publisher><date type="published" when="2012-08-24">2012-08-24</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">33</biblScope></imprint><idno type="ISSN">0957-4484</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0957-4484</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aboulaich</term><term>Absorption spectra</term><term>Acros organics</term><term>Aeaps</term><term>Aetpe</term><term>Amine</term><term>Amine groups</term><term>Aptms</term><term>Aptms ligand</term><term>Aqueous media</term><term>Aqueous medium</term><term>Average diameter</term><term>Bioavailable</term><term>Biological medium</term><term>Calibration curve</term><term>Calibration curves</term><term>Characteristic peaks</term><term>Chem</term><term>Coli</term><term>Colloidal stability</term><term>Complete growth arrest</term><term>Corresponding histograms</term><term>Crucial role</term><term>Cytotoxic effects</term><term>Cytotoxicity</term><term>Different concentrations</term><term>Dynamic light</term><term>Effective masses</term><term>Emission spectra</term><term>Escherichia coli</term><term>Ethanol</term><term>Excitation</term><term>Excitonic absorption</term><term>Fundamental parameters approach</term><term>Good accordance</term><term>Growth inhibition tests</term><term>Gure</term><term>Hydrodynamic diameter</term><term>Hydrodynamic diameters</term><term>Induction factors</term><term>Large number</term><term>Ligand</term><term>Luminescence values</term><term>Mater</term><term>Microtiter plates</term><term>Moussodia balan</term><term>Nanocrystals</term><term>Nanoparticles</term><term>Nanotechnology</term><term>Narrow size distribution</term><term>Oleic acid</term><term>Particle size</term><term>Phys</term><term>Positive charges</term><term>Powder diffraction</term><term>Primary amine groups</term><term>Primary source</term><term>Room temperature</term><term>Same medium</term><term>Siloxane shell</term><term>Status solidi</term><term>Surface functionalization</term><term>Surface hydroxyl groups</term><term>Tetramethylammonium hydroxide</term><term>Toluene</term><term>Topas application</term><term>Toxicity</term><term>Transmission electron microscopy</term><term>Uorescent probes</term><term>Water molecules</term><term>Yellow emission</term><term>Zhang</term><term>Zinc acetate</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Aboulaich</term><term>Absorption spectra</term><term>Acros organics</term><term>Aeaps</term><term>Aetpe</term><term>Amine</term><term>Amine groups</term><term>Aptms</term><term>Aptms ligand</term><term>Aqueous media</term><term>Aqueous medium</term><term>Average diameter</term><term>Bioavailable</term><term>Biological medium</term><term>Calibration curve</term><term>Calibration curves</term><term>Characteristic peaks</term><term>Chem</term><term>Coli</term><term>Colloidal stability</term><term>Complete growth arrest</term><term>Corresponding histograms</term><term>Crucial role</term><term>Cytotoxic effects</term><term>Cytotoxicity</term><term>Different concentrations</term><term>Dynamic light</term><term>Effective masses</term><term>Emission spectra</term><term>Escherichia coli</term><term>Ethanol</term><term>Excitation</term><term>Excitonic absorption</term><term>Fundamental parameters approach</term><term>Good accordance</term><term>Growth inhibition tests</term><term>Gure</term><term>Hydrodynamic diameter</term><term>Hydrodynamic diameters</term><term>Induction factors</term><term>Large number</term><term>Ligand</term><term>Luminescence values</term><term>Mater</term><term>Microtiter plates</term><term>Moussodia balan</term><term>Nanocrystals</term><term>Nanoparticles</term><term>Nanotechnology</term><term>Narrow size distribution</term><term>Oleic acid</term><term>Particle size</term><term>Phys</term><term>Positive charges</term><term>Powder diffraction</term><term>Primary amine groups</term><term>Primary source</term><term>Room temperature</term><term>Same medium</term><term>Siloxane shell</term><term>Status solidi</term><term>Surface functionalization</term><term>Surface hydroxyl groups</term><term>Tetramethylammonium hydroxide</term><term>Toluene</term><term>Topas application</term><term>Toxicity</term><term>Transmission electron microscopy</term><term>Uorescent probes</term><term>Water molecules</term><term>Yellow emission</term><term>Zhang</term><term>Zinc acetate</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>éthanol</term><term>Nanotechnologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Luminescent ZnO nanocrystals were synthesized by basic hydrolysis of Zn(OAc)2 in the presence of oleic acid and then functionalized with (poly)aminotrimethoxysilanes in the presence of tetramethylammonium hydroxide to render the QDs water-dispersible. The highest photoluminescence quantum yield (17%) was achieved using N1-(2-aminoethyl)-N2-[3-(trimethoxysilyl)propyl]-1,2-ethanediamine as surface ligand. Transmission electron microscopy and powder x-ray diffraction showed highly crystalline materials with a ZnO nanoparticle diameter of about 4nm. The cytotoxicity of the different siloxane-capped ZnO QDs towards growing Escherichia coli bacterial cells was evaluated in MOPS-minimal medium. Although concentrations of 5mM in QDs caused a complete growth arrest in E.coli, siloxane-capped ZnO QDs appeared weakly toxic at lower doses (0.5 or 1mM). The concentration of bioavailable Zn 2+ ions leaked from ZnO QDs was evaluated using the biosensor bacteria Cupriavidus metallidurans AE1433. The results obtained clearly demonstrate that concentrations of bioavailable Zn2+ are too low to explain the inhibitory effects of the ZnO QDs against bacteria cells at 1mM and that the siloxane shell prevents ZnO QDs from dissolution contrary to uncapped ZnO nanoparticles. Because of their low cytotoxicity, good biocompatibility, low cost and large number of functional amine end groups, which makes them easy to tailor for end-user purposes, siloxane-capped ZnO QDs offer a high potential as fluorescent probes and as biosensors.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/LrgpV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000648 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000648 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= LrgpV1
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:E2AA84F9AC193229D3CBB8CC7CF133A6B15C5A46
|texte= Physicochemical properties and cellular toxicity of (poly)aminoalkoxysilanes-functionalized ZnO quantum dots
}}
| This area was generated with Dilib version V0.6.32. |  |