CobaltMaghrebV1, PascalFrancis, Corpus, bibRecord, 000082

Some new biologically active metal-based sulfonamide

Identifieur interne : 000082 ( PascalFrancis/Corpus ); précédent : 000081; suivant : 000083

Some new biologically active metal-based sulfonamide

Auteurs : Zahid H. Chohan ; Hazoor A. Shad ; Moulay H. Youssoufi ; TAIBI BEN HADDA

Source :

European journal of medicinal chemistry [ 0223-5234 ] ; 2010.

RBID : Pascal:10-0437154

Descripteurs français

Pascal (Inist)
- Sulfonamide, Métal divalent Complexe, Antibactérien, Antifongique, Cytotoxicité, Activité biologique, In vitro, Synthèse chimique, Cuivre Complexe, Cobalt Complexe, Nickel Complexe, Zinc Complexe, Base Schiff, Brome Composé organique, Complexe aqua, Coordinat organique, Conductivité ionique, Susceptibilité magnétique, Imine, Propriété électrique, Propriété magnétique, Benzènesulfonamide(N-[pyrimidin-2-yl]-4-[5-bromo-2-hydroxybenzylidèneamino]).

English descriptors

KwdEn :
- Antibacterial agent, Antifungal agent, Aqua complex, Biological activity, Bromine Organic compounds, Chemical synthesis, Cobalt Complexes, Copper Complexes, Cytotoxicity, Divalent metal Complexes, Electrical properties, Imine, In vitro, Ionic conductivity, Magnetic properties, Magnetic susceptibility, Nickel Complexes, Organic ligand, Schiff base, Sulfonamide, Zinc Complexes.

Abstract

A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, ¹H and ¹³C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methyldene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 EJMCA5`
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A08	`01`	`1`	`ENG`	`@1 Some new biologically active metal-based sulfonamide`
A11	`01`	`1`		`@1 CHOHAN (Zahid H.)`
A11	`02`	`1`		`@1 SHAD (Hazoor A.)`
A11	`03`	`1`		`@1 YOUSSOUFI (Moulay H.)`
A11	`04`	`1`		`@1 TAIBI BEN HADDA`
A14	`01`			`@1 Department of Chemistry, Bahauddin Zakariya University @2 Multan-60800 @3 PAK @Z 1 aut. @Z 2 aut.`
A14	`02`			`@1 Laboratoire Chimie des Matériaux, Faculté des Sciences, Université Mohammed Premier @2 60000 Oujda @3 MAR @Z 3 aut. @Z 4 aut.`
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A64	`01`	`1`		`@0 European journal of medicinal chemistry`
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C01	`01`		`ENG`	@0 A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, ¹H and ¹³C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methyldene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains.
C02	`01`	`X`		`@0 002B02S04`
C02	`02`	`X`		`@0 002B02S02`
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C03	`01`	`X`	`ENG`	`@0 Sulfonamide @5 01`
C03	`01`	`X`	`SPA`	`@0 Sulfonamida @5 01`
C03	`02`	`X`	`FRE`	`@0 Métal divalent Complexe @2 NC @2 NA @5 02`
C03	`02`	`X`	`ENG`	`@0 Divalent metal Complexes @2 NC @2 NA @5 02`
C03	`02`	`X`	`SPA`	`@0 Metal divalente Complejo @2 NC @2 NA @5 02`
C03	`03`	`X`	`FRE`	`@0 Antibactérien @5 03`
C03	`03`	`X`	`ENG`	`@0 Antibacterial agent @5 03`
C03	`03`	`X`	`SPA`	`@0 Antibacteriano @5 03`
C03	`04`	`X`	`FRE`	`@0 Antifongique @5 04`
C03	`04`	`X`	`ENG`	`@0 Antifungal agent @5 04`
C03	`04`	`X`	`SPA`	`@0 Antifúngico @5 04`
C03	`05`	`X`	`FRE`	`@0 Cytotoxicité @5 05`
C03	`05`	`X`	`ENG`	`@0 Cytotoxicity @5 05`
C03	`05`	`X`	`SPA`	`@0 Citotoxicidad @5 05`
C03	`06`	`X`	`FRE`	`@0 Activité biologique @5 06`
C03	`06`	`X`	`ENG`	`@0 Biological activity @5 06`
C03	`06`	`X`	`SPA`	`@0 Actividad biológica @5 06`
C03	`07`	`X`	`FRE`	`@0 In vitro @5 07`
C03	`07`	`X`	`ENG`	`@0 In vitro @5 07`
C03	`07`	`X`	`SPA`	`@0 In vitro @5 07`
C03	`08`	`X`	`FRE`	`@0 Synthèse chimique @5 08`
C03	`08`	`X`	`ENG`	`@0 Chemical synthesis @5 08`
C03	`08`	`X`	`SPA`	`@0 Síntesis química @5 08`
C03	`09`	`X`	`FRE`	`@0 Cuivre Complexe @2 NC @2 NA @5 09`
C03	`09`	`X`	`ENG`	`@0 Copper Complexes @2 NC @2 NA @5 09`
C03	`09`	`X`	`SPA`	`@0 Cobre Complejo @2 NC @2 NA @5 09`
C03	`10`	`X`	`FRE`	`@0 Cobalt Complexe @2 NC @2 NA @5 10`
C03	`10`	`X`	`ENG`	`@0 Cobalt Complexes @2 NC @2 NA @5 10`
C03	`10`	`X`	`SPA`	`@0 Cobalto Complejo @2 NC @2 NA @5 10`
C03	`11`	`X`	`FRE`	`@0 Nickel Complexe @2 NC @2 FX @2 NA @5 11`
C03	`11`	`X`	`ENG`	`@0 Nickel Complexes @2 NC @2 FX @2 NA @5 11`
C03	`11`	`X`	`SPA`	`@0 Niquel Complejo @2 NC @2 FX @2 NA @5 11`
C03	`12`	`X`	`FRE`	`@0 Zinc Complexe @2 NC @2 NA @5 12`
C03	`12`	`X`	`ENG`	`@0 Zinc Complexes @2 NC @2 NA @5 12`
C03	`12`	`X`	`SPA`	`@0 Zinc Complejo @2 NC @2 NA @5 12`
C03	`13`	`X`	`FRE`	`@0 Base Schiff @5 14`
C03	`13`	`X`	`ENG`	`@0 Schiff base @5 14`
C03	`13`	`X`	`SPA`	`@0 Base Schiff @5 14`
C03	`14`	`X`	`FRE`	`@0 Brome Composé organique @2 NC @2 FR @2 FX @2 NA @5 15`
C03	`14`	`X`	`ENG`	`@0 Bromine Organic compounds @2 NC @2 FR @2 FX @2 NA @5 15`
C03	`14`	`X`	`SPA`	`@0 Bromo Compuesto orgánico @2 NC @2 FR @2 FX @2 NA @5 15`
C03	`15`	`X`	`FRE`	`@0 Complexe aqua @5 16`
C03	`15`	`X`	`ENG`	`@0 Aqua complex @5 16`
C03	`15`	`X`	`SPA`	`@0 Complejo aqua @5 16`
C03	`16`	`X`	`FRE`	`@0 Coordinat organique @5 17`
C03	`16`	`X`	`ENG`	`@0 Organic ligand @5 17`
C03	`16`	`X`	`SPA`	`@0 Ligando orgánico @5 17`
C03	`17`	`X`	`FRE`	`@0 Conductivité ionique @5 18`
C03	`17`	`X`	`ENG`	`@0 Ionic conductivity @5 18`
C03	`17`	`X`	`SPA`	`@0 Conductividad iónica @5 18`
C03	`18`	`X`	`FRE`	`@0 Susceptibilité magnétique @5 19`
C03	`18`	`X`	`ENG`	`@0 Magnetic susceptibility @5 19`
C03	`18`	`X`	`SPA`	`@0 Susceptibilidad magnética @5 19`
C03	`19`	`X`	`FRE`	`@0 Imine @5 32`
C03	`19`	`X`	`ENG`	`@0 Imine @5 32`
C03	`19`	`X`	`SPA`	`@0 Imina @5 32`
C03	`20`	`X`	`FRE`	`@0 Propriété électrique @5 33`
C03	`20`	`X`	`ENG`	`@0 Electrical properties @5 33`
C03	`20`	`X`	`SPA`	`@0 Propiedad eléctrica @5 33`
C03	`21`	`X`	`FRE`	`@0 Propriété magnétique @5 34`
C03	`21`	`X`	`ENG`	`@0 Magnetic properties @5 34`
C03	`21`	`X`	`SPA`	`@0 Propiedad magnética @5 34`
C03	`22`	`X`	`FRE`	`@0 Benzènesulfonamide(N-[pyrimidin-2-yl]-4-[5-bromo-2-hydroxybenzylidèneamino]) @2 NK @2 FC @4 INC @5 76`
C07	`01`	`X`	`FRE`	`@0 Métal transition Complexe @2 NC @2 NA @5 13`
C07	`01`	`X`	`ENG`	`@0 Transition metal Complexes @2 NC @2 NA @5 13`
C07	`01`	`X`	`SPA`	`@0 Metal transición Complejo @2 NC @2 NA @5 13`
N21				`@1 284`

Format Inist (serveur)

NO :	PASCAL 10-0437154 INIST
ET :	Some new biologically active metal-based sulfonamide
AU :	CHOHAN (Zahid H.); SHAD (Hazoor A.); YOUSSOUFI (Moulay H.); TAIBI BEN HADDA
AF :	Department of Chemistry, Bahauddin Zakariya University/Multan-60800/Pakistan (1 aut., 2 aut.); Laboratoire Chimie des Matériaux, Faculté des Sciences, Université Mohammed Premier/60000 Oujda/Maroc (3 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	European journal of medicinal chemistry; ISSN 0223-5234; Coden EJMCA5; Royaume-Uni; Da. 2010; Vol. 45; No. 7; Pp. 2893-2901; Bibl. 66 ref.
LA :	Anglais
EA :	A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, ¹H and ¹³C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methyldene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzen esulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains.
CC :	002B02S04; 002B02S02
FD :	Sulfonamide; Métal divalent Complexe; Antibactérien; Antifongique; Cytotoxicité; Activité biologique; In vitro; Synthèse chimique; Cuivre Complexe; Cobalt Complexe; Nickel Complexe; Zinc Complexe; Base Schiff; Brome Composé organique; Complexe aqua; Coordinat organique; Conductivité ionique; Susceptibilité magnétique; Imine; Propriété électrique; Propriété magnétique; Benzènesulfonamide(N-[pyrimidin-2-yl]-4-[5-bromo-2-hydroxybenzylidèneamino])
FG :	Métal transition Complexe
ED :	Sulfonamide; Divalent metal Complexes; Antibacterial agent; Antifungal agent; Cytotoxicity; Biological activity; In vitro; Chemical synthesis; Copper Complexes; Cobalt Complexes; Nickel Complexes; Zinc Complexes; Schiff base; Bromine Organic compounds; Aqua complex; Organic ligand; Ionic conductivity; Magnetic susceptibility; Imine; Electrical properties; Magnetic properties
EG :	Transition metal Complexes
SD :	Sulfonamida; Metal divalente Complejo; Antibacteriano; Antifúngico; Citotoxicidad; Actividad biológica; In vitro; Síntesis química; Cobre Complejo; Cobalto Complejo; Niquel Complejo; Zinc Complejo; Base Schiff; Bromo Compuesto orgánico; Complejo aqua; Ligando orgánico; Conductividad iónica; Susceptibilidad magnética; Imina; Propiedad eléctrica; Propiedad magnética
LO :	INIST-12640.354000182195100240
ID :	10-0437154

Links to Exploration step

Pascal:10-0437154

Le document en format XML

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<front><div type="abstract" xml:lang="en">A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, <sup>1</sup>
H and <sup>13</sup>
C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methyldene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains.</div>
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<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, <sup>1</sup>
H and <sup>13</sup>
C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methyldene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S04</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B02S02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Sulfonamide</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Sulfonamide</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sulfonamida</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Métal divalent Complexe</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Divalent metal Complexes</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Metal divalente Complejo</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Antibactérien</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Antibacterial agent</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Antibacteriano</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Antifongique</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Antifungal agent</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Antifúngico</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Cytotoxicité</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Cytotoxicity</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Citotoxicidad</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Activité biologique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Biological activity</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Actividad biológica</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>In vitro</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>In vitro</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>In vitro</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Synthèse chimique</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Chemical synthesis</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Síntesis química</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Cuivre Complexe</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Copper Complexes</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Cobre Complejo</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Cobalt Complexe</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Cobalt Complexes</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Cobalto Complejo</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Nickel Complexe</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Nickel Complexes</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Niquel Complejo</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Zinc Complexe</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Zinc Complexes</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Zinc Complejo</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>12</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Base Schiff</s0>
<s5>14</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Schiff base</s0>
<s5>14</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Base Schiff</s0>
<s5>14</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Brome Composé organique</s0>
<s2>NC</s2>
<s2>FR</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>15</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Bromine Organic compounds</s0>
<s2>NC</s2>
<s2>FR</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>15</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Bromo Compuesto orgánico</s0>
<s2>NC</s2>
<s2>FR</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>15</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Complexe aqua</s0>
<s5>16</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Aqua complex</s0>
<s5>16</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Complejo aqua</s0>
<s5>16</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Coordinat organique</s0>
<s5>17</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Organic ligand</s0>
<s5>17</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Ligando orgánico</s0>
<s5>17</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Conductivité ionique</s0>
<s5>18</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG"><s0>Ionic conductivity</s0>
<s5>18</s5>
</fC03>
<fC03 i1="17" i2="X" l="SPA"><s0>Conductividad iónica</s0>
<s5>18</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Susceptibilité magnétique</s0>
<s5>19</s5>
</fC03>
<fC03 i1="18" i2="X" l="ENG"><s0>Magnetic susceptibility</s0>
<s5>19</s5>
</fC03>
<fC03 i1="18" i2="X" l="SPA"><s0>Susceptibilidad magnética</s0>
<s5>19</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>Imine</s0>
<s5>32</s5>
</fC03>
<fC03 i1="19" i2="X" l="ENG"><s0>Imine</s0>
<s5>32</s5>
</fC03>
<fC03 i1="19" i2="X" l="SPA"><s0>Imina</s0>
<s5>32</s5>
</fC03>
<fC03 i1="20" i2="X" l="FRE"><s0>Propriété électrique</s0>
<s5>33</s5>
</fC03>
<fC03 i1="20" i2="X" l="ENG"><s0>Electrical properties</s0>
<s5>33</s5>
</fC03>
<fC03 i1="20" i2="X" l="SPA"><s0>Propiedad eléctrica</s0>
<s5>33</s5>
</fC03>
<fC03 i1="21" i2="X" l="FRE"><s0>Propriété magnétique</s0>
<s5>34</s5>
</fC03>
<fC03 i1="21" i2="X" l="ENG"><s0>Magnetic properties</s0>
<s5>34</s5>
</fC03>
<fC03 i1="21" i2="X" l="SPA"><s0>Propiedad magnética</s0>
<s5>34</s5>
</fC03>
<fC03 i1="22" i2="X" l="FRE"><s0>Benzènesulfonamide(N-[pyrimidin-2-yl]-4-[5-bromo-2-hydroxybenzylidèneamino])</s0>
<s2>NK</s2>
<s2>FC</s2>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Métal transition Complexe</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>13</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Transition metal Complexes</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>13</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Metal transición Complejo</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>13</s5>
</fC07>
<fN21><s1>284</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 10-0437154 INIST</NO>
<ET>Some new biologically active metal-based sulfonamide</ET>
<AU>CHOHAN (Zahid H.); SHAD (Hazoor A.); YOUSSOUFI (Moulay H.); TAIBI BEN HADDA</AU>
<AF>Department of Chemistry, Bahauddin Zakariya University/Multan-60800/Pakistan (1 aut., 2 aut.); Laboratoire Chimie des Matériaux, Faculté des Sciences, Université Mohammed Premier/60000 Oujda/Maroc (3 aut., 4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>European journal of medicinal chemistry; ISSN 0223-5234; Coden EJMCA5; Royaume-Uni; Da. 2010; Vol. 45; No. 7; Pp. 2893-2901; Bibl. 66 ref.</SO>
<LA>Anglais</LA>
<EA>A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, <sup>1</sup>
H and <sup>13</sup>
C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methyldene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzen esulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains.</EA>
<CC>002B02S04; 002B02S02</CC>
<FD>Sulfonamide; Métal divalent Complexe; Antibactérien; Antifongique; Cytotoxicité; Activité biologique; In vitro; Synthèse chimique; Cuivre Complexe; Cobalt Complexe; Nickel Complexe; Zinc Complexe; Base Schiff; Brome Composé organique; Complexe aqua; Coordinat organique; Conductivité ionique; Susceptibilité magnétique; Imine; Propriété électrique; Propriété magnétique; Benzènesulfonamide(N-[pyrimidin-2-yl]-4-[5-bromo-2-hydroxybenzylidèneamino])</FD>
<FG>Métal transition Complexe</FG>
<ED>Sulfonamide; Divalent metal Complexes; Antibacterial agent; Antifungal agent; Cytotoxicity; Biological activity; In vitro; Chemical synthesis; Copper Complexes; Cobalt Complexes; Nickel Complexes; Zinc Complexes; Schiff base; Bromine Organic compounds; Aqua complex; Organic ligand; Ionic conductivity; Magnetic susceptibility; Imine; Electrical properties; Magnetic properties</ED>
<EG>Transition metal Complexes</EG>
<SD>Sulfonamida; Metal divalente Complejo; Antibacteriano; Antifúngico; Citotoxicidad; Actividad biológica; In vitro; Síntesis química; Cobre Complejo; Cobalto Complejo; Niquel Complejo; Zinc Complejo; Base Schiff; Bromo Compuesto orgánico; Complejo aqua; Ligando orgánico; Conductividad iónica; Susceptibilidad magnética; Imina; Propiedad eléctrica; Propiedad magnética</SD>
<LO>INIST-12640.354000182195100240</LO>
<ID>10-0437154</ID>
</server>
</inist>
</record>

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Some new biologically active metal-based sulfonamide

Some new biologically active metal-based sulfonamide

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