Recombinant Pvs48/45 Antigen Expressed in E. coli Generates Antibodies that Block Malaria Transmission in Anopheles albimanus Mosquitoes
Identifieur interne : 000065 ( Main/Merge ); précédent : 000064; suivant : 000066Recombinant Pvs48/45 Antigen Expressed in E. coli Generates Antibodies that Block Malaria Transmission in Anopheles albimanus Mosquitoes
Auteurs : Myriam Arévalo-Herrera [Colombie] ; Andrés F. Vallejo [Colombie] ; Kelly Rubiano [Colombie] ; Yezid Solarte [Colombie] ; Catherin Marin [Colombie] ; Angélica Castellanos [Colombie] ; Nora Céspedes [Colombie] ; S Crates Herrera [Colombie]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Transmission of malaria parasites from humans to
Url:
DOI: 10.1371/journal.pone.0119335
PubMed: 25775466
PubMed Central: 4361554
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PMC:4361554Le document en format XML
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48/45 Antigen Expressed in <italic>E</italic>
. <italic>coli</italic>
Generates Antibodies that Block Malaria Transmission in <italic>Anopheles albimanus</italic>
Mosquitoes</title>
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<author><name sortKey="Cespedes, Nora" sort="Cespedes, Nora" uniqKey="Cespedes N" first="Nora" last="Céspedes">Nora Céspedes</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recombinant <italic>Pvs</italic>
48/45 Antigen Expressed in <italic>E</italic>
. <italic>coli</italic>
Generates Antibodies that Block Malaria Transmission in <italic>Anopheles albimanus</italic>
Mosquitoes</title>
<author><name sortKey="Arevalo Herrera, Myriam" sort="Arevalo Herrera, Myriam" uniqKey="Arevalo Herrera M" first="Myriam" last="Arévalo-Herrera">Myriam Arévalo-Herrera</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>School of Health, Universidad del Valle, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>School of Health, Universidad del Valle, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vallejo, Andres F" sort="Vallejo, Andres F" uniqKey="Vallejo A" first="Andrés F." last="Vallejo">Andrés F. Vallejo</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Caucaseco Scientific Research Center, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Caucaseco Scientific Research Center, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rubiano, Kelly" sort="Rubiano, Kelly" uniqKey="Rubiano K" first="Kelly" last="Rubiano">Kelly Rubiano</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Caucaseco Scientific Research Center, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Caucaseco Scientific Research Center, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Solarte, Yezid" sort="Solarte, Yezid" uniqKey="Solarte Y" first="Yezid" last="Solarte">Yezid Solarte</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>School of Health, Universidad del Valle, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>School of Health, Universidad del Valle, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marin, Catherin" sort="Marin, Catherin" uniqKey="Marin C" first="Catherin" last="Marin">Catherin Marin</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Primates Center Foundation, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
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<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Castellanos, Angelica" sort="Castellanos, Angelica" uniqKey="Castellanos A" first="Angélica" last="Castellanos">Angélica Castellanos</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Primates Center Foundation, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Primates Center Foundation, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cespedes, Nora" sort="Cespedes, Nora" uniqKey="Cespedes N" first="Nora" last="Céspedes">Nora Céspedes</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Herrera, S Crates" sort="Herrera, S Crates" uniqKey="Herrera S" first="S Crates" last="Herrera">S Crates Herrera</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Malaria Vaccine and Drug Development Center, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Malaria Vaccine and Drug Development Center, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Caucaseco Scientific Research Center, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Caucaseco Scientific Research Center, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Primates Center Foundation, Cali, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Primates Center Foundation, Cali</wicri:regionArea>
<wicri:noRegion>Cali</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015">2015</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p>Transmission of malaria parasites from humans to <italic>Anopheles</italic>
mosquitoes can be inhibited by specific antibodies elicited during malaria infection, which target surface <italic>Plasmodium</italic>
gametocyte/gamete proteins. Some of these proteins may have potential for vaccine development. <italic>Pvs</italic>
48/45 is a <italic>P</italic>
. <italic>vivax</italic>
gametocyte surface antigen orthologous to <italic>Pfs</italic>
48/45, which may play a role during parasite fertilization and thus has potential for transmission blocking (TB) activity. Here we describe the expression of a recombinant <italic>Pvs</italic>
48/45 protein expressed in <italic>Escherichia coli</italic>
as a ∼60kDa construct which we tested for antigenicity using human sera and for its immunogenicity and transmission blocking activity of specific anti-mouse and anti-monkey <italic>Pvs</italic>
48/45 antibodies. The protein reacted with sera of individuals from malaria-endemic areas and in addition induced specific IgG antibody responses in BALB/c mice and <italic>Aotus l</italic>
. <italic>griseimembra</italic>
monkeys. Sera from both immunized animal species recognized native <italic>P</italic>
. <italic>vivax</italic>
protein in Western blot (WB) and immunofluorescence assays. Moreover, sera from immunized mice and monkeys produced significant inhibition of parasite transmission to <italic>An</italic>
. <italic>Albimanus</italic>
mosquitoes as shown by membrane feeding assays. Results indicate the presence of reactive epitopes in the <italic>Pvs</italic>
48/45 recombinant product that induce antibodies with TB activity. Further testing of this protein is ongoing to determine its vaccine potential.</p>
</div>
</front>
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