A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillofacial surgery
Identifieur interne : 000C15 ( Main/Exploration ); précédent : 000C14; suivant : 000C16A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillofacial surgery
Auteurs : Anita A. Ignatius [Allemagne] ; Michael Ohnmacht [Allemagne] ; Lutz E. Claes [Allemagne] ; Joachim Kreidler [Allemagne] ; Frank Palm [Allemagne]Source :
- Journal of Biomedical Materials Research [ 0021-9304 ] ; 2001.
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Abstract
The aim of the study was the development of a resorbable membrane for guided bone regeneration (GBR) with improved biocompatibility, which should be stiff enough to avoid membrane collapse during bone healing. Combining a bioactive ceramic with a resorbable polymer may improve the biocompatibility and osteoconductivity of resorbable devices. The present article describes the preparation, the mechanical properties, and the in vitro degradation characteristic of a composite membrane made of poly(L, DL‐lactide) and α‐tricalcium phosphate in comparison to a membrane made of pure poly(L, DL‐lactide). The tensile strength and the elastic modulus as well as the molecular weight of the membranes were measured after in vitro degradation in buffer at 37 °C up to 28 weeks. The initial tensile strength of the composite and the polymer membrane was 37.3 ± 2.4 MPa and 27.7 ± 2.3 MPa and the elastic modulus 3106 ± 108 MPa and 3101 ± 104 MPa, respectively. The mechanical properties remained constant up to 8 weeks and then decreased slowly until week 28. The molecular weight of both membranes decreased steadily from 170,000 D to 30,000 D. It was concluded that the mechanical requirements for a membrane for GBR were fulfilled by the composite membrane. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 564–569, 2001
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DOI: 10.1002/jbm.1055
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