A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillofacial surgery
Identifieur interne : 000F64 ( Istex/Corpus ); précédent : 000F63; suivant : 000F65A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillofacial surgery
Auteurs : Anita A. Ignatius ; Michael Ohnmacht ; Lutz E. Claes ; Joachim Kreidler ; Frank PalmSource :
- Journal of Biomedical Materials Research [ 0021-9304 ] ; 2001.
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Abstract
The aim of the study was the development of a resorbable membrane for guided bone regeneration (GBR) with improved biocompatibility, which should be stiff enough to avoid membrane collapse during bone healing. Combining a bioactive ceramic with a resorbable polymer may improve the biocompatibility and osteoconductivity of resorbable devices. The present article describes the preparation, the mechanical properties, and the in vitro degradation characteristic of a composite membrane made of poly(L, DL‐lactide) and α‐tricalcium phosphate in comparison to a membrane made of pure poly(L, DL‐lactide). The tensile strength and the elastic modulus as well as the molecular weight of the membranes were measured after in vitro degradation in buffer at 37 °C up to 28 weeks. The initial tensile strength of the composite and the polymer membrane was 37.3 ± 2.4 MPa and 27.7 ± 2.3 MPa and the elastic modulus 3106 ± 108 MPa and 3101 ± 104 MPa, respectively. The mechanical properties remained constant up to 8 weeks and then decreased slowly until week 28. The molecular weight of both membranes decreased steadily from 170,000 D to 30,000 D. It was concluded that the mechanical requirements for a membrane for GBR were fulfilled by the composite membrane. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 564–569, 2001
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DOI: 10.1002/jbm.1055
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ISTEX:16B4934B8D804169DA6A4F827FC603EBFECFD7E7Le document en format XML
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Combining a bioactive ceramic with a resorbable polymer may improve the biocompatibility and osteoconductivity of resorbable devices. The present article describes the preparation, the mechanical properties, and the in vitro degradation characteristic of a composite membrane made of poly(L, DL‐lactide) and α‐tricalcium phosphate in comparison to a membrane made of pure poly(L, DL‐lactide). The tensile strength and the elastic modulus as well as the molecular weight of the membranes were measured after in vitro degradation in buffer at 37 °C up to 28 weeks. The initial tensile strength of the composite and the polymer membrane was 37.3 ± 2.4 MPa and 27.7 ± 2.3 MPa and the elastic modulus 3106 ± 108 MPa and 3101 ± 104 MPa, respectively. The mechanical properties remained constant up to 8 weeks and then decreased slowly until week 28. The molecular weight of both membranes decreased steadily from 170,000 D to 30,000 D. 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Combining a bioactive ceramic with a resorbable polymer may improve the biocompatibility and osteoconductivity of resorbable devices. The present article describes the preparation, the mechanical properties, and the <i>in vitro</i> degradation characteristic of a composite membrane made of poly(L, DL‐lactide) and α‐tricalcium phosphate in comparison to a membrane made of pure poly(L, DL‐lactide). The tensile strength and the elastic modulus as well as the molecular weight of the membranes were measured after <i>in vitro</i> degradation in buffer at 37 °C up to 28 weeks. The initial tensile strength of the composite and the polymer membrane was 37.3 ± 2.4 MPa and 27.7 ± 2.3 MPa and the elastic modulus 3106 ± 108 MPa and 3101 ± 104 MPa, respectively. The mechanical properties remained constant up to 8 weeks and then decreased slowly until week 28. The molecular weight of both membranes decreased steadily from 170,000 D to 30,000 D. It was concluded that the mechanical requirements for a membrane for GBR were fulfilled by the composite membrane. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 564–569, 2001</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillofacial surgery</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>A Resorbable Composite Membrane for Guided Bone Regeneration</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillofacial surgery</title></titleInfo><name type="personal"><namePart type="given">Anita A.</namePart><namePart type="family">Ignatius</namePart><affiliation>Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Ohnmacht</namePart><affiliation>Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lutz E.</namePart><namePart type="family">Claes</namePart><affiliation>Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany</affiliation><description>Correspondence: Institute of Orthopaedic Research and Biomechanics, Universität Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joachim</namePart><namePart type="family">Kreidler</namePart><affiliation>Department of Oral and Maxillofacial Surgery, University of Ulm, Bundeswehrkrankenhaus Oberer Eselsberg 40, 89081 Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frank</namePart><namePart type="family">Palm</namePart><affiliation>Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2001</dateIssued><dateCaptured encoding="w3cdtf">2001-01-23</dateCaptured><dateValid encoding="w3cdtf">2001-05-24</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">7</extent><extent unit="references">36</extent><extent unit="words">4111</extent></physicalDescription><abstract lang="en">The aim of the study was the development of a resorbable membrane for guided bone regeneration (GBR) with improved biocompatibility, which should be stiff enough to avoid membrane collapse during bone healing. Combining a bioactive ceramic with a resorbable polymer may improve the biocompatibility and osteoconductivity of resorbable devices. The present article describes the preparation, the mechanical properties, and the in vitro degradation characteristic of a composite membrane made of poly(L, DL‐lactide) and α‐tricalcium phosphate in comparison to a membrane made of pure poly(L, DL‐lactide). The tensile strength and the elastic modulus as well as the molecular weight of the membranes were measured after in vitro degradation in buffer at 37 °C up to 28 weeks. The initial tensile strength of the composite and the polymer membrane was 37.3 ± 2.4 MPa and 27.7 ± 2.3 MPa and the elastic modulus 3106 ± 108 MPa and 3101 ± 104 MPa, respectively. The mechanical properties remained constant up to 8 weeks and then decreased slowly until week 28. The molecular weight of both membranes decreased steadily from 170,000 D to 30,000 D. It was concluded that the mechanical requirements for a membrane for GBR were fulfilled by the composite membrane. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 564–569, 2001</abstract><note type="funding">Bundesministerium für Bildung und Forschung, bmb+f</note><subject lang="en"><genre>keywords</genre><topic>resorbable membranes</topic><topic>guided bone regeneration</topic><topic>poly(lactide), α‐tricalcium phosphate</topic><topic>composite</topic><topic>in vitro degradation</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Biomedical Materials Research</title><subTitle>An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials</subTitle></titleInfo><titleInfo type="abbreviated"><title>J. Biomed. Mater. Res.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Report</topic></subject><identifier type="ISSN">0021-9304</identifier><identifier type="eISSN">1097-4636</identifier><identifier type="DOI">10.1002/(ISSN)1097-4636</identifier><identifier type="PublisherID">JBM</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>58</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>564</start><end>569</end><total>6</total></extent></part></relatedItem><relatedItem type="preceding"><titleInfo><title>Journal of Applied Biomaterials</title></titleInfo><identifier type="ISSN">1045-4861</identifier><part><date point="end">1995</date><detail type="volume"><caption>last vol.</caption><number>6</number></detail><detail type="issue"><caption>last no.</caption><number>4</number></detail></part></relatedItem><identifier type="istex">16B4934B8D804169DA6A4F827FC603EBFECFD7E7</identifier><identifier type="DOI">10.1002/jbm.1055</identifier><identifier type="ArticleID">JBM1055</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 John Wiley & Sons, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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