Sorghum [Sorghum bicolor (L.) Moench] Leaf Sheath Dye Protects Against Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Rats
Identifieur interne : 000126 ( Main/Exploration ); précédent : 000125; suivant : 000127Sorghum [Sorghum bicolor (L.) Moench] Leaf Sheath Dye Protects Against Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Rats
Auteurs : Adedayo O. Ademiluyi ; Ganiyu Oboh ; Oluwaseun J. Agbebi ; Aline A. Boligon ; Margareth L. AthaydeSource :
- Journal of Medicinal Food [ 1096-620X ] ; 2014.
Abstract
This study sought to determine the protective effect of dietary inclusion of sorghum leaf sheath dye on cisplatin-induced hepatotoxicity and oxidative stress in rats. Adult male rats were randomly divided into four groups with six animals in each group. Groups I and II were fed a basal diet, while groups III and IV were fed diets containing 0.5% and 1% sorghum leaf sheath dye, respectively, for 20 days before cisplatin administration. Hepatotoxicity was induced by a single dose of cisplatin (7 mg/kg body weight, i.p.), and the experiment was terminated at 3 days after cisplatin injection. The liver and plasma were studied for hepatotoxicity and antioxidant capacity. Cisplatin caused a significant (
Url:
DOI: 10.1089/jmf.2013.0013
PubMed: 25133450
PubMed Central: 4259168
Affiliations:
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Le document en format XML
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(L.) Moench] Leaf Sheath Dye Protects Against Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Rats</title>
<author><name sortKey="Ademiluyi, Adedayo O" sort="Ademiluyi, Adedayo O" uniqKey="Ademiluyi A" first="Adedayo O." last="Ademiluyi">Adedayo O. Ademiluyi</name>
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<author><name sortKey="Agbebi, Oluwaseun J" sort="Agbebi, Oluwaseun J" uniqKey="Agbebi O" first="Oluwaseun J." last="Agbebi">Oluwaseun J. Agbebi</name>
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<author><name sortKey="Athayde, Margareth L" sort="Athayde, Margareth L" uniqKey="Athayde M" first="Margareth L." last="Athayde">Margareth L. Athayde</name>
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<series><title level="j">Journal of Medicinal Food</title>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>This study sought to determine the protective effect of dietary inclusion of sorghum leaf sheath dye on cisplatin-induced hepatotoxicity and oxidative stress in rats. Adult male rats were randomly divided into four groups with six animals in each group. Groups I and II were fed a basal diet, while groups III and IV were fed diets containing 0.5% and 1% sorghum leaf sheath dye, respectively, for 20 days before cisplatin administration. Hepatotoxicity was induced by a single dose of cisplatin (7 mg/kg body weight, i.p.), and the experiment was terminated at 3 days after cisplatin injection. The liver and plasma were studied for hepatotoxicity and antioxidant capacity. Cisplatin caused a significant (<italic>P<</italic>
.05) alteration in plasma and liver enzymatic (catalase, glutathione-<italic>S</italic>
-transferase [GST], and superoxide dismutase [SOD]) and nonenzymatic (glutathione [GSH] and vitamin C) antioxidant indices with a concomitant increase in the malondialdehyde (MDA) content; however, there was a significant (<italic>P</italic>
<.05) restoration of the antioxidant status coupled with a significant (<italic>P</italic>
<.05) decrease in the tissue MDA content, after consumption of diets containing sorghum leaf sheath dye. Furthermore, dietary inclusion of sorghum leaf sheath dye caused a marked reduction in the activities of alanine aminotransferase and aspartate aminotransferase after cisplatin administration. However, the ability of the dye to prevent significant cisplatin-induced alteration of both plasma and liver antioxidant indices suggests an antioxidant mechanism of action. Hence, this protective effect of <italic>Sorghum bicolor</italic>
leaf sheath dye against cisplatin-induced hepatotoxicity in rats reflects its potential and beneficial role in the prevention of liver damage associated with cisplatin administration.</p>
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<tree><noCountry><name sortKey="Ademiluyi, Adedayo O" sort="Ademiluyi, Adedayo O" uniqKey="Ademiluyi A" first="Adedayo O." last="Ademiluyi">Adedayo O. Ademiluyi</name>
<name sortKey="Agbebi, Oluwaseun J" sort="Agbebi, Oluwaseun J" uniqKey="Agbebi O" first="Oluwaseun J." last="Agbebi">Oluwaseun J. Agbebi</name>
<name sortKey="Athayde, Margareth L" sort="Athayde, Margareth L" uniqKey="Athayde M" first="Margareth L." last="Athayde">Margareth L. Athayde</name>
<name sortKey="Boligon, Aline A" sort="Boligon, Aline A" uniqKey="Boligon A" first="Aline A." last="Boligon">Aline A. Boligon</name>
<name sortKey="Oboh, Ganiyu" sort="Oboh, Ganiyu" uniqKey="Oboh G" first="Ganiyu" last="Oboh">Ganiyu Oboh</name>
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