Sorghum [Sorghum bicolor (L.) Moench] Leaf Sheath Dye Protects Against Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Rats
Identifieur interne : 000316 ( Pmc/Corpus ); précédent : 000315; suivant : 000317Sorghum [Sorghum bicolor (L.) Moench] Leaf Sheath Dye Protects Against Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Rats
Auteurs : Adedayo O. Ademiluyi ; Ganiyu Oboh ; Oluwaseun J. Agbebi ; Aline A. Boligon ; Margareth L. AthaydeSource :
- Journal of Medicinal Food [ 1096-620X ] ; 2014.
Abstract
This study sought to determine the protective effect of dietary inclusion of sorghum leaf sheath dye on cisplatin-induced hepatotoxicity and oxidative stress in rats. Adult male rats were randomly divided into four groups with six animals in each group. Groups I and II were fed a basal diet, while groups III and IV were fed diets containing 0.5% and 1% sorghum leaf sheath dye, respectively, for 20 days before cisplatin administration. Hepatotoxicity was induced by a single dose of cisplatin (7 mg/kg body weight, i.p.), and the experiment was terminated at 3 days after cisplatin injection. The liver and plasma were studied for hepatotoxicity and antioxidant capacity. Cisplatin caused a significant (
Url:
DOI: 10.1089/jmf.2013.0013
PubMed: 25133450
PubMed Central: 4259168
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sorghum [<italic>Sorghum bicolor</italic> (L.) Moench] Leaf Sheath Dye Protects Against Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Rats</title><author><name sortKey="Ademiluyi, Adedayo O" sort="Ademiluyi, Adedayo O" uniqKey="Ademiluyi A" first="Adedayo O." last="Ademiluyi">Adedayo O. Ademiluyi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Oboh, Ganiyu" sort="Oboh, Ganiyu" uniqKey="Oboh G" first="Ganiyu" last="Oboh">Ganiyu Oboh</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Agbebi, Oluwaseun J" sort="Agbebi, Oluwaseun J" uniqKey="Agbebi O" first="Oluwaseun J." last="Agbebi">Oluwaseun J. Agbebi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Boligon, Aline A" sort="Boligon, Aline A" uniqKey="Boligon A" first="Aline A." last="Boligon">Aline A. Boligon</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Athayde, Margareth L" sort="Athayde, Margareth L" uniqKey="Athayde M" first="Margareth L." last="Athayde">Margareth L. Athayde</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25133450</idno><idno type="pmc">4259168</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259168</idno><idno type="RBID">PMC:4259168</idno><idno type="doi">10.1089/jmf.2013.0013</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000316</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000316</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sorghum [<italic>Sorghum bicolor</italic> (L.) Moench] Leaf Sheath Dye Protects Against Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Rats</title><author><name sortKey="Ademiluyi, Adedayo O" sort="Ademiluyi, Adedayo O" uniqKey="Ademiluyi A" first="Adedayo O." last="Ademiluyi">Adedayo O. Ademiluyi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Oboh, Ganiyu" sort="Oboh, Ganiyu" uniqKey="Oboh G" first="Ganiyu" last="Oboh">Ganiyu Oboh</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Agbebi, Oluwaseun J" sort="Agbebi, Oluwaseun J" uniqKey="Agbebi O" first="Oluwaseun J." last="Agbebi">Oluwaseun J. Agbebi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Boligon, Aline A" sort="Boligon, Aline A" uniqKey="Boligon A" first="Aline A." last="Boligon">Aline A. Boligon</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Athayde, Margareth L" sort="Athayde, Margareth L" uniqKey="Athayde M" first="Margareth L." last="Athayde">Margareth L. Athayde</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Medicinal Food</title><idno type="ISSN">1096-620X</idno><idno type="eISSN">1557-7600</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>This study sought to determine the protective effect of dietary inclusion of sorghum leaf sheath dye on cisplatin-induced hepatotoxicity and oxidative stress in rats. Adult male rats were randomly divided into four groups with six animals in each group. Groups I and II were fed a basal diet, while groups III and IV were fed diets containing 0.5% and 1% sorghum leaf sheath dye, respectively, for 20 days before cisplatin administration. Hepatotoxicity was induced by a single dose of cisplatin (7 mg/kg body weight, i.p.), and the experiment was terminated at 3 days after cisplatin injection. The liver and plasma were studied for hepatotoxicity and antioxidant capacity. Cisplatin caused a significant (<italic>P<</italic>.05) alteration in plasma and liver enzymatic (catalase, glutathione-<italic>S</italic>-transferase [GST], and superoxide dismutase [SOD]) and nonenzymatic (glutathione [GSH] and vitamin C) antioxidant indices with a concomitant increase in the malondialdehyde (MDA) content; however, there was a significant (<italic>P</italic><.05) restoration of the antioxidant status coupled with a significant (<italic>P</italic><.05) decrease in the tissue MDA content, after consumption of diets containing sorghum leaf sheath dye. Furthermore, dietary inclusion of sorghum leaf sheath dye caused a marked reduction in the activities of alanine aminotransferase and aspartate aminotransferase after cisplatin administration. However, the ability of the dye to prevent significant cisplatin-induced alteration of both plasma and liver antioxidant indices suggests an antioxidant mechanism of action. Hence, this protective effect of <italic>Sorghum bicolor</italic> leaf sheath dye against cisplatin-induced hepatotoxicity in rats reflects its potential and beneficial role in the prevention of liver damage associated with cisplatin administration.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Food</journal-id><journal-id journal-id-type="iso-abbrev">J Med Food</journal-id><journal-id journal-id-type="publisher-id">jmf</journal-id><journal-title-group><journal-title>Journal of Medicinal Food</journal-title></journal-title-group><issn pub-type="ppub">1096-620X</issn><issn pub-type="epub">1557-7600</issn><publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25133450</article-id><article-id pub-id-type="pmc">4259168</article-id><article-id pub-id-type="publisher-id">10.1089/jmf.2013.0013</article-id><article-id pub-id-type="doi">10.1089/jmf.2013.0013</article-id><article-categories><subj-group subj-group-type="heading"><subject>Full Communications</subject></subj-group></article-categories><title-group><article-title>Sorghum [<italic>Sorghum bicolor</italic> (L.) Moench] Leaf Sheath Dye Protects Against Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Rats</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Ademiluyi</surname><given-names>Adedayo O.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Oboh</surname><given-names>Ganiyu</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Agbebi</surname><given-names>Oluwaseun J.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boligon</surname><given-names>Aline A.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Athayde</surname><given-names>Margareth L.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><aff id="aff1"><label><sup>1</sup></label>Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry,<institution>Federal University of Technology</institution>, Akure,<country>Nigeria</country>.</aff><aff id="aff2"><label><sup>2</sup></label>Program of Post-Graduation in Pharmaceutical Sciences,<institution>Federal University of Santa Maria</institution>, Santa Maria, Rio Grande do Sul,<country>Brazil</country>.</aff></contrib-group><author-notes><corresp><italic>Address correspondence to: Adedayo Oluwaseun Ademiluyi, PhD, Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry,</italic><institution><italic>Federal University of Technology,</italic></institution><italic>Akure, PMB 704, Akure 340001,</italic><country>Nigeria,</country><italic>E-mail:</italic><email xlink:href="mailto:ademiluyidayo@yahoo.co.uk">ademiluyidayo@yahoo.co.uk</email><italic>or</italic><email xlink:href="mailto:aoademiluyi@futa.edu.ng">aoademiluyi@futa.edu.ng</email></corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>12</month><year>2014</year><pmc-comment>string-date: December 2014</pmc-comment>
</pub-date><volume>17</volume><issue>12</issue><fpage>1332</fpage><lpage>1338</lpage><history><date date-type="received"><day>01</day><month>6</month><year>2013</year><pmc-comment>string-date: Manuscript received 1 June 2013</pmc-comment>
</date><date date-type="accepted"><day>12</day><month>6</month><year>2014</year><pmc-comment>string-date: Revision accepted 12 June 2014</pmc-comment>
</date></history><permissions><copyright-statement>Copyright 2014, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="jmf.2013.0013.pdf"></self-uri><abstract><title>Abstract</title><p>This study sought to determine the protective effect of dietary inclusion of sorghum leaf sheath dye on cisplatin-induced hepatotoxicity and oxidative stress in rats. Adult male rats were randomly divided into four groups with six animals in each group. Groups I and II were fed a basal diet, while groups III and IV were fed diets containing 0.5% and 1% sorghum leaf sheath dye, respectively, for 20 days before cisplatin administration. Hepatotoxicity was induced by a single dose of cisplatin (7 mg/kg body weight, i.p.), and the experiment was terminated at 3 days after cisplatin injection. The liver and plasma were studied for hepatotoxicity and antioxidant capacity. Cisplatin caused a significant (<italic>P<</italic>.05) alteration in plasma and liver enzymatic (catalase, glutathione-<italic>S</italic>-transferase [GST], and superoxide dismutase [SOD]) and nonenzymatic (glutathione [GSH] and vitamin C) antioxidant indices with a concomitant increase in the malondialdehyde (MDA) content; however, there was a significant (<italic>P</italic><.05) restoration of the antioxidant status coupled with a significant (<italic>P</italic><.05) decrease in the tissue MDA content, after consumption of diets containing sorghum leaf sheath dye. Furthermore, dietary inclusion of sorghum leaf sheath dye caused a marked reduction in the activities of alanine aminotransferase and aspartate aminotransferase after cisplatin administration. However, the ability of the dye to prevent significant cisplatin-induced alteration of both plasma and liver antioxidant indices suggests an antioxidant mechanism of action. Hence, this protective effect of <italic>Sorghum bicolor</italic> leaf sheath dye against cisplatin-induced hepatotoxicity in rats reflects its potential and beneficial role in the prevention of liver damage associated with cisplatin administration.</p></abstract><kwd-group kwd-group-type="author"><title><bold>Key Words:</bold> </title><kwd><italic>anthocyanin</italic></kwd><kwd><italic>antioxidants</italic></kwd><kwd><italic>cis-dichlorodiammineplatinum (II) (CDDP)</italic></kwd><kwd><italic>liver damage</italic></kwd><kwd><italic>oxidative stress</italic></kwd><kwd><italic>red dye</italic></kwd><kwd><italic>Sorghum bicolor (L.) Moench</italic></kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="2"></table-count><ref-count count="52"></ref-count><page-count count="7"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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