Genotoxicity in wood mice (Apodemus sylvaticus) along a pollution gradient: Exposure‐, age‐, and gender‐related effects
Identifieur interne : 000772 ( Istex/Curation ); précédent : 000771; suivant : 000773Genotoxicity in wood mice (Apodemus sylvaticus) along a pollution gradient: Exposure‐, age‐, and gender‐related effects
Auteurs : Jan Scheirs [Belgique] ; An De Coen [Belgique] ; Adrian Covaci [Belgique] ; Joke Beernaert [Belgique] ; Valentine Mubiana Kayawe [Belgique] ; Mercè Caturla [Belgique] ; Hans De Wolf [Belgique] ; Philippe Baert [Belgique] ; Patrick Van Oostveldt [Belgique] ; Ron Verhagen [Belgique] ; Ronny Blust [Belgique] ; Wim De Coen [Belgique]Source :
- Environmental Toxicology and Chemistry [ 0730-7268 ] ; 2006-08.
English descriptors
Abstract
We investigated the effects of environmental pollution on genetic damage in wood mice (Apodemus sylvaticus) by means of the comet assay, with special attention to the role of age and gender as potential confounding variables. The present study was carried out at four sites along a pollution gradient in the vicinity of Antwerp (Belgium), with a nonferrous smelter as the main pollution source. We measured the concentration of heavy metals (Cd, Co, Cr, Cu, Fe, Mn, Pb, and Zn) in mouse liver and kidney and the concentration of organochlorine compounds (polychlorinated biphenyls and 1,1‐dichloro‐2,2‐bis(p‐chlorophenyl)ethylene) in mouse muscle tissue to assess individual exposure. Cadmium exposure was very high at the sites closest to the smelter, and exposure to this metal decreased with increasing distance from the smelter. Exposure to the other pollutants was low to moderate at the different sites. Genetic damage was higher in mice from populations in the vicinity of the nonferrous smelter compared with that in the control populations. A significant increase in genetic damage with age was observed at the most polluted sites, but not at the control sites. Genetic damage was higher in male mice than in female mice at the most polluted site, but not at the other areas. Yet, no obvious relationship was found between individual pollutant levels and individual genetic damage levels. We conclude that the comet assay can be used to compare genotoxicity at the population level if the confounding variables of gender and age are taken into account. However, its use for individual health risk assessment remains questionable.
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DOI: 10.1897/05-419R.1
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Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biology, Evolutionary Biology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Kayawe, Valentine Mubiana" sort="Kayawe, Valentine Mubiana" uniqKey="Kayawe V" first="Valentine Mubiana" last="Kayawe">Valentine Mubiana Kayawe</name><affiliation wicri:level="1"><mods:affiliation>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Caturla, Merce" sort="Caturla, Merce" uniqKey="Caturla M" first="Mercè" last="Caturla">Mercè Caturla</name><affiliation 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last="Verhagen">Ron Verhagen</name><affiliation wicri:level="1"><mods:affiliation>Department of Biology, Evolutionary Biology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biology, Evolutionary Biology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Blust, Ronny" sort="Blust, Ronny" uniqKey="Blust R" first="Ronny" last="Blust">Ronny Blust</name><affiliation wicri:level="1"><mods:affiliation>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="De Coen, Wim" sort="De Coen, Wim" uniqKey="De Coen W" first="Wim" last="De Coen">Wim De Coen</name><affiliation wicri:level="1"><mods:affiliation>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C57F092ABB6ADBC76A0E479C63E668E113F6E5E4</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1897/05-419R.1</idno><idno type="url">https://api.istex.fr/document/C57F092ABB6ADBC76A0E479C63E668E113F6E5E4/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B84</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B84</idno><idno type="wicri:Area/Istex/Curation">000772</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Genotoxicity in wood mice (Apodemus sylvaticus) along a pollution gradient: Exposure‐, age‐, and gender‐related effects</title><author><name sortKey="Scheirs, Jan" sort="Scheirs, Jan" uniqKey="Scheirs J" first="Jan" last="Scheirs">Jan Scheirs</name><affiliation wicri:level="1"><mods:affiliation>Department of Biology, Evolutionary Biology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biology, Evolutionary Biology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="De Coen, An" sort="De Coen, An" uniqKey="De Coen A" first="An" last="De Coen">An De Coen</name><affiliation wicri:level="1"><mods:affiliation>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Covaci, Adrian" sort="Covaci, Adrian" uniqKey="Covaci A" first="Adrian" last="Covaci">Adrian Covaci</name><affiliation wicri:level="1"><mods:affiliation>Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk</wicri:regionArea></affiliation></author><author><name sortKey="Beernaert, Joke" sort="Beernaert, Joke" uniqKey="Beernaert J" first="Joke" last="Beernaert">Joke Beernaert</name><affiliation wicri:level="1"><mods:affiliation>Department of Biology, Evolutionary Biology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biology, Evolutionary Biology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Kayawe, Valentine Mubiana" sort="Kayawe, Valentine Mubiana" uniqKey="Kayawe V" first="Valentine Mubiana" last="Kayawe">Valentine Mubiana Kayawe</name><affiliation wicri:level="1"><mods:affiliation>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Caturla, Merce" sort="Caturla, Merce" uniqKey="Caturla M" first="Mercè" last="Caturla">Mercè Caturla</name><affiliation wicri:level="1"><mods:affiliation>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="De Wolf, Hans" sort="De Wolf, Hans" uniqKey="De Wolf H" first="Hans" last="De Wolf">Hans De Wolf</name><affiliation wicri:level="1"><mods:affiliation>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Baert, Philippe" sort="Baert, Philippe" uniqKey="Baert P" first="Philippe" last="Baert">Philippe Baert</name><affiliation wicri:level="1"><mods:affiliation>Biochemistry and Molecular Cytology, University of Ghent, Coupure links 653, 9000 Gent, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Biochemistry and Molecular Cytology, University of Ghent, Coupure links 653, 9000 Gent</wicri:regionArea></affiliation></author><author><name sortKey="Van Oostveldt, Patrick" sort="Van Oostveldt, Patrick" uniqKey="Van Oostveldt P" first="Patrick" last="Van Oostveldt">Patrick Van Oostveldt</name><affiliation wicri:level="1"><mods:affiliation>Biochemistry and Molecular Cytology, University of Ghent, Coupure links 653, 9000 Gent, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Biochemistry and Molecular Cytology, University of Ghent, Coupure links 653, 9000 Gent</wicri:regionArea></affiliation></author><author><name sortKey="Verhagen, Ron" sort="Verhagen, Ron" uniqKey="Verhagen R" first="Ron" last="Verhagen">Ron Verhagen</name><affiliation wicri:level="1"><mods:affiliation>Department of Biology, Evolutionary Biology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biology, Evolutionary Biology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Blust, Ronny" sort="Blust, Ronny" uniqKey="Blust R" first="Ronny" last="Blust">Ronny Blust</name><affiliation wicri:level="1"><mods:affiliation>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="De Coen, Wim" sort="De Coen, Wim" uniqKey="De Coen W" first="Wim" last="De Coen">Wim De Coen</name><affiliation wicri:level="1"><mods:affiliation>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ecophysiology, Biochemistry, and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Environmental Toxicology and Chemistry</title><title level="j" type="sub">An International Journal</title><title level="j" type="abbrev">Environmental Toxicology and Chemistry</title><idno type="ISSN">0730-7268</idno><idno type="eISSN">1552-8618</idno><imprint><publisher>Wiley Periodicals, Inc.</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-08">2006-08</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="2154">2154</biblScope><biblScope unit="page" to="2162">2162</biblScope></imprint><idno type="ISSN">0730-7268</idno></series><idno type="istex">C57F092ABB6ADBC76A0E479C63E668E113F6E5E4</idno><idno type="DOI">10.1897/05-419R.1</idno><idno type="ArticleID">ETC5620250824</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0730-7268</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apodemus sylvaticus</term><term>Comet assay</term><term>DNA damage</term><term>Heavy metals</term><term>Organochlorine compounds</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the effects of environmental pollution on genetic damage in wood mice (Apodemus sylvaticus) by means of the comet assay, with special attention to the role of age and gender as potential confounding variables. The present study was carried out at four sites along a pollution gradient in the vicinity of Antwerp (Belgium), with a nonferrous smelter as the main pollution source. We measured the concentration of heavy metals (Cd, Co, Cr, Cu, Fe, Mn, Pb, and Zn) in mouse liver and kidney and the concentration of organochlorine compounds (polychlorinated biphenyls and 1,1‐dichloro‐2,2‐bis(p‐chlorophenyl)ethylene) in mouse muscle tissue to assess individual exposure. Cadmium exposure was very high at the sites closest to the smelter, and exposure to this metal decreased with increasing distance from the smelter. Exposure to the other pollutants was low to moderate at the different sites. Genetic damage was higher in mice from populations in the vicinity of the nonferrous smelter compared with that in the control populations. A significant increase in genetic damage with age was observed at the most polluted sites, but not at the control sites. Genetic damage was higher in male mice than in female mice at the most polluted site, but not at the other areas. Yet, no obvious relationship was found between individual pollutant levels and individual genetic damage levels. We conclude that the comet assay can be used to compare genotoxicity at the population level if the confounding variables of gender and age are taken into account. However, its use for individual health risk assessment remains questionable.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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