Drug use in children: cohort study in three European countries
Identifieur interne : 000E07 ( Istex/Checkpoint ); précédent : 000E06; suivant : 000E08Drug use in children: cohort study in three European countries
Auteurs : Miriam C J M. Sturkenboom [Pays-Bas] ; Katia M C. Verhamme [Pays-Bas] ; Alfredo Nicolosi [Italie, États-Unis] ; Macey L. Murray ; Antje Neubert ; Daan Caudri [Pays-Bas] ; Gino Picelli [Italie] ; Elif Fatma Sen [Pays-Bas] ; Carlo Giaquinto [Italie] ; Luigi Cantarutti [Italie] ; Paola Baiardi [Italie] ; Maria-Grazia Felisi [Italie] ; Adriana Ceci [Italie] ; Ian C K. WongSource :
- BMJ [ 0959-8138 ] ; 2008.
Abstract
Objective To provide an overview of drug use in children in three European countries. Design Retrospective cohort study, 2000-5. Setting Primary care research databases in the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet). Participants 675 868 children aged up to 14 (Italy) or 18 (UK and Netherlands). Main outcome measure Prevalence of use per year calculated by drug class (anatomical and therapeutic). Prevalence of “recurrent/chronic” use (three or more prescriptions a year) and “non-recurrent” or “acute” use (less than three prescriptions a year) within each therapeutic class. Descriptions of the top five most commonly used drugs evaluated for off label status within each anatomical class. Results Three levels of drug use could be distinguished in the study population: high (>10/100 children per year), moderate (1-10/100 children per year), and low (<1/100 children per year). For all age categories, anti-infective, dermatological, and respiratory drugs were in the high use group, whereas cardiovascular and antineoplastic drugs were always in the low use group. Emollients, topical steroids, and asthma drugs had the highest prevalence of recurrent use, but relative use of low prevalence drugs was more often recurrent than acute. In the top five highest prevalence drugs topical inhaled and systemic steroids, oral contraceptives, and topical or systemic antifungal drugs were most commonly used off label. Conclusion This overview of outpatient paediatric prescription patterns in a large European population could provide information to prioritise paediatric therapeutic research needs.
Url:
DOI: 10.1136/bmj.a2245
Affiliations:
- Italie, Pays-Bas, États-Unis
- Hollande-Méridionale, Lombardie, État de New York
- Milan, New York, Rotterdam
- Université Columbia
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Wong</name><affiliation><wicri:noCountry code="subField">1AX</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">BMJ</title><title level="j" type="abbrev">BMJ</title><idno type="ISSN">0959-8138</idno><idno type="eISSN">1468-5833</idno><imprint><publisher>British Medical Journal Publishing Group</publisher><date type="published" when="2008">2008</date><biblScope unit="volume">337</biblScope></imprint><idno type="ISSN">0959-8138</idno></series><idno type="istex">1875612FEB7E6F371BD0A200D80D6C7A3CAA3B59</idno><idno type="DOI">10.1136/bmj.a2245</idno><idno type="href">bmj-337-bmj-a2245.pdf</idno><idno type="ArticleID">stum531863</idno><idno type="PMID">19029175</idno><idno type="local">bmj;337/nov24_2/a2245</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-8138</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective To provide an overview of drug use in children in three European countries. Design Retrospective cohort study, 2000-5. Setting Primary care research databases in the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet). Participants 675 868 children aged up to 14 (Italy) or 18 (UK and Netherlands). Main outcome measure Prevalence of use per year calculated by drug class (anatomical and therapeutic). Prevalence of “recurrent/chronic” use (three or more prescriptions a year) and “non-recurrent” or “acute” use (less than three prescriptions a year) within each therapeutic class. Descriptions of the top five most commonly used drugs evaluated for off label status within each anatomical class. Results Three levels of drug use could be distinguished in the study population: high (>10/100 children per year), moderate (1-10/100 children per year), and low (<1/100 children per year). For all age categories, anti-infective, dermatological, and respiratory drugs were in the high use group, whereas cardiovascular and antineoplastic drugs were always in the low use group. Emollients, topical steroids, and asthma drugs had the highest prevalence of recurrent use, but relative use of low prevalence drugs was more often recurrent than acute. In the top five highest prevalence drugs topical inhaled and systemic steroids, oral contraceptives, and topical or systemic antifungal drugs were most commonly used off label. Conclusion This overview of outpatient paediatric prescription patterns in a large European population could provide information to prioritise paediatric therapeutic research needs.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Hollande-Méridionale</li><li>Lombardie</li><li>État de New York</li></region><settlement><li>Milan</li><li>New York</li><li>Rotterdam</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><noCountry><name sortKey="Murray, Macey L" sort="Murray, Macey L" uniqKey="Murray M" first="Macey L" last="Murray">Macey L. Murray</name><name sortKey="Neubert, Antje" sort="Neubert, Antje" uniqKey="Neubert A" first="Antje" last="Neubert">Antje Neubert</name><name sortKey="Wong, Ian C K" sort="Wong, Ian C K" uniqKey="Wong I" first="Ian C K" last="Wong">Ian C K. Wong</name></noCountry><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Sturkenboom, Miriam C J M" sort="Sturkenboom, Miriam C J M" uniqKey="Sturkenboom M" first="Miriam C J M" last="Sturkenboom">Miriam C J M. Sturkenboom</name></region><name sortKey="Caudri, Daan" sort="Caudri, Daan" uniqKey="Caudri D" first="Daan" last="Caudri">Daan Caudri</name><name sortKey="Sen, Elif Fatma" sort="Sen, Elif Fatma" uniqKey="Sen E" first="Elif Fatma" last="Sen">Elif Fatma Sen</name><name sortKey="Sturkenboom, Miriam C J M" sort="Sturkenboom, Miriam C J M" uniqKey="Sturkenboom M" first="Miriam C J M" last="Sturkenboom">Miriam C J M. Sturkenboom</name><name sortKey="Sturkenboom, Miriam C J M" sort="Sturkenboom, Miriam C J M" uniqKey="Sturkenboom M" first="Miriam C J M" last="Sturkenboom">Miriam C J M. Sturkenboom</name><name sortKey="Verhamme, Katia M C" sort="Verhamme, Katia M C" uniqKey="Verhamme K" first="Katia M C" last="Verhamme">Katia M C. Verhamme</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Nicolosi, Alfredo" sort="Nicolosi, Alfredo" uniqKey="Nicolosi A" first="Alfredo" last="Nicolosi">Alfredo Nicolosi</name></region><name sortKey="Baiardi, Paola" sort="Baiardi, Paola" uniqKey="Baiardi P" first="Paola" last="Baiardi">Paola Baiardi</name><name sortKey="Cantarutti, Luigi" sort="Cantarutti, Luigi" uniqKey="Cantarutti L" first="Luigi" last="Cantarutti">Luigi Cantarutti</name><name sortKey="Ceci, Adriana" sort="Ceci, Adriana" uniqKey="Ceci A" first="Adriana" last="Ceci">Adriana Ceci</name><name sortKey="Felisi, Maria Grazia" sort="Felisi, Maria Grazia" uniqKey="Felisi M" first="Maria-Grazia" last="Felisi">Maria-Grazia Felisi</name><name sortKey="Giaquinto, Carlo" sort="Giaquinto, Carlo" uniqKey="Giaquinto C" first="Carlo" last="Giaquinto">Carlo Giaquinto</name><name sortKey="Picelli, Gino" sort="Picelli, Gino" uniqKey="Picelli G" first="Gino" last="Picelli">Gino Picelli</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Nicolosi, Alfredo" sort="Nicolosi, Alfredo" uniqKey="Nicolosi A" first="Alfredo" last="Nicolosi">Alfredo Nicolosi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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