Subthalamic nucleus deep brain stimulation improves somatosensory function in Parkinson's disease.
Identifieur interne : 000812 ( PubMed/Corpus ); précédent : 000811; suivant : 000813Subthalamic nucleus deep brain stimulation improves somatosensory function in Parkinson's disease.
Auteurs : Joshua E. Aman ; Aviva Abosch ; Maggie Bebler ; Chia-Hao Lu ; Jürgen KonczakSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Deep Brain Stimulation (methods), Female, Functional Laterality, Hand (innervation), Humans, Logistic Models, Male, Middle Aged, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Perception (physiology), Psychomotor Performance, Psychophysics, Somatosensory Disorders (diagnosis), Somatosensory Disorders (etiology), Subthalamic Nucleus (physiology), Touch (physiology), Verbal Behavior.
- MESH :
- diagnosis : Somatosensory Disorders.
- etiology : Somatosensory Disorders.
- innervation : Hand.
- methods : Deep Brain Stimulation.
- physiology : Perception, Subthalamic Nucleus, Touch.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Adult, Aged, Female, Functional Laterality, Humans, Logistic Models, Male, Middle Aged, Psychomotor Performance, Psychophysics, Verbal Behavior.
Abstract
An established treatment for the motor symptoms of Parkinson's disease (PD) is deep brain stimulation (DBS) of the subthalamic nucleus (STN). Mounting evidence suggests that PD is also associated with somatosensory deficits, yet the effect of STN-DBS on somatosensory processing is largely unknown. This study investigated whether STN-DBS affects somatosensory processing, specifically the processing of tactile and proprioceptive cues, by systematically examining the accuracy of haptic perception of object size. (Haptic perception refers to one's ability to extract object features such as shape and size by active touch.) Without vision, 13 PD patients with implanted STN-DBS and 13 healthy controls haptically explored the heights of 2 successively presented 3-dimensional (3D) blocks using a precision grip. Participants verbally indicated which block was taller and then used their nonprobing hand to motorically match the perceived size of the comparison block. Patients were tested during ON and OFF stimulation, following a 12-hour medication washout period. First, when compared to controls, the PD group's haptic discrimination threshold during OFF stimulation was elevated by 192% and mean hand aperture error was increased by 105%. Second, DBS lowered the haptic discrimination threshold by 26% and aperture error decreased by 20%. Third, during DBS ON, probing with the motorically more affected hand decreased haptic precision compared to probing with the less affected hand. This study offers the first evidence that STN-DBS improves haptic precision, further indicating that somatosensory function is improved by STN-DBS. We conclude that DBS-related improvements are not explained by improvements in motor function alone, but rather by enhanced somatosensory processing.
DOI: 10.1002/mds.25731
PubMed: 24243788
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pubmed:24243788Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus deep brain stimulation improves somatosensory function in Parkinson's disease.</title><author><name sortKey="Aman, Joshua E" sort="Aman, Joshua E" uniqKey="Aman J" first="Joshua E" last="Aman">Joshua E. Aman</name><affiliation><nlm:affiliation>Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, Minnesota, USA; Center for Clinical Movement Science, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name></author><author><name sortKey="Bebler, Maggie" sort="Bebler, Maggie" uniqKey="Bebler M" first="Maggie" last="Bebler">Maggie Bebler</name></author><author><name sortKey="Lu, Chia Hao" sort="Lu, Chia Hao" uniqKey="Lu C" first="Chia-Hao" last="Lu">Chia-Hao Lu</name></author><author><name sortKey="Konczak, Jurgen" sort="Konczak, Jurgen" uniqKey="Konczak J" first="Jürgen" last="Konczak">Jürgen Konczak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24243788</idno><idno type="pmid">24243788</idno><idno type="doi">10.1002/mds.25731</idno><idno type="wicri:Area/PubMed/Corpus">000812</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic nucleus deep brain stimulation improves somatosensory function in Parkinson's disease.</title><author><name sortKey="Aman, Joshua E" sort="Aman, Joshua E" uniqKey="Aman J" first="Joshua E" last="Aman">Joshua E. Aman</name><affiliation><nlm:affiliation>Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, Minnesota, USA; Center for Clinical Movement Science, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name></author><author><name sortKey="Bebler, Maggie" sort="Bebler, Maggie" uniqKey="Bebler M" first="Maggie" last="Bebler">Maggie Bebler</name></author><author><name sortKey="Lu, Chia Hao" sort="Lu, Chia Hao" uniqKey="Lu C" first="Chia-Hao" last="Lu">Chia-Hao Lu</name></author><author><name sortKey="Konczak, Jurgen" sort="Konczak, Jurgen" uniqKey="Konczak J" first="Jürgen" last="Konczak">Jürgen Konczak</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Functional Laterality</term><term>Hand (innervation)</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Perception (physiology)</term><term>Psychomotor Performance</term><term>Psychophysics</term><term>Somatosensory Disorders (diagnosis)</term><term>Somatosensory Disorders (etiology)</term><term>Subthalamic Nucleus (physiology)</term><term>Touch (physiology)</term><term>Verbal Behavior</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Somatosensory Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Somatosensory Disorders</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Hand</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Perception</term><term>Subthalamic Nucleus</term><term>Touch</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Psychomotor Performance</term><term>Psychophysics</term><term>Verbal Behavior</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An established treatment for the motor symptoms of Parkinson's disease (PD) is deep brain stimulation (DBS) of the subthalamic nucleus (STN). Mounting evidence suggests that PD is also associated with somatosensory deficits, yet the effect of STN-DBS on somatosensory processing is largely unknown. This study investigated whether STN-DBS affects somatosensory processing, specifically the processing of tactile and proprioceptive cues, by systematically examining the accuracy of haptic perception of object size. (Haptic perception refers to one's ability to extract object features such as shape and size by active touch.) Without vision, 13 PD patients with implanted STN-DBS and 13 healthy controls haptically explored the heights of 2 successively presented 3-dimensional (3D) blocks using a precision grip. Participants verbally indicated which block was taller and then used their nonprobing hand to motorically match the perceived size of the comparison block. Patients were tested during ON and OFF stimulation, following a 12-hour medication washout period. First, when compared to controls, the PD group's haptic discrimination threshold during OFF stimulation was elevated by 192% and mean hand aperture error was increased by 105%. Second, DBS lowered the haptic discrimination threshold by 26% and aperture error decreased by 20%. Third, during DBS ON, probing with the motorically more affected hand decreased haptic precision compared to probing with the less affected hand. This study offers the first evidence that STN-DBS improves haptic precision, further indicating that somatosensory function is improved by STN-DBS. We conclude that DBS-related improvements are not explained by improvements in motor function alone, but rather by enhanced somatosensory processing.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24243788</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>04</Day></DateCreated><DateCompleted><Year>2014</Year><Month>10</Month><Day>29</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>2</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Subthalamic nucleus deep brain stimulation improves somatosensory function in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>221-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25731</ELocationID><Abstract><AbstractText>An established treatment for the motor symptoms of Parkinson's disease (PD) is deep brain stimulation (DBS) of the subthalamic nucleus (STN). Mounting evidence suggests that PD is also associated with somatosensory deficits, yet the effect of STN-DBS on somatosensory processing is largely unknown. This study investigated whether STN-DBS affects somatosensory processing, specifically the processing of tactile and proprioceptive cues, by systematically examining the accuracy of haptic perception of object size. (Haptic perception refers to one's ability to extract object features such as shape and size by active touch.) Without vision, 13 PD patients with implanted STN-DBS and 13 healthy controls haptically explored the heights of 2 successively presented 3-dimensional (3D) blocks using a precision grip. Participants verbally indicated which block was taller and then used their nonprobing hand to motorically match the perceived size of the comparison block. Patients were tested during ON and OFF stimulation, following a 12-hour medication washout period. First, when compared to controls, the PD group's haptic discrimination threshold during OFF stimulation was elevated by 192% and mean hand aperture error was increased by 105%. Second, DBS lowered the haptic discrimination threshold by 26% and aperture error decreased by 20%. Third, during DBS ON, probing with the motorically more affected hand decreased haptic precision compared to probing with the less affected hand. This study offers the first evidence that STN-DBS improves haptic precision, further indicating that somatosensory function is improved by STN-DBS. We conclude that DBS-related improvements are not explained by improvements in motor function alone, but rather by enhanced somatosensory processing.</AbstractText><CopyrightInformation>© 2013 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aman</LastName><ForeName>Joshua E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, Minnesota, USA; Center for Clinical Movement Science, University of Minnesota, Minneapolis, Minnesota, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abosch</LastName><ForeName>Aviva</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Bebler</LastName><ForeName>Maggie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Chia-Hao</ForeName><Initials>CH</Initials></Author><Author ValidYN="Y"><LastName>Konczak</LastName><ForeName>Jürgen</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>11</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D046690">Deep Brain Stimulation</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006225">Hand</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016015">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010465">Perception</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011597">Psychomotor Performance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011601">Psychophysics</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020886">Somatosensory Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020531">Subthalamic Nucleus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014110">Touch</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014705">Verbal Behavior</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DBS</Keyword><Keyword MajorTopicYN="N">STN</Keyword><Keyword MajorTopicYN="N">basal ganglia</Keyword><Keyword MajorTopicYN="N">deep brain stimulation</Keyword><Keyword MajorTopicYN="N">haptic perception</Keyword><Keyword MajorTopicYN="N">human</Keyword><Keyword MajorTopicYN="N">sensorimotor</Keyword><Keyword MajorTopicYN="N">somatosensory</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>3</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>8</Month><Day>30</Day></PubMedPubDate><PubMedPubDate 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