Towards a User-Friendly Brain-Computer Interface: Initial Tests in ALS and PLS Patients
Identifieur interne : 000E83 ( Pmc/Curation ); précédent : 000E82; suivant : 000E84Towards a User-Friendly Brain-Computer Interface: Initial Tests in ALS and PLS Patients
Auteurs : Ou Bai [États-Unis] ; Peter Lin [États-Unis] ; Dandan Huang [États-Unis] ; Ding-Yu Fei [États-Unis] ; Mary Kay Floeter [États-Unis]Source :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [ 1388-2457 ] ; 2010.
Abstract
Patients usually require long-term training for effective EEG-based brain-computer interface (BCI) control due to fatigue caused by the demands for focused attention during prolonged BCI operation. We intended to develop a user-friendly BCI requiring minimal training and less mental load.
Testing of BCI performance was investigated in three patients with amyotrophic lateral sclerosis (ALS) and three patients with primary lateral sclerosis (PLS), who had no previous BCI experience. All patients performed binary control of cursor movement. One ALS patient and one PLS patient performed four-directional cursor control in a two-dimensional domain under a BCI paradigm associated with human natural motor behavior using motor execution and motor imagery. Subjects practiced for 5-10 minutes and then participated in a multi-session study of either binary control or four-directional control including online BCI game over 1.5 – 2 hours in a single visit.
Event-related desynchronization and event-related synchronization in the beta band were observed in all patients during the production of voluntary movement either by motor execution or motor imagery. The online binary control of cursor movement was achieved with an average accuracy about 82.1±8.2% with motor execution and about 80% with motor imagery, whereas offline accuracy was achieved with 91.4±3.4% with motor execution and 83.3±8.9% with motor imagery after optimization. In addition, four-directional cursor control was achieved with an accuracy of 50-60% with motor execution and motor imagery.
Patients with ALS or PLS may achieve BCI control without extended training, and fatigue might be reduced during operation of a BCI associated with human natural motor behavior.
The development of a user-friendly BCI will promote practical BCI applications in paralyzed patients.
Url:
DOI: 10.1016/j.clinph.2010.02.157
PubMed: 20347612
PubMed Central: 2895010
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Patients usually require long-term training for effective EEG-based brain-computer interface (BCI) control due to fatigue caused by the demands for focused attention during prolonged BCI operation. We intended to develop a user-friendly BCI requiring minimal training and less mental load.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Testing of BCI performance was investigated in three patients with amyotrophic lateral sclerosis (ALS) and three patients with primary lateral sclerosis (PLS), who had no previous BCI experience. All patients performed binary control of cursor movement. One ALS patient and one PLS patient performed four-directional cursor control in a two-dimensional domain under a BCI paradigm associated with human natural motor behavior using motor execution and motor imagery. Subjects practiced for 5-10 minutes and then participated in a multi-session study of either binary control or four-directional control including online BCI game over 1.5 – 2 hours in a single visit.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Event-related desynchronization and event-related synchronization in the beta band were observed in all patients during the production of voluntary movement either by motor execution or motor imagery. The online binary control of cursor movement was achieved with an average accuracy about 82.1±8.2% with motor execution and about 80% with motor imagery, whereas offline accuracy was achieved with 91.4±3.4% with motor execution and 83.3±8.9% with motor imagery after optimization. In addition, four-directional cursor control was achieved with an accuracy of 50-60% with motor execution and motor imagery.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Patients with ALS or PLS may achieve BCI control without extended training, and fatigue might be reduced during operation of a BCI associated with human natural motor behavior.</p>
</sec>
<sec id="S5"><title>Significance</title>
<p id="P5">The development of a user-friendly BCI will promote practical BCI applications in paralyzed patients.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100883319</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21365</journal-id>
<journal-id journal-id-type="nlm-ta">Clin Neurophysiol</journal-id>
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<article-id pub-id-type="manuscript">NIHMS185609</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Towards a User-Friendly Brain-Computer Interface: Initial Tests in ALS and PLS Patients</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bai</surname>
<given-names>Ou</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lin</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Dandan</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fei</surname>
<given-names>Ding-Yu</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Floeter</surname>
<given-names>Mary Kay</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
EEG & BCI Laboratory, Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA</aff>
<aff id="A2"><label>2</label>
Department of Neurology, Santa Clara Valley Medical Center, San Jose, CA 95128, USA</aff>
<aff id="A3"><label>3</label>
Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA</aff>
<aff id="A4"><label>4</label>
EMG Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA</aff>
<author-notes><corresp id="CR1"><label>*</label>
Correspondence to: 401 West Main Street, Room 1252 Richmond, VA 23284-3067 TEL: (804) 827-3607 FAX: (804) 828-4454 <email>obai@vcu.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>15</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>8</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>8</month>
<year>2011</year>
</pub-date>
<volume>121</volume>
<issue>8</issue>
<fpage>1293</fpage>
<lpage>1303</lpage>
<permissions><copyright-statement>© 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Objective</title>
<p id="P1">Patients usually require long-term training for effective EEG-based brain-computer interface (BCI) control due to fatigue caused by the demands for focused attention during prolonged BCI operation. We intended to develop a user-friendly BCI requiring minimal training and less mental load.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Testing of BCI performance was investigated in three patients with amyotrophic lateral sclerosis (ALS) and three patients with primary lateral sclerosis (PLS), who had no previous BCI experience. All patients performed binary control of cursor movement. One ALS patient and one PLS patient performed four-directional cursor control in a two-dimensional domain under a BCI paradigm associated with human natural motor behavior using motor execution and motor imagery. Subjects practiced for 5-10 minutes and then participated in a multi-session study of either binary control or four-directional control including online BCI game over 1.5 – 2 hours in a single visit.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Event-related desynchronization and event-related synchronization in the beta band were observed in all patients during the production of voluntary movement either by motor execution or motor imagery. The online binary control of cursor movement was achieved with an average accuracy about 82.1±8.2% with motor execution and about 80% with motor imagery, whereas offline accuracy was achieved with 91.4±3.4% with motor execution and 83.3±8.9% with motor imagery after optimization. In addition, four-directional cursor control was achieved with an accuracy of 50-60% with motor execution and motor imagery.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Patients with ALS or PLS may achieve BCI control without extended training, and fatigue might be reduced during operation of a BCI associated with human natural motor behavior.</p>
</sec>
<sec id="S5"><title>Significance</title>
<p id="P5">The development of a user-friendly BCI will promote practical BCI applications in paralyzed patients.</p>
</sec>
</abstract>
<kwd-group><kwd>EEG</kwd>
<kwd>brain-computer interface (BCI)</kwd>
<kwd>event-related desynchronization (ERD)</kwd>
<kwd>event-related synchronization (ERS)</kwd>
<kwd>user-friendly</kwd>
<kwd>amyotrophic lateral sclerosis (ALS)</kwd>
<kwd>primary lateral sclerosis (PLS)</kwd>
<kwd>motor control</kwd>
</kwd-group>
<contract-num rid="NS1">ZIA NS002976-11
||NS</contract-num>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>
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