Is impaired set-shifting an endophenotype of anorexia nervosa?
Identifieur interne : 000B12 ( PascalFrancis/Checkpoint ); précédent : 000B11; suivant : 000B13Is impaired set-shifting an endophenotype of anorexia nervosa?
Auteurs : Joanna Holliday [Royaume-Uni] ; Kate Tchanturia ; Sabine Landau ; David Collier ; Janet TreasureSource :
- The American journal of psychiatry [ 0002-953X ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Anorexie mentale, Aigu, Rémission, Etude comparative, Fratrie, Aptitude intellectuelle, Flexibilité intellectuelle, Traitement information, Fonction exécutive, Neuropsychologie, Cognition, Marqueur biologique, Génétique, Déterminisme génétique, Etude familiale, Etude multicentrique, Femelle, Homme, Endophénotype, Parenté premier degré.
- Wicri :
English descriptors
- KwdEn :
- Acute, Anorexia nervosa, Biological marker, Cognition, Comparative study, Endophenotype, Executive function, Family study, Female, First degree relatives, Genetic determinism, Genetics, Human, Information processing, Intellectual ability, Intellectual flexibility, Multicenter study, Neuropsychologia, Remission, Sibling.
Abstract
Objective: Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance. Method: Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N= 23) anorexia nervosa were compared to assess state versus trait effects. Results: Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures. Conclusions: Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:06-0356604Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Is impaired set-shifting an endophenotype of anorexia nervosa?</title><author><name sortKey="Holliday, Joanna" sort="Holliday, Joanna" uniqKey="Holliday J" first="Joanna" last="Holliday">Joanna Holliday</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Psychological Medicine, the Social, Genetic and Developmental Psychiatry Research Centre, and the Department of Biostatistics and Computing, Institute of Psychiatry, King's College London (KCL)</s1><s2>London</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>KCL Department of Academic Psychiatry, Guy's, King's and St. Thomas's Medical School</s1><s2>London</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tchanturia, Kate" sort="Tchanturia, Kate" uniqKey="Tchanturia K" first="Kate" last="Tchanturia">Kate Tchanturia</name></author><author><name sortKey="Landau, Sabine" sort="Landau, Sabine" uniqKey="Landau S" first="Sabine" last="Landau">Sabine Landau</name></author><author><name sortKey="Collier, David" sort="Collier, David" uniqKey="Collier D" first="David" last="Collier">David Collier</name></author><author><name sortKey="Treasure, Janet" sort="Treasure, Janet" uniqKey="Treasure J" first="Janet" last="Treasure">Janet Treasure</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0356604</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 06-0356604 INIST</idno><idno type="RBID">Pascal:06-0356604</idno><idno type="wicri:Area/PascalFrancis/Corpus">000C83</idno><idno type="wicri:Area/PascalFrancis/Curation">000823</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Is impaired set-shifting an endophenotype of anorexia nervosa?</title><author><name sortKey="Holliday, Joanna" sort="Holliday, Joanna" uniqKey="Holliday J" first="Joanna" last="Holliday">Joanna Holliday</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Psychological Medicine, the Social, Genetic and Developmental Psychiatry Research Centre, and the Department of Biostatistics and Computing, Institute of Psychiatry, King's College London (KCL)</s1><s2>London</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>KCL Department of Academic Psychiatry, Guy's, King's and St. Thomas's Medical School</s1><s2>London</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tchanturia, Kate" sort="Tchanturia, Kate" uniqKey="Tchanturia K" first="Kate" last="Tchanturia">Kate Tchanturia</name></author><author><name sortKey="Landau, Sabine" sort="Landau, Sabine" uniqKey="Landau S" first="Sabine" last="Landau">Sabine Landau</name></author><author><name sortKey="Collier, David" sort="Collier, David" uniqKey="Collier D" first="David" last="Collier">David Collier</name></author><author><name sortKey="Treasure, Janet" sort="Treasure, Janet" uniqKey="Treasure J" first="Janet" last="Treasure">Janet Treasure</name></author></analytic><series><title level="j" type="main">The American journal of psychiatry</title><title level="j" type="abbreviated">Am. j. psychiatr.</title><idno type="ISSN">0002-953X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The American journal of psychiatry</title><title level="j" type="abbreviated">Am. j. psychiatr.</title><idno type="ISSN">0002-953X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term><term>Anorexia nervosa</term><term>Biological marker</term><term>Cognition</term><term>Comparative study</term><term>Endophenotype</term><term>Executive function</term><term>Family study</term><term>Female</term><term>First degree relatives</term><term>Genetic determinism</term><term>Genetics</term><term>Human</term><term>Information processing</term><term>Intellectual ability</term><term>Intellectual flexibility</term><term>Multicenter study</term><term>Neuropsychologia</term><term>Remission</term><term>Sibling</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anorexie mentale</term><term>Aigu</term><term>Rémission</term><term>Etude comparative</term><term>Fratrie</term><term>Aptitude intellectuelle</term><term>Flexibilité intellectuelle</term><term>Traitement information</term><term>Fonction exécutive</term><term>Neuropsychologie</term><term>Cognition</term><term>Marqueur biologique</term><term>Génétique</term><term>Déterminisme génétique</term><term>Etude familiale</term><term>Etude multicentrique</term><term>Femelle</term><term>Homme</term><term>Endophénotype</term><term>Parenté premier degré</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance. Method: Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N= 23) anorexia nervosa were compared to assess state versus trait effects. Results: Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures. Conclusions: Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0002-953X</s0></fA01><fA02 i1="01"><s0>AJPSAO</s0></fA02><fA03 i2="1"><s0>Am. j. psychiatr.</s0></fA03><fA05><s2>162</s2></fA05><fA06><s2>12</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Is impaired set-shifting an endophenotype of anorexia nervosa?</s1></fA08><fA11 i1="01" i2="1"><s1>HOLLIDAY (Joanna)</s1></fA11><fA11 i1="02" i2="1"><s1>TCHANTURIA (Kate)</s1></fA11><fA11 i1="03" i2="1"><s1>LANDAU (Sabine)</s1></fA11><fA11 i1="04" i2="1"><s1>COLLIER (David)</s1></fA11><fA11 i1="05" i2="1"><s1>TREASURE (Janet)</s1></fA11><fA14 i1="01"><s1>Division of Psychological Medicine, the Social, Genetic and Developmental Psychiatry Research Centre, and the Department of Biostatistics and Computing, Institute of Psychiatry, King's College London (KCL)</s1><s2>London</s2><s3>GBR</s3></fA14><fA14 i1="02"><s1>KCL Department of Academic Psychiatry, Guy's, King's and St. Thomas's Medical School</s1><s2>London</s2><s3>GBR</s3></fA14><fA20><s1>2269-2275</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>3283</s2><s5>354000134431150070</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>35 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0356604</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>The American journal of psychiatry</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Objective: Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance. Method: Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N= 23) anorexia nervosa were compared to assess state versus trait effects. Results: Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures. Conclusions: Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.</s0></fC01><fC02 i1="01" i2="X"><s0>002B18C01A</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Anorexie mentale</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Anorexia nervosa</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Anorexia mental</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Aigu</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Acute</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Agudo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Rémission</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Remission</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Remisión</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Etude comparative</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Comparative study</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Estudio comparativo</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Fratrie</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Sibling</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hermandad</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Aptitude intellectuelle</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Intellectual ability</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Aptitud intelectual</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Flexibilité intellectuelle</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Intellectual flexibility</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Flexibilidad intelectual</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Traitement information</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Information processing</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Procesamiento información</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Fonction exécutive</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Executive function</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Función ejecutiva</s0><s5>09</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Neuropsychologie</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Neuropsychologia</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Neurosicología</s0><s5>10</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Cognition</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Cognition</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Cognición</s0><s5>11</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Marqueur biologique</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Biological marker</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Marcador biológico</s0><s5>12</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Génétique</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Genetics</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Genética</s0><s5>13</s5></fC03><fC03 i1="14" i2="X" l="FRE"><s0>Déterminisme génétique</s0><s5>17</s5></fC03><fC03 i1="14" i2="X" l="ENG"><s0>Genetic determinism</s0><s5>17</s5></fC03><fC03 i1="14" i2="X" l="SPA"><s0>Determinismo genético</s0><s5>17</s5></fC03><fC03 i1="15" i2="X" l="FRE"><s0>Etude familiale</s0><s5>18</s5></fC03><fC03 i1="15" i2="X" l="ENG"><s0>Family study</s0><s5>18</s5></fC03><fC03 i1="15" i2="X" l="SPA"><s0>Estudio familiar</s0><s5>18</s5></fC03><fC03 i1="16" i2="X" l="FRE"><s0>Etude multicentrique</s0><s5>19</s5></fC03><fC03 i1="16" i2="X" l="ENG"><s0>Multicenter study</s0><s5>19</s5></fC03><fC03 i1="16" i2="X" l="SPA"><s0>Estudio multicéntrico</s0><s5>19</s5></fC03><fC03 i1="17" i2="X" l="FRE"><s0>Femelle</s0><s5>20</s5></fC03><fC03 i1="17" i2="X" l="ENG"><s0>Female</s0><s5>20</s5></fC03><fC03 i1="17" i2="X" l="SPA"><s0>Hembra</s0><s5>20</s5></fC03><fC03 i1="18" i2="X" l="FRE"><s0>Homme</s0><s5>21</s5></fC03><fC03 i1="18" i2="X" l="ENG"><s0>Human</s0><s5>21</s5></fC03><fC03 i1="18" i2="X" l="SPA"><s0>Hombre</s0><s5>21</s5></fC03><fC03 i1="19" i2="X" l="FRE"><s0>Endophénotype</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="19" i2="X" l="ENG"><s0>Endophenotype</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="20" i2="X" l="FRE"><s0>Parenté premier degré</s0><s4>CD</s4><s5>97</s5></fC03><fC03 i1="20" i2="X" l="ENG"><s0>First degree relatives</s0><s4>CD</s4><s5>97</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Trouble comportement alimentaire</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Eating disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Trastorno conducta alimentaria</s0><s5>37</s5></fC07><fN21><s1>240</s1></fN21><fN44 i1="01"><s1>PSI</s1></fN44><fN82><s1>PSI</s1></fN82></pA></standard></inist><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Collier, David" sort="Collier, David" uniqKey="Collier D" first="David" last="Collier">David Collier</name><name sortKey="Landau, Sabine" sort="Landau, Sabine" uniqKey="Landau S" first="Sabine" last="Landau">Sabine Landau</name><name sortKey="Tchanturia, Kate" sort="Tchanturia, Kate" uniqKey="Tchanturia K" first="Kate" last="Tchanturia">Kate Tchanturia</name><name sortKey="Treasure, Janet" sort="Treasure, Janet" uniqKey="Treasure J" first="Janet" last="Treasure">Janet Treasure</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Holliday, Joanna" sort="Holliday, Joanna" uniqKey="Holliday J" first="Joanna" last="Holliday">Joanna Holliday</name></region><name sortKey="Holliday, Joanna" sort="Holliday, Joanna" uniqKey="Holliday J" first="Joanna" last="Holliday">Joanna Holliday</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B12 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000B12 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= HapticV1
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:06-0356604
|texte= Is impaired set-shifting an endophenotype of anorexia nervosa?
}}
| This area was generated with Dilib version V0.6.23. |  |