HapticV1, PascalFrancis, Corpus, bibRecord, 000C83

Is impaired set-shifting an endophenotype of anorexia nervosa?

Identifieur interne : 000C83 ( PascalFrancis/Corpus ); précédent : 000C82; suivant : 000C84

Is impaired set-shifting an endophenotype of anorexia nervosa?

Auteurs : Joanna Holliday ; Kate Tchanturia ; Sabine Landau ; David Collier ; Janet Treasure

Source :

The American journal of psychiatry [ 0002-953X ] ; 2005.

RBID : Pascal:06-0356604

Descripteurs français

Pascal (Inist)
- Anorexie mentale, Aigu, Rémission, Etude comparative, Fratrie, Aptitude intellectuelle, Flexibilité intellectuelle, Traitement information, Fonction exécutive, Neuropsychologie, Cognition, Marqueur biologique, Génétique, Déterminisme génétique, Etude familiale, Etude multicentrique, Femelle, Homme, Endophénotype, Parenté premier degré.

English descriptors

KwdEn :
- Acute, Anorexia nervosa, Biological marker, Cognition, Comparative study, Endophenotype, Executive function, Family study, Female, First degree relatives, Genetic determinism, Genetics, Human, Information processing, Intellectual ability, Intellectual flexibility, Multicenter study, Neuropsychologia, Remission, Sibling.

Abstract

Objective: Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance. Method: Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N= 23) anorexia nervosa were compared to assess state versus trait effects. Results: Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures. Conclusions: Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`04`	`1`		`@1 COLLIER (David)`
A11	`05`	`1`		`@1 TREASURE (Janet)`
A14	`01`			`@1 Division of Psychological Medicine, the Social, Genetic and Developmental Psychiatry Research Centre, and the Department of Biostatistics and Computing, Institute of Psychiatry, King's College London (KCL) @2 London @3 GBR`
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C01	`01`		`ENG`	@0 Objective: Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance. Method: Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N= 23) anorexia nervosa were compared to assess state versus trait effects. Results: Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures. Conclusions: Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.
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Format Inist (serveur)

NO :	PASCAL 06-0356604 INIST
ET :	Is impaired set-shifting an endophenotype of anorexia nervosa?
AU :	HOLLIDAY (Joanna); TCHANTURIA (Kate); LANDAU (Sabine); COLLIER (David); TREASURE (Janet)
AF :	Division of Psychological Medicine, the Social, Genetic and Developmental Psychiatry Research Centre, and the Department of Biostatistics and Computing, Institute of Psychiatry, King's College London (KCL)/London/Royaume-Uni; KCL Department of Academic Psychiatry, Guy's, King's and St. Thomas's Medical School/London/Royaume-Uni
DT :	Publication en série; Niveau analytique
SO :	The American journal of psychiatry; ISSN 0002-953X; Coden AJPSAO; Etats-Unis; Da. 2005; Vol. 162; No. 12; Pp. 2269-2275; Bibl. 35 ref.
LA :	Anglais
EA :	Objective: Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance. Method: Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N= 23) anorexia nervosa were compared to assess state versus trait effects. Results: Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures. Conclusions: Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.
CC :	002B18C01A
FD :	Anorexie mentale; Aigu; Rémission; Etude comparative; Fratrie; Aptitude intellectuelle; Flexibilité intellectuelle; Traitement information; Fonction exécutive; Neuropsychologie; Cognition; Marqueur biologique; Génétique; Déterminisme génétique; Etude familiale; Etude multicentrique; Femelle; Homme; Endophénotype; Parenté premier degré
FG :	Trouble comportement alimentaire
ED :	Anorexia nervosa; Acute; Remission; Comparative study; Sibling; Intellectual ability; Intellectual flexibility; Information processing; Executive function; Neuropsychologia; Cognition; Biological marker; Genetics; Genetic determinism; Family study; Multicenter study; Female; Human; Endophenotype; First degree relatives
EG :	Eating disorder
SD :	Anorexia mental; Agudo; Remisión; Estudio comparativo; Hermandad; Aptitud intelectual; Flexibilidad intelectual; Procesamiento información; Función ejecutiva; Neurosicología; Cognición; Marcador biológico; Genética; Determinismo genético; Estudio familiar; Estudio multicéntrico; Hembra; Hombre
LO :	INIST-3283.354000134431150070
ID :	06-0356604

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Pascal:06-0356604

Le document en format XML

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<front><div type="abstract" xml:lang="en">Objective: Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance. Method: Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N= 23) anorexia nervosa were compared to assess state versus trait effects. Results: Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures. Conclusions: Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.</div>
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<fC01 i1="01" l="ENG"><s0>Objective: Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance. Method: Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N= 23) anorexia nervosa were compared to assess state versus trait effects. Results: Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures. Conclusions: Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.</s0>
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<s5>02</s5>
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<s5>03</s5>
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<s5>96</s5>
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<server><NO>PASCAL 06-0356604 INIST</NO>
<ET>Is impaired set-shifting an endophenotype of anorexia nervosa?</ET>
<AU>HOLLIDAY (Joanna); TCHANTURIA (Kate); LANDAU (Sabine); COLLIER (David); TREASURE (Janet)</AU>
<AF>Division of Psychological Medicine, the Social, Genetic and Developmental Psychiatry Research Centre, and the Department of Biostatistics and Computing, Institute of Psychiatry, King's College London (KCL)/London/Royaume-Uni; KCL Department of Academic Psychiatry, Guy's, King's and St. Thomas's Medical School/London/Royaume-Uni</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The American journal of psychiatry; ISSN 0002-953X; Coden AJPSAO; Etats-Unis; Da. 2005; Vol. 162; No. 12; Pp. 2269-2275; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance. Method: Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N= 23) anorexia nervosa were compared to assess state versus trait effects. Results: Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures. Conclusions: Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.</EA>
<CC>002B18C01A</CC>
<FD>Anorexie mentale; Aigu; Rémission; Etude comparative; Fratrie; Aptitude intellectuelle; Flexibilité intellectuelle; Traitement information; Fonction exécutive; Neuropsychologie; Cognition; Marqueur biologique; Génétique; Déterminisme génétique; Etude familiale; Etude multicentrique; Femelle; Homme; Endophénotype; Parenté premier degré</FD>
<FG>Trouble comportement alimentaire</FG>
<ED>Anorexia nervosa; Acute; Remission; Comparative study; Sibling; Intellectual ability; Intellectual flexibility; Information processing; Executive function; Neuropsychologia; Cognition; Biological marker; Genetics; Genetic determinism; Family study; Multicenter study; Female; Human; Endophenotype; First degree relatives</ED>
<EG>Eating disorder</EG>
<SD>Anorexia mental; Agudo; Remisión; Estudio comparativo; Hermandad; Aptitud intelectual; Flexibilidad intelectual; Procesamiento información; Función ejecutiva; Neurosicología; Cognición; Marcador biológico; Genética; Determinismo genético; Estudio familiar; Estudio multicéntrico; Hembra; Hombre</SD>
<LO>INIST-3283.354000134431150070</LO>
<ID>06-0356604</ID>
</server>
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Is impaired set-shifting an endophenotype of anorexia nervosa?

Is impaired set-shifting an endophenotype of anorexia nervosa?

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