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Occlusive IOLs for Intractable Diplopia Demonstrate a Novel Near-Infrared Window of Transmission for SLO/OCT Imaging and Clinical Assessment

Identifieur interne : 001933 ( Ncbi/Merge ); précédent : 001932; suivant : 001934

Occlusive IOLs for Intractable Diplopia Demonstrate a Novel Near-Infrared Window of Transmission for SLO/OCT Imaging and Clinical Assessment

Auteurs : Imran H. Yusuf ; Stuart N. Peirson ; C. K. Patel

Source :

RBID : PMC:3109049

Abstract

This study identifies an NIR window of transmission across the occlusive intraocular lens (IOL) and scanning laser ophthalmoscopy/optical coherence tomography (SLO/OCT) as the first sensitive posterior segment imaging modality in this patient group. The results may change the view of occlusive IOLs and the management of intractable diplopia.


Url:
DOI: 10.1167/iovs.10-6767
PubMed: 21372014
PubMed Central: 3109049

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PMC:3109049

Le document en format XML

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<name sortKey="Yusuf, Imran H" sort="Yusuf, Imran H" uniqKey="Yusuf I" first="Imran H." last="Yusuf">Imran H. Yusuf</name>
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<name sortKey="Peirson, Stuart N" sort="Peirson, Stuart N" uniqKey="Peirson S" first="Stuart N." last="Peirson">Stuart N. Peirson</name>
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<name sortKey="Patel, C K" sort="Patel, C K" uniqKey="Patel C" first="C. K." last="Patel">C. K. Patel</name>
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<title xml:lang="en" level="a" type="main">Occlusive IOLs for Intractable Diplopia Demonstrate a Novel Near-Infrared Window of Transmission for SLO/OCT Imaging and Clinical Assessment</title>
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<name sortKey="Patel, C K" sort="Patel, C K" uniqKey="Patel C" first="C. K." last="Patel">C. K. Patel</name>
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<title level="j">Investigative Ophthalmology & Visual Science</title>
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<div type="abstract" xml:lang="en">
<p>This study identifies an NIR window of transmission across the occlusive intraocular lens (IOL) and scanning laser ophthalmoscopy/optical coherence tomography (SLO/OCT) as the first sensitive posterior segment imaging modality in this patient group. The results may change the view of occlusive IOLs and the management of intractable diplopia.</p>
</div>
</front>
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<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Invest Ophthalmol Vis Sci</journal-id>
<journal-id journal-id-type="hwp">iovs</journal-id>
<journal-id journal-id-type="pmc">iovs</journal-id>
<journal-id journal-id-type="publisher-id">IOVS</journal-id>
<journal-title-group>
<journal-title>Investigative Ophthalmology & Visual Science</journal-title>
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<issn pub-type="ppub">0146-0404</issn>
<issn pub-type="epub">1552-5783</issn>
<publisher>
<publisher-name>Association for Research in Vision and Ophthalmology, Inc.</publisher-name>
</publisher>
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<article-meta>
<article-id pub-id-type="pmid">21372014</article-id>
<article-id pub-id-type="pmc">3109049</article-id>
<article-id pub-id-type="publisher-id">10-6767</article-id>
<article-id pub-id-type="doi">10.1167/iovs.10-6767</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Articles</subject>
<subj-group>
<subject>Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Occlusive IOLs for Intractable Diplopia Demonstrate a Novel Near-Infrared Window of Transmission for SLO/OCT Imaging and Clinical Assessment</article-title>
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<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Yusuf</surname>
<given-names>Imran H.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
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<contrib contrib-type="author">
<name>
<surname>Peirson</surname>
<given-names>Stuart N.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
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<contrib contrib-type="author" corresp="yes">
<name>
<surname>Patel</surname>
<given-names>C. K.</given-names>
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<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<aff id="aff1">From the
<label>1</label>
Nuffield Laboratory of Ophthalmology and</aff>
<aff id="aff2">the
<label>2</label>
Oxford Eye Hospital, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom.</aff>
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<author-notes>
<corresp>Corresponding author: C. K. Patel,
<addr-line>The Oxford Eye Hospital, West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK</addr-line>
;
<email>ckpatel@btinternet.com</email>
.</corresp>
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<month>5</month>
<year>2011</year>
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<pub-date pub-type="pmc-release">
<day>1</day>
<month>11</month>
<year>2011</year>
</pub-date>
<pmc-comment> PMC Release delay is 6 months and 0 days and was based on the . </pmc-comment>
<volume>52</volume>
<issue>6</issue>
<fpage>3737</fpage>
<lpage>3743</lpage>
<history>
<date date-type="received">
<day>22</day>
<month>10</month>
<year>2010</year>
</date>
<date date-type="rev-recd">
<day>4</day>
<month>1</month>
<year>2011</year>
</date>
<date date-type="rev-recd">
<day>24</day>
<month>1</month>
<year>2011</year>
</date>
<date date-type="accepted">
<day>26</day>
<month>1</month>
<year>2011</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © Association for Research in Vision and Ophthalmology</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="z7g00611003737.pdf"></self-uri>
<abstract abstract-type="precis">
<p>This study identifies an NIR window of transmission across the occlusive intraocular lens (IOL) and scanning laser ophthalmoscopy/optical coherence tomography (SLO/OCT) as the first sensitive posterior segment imaging modality in this patient group. The results may change the view of occlusive IOLs and the management of intractable diplopia.</p>
</abstract>
<abstract>
<sec>
<title>Purpose.</title>
<p>Occlusive intraocular lens (IOL) implantation is an effective therapeutic option in patients with intractable diplopia, visual confusion, and unsightly leukocoria. However, their use has been restricted by concerns that inability to visualize the retina may prevent the diagnosis of important posterior pole diseases. In this study, transmission spectra of occlusive IOLs were defined as a basis for acquiring scanning laser ophthalmoscopy/optical coherence tomography (SLO/OCT) images.</p>
</sec>
<sec>
<title>Methods.</title>
<p>Fifteen IOLs of three designs were examined: black small and large PMMA and black Lotus (Morcher GmbH, Stuttgart, Germany). Each IOL was placed between a broad-spectrum white light source and a spectroradiometer, to generate transmission spectra for each lens and determine the cutoff wavelength. Transmission in the near-infrared (NIR) range was confirmed with an 850-nm LED. A model eye was implanted with occlusive IOLs, and SLO/OCT scans were acquired with seven clinical SLO/OCT imaging systems.</p>
</sec>
<sec>
<title>Results.</title>
<p>Occlusive IOLs demonstrated high levels of transmission of NIR light. It was determined that most SLO/OCT scanners would achieve 99% to 100% transmission at their operational wavelengths of NIR light. Furthermore, all clinical SLO/OCT imaging systems were capable of imaging fine retinal features without attenuation through occlusive IOLs in a model eye.</p>
</sec>
<sec>
<title>Conclusions.</title>
<p>In this study, a novel NIR window of high-level transmission was identified across the occlusive IOLs with applications to SLO/OCT imaging and NIR-based clinical assessment. The ability to acquire high-quality SLO/OCT scans to detect posterior pole disease may fundamentally change the current view on occlusive IOLs and encourage their use in patients with intractable diplopia.</p>
</sec>
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<name sortKey="Yusuf, Imran H" sort="Yusuf, Imran H" uniqKey="Yusuf I" first="Imran H." last="Yusuf">Imran H. Yusuf</name>
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