Neural correlates of multi-sensory cue integration in macaque area MSTd
Identifieur interne : 000F15 ( Ncbi/Merge ); précédent : 000F14; suivant : 000F16Neural correlates of multi-sensory cue integration in macaque area MSTd
Auteurs : Yong Gu [États-Unis] ; Dora E. Angelaki [États-Unis] ; Gregory C. Deangelis [États-Unis]Source :
- Nature neuroscience [ 1097-6256 ] ; 2008.
Abstract
Human observers combine multiple sensory cues synergistically to achieve greater perceptual sensitivity, but little is known about the underlying neuronal mechanisms. We recorded from neurons in the dorsal medial superior temporal area (MSTd) during a task in which trained monkeys combine visual and vestibular cues near optimally to discriminate heading. During bimodal stimulation, MSTd neurons combine visual and vestibular inputs linearly with sub-additive weights. Neurons with congruent heading preferences for visual and vestibular stimuli show improvements in sensitivity that parallel behavioral effects. In contrast, neurons with opposite preferences show diminished sensitivity under cue combination. Responses of congruent cells are more strongly correlated with monkeys' perceptual decisions than opposite cells, suggesting that the animal monitors the activity of congruent cells to a greater extent during cue integration. These findings demonstrate perceptual cue integration in non-human primates and identify a population of neurons that may form its neural basis.
Url:
DOI: 10.1038/nn.2191
PubMed: 18776893
PubMed Central: 2713666
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Angelaki</name><affiliation wicri:level="2"><nlm:aff id="A1">Department. of Anatomy & Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department. of Anatomy & Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Deangelis, Gregory C" sort="Deangelis, Gregory C" uniqKey="Deangelis G" first="Gregory C." last="Deangelis">Gregory C. Deangelis</name><affiliation wicri:level="2"><nlm:aff id="A1">Department. of Anatomy & Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department. of Anatomy & Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Brain and Cognitive Sciences, Center for Visual Science, University of Rochester, 245 Meliora Hall, Rochester NY 14627 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Brain and Cognitive Sciences, Center for Visual Science, University of Rochester, 245 Meliora Hall</wicri:cityArea></affiliation></author></analytic><series><title level="j">Nature neuroscience</title><idno type="ISSN">1097-6256</idno><idno type="eISSN">1546-1726</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Human observers combine multiple sensory cues synergistically to achieve greater perceptual sensitivity, but little is known about the underlying neuronal mechanisms. We recorded from neurons in the dorsal medial superior temporal area (MSTd) during a task in which trained monkeys combine visual and vestibular cues near optimally to discriminate heading. During bimodal stimulation, MSTd neurons combine visual and vestibular inputs linearly with sub-additive weights. Neurons with congruent heading preferences for visual and vestibular stimuli show improvements in sensitivity that parallel behavioral effects. In contrast, neurons with opposite preferences show diminished sensitivity under cue combination. Responses of congruent cells are more strongly correlated with monkeys' perceptual decisions than opposite cells, suggesting that the animal monitors the activity of congruent cells to a greater extent during cue integration. These findings demonstrate perceptual cue integration in non-human primates and identify a population of neurons that may form its neural basis.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9809671</journal-id><journal-id journal-id-type="pubmed-jr-id">21092</journal-id><journal-id journal-id-type="nlm-ta">Nat Neurosci</journal-id><journal-title>Nature neuroscience</journal-title><issn pub-type="ppub">1097-6256</issn><issn pub-type="epub">1546-1726</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18776893</article-id><article-id pub-id-type="pmc">2713666</article-id><article-id pub-id-type="doi">10.1038/nn.2191</article-id><article-id pub-id-type="manuscript">NIHMS118545</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Neural correlates of multi-sensory cue integration in macaque area MSTd</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gu</surname><given-names>Yong</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Angelaki</surname><given-names>Dora E.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>DeAngelis</surname><given-names>Gregory C.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department. of Anatomy & Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110 USA</aff><aff id="A2"><label>2</label>Department of Brain and Cognitive Sciences, Center for Visual Science, University of Rochester, 245 Meliora Hall, Rochester NY 14627 USA</aff><author-notes><corresp id="cor1">Address for correspondence: Gregory C. DeAngelis, Professor of Brain and Cognitive Sciences, Center for Visual Science, University of Rochester, 245 Meliora Hall, Rochester, NY 14627, Office Phone: (585)275-8677, FAX: (585)271-3043, Email: <email>gdeangelis@cvs.rochester.edu</email></corresp><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">equal author contributions</p></fn><fn id="FN2"><p id="P2"><bold>Author contributions</bold>: G.Y, D.E.A. and G.C.D. designed the experiments; G.Y. collected the data and performed data analyses; G.Y, D.E.A. and G.C.D. refined the analyses and wrote the paper.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>5</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>7</day><month>9</month><year>2008</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>10</month><year>2009</year></pub-date><volume>11</volume><issue>10</issue><fpage>1201</fpage><lpage>1210</lpage><related-article journal-id-type="nlm-ta" journal-id="Nat Neurosci" related-article-type="commentary" page="1121" id="N0x1c1f520N0x28b1d68" xlink:href="18818590" ext-link-type="pubmed" vol="11"></related-article><abstract><p id="P3">Human observers combine multiple sensory cues synergistically to achieve greater perceptual sensitivity, but little is known about the underlying neuronal mechanisms. We recorded from neurons in the dorsal medial superior temporal area (MSTd) during a task in which trained monkeys combine visual and vestibular cues near optimally to discriminate heading. During bimodal stimulation, MSTd neurons combine visual and vestibular inputs linearly with sub-additive weights. Neurons with congruent heading preferences for visual and vestibular stimuli show improvements in sensitivity that parallel behavioral effects. In contrast, neurons with opposite preferences show diminished sensitivity under cue combination. Responses of congruent cells are more strongly correlated with monkeys' perceptual decisions than opposite cells, suggesting that the animal monitors the activity of congruent cells to a greater extent during cue integration. These findings demonstrate perceptual cue integration in non-human primates and identify a population of neurons that may form its neural basis.</p></abstract><contract-num rid="EY1">R01 EY017866-03</contract-num><contract-num rid="EY1">R01 EY016178-04</contract-num><contract-sponsor id="EY1">National Eye Institute : NEI</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Missouri (État)</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Gu, Yong" sort="Gu, Yong" uniqKey="Gu Y" first="Yong" last="Gu">Yong Gu</name></region><name sortKey="Angelaki, Dora E" sort="Angelaki, Dora E" uniqKey="Angelaki D" first="Dora E." last="Angelaki">Dora E. Angelaki</name><name sortKey="Deangelis, Gregory C" sort="Deangelis, Gregory C" uniqKey="Deangelis G" first="Gregory C." last="Deangelis">Gregory C. Deangelis</name><name sortKey="Deangelis, Gregory C" sort="Deangelis, Gregory C" uniqKey="Deangelis G" first="Gregory C." last="Deangelis">Gregory C. Deangelis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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