Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2
Identifieur interne : 003235 ( Ncbi/Curation ); précédent : 003234; suivant : 003236Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2
Auteurs : Adam B. Goldring [États-Unis] ; Dylan F. Cooke [États-Unis] ; Mary K. L. Baldwin [États-Unis] ; Gregg H. Recanzone [États-Unis] ; Adam G. Gordon [États-Unis] ; Tingrui Pan [États-Unis] ; Scott I. Simon [États-Unis] ; Leah Krubitzer [États-Unis]Source :
- Journal of Neurophysiology [ 0022-3077 ] ; 2014.
Abstract
The role that posterior parietal (PPC) and motor cortices play in modulating neural responses in somatosensory areas 1 and 2 was examined with reversible deactivation by transient cooling. Multiunit recordings from neurons in areas 1 and 2 were collected from six anesthetized adult monkeys (
Url:
DOI: 10.1152/jn.00141.2014
PubMed: 25143537
PubMed Central: 4233279
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<front><div type="abstract" xml:lang="en"><p>The role that posterior parietal (PPC) and motor cortices play in modulating neural responses in somatosensory areas 1 and 2 was examined with reversible deactivation by transient cooling. Multiunit recordings from neurons in areas 1 and 2 were collected from six anesthetized adult monkeys (<italic>Macaca mulatta</italic>
) before, during, and after reversible deactivation of areas 5L or 7b or motor cortex (M1/PM), while select locations on the hand and forelimb were stimulated. Response changes were quantified as increases and decreases to stimulus-driven activity relative to baseline and analyzed during three recording epochs: during deactivation (“cool”) and at two time points after deactivation (“rewarm 1,” “rewarm 2”). Although the type of response change observed was variable, for neurons at the recording sites tested >90% exhibited a significant change in response during cooling of 7b while cooling area 5L or M1/PM produced a change in 75% and 64% of sites, respectively. These results suggest that regions in the PPC, and to a lesser extent motor cortex, shape the response characteristics of neurons in areas 1 and 2 and that this kind of feedback modulation is necessary for normal somatosensory processing. Furthermore, this modulation appears to happen on a minute-by-minute basis and may serve as the substrate for phenomena such as somatosensory attention.</p>
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